Other members of the Mucositis Guidelines Leadership Group of the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO) are: Noor Al-Dasooqi, PhD; Michael Brennan, DDS, MHS; Rachel Gibson, PhD; Janet Fulton, PhD, RN; Ian Hewson, BDS; Siri B. Jensen, DDS, PhD; Richard Logan, BDS, MDS, PhD; Kerstin E.O. Öhrn, PhD, RDH; Triantafyllia Sarri, DDS, MSc; Deborah Saunders, DDS; Inger von Bültzingslöwen, DDS, PhD; and Noam Yarom, DMD.
MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy
Article first published online: 25 FEB 2014
© 2014 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Volume 120, Issue 10, pages 1453–1461, 15 May 2014
How to Cite
Lalla, R. V., Bowen, J., Barasch, A., Elting, L., Epstein, J., Keefe, D. M., McGuire, D. B., Migliorati, C., Nicolatou-Galitis, O., Peterson, D. E., Raber-Durlacher, J. E., Sonis, S. T., Elad, S. and The Mucositis Guidelines Leadership Group of the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO). (2014), MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer, 120: 1453–1461. doi: 10.1002/cncr.28592
Other contributors to the guidelines update included Justin Allemano, Abdul Rahman Al-Azri, Heliton Spindola Antunes, Anura Ariyawardana, Emma Bateman, Nicole Blijlevens, Christine B. Boers-Doets, Paolo Bossi, Carlton G. Brown, Yu-Chia Chang, Karis K. Cheng, Catherine Cooksley, Elvira P. Correa, Kristopher Dennis, Mario Di Palma, Scott Drucker, June Eilers, Carmen Escalante, Cherry L. Estilo, Hele Everaus, Margot Fijlstra, Monica Fliedner, Annette Freidank, Erich Gerber, Faith Gibson, Jesùs Garcia Gomez, Josiah Halm, Guido Hita, Ronald D. Hutchins, Brian Hodgson, Allan Hovan, Virginia Jarvis, Emily E. King, Vassilios E. Kouloulias, Marie C. Latortue, Judith Lees, Nilza Nelly Fontana Lopes, Charles Loprinzi, Marisol Michelet, Takehiko Mori, Raj G. Nair, Pasquale Niscola, Loree K. Oberle-Edwards, Anthony Osaguona, Pratibha Parelkar, Jumin Park, Ira Parker, Bo G. Pettersson, Carin Potting, Nikhil G. Rao, Dorothea Riesenbeck, Tanya Rouleau, Mark M. Schubert, Sol Silverman Jr, Yoshihiko Soga, Fred K.L. Spijkervet, Monique Stokman, Andrea M. Stringer, Wim J.E. Tissing, Walter J.F.M. van der Velden, Marianne D. van de Wetering, Madhuri Vithala, Dianna S. Weikel, Roger Yazbeck, Eric Yeoh, and Yehuda Zadik.
Disclaimer: The Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO) Mucositis Guidelines are developed to facilitate the evidence-based management of mucositis. However, clinicians should also use their own judgment in making treatment decisions for individual patients. The guideline authors and the MASCC/ISOO do not guarantee or take responsibility for clinical outcomes in individual patients.
These guidelines refer to the use of the listed agents for the specific indication listed (ie, the prevention or treatment of mucositis or related symptoms). These guidelines do not apply to the use of the listed agents for other indications. For example, although it is suggested that chlorhexidine mouthwash not be used to prevent oral mucositis in patients receiving head and neck radiation therapy, clinicians may choose to use this agent for other indications in this or other populations.
- Issue published online: 6 MAY 2014
- Article first published online: 25 FEB 2014
- Manuscript Accepted: 20 DEC 2013
- Manuscript Revised: 21 NOV 2013
- Manuscript Received: 12 SEP 2013
Erratum: Lalla RV, Bowen J, Barasch A, Elting L, Epstein J, Keefe DM, McGuire DB, Migliorati C, Nicolatou-Galitis G, Peterson DE, Raber-Durlacher JE, Sonis ST, Elad S, and the Mucositis Guidelines Leadership Group of the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO). MASCC/ISOO Clinical Practice Guidelines for the Management of Mucositis Secondary to Cancer Therapy. Cancer. 2014;120:1453-1661.
Vol. 121, Issue 8, 1339, Article first published online: 17 DEC 2014
- Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO)
Mucositis is a highly significant, and sometimes dose-limiting, toxicity of cancer therapy. The goal of this systematic review was to update the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO) Clinical Practice Guidelines for mucositis.
A literature search was conducted to identify eligible published articles, based on predefined inclusion/exclusion criteria. Each article was independently reviewed by 2 reviewers. Studies were rated according to the presence of major and minor flaws as per previously published criteria. The body of evidence for each intervention, in each treatment setting, was assigned a level of evidence, based on previously published criteria. Guidelines were developed based on the level of evidence, with 3 possible guideline determinations: recommendation, suggestion, or no guideline possible.
The literature search identified 8279 papers, 1032 of which were retrieved for detailed evaluation based on titles and abstracts. Of these, 570 qualified for final inclusion in the systematic reviews. Sixteen new guidelines were developed for or against the use of various interventions in specific treatment settings. In total, the MASCC/ISOO Mucositis Guidelines now include 32 guidelines: 22 for oral mucositis and 10 for gastrointestinal mucositis. This article describes these updated guidelines.
The updated MASCC/ISOO Clinical Practice Guidelines for mucositis will help clinicians provide evidence-based management of mucositis secondary to cancer therapy. Cancer 2014;120:1453–1461. © 2014 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society.