Striking dichotomy in outcome of MYCN-amplified neuroblastoma in the contemporary era
Article first published online: 1 APR 2014
© 2014 American Cancer Society
Volume 120, Issue 13, pages 2050–2059, 1 July 2014
How to Cite
Kushner, B. H., Modak, S., Kramer, K., LaQuaglia, M. P., Yataghene, K., Basu, E. M., Roberts, S. S. and Cheung, N.-K. V. (2014), Striking dichotomy in outcome of MYCN-amplified neuroblastoma in the contemporary era. Cancer, 120: 2050–2059. doi: 10.1002/cncr.28687
- Issue published online: 17 JUN 2014
- Article first published online: 1 APR 2014
- Manuscript Accepted: 24 FEB 2014
- Manuscript Revised: 21 FEB 2014
- Manuscript Received: 20 NOV 2013
- contemporary therapy;
The authors exploited a large database to investigate the outcomes of patients with high-risk neuroblastoma in the contemporary era.
All patients with high-risk neuroblastoma aged <12 years who were treated during induction at the authors' institution from 2000 through 2011 were studied, including 118 patients with MYCN-amplified [MYCN(+)] disease and 127 patients aged >18 months with MYCN-nonamplified [MYCN(−)] stage 4 disease.
A complete response/very good partial response (CR/VGPR) to induction was correlated with significantly superior event-free survival (EFS) (P < .001) and overall survival (OS) (P < .001) compared with a partial response or less. Patients with MYCN(+) and MYCN(−) disease had similar rates of CR/VGPR to induction (P = .366), and those with MYCN(+) and MYCN(−) disease who attained a CR/VGPR had similar EFS (P = .346) and OS (P = .542). In contrast, only MYCN(+) patients had progressive disease as a response to induction (P < .001), and early death from progressive disease (<366 days after diagnosis) was significantly more common (P < .001) among those with MYCN(+) disease. Overall, among patients who had a partial response or less, MYCN(+) patients had significantly inferior EFS (P < .001) and OS (P < .001) compared with MYCN(−) patients, which accounted for the significantly worse EFS (P = .008) and OS (P = .002) for the entire MYCN(+) cohort versus the MYCN(−) cohort.
Patients with MYCN(−), high-risk neuroblastoma display a broad, continuous spectrum with regard to response and outcome, whereas MYCN(+) patients either have an excellent response to induction associated with good long-term outcome or develop early progressive disease with a poor outcome. This extreme dichotomy in the clinical course of MYCN(+) patients points to underlying biologic differences with MYCN(+) neuroblastoma, the elucidation of which may have far-reaching implications, including improved risk classification at diagnosis and the identification of targets for treatment. Cancer 2014;120:2050–2059. © 2014 American Cancer Society.