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To the authors' knowledge, the 2014 Surgeon General's report “The Health Consequences of Smoking-50 Years of Progress” provides the first large evidence review of the effects of smoking on the outcomes of patients with cancer, concluding that smoking causes adverse health outcomes, increases all-cause mortality, and increases cancer-specific mortality. This causal evidence has profound implications on providing high-quality cancer care by emphasizing the need to address tobacco use in all patients with cancer.