Associations of objectively assessed physical activity and sedentary time with health-related quality of life among colon cancer survivors

Authors

  • Jeff K. Vallance PhD,

    Corresponding author
    1. Faculty of Health Disciplines, Athabasca University, Athabasca, Canada
    • Corresponding author: Jeff Vallance, PhD, Faculty of Health Disciplines, Athabasca University, 1 University Drive, Athabasca, AB, T9S-3A3, Canada; Fax: (403) 488-7182; jeffv@athabascau.ca

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  • Terry Boyle PhD,

    1. Epidemiology Group, Western Australia Institute for Medical Research, The University of Western Australia, Perth, Australia
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  • Kerry S. Courneya PhD,

    1. Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Canada
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  • Brigid M. Lynch PhD

    1. Physical Activity Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    2. Melbourne School of Population and Global Health, The University of Melbourne, Australia
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  • We acknowledge Parneet Sethi and Dr. Elisabeth Winkler for their assistance in data processing and analyses.

Abstract

BACKGROUND

The primary purpose of this study was to determine associations of accelerometer-assessed moderate- to vigorous-intensity physical activity (MVPA) and sedentary time with health-related quality of life (HRQoL) and physical function and well-being in colon cancer survivors.

METHODS

Colon cancer survivors (N = 178) from Alberta, Canada (n = 92) and Western Australia (n = 86) completed a mailed survey that assessed HRQoL (Functional Assessment of Cancer Therapy–Colorectal), physical function and well-being (Trial Outcome Index–Colorectal), and relevant covariates. MVPA and sedentary time were assessed using the Actigraph GT3X+ accelerometer (60-second epochs) via a 7-day monitoring protocol. Average daily MVPA and sedentary time was corrected for wear time and then examined as quartiles.

RESULTS

Adjusting for relevant demographic, behavioral, and clinical covariates, a significant difference in HRQoL scores emerged between quartile 1 (Q1) and Q4 (Mdiff = 11.5, P = .038). For physical function and well-being, a significant difference emerged between Q1 and Q4 (Mdiff = 9.1, P = .009). For fatigue, a significant difference emerged between Q1 and Q4 (Mdiff = 7.1, P = .05). Significant differences were also observed for between Q1 and Q3 (Mdiff = 2.4, P = .041), and Q1 and Q4 (Mdiff = 3.5, P = .002) for colorectal cancer–specific symptoms. There were no statistically significant associations of sedentary time with HRQoL, physical function and well-being, fatigue, or colorectal cancer–specific symptoms.

CONCLUSIONS

Objectively measured MVPA, but not sedentary time, was associated with better HRQoL, physical function and well-being, and colorectal cancer–specific symptoms in colon cancer survivors. For MVPA, differences met or exceeded contemporary cutpoints for determining clinically important differences. Cancer 2014;120:2919–2926. © 2014 American Cancer Society.

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