We thank Barbara Silver and Remi Nout, MD for reviewing the article.
Complications of pelvic radiation in patients treated for gynecologic malignancies
Article first published online: 23 JUL 2014
© 2014 American Cancer Society
Volume 120, Issue 24, pages 3870–3883, December 15, 2014
How to Cite
Viswanathan, A. N., Lee, L. J., Eswara, J. R., Horowitz, N. S., Konstantinopoulos, P. A., Mirabeau-Beale, K. L., Rose, B. S., von Keudell, A. G. and Wo, J. Y. (2014), Complications of pelvic radiation in patients treated for gynecologic malignancies. Cancer, 120: 3870–3883. doi: 10.1002/cncr.28849
- Issue published online: 4 DEC 2014
- Article first published online: 23 JUL 2014
- Manuscript Accepted: 1 MAY 2014
- Manuscript Revised: 30 APR 2014
- Manuscript Received: 28 MAR 2014
- gynecologic cancer
Radiation therapy is a critical treatment modality in the management of patients with gynecologic tumors. New highly conformal external-beam and brachytherapy techniques have led to important reductions in recurrence and patient morbidity and mortality. However, patients who receive pelvic radiation for gynecologic malignancies may experience a unique constellation of toxicity because of the anatomic locations, combination with concurrent chemotherapy and/or surgery, as well as potential surgical interventions. Although side effects are often categorized into acute versus late toxicities, several late toxicities represent continuation and evolution of the same pathologic process. Comorbidities and radiation dose can significantly increase the risk of morbidity. Current understanding of the incidence of various morbidities in patients treated with current radiation techniques for gynecologic malignancies, the impact of chemotherapy and surgery, treatment options for those effects, and future areas of research are highlighted. Cancer 2014;120:3870–3883. © 2014 American Cancer Society.