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Cancer

Cover image for Cancer

15 January 2004

Volume 100, Issue 2

Pages 215–435

  1. Ethics and Law in Oncology

    1. Top of page
    2. Ethics and Law in Oncology
    3. Editorial
    4. Review Articles
    5. Original Articles
    6. Correspondence
    1. You have free access to this content
      A clinically comprehensive ethical framework for offering and recommending cancer treatment before and during pregnancy (pages 215–222)

      Frank A. Chervenak, Laurence B. McCullough, Robert C. Knapp, Thomas A. Caputo and Hugh R. K. Barber

      Version of Record online: 8 DEC 2003 | DOI: 10.1002/cncr.11564

      The authors describe a clinically comprehensive ethical framework for addressing the challenges of managing cancer during pregnancy. The framework is based on the ethical principles of beneficence and respect for autonomy and the concept of the fetus as a patient.

  2. Editorial

    1. Top of page
    2. Ethics and Law in Oncology
    3. Editorial
    4. Review Articles
    5. Original Articles
    6. Correspondence
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      Smoking causes colon carcinoma (pages 223–224)

      Graham A. Colditz and Kathleen P. Yaus

      Version of Record online: 1 DEC 2003 | DOI: 10.1002/cncr.20011

      In the study by Colangelo et. al., the authors reported their findings regarding the correlation between smoking and mortality from colorectal carcinoma in a cohort of 39,299 subjects with an average of 26 years of follow-up. The editorial concludes that smoking causes colon cancer and tobacco control should be the highest public health priority.

      See also pages 288–93.

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      Human papillomavirus infections : Truth or consequences (pages 225–227)

      Bradley J. Monk and Dorothy J. Wiley

      Version of Record online: 1 DEC 2003 | DOI: 10.1002/cncr.20012

      In this issue of Cancer, Anhang et al. present a review of written and verbal media reports that concern human papillomavirus infection, cervical cancer screening, and sexually transmitted infection. Their findings suggest that it is little wonder that the public is informed so inadequately about the virus, the consequences of infection, and the natural history of cervical neoplasia.

      See also pages 308–14.

  3. Review Articles

    1. Top of page
    2. Ethics and Law in Oncology
    3. Editorial
    4. Review Articles
    5. Original Articles
    6. Correspondence
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      Chemotherapy-induced neutropenia : Risks, consequences, and new directions for its management (pages 228–237)

      Jeffrey Crawford, David C. Dale and Gary H. Lyman

      Version of Record online: 12 DEC 2003 | DOI: 10.1002/cncr.11882

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      Neutropenia is the primary dose-limiting toxicity of cancer chemotherapy and is associated with substantial clinical and economic impacts. Accurately predicting the risk of chemotherapy-induced neutropenia in individual patients could prevent neutropenic complications, facilitate delivery of optimal cancer treatment, and improve patient quality of life.

  4. Original Articles

    1. Top of page
    2. Ethics and Law in Oncology
    3. Editorial
    4. Review Articles
    5. Original Articles
    6. Correspondence
    1. Disease Site

      Breast Disease
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      Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project : Twelve-year observations concerning lobular carcinoma in situ (pages 238–244)

      Edwin R. Fisher, Stephanie R. Land, Bernard Fisher, Eleftherios Mamounas, Linda Gilarski and Norman Wolmark

      Version of Record online: 8 DEC 2003 | DOI: 10.1002/cncr.11883

      The authors describe and discuss clinicopathologic features of lobular carcinoma in situ that are related to its natural history, treatment, and outcome.

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      Stereotactic vacuum-assisted breast biopsy in 2874 patients : A multicenter study (pages 245–251)

      Ute Kettritz, Kerstin Rotter, Ingrid Schreer, Margarete Murauer, Rüdiger Schulz-Wendtland, Daniela Peter and Sylvia H. Heywang-Köbrunner

      Version of Record online: 8 DEC 2003 | DOI: 10.1002/cncr.11887

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      The accuracy and clinical utility of vacuum-assisted breast biopsy (VAB) were evaluated in a multicenter setting using a strict quality assurance protocol. VAB was found to be of sufficient sensitivity and specificity to replace surgical biopsy for the diagnosis of breast carcinoma. VAB improved treatment planning for patients with breast carcinoma.

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      Molecular markers for prognosis after isolated postmastectomy chest wall recurrence (pages 252–263)

      Bruce G. Haffty, Analene Hauser, Doo Ho Choi, Nicole Parisot, David Rimm, Bonnie King and Darryl Carter

      Version of Record online: 20 NOV 2003 | DOI: 10.1002/cncr.11915

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      Patients with breast carcinoma who had postmastectomy chest wall recurrences and received full-course external beam radiation therapy were followed for more than 10 years. The authors assessed the prognostic value of molecular markers at the time of local recurrence and compared these markers with clinical variables.

    4. Endocrine Disease
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      Frequency of HLA-C alleles in differentiated thyroid carcinoma in southeastern Spain : HLA-Cw7 as a poor prognosis factor (pages 264–269)

      Antonio Ríos, José Manuel Rodríguez, María Rosa Moya, Pedro José Galindo, Manuel Canteras, María Rocío Alvarez and Pascual Parrilla

      Version of Record online: 20 NOV 2003 | DOI: 10.1002/cncr.11914

      The current study analyzed HLA-C allele frequencies in patients with differentiated thyroid carcinoma (n = 63) using molecular biology techniques. The principal conclusion was that the HLA-Cw7 allele may be able to help to identify patients with differentiated thyroid carcinoma who have a poor prognosis.

    5. Gastrointestinal Tract
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      Elevated perioperative serum vascular endothelial growth factor levels in patients with colon carcinoma (pages 270–278)

      Ferdinando De Vita, Michele Orditura, Eva Lieto, Stefania Infusino, Floriana Morgillo, Erika Martinelli, Paolo Castellano, Ciro Romano, Fortunato Ciardiello, Giuseppe Catalano, Carlo Pignatelli and Gennaro Galizia

      Version of Record online: 12 DEC 2003 | DOI: 10.1002/cncr.11911

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      In this study, high preoperative serum vascular endothelial growth factor levels were associated with poor outcome in patients with colon carcinoma who underwent surgery.

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      Randomized multicenter Phase II trial of two different schedules of irinotecan combined with capecitabine as first-line treatment in metastatic colorectal carcinoma (pages 279–287)

      Emilio Bajetta, Maria Di Bartolomeo, Luigi Mariani, Antonio Cassata, Salvatore Artale, Sergio Frustaci, Graziella Pinotti, Andrea Bonetti, Ignazio Carreca, Guido Biasco, Luigi Bonaglia, Giovanni Marini, Antonio Iannelli, Diego Cortinovis, Ermina Ferrario, Elena Beretta, Antonio Lambiase, Roberto Buzzoni and for the Italian Trials in Medical Oncology (I.T.M.O.) Group

      Version of Record online: 8 DEC 2003 | DOI: 10.1002/cncr.11910

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      The current Phase II study evaluated two different schedules of irinotecan combined with capecitabine as first-line treatment in metastatic colorectal carcinoma. A total of 140 patients were treated and objective responses were observed in 46% of them with an acceptable safety profile.

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      Cigarette smoking and colorectal carcinoma mortality in a cohort with long-term follow-up (pages 288–293)

      Laura A. Colangelo, Susan M. Gapstur, Peter H. Gann and Alan R. Dyer

      Version of Record online: 1 DEC 2003 | DOI: 10.1002/cncr.11923

      The risk of colorectal carcinoma mortality was found to have a marginally significant trend (P = 0.06) for cigarette smoking for men and women combined in multivariate Cox regression analysis. In an age-stratified analysis in the younger patient group (age < 50 years), for women and for men and women combined, there appeared to be dose-response relations (P value for trend = 0.008 and 0.03, respectively) between smoking and colorectal carcinoma mortality.

      See also pages 223–4.

    8. Genitourinary Disease
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      Androgen ablation therapy for prostate carcinoma suppresses the immunoreactive telomerase subunit hTERT (pages 294–299)

      Kenneth A. Iczkowski, Wei Huang, Roberta Mazzucchelli, Cooley G. Pantazis, Gary R. Stevens and Rodolfo Montironi

      Version of Record online: 20 NOV 2003 | DOI: 10.1002/cncr.20002

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      Comparison of prostate carcinoma specimens before and after combined antiandrogen and luteinizing hormone-releasing hormone–analog therapy demonstrated significant declines in the mean telomerase hTERT reactivity in 30 treated men in contrast to control specimens from 30 untreated men. Treatment-induced suppression of telomerase reactivity was maximal in high-grade tumors.

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      Long-term outcomes after radical prostatectomy performed in a community-based health maintenance organization (pages 300–307)

      Ying Zhang M.S., Andrew Glass, Nicole Bennett, Karen A. Oyama, Edmund Gehan and Edward P. Gelmann

      Version of Record online: 20 NOV 2003 | DOI: 10.1002/cncr.11886

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      In reviewing data from 750 patients who underwent radical prostatectomy for localized prostate carcinoma between 1970 and 1996 at their community-based health maintenance organization (HMO), the authors found that radical prostatectomy in an HMO setting produced long-term progression free and overall survival rates comparable to the rates reported by university-based practices and long-term survival similar to the unaffected age-matched population.

    10. Gynecologic Oncology
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      News media coverage of human papillomavirus (pages 308–314)

      Rebecca Anhang, Jo Ellen Stryker, Thomas C. Wright Jr. and Sue J. Goldie

      Version of Record online: 1 DEC 2003 | DOI: 10.1002/cncr.20006

      Media coverage of human papillomavirus (HPV) is not comprehensive, with many stories failing to include basic information and many presenting facts without important caveats or nuances that may impact women's perceived susceptibility to HPV and anxiety levels about the virus. Now that HPV DNA testing is being introduced into a population largely unfamiliar with HPV, HPV information sources, including media, educational materials, and clinical counseling, must be adapted to ensure that women's informational needs are fulfilled.

      See also pages 225–7.

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      Women's desired information about human papillomavirus (pages 315–320)

      Rebecca Anhang, Thomas C. Wright Jr., Laura Smock and Sue J. Goldie

      Version of Record online: 1 DEC 2003 | DOI: 10.1002/cncr.20007

      Women in focus groups posed questions about human papillomavirus (HPV) that emphasized the following core areas: 1) transmission; 2) prevention; 3) treatment and progression without treatment; and 4) risk of cervical carcinoma. In addition to these areas of basic information, women sought clarification regarding the level of alarm warranted by an HPV diagnosis and the difference between Papanicolaou smear results and HPV test results. They also requested personalized risk profiles to assess their own likelihood of contracting HPV and cervical carcinoma.

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      A Phase II trial of aprinocarsen, an antisense oligonucleotide inhibitor of protein kinase C α, administered as a 21-day infusion to patients with advanced ovarian carcinoma (pages 321–326)

      Ranjana Advani, Prema Peethambaram, Bert L. Lum, George A. Fisher, Lynn Hartmann, Harry J. Long, Joanne Halsey, Jon T. Holmlund, Andrew Dorr and Branimir I. Sikic

      Version of Record online: 20 NOV 2003 | DOI: 10.1002/cncr.11909

      Despite activity observed in patients with ovarian carcinoma in a Phase I trial, only minimal activity was observed in this Phase II, single-agent trial of aprinocarsen in patients with advanced ovarian carcinoma. Further studies may be warranted in combination with platinum-based chemotherapy regimens.

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      Human papillomavirus-31-related types predict better survival in cervical carcinoma (pages 327–334)

      Lee-Wen Huang, Shiouh-Lirng Chao and Jiann-Loung Hwang

      Version of Record online: 11 DEC 2003 | DOI: 10.1002/cncr.20003

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      The human papillomavirus (HPV) genotypes of 152 patients with cervical carcinoma were investigated retrospectively. The presence of HPV-31-related types was found to be an independent predictor of better survival in patients with this disease.

    14. Head and Neck Disease
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      Comparative genomic hybridization in primary sinonasal adenocarcinomas (pages 335–341)

      Manuela Ariza, José Luis Llorente, Cesar Alvarez-Marcas, Lucia Baragaño, Ana Salas, Nuria Rodriguez Prado, Mario Hermsen, Carlos Suárez and Andres Sampedro

      Version of Record online: 11 DEC 2003 | DOI: 10.1002/cncr.11931

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      Sinonasal adenocarcinomas were investigated for genetic imbalances using comparative genomic hybridization. A remarkably large number of chromosomal gains, chromosomal losses, and high-level amplifications were observed.

    15. Hematologic Malignancies
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      Phase II study of pentostatin in advanced T-cell lymphoid malignancies : Update of an M. D. Anderson Cancer Center series (pages 342–349)

      Apostolia-Maria Tsimberidou, Francis Giles, Madeleine Duvic, Luis Fayad and Razelle Kurzrock M.D.

      Version of Record online: 20 NOV 2003 | DOI: 10.1002/cncr.11899

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      Pentostatin is an adenosine deaminase inhibitor that demonstrated a 55% response rate in patients with advanced or refractory T-cell lymphomas.

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      Long-term follow-up of patients with intermediate or high-grade non-Hodgkin lymphoma treated with a combination of cyclophosphamide, epirubicin, vincristine, and prednisone (pages 350–355)

      Fausto Rossini, Elisabetta Terruzzi, Daniele Perego, Isabella Miccolis, Franca Rivolta, Elena Manca and Enrico M. Pogliani

      Version of Record online: 11 DEC 2003 | DOI: 10.1002/cncr.11907

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      In the regimen of cyclofosfamide, epirubicin, vincristune, and prednisone (CEOP), epirubicin replaced doxorubicin, with the aim of reducing cardiotoxicity. Long-term follow-up confirmed that CEOP is an effective and well-tolerated chemotherapy regimen for treatment of intermediate- and high-grade lymphoma. The results of the current study were promising, especially among elderly patients.

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      Expression of matrix metalloproteinase 9 is a prognostic factor in patients with non-Hodgkin lymphoma (pages 356–365)

      Koh-ichi Sakata, Masaaki Satoh, Masanori Someya, Hiroko Asanuma, Hisayasu Nagakura, Atushi Oouchi, Kensei Nakata, Katsuhisa Kogawa, Kazumitsu Koito, Masato Hareyama and Tetsuo Himi

      Version of Record online: 19 NOV 2003 | DOI: 10.1002/cncr.11905

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      Matrix metalloproteinase 9 (MMP9) expression was observed in patients with aggressive non-Hodgkin lymphoma and MMP9 expression was characterized by poor overall survival.

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      Treatment outcome and pattern of failure in 77 patients with sinonasal natural killer/T-cell or T-cell lymphoma (pages 366–375)

      Chi-Cheng Li, Hwei-Fang Tien, Jih-Luh Tang, Ming Yao, Yao-Chang Chen, Ih-Jen Su, Su-Ming Hsu and Ruey-Long Hong

      Version of Record online: 8 DEC 2003 | DOI: 10.1002/cncr.11908

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      Seventy-seven patients with sinonasal natural killer/T-cell or T-cell lymphoma were treated with radiotherapy, chemotherapy, or combined modalities. Substantial incidences of local and distant failure were seen in patients with both locoregional and systemic disease.

    19. Hepatobiliary Disease
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      Prospective randomized controlled study of interferon-alpha in preventing hepatocellular carcinoma recurrence after medical ablation therapy for primary tumors (pages 376–382)

      Shi-Ming Lin, Chun-Jung Lin, Chao-Wei Hsu, Dar-In Tai, I-Shyan Sheen, Deng-Yn Lin and Yun-Fan Liaw

      Version of Record online: 12 DEC 2003 | DOI: 10.1002/cncr.20004

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      Interferon therapy may reduce hepatocellular carcinoma recurrence after medical ablation therapy for primary tumors.

    20. Melanoma
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      Elective radiotherapy provides regional control for patients with cutaneous melanoma of the head and neck (pages 383–389)

      Mark D. Bonnen, Matthew T. Ballo, Jeffrey N. Myers, Adam S. Garden, Eduardo M. Diaz Jr., Jeffrey E. Gershenwald, William H. Morrison, Jeffrey E. Lee, Mary Jane Oswald, Merrick I. Ross and K. Kian Ang

      Version of Record online: 11 DEC 2003 | DOI: 10.1002/cncr.11921

      Patients with clinically lymph node-negative cutaneous head and neck melanomas measuring ≥ 1.5 mm thick or Clark level ≥ IV had both high rates of lymph node involvement and substantial incidences of lymph node recurrence after wide local excisions of primary lesions. The current single-institutional experience showed that elective lymph node irradiation resulted in very satisfactory regional control.

    21. Neuro-Oncology
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      Large cell neuroblastoma : A distinct phenotype of neuroblastoma with aggressive clinical behavior (pages 390–397)

      Tamás Tornóczky, Endre Kálmán, Pál G. Kajtár, Tibor Nyári, Andrew D. J. Pearson, Deborah A. Tweddle, Julian Board and Hiroyuki Shimada

      Version of Record online: 11 DEC 2003 | DOI: 10.1002/cncr.20005

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      Among cases of undifferentiated and poorly differentiated neuroblastoma, the authors identified a group of rare tumors, known as large cell neuroblastomas (LCNs), that are composed of large cells with sharply outlined nuclear membranes and 1–4 prominent nucleoli. Because of its unique clinicopathologic characteristics, the authors propose that LCN be considered a distinct entity within the neuroblastoma category.

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      Phase II study of alpha-tocopherol in improving the cognitive function of patients with temporal lobe radionecrosis (pages 398–404)

      Agnes S. Chan, Mei-Chun Cheung, Stephen C. Law and John H. Chan

      Version of Record online: 8 DEC 2003 | DOI: 10.1002/cncr.11885

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      A megadose of alpha-tocopherol (2000 international units per day) was delivered to a group of patients with temporal lobe radionecrosis. Significant improvement in their cognitive function was found after one year of receiving medication. Alpha-tocopherol represents a possible intervention for improving the cognitive dysfunction of patients with temporal lobe radionecrosis.

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      Stereotaxic implantation of 5-fluorouracil-releasing microspheres in malignant glioma : A Phase I study (pages 405–410)

      Philippe Menei, Eric Jadaud, Nathalie Faisant, Michèle Boisdron-Celle, Sophie Michalak, Dominique Fournier, Manuel Delhaye and Jean-Pierre Benoit

      Version of Record online: 11 DEC 2003 | DOI: 10.1002/cncr.11922

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      5-Fluorouracil-releasing microspheres can be implanted by stereotaxy in deep, inoperable brain tumors. This new approach for radiosensitization may be developed for other tumors.

    24. Discipline

      Epidemiology
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      Genetic polymorphisms in the Hmong population : Implications for cancer etiology and survival (pages 411–417)

      William R. Kiffmeyer, Erica Langer, Stella M. Davies, Julie Envall, Leslie L. Robison and Julie A. Ross

      Version of Record online: 8 DEC 2003 | DOI: 10.1002/cncr.11913

      The current report is the first to describe a broad range of gene allele frequencies in the Hmong population. The differences observed between this population and other Asian populations have implications for studies of cancer etiology and survival.

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      Racial disparities in the use of and indications for colorectal procedures in Medicare beneficiaries (pages 418–424)

      Gregory S. Cooper and Siran M. Koroukian

      Version of Record online: 11 DEC 2003 | DOI: 10.1002/cncr.20014

      Using national-level Medicare claims from 1999, it was found that African Americans had lower rates of colorectal procedure use compared with Caucasians, with the differences primarily in the use of screening as opposed to diagnostic indications. The findings likely contribute to the known racial disparity in disease stage at the time patients present with colorectal carcinoma.

    26. Radiation Oncology
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      Quality of life as a survival predictor for patients with advanced head and neck carcinoma treated with radiotherapy (pages 425–432)

      Fu-Min Fang, Yi-Tien Liu, Yeh Tang, Chong-Jong Wang and Sheung-Fat Ko

      Version of Record online: 11 DEC 2003 | DOI: 10.1002/cncr.20010

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      Pretreatment fatigue level was found to be a significant survival predictor for patients with advanced head and neck carcinoma treated with radiotherapy.

  5. Correspondence

    1. Top of page
    2. Ethics and Law in Oncology
    3. Editorial
    4. Review Articles
    5. Original Articles
    6. Correspondence
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      Surgical margins in cutaneous melanoma (2 cm versus 5 cm for lesions measuring less than 2.1-mm thick) (pages 433–434)

      Marko B. Lens, Julia A. Newton-Bishop and Martin Dawes

      Version of Record online: 17 DEC 2003 | DOI: 10.1002/cncr.11902

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      Author reply (page 434)

      Olivier Rixe and David Khayat

      Version of Record online: 17 DEC 2003 | DOI: 10.1002/cncr.11900

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