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Cancer

Cover image for Cancer

1 February 2004

Volume 100, Issue 3

Pages 437–656

  1. Editorial

    1. Top of page
    2. Editorial
    3. Review Articles
    4. Original Articles
    5. Communication
    6. Book Review
    7. Correspondence
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      A potential role for perioperative hepatic arterial infusion chemotherapy? (pages 437–440)

      N. Joseph Espat

      Version of Record online: 19 DEC 2003 | DOI: 10.1002/cncr.11941

      The liver is the most common site of distant failure and cause of disease-related mortality in patients with advanced colon carcinoma. In the study by Sadahiro et al., a randomized controlled study evaluated the effects of prophylactic hepatic arterial infusion chemotherapy for the prevention of liver metastasis in patients with TNM Stage II or Stage III colon carcinoma.

      See also pages 590–7.

  2. Review Articles

    1. Top of page
    2. Editorial
    3. Review Articles
    4. Original Articles
    5. Communication
    6. Book Review
    7. Correspondence
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      New agents in acute myeloid leukemia and other myeloid disorders (pages 441–454)

      Farhad Ravandi, Hagop Kantarjian, Francis Giles and Jorge Cortes

      Version of Record online: 18 DEC 2003 | DOI: 10.1002/cncr.11935

      Recent progress in molecular biology has yielded a large number of new agents targeted toward various facets of neoplastic change in myeloid disorders. This review summarizes the active areas of clinical/translational research in treating patients with these malignancies.

  3. Original Articles

    1. Top of page
    2. Editorial
    3. Review Articles
    4. Original Articles
    5. Communication
    6. Book Review
    7. Correspondence
    1. Disease Site

      Breast Disease
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      Proliferative activity in primary breast carcinomas is a salient prognostic factor (pages 455–464)

      Jean-Jacques Michels, Jacques Marnay, Thierry Delozier, Yves Denoux and Jacques Chasle

      Version of Record online: 18 DEC 2003 | DOI: 10.1002/cncr.11916

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      The authors found that S phase fraction, in conjunction with mitotic activity, is one of the most important prognostic factors for patients with breast carcinoma, especially those with lymph node–negative disease.

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      Effects of pregnancy after treatment for breast carcinoma on survival and risk of recurrence (pages 465–469)

      L. Johnetta Blakely, Aman U. Buzdar, Jose A. Lozada, Samer A. Shullaih, Emma Hoy, Terry L. Smith and Gabriel N. Hortobagyi

      Version of Record online: 15 DEC 2003 | DOI: 10.1002/cncr.11929

      The authors sought to assess the effect of pregnancy on risk of recurrence for women who previously had been treated for breast carcinoma. It was found that pregnancy was not associated with an increased risk of recurrence in these women.

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      Noninflammatory breast carcinoma with skin involvement : Clinical diagnosis is relevant to appropriate classification in the TNM system (pages 470–478)

      Uwe Güth, Holger Moch, Linda Herberich and Wolfgang Holzgreve

      Version of Record online: 18 DEC 2003 | DOI: 10.1002/cncr.11938

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      Relative to breast carcinoma with ‘classic’ skin changes (e.g., edema, peau d'orange, ulceration), breast carcinoma with skin involvement that is only histologically proven, with no clinical signs or only discreet signs, has much less malignant potential. This finding corroborates the recommendation that the latter type of breast carcinoma not be classified as a T4 lesion in the TNM system.

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      Breast magnetic resonance image screening and ductal lavage in women at high genetic risk for breast carcinoma (pages 479–489)

      Anne-Renee Hartman, Bruce L. Daniel, Allison W. Kurian, Meredith A. Mills, Kent W. Nowels, Frederick M. Dirbas, Kerry E. Kingham, Nicki M. Chun, Robert J. Herfkens, James M. Ford and Sylvia K. Plevritis

      Version of Record online: 19 DEC 2003 | DOI: 10.1002/cncr.11926

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      Screening breast magnetic resonance imaging (MRI), mammography, and ductal lavage (DL) were performed annually in a cohort of women with BRCA1 or BRCA2 mutations or with a > 10% risk of breast carcinoma at 10 years. MRI detected high-grade ductal carcinoma in situ in one woman and high-risk lesions in three women; mammograms were normal in all but one woman; and DL detected cellular atypia in seven women, including one who had normal imaging findings. Both MRI and DL detected high-risk lesions in women at increased genetic risk for breast carcinoma.

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      Potential applicability of balloon catheter–based accelerated partial breast irradiation after conservative surgery for breast carcinoma (pages 490–498)

      Timothy M. Pawlik, Allison Perry, Eric A. Strom, Gildy V. Babiera, Thomas A. Buchholz, Eva Singletary, George H. Perkins, Merrick I. Ross, Naomi R. Schecter, Funda Meric-Bernstam, Frederick C. Ames, Kelly K. Hunt and Henry M. Kuerer

      Version of Record online: 18 DEC 2003 | DOI: 10.1002/cncr.11939

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      Balloon catheter–based accelerated partial breast irradiation (APBI) is currently being used to treat women after breast-conserving surgery. Eligibility for balloon catheter–based APBI, however, can be limited by the size of the lumpectomy cavity. The current study showed that approximately 20% of women presenting for breast-conserving therapy are potential candidates for balloon catheter–based APBI.

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      Prognostic significance of phosphorylated P38 mitogen-activated protein kinase and HER-2 expression in lymph node-positive breast carcinoma (pages 499–506)

      Francisco J. Esteva, Aysegul A. Sahin, Terry L. Smith, Ying Yang, Lajos Pusztai, Rita Nahta, Thomas A. Buchholz, Aman U. Buzdar, Gabriel N. Hortobagyi and Sarah S. Bacus

      Version of Record online: 18 DEC 2003 | DOI: 10.1002/cncr.11940

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      In the current study, p38 mitogen-activated protein kinase (MAPK) phosphorylation occurred in 20% of patients with primary breast carcinomas and may be associated with poor outcome in patients with positive lymph nodes. Further studies are needed to define the interaction between phosphorylated p38 MAPK and HER-2 expression in breast carcinoma.

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      A retrospective analysis of health care costs for bone fractures in women with early-stage breast carcinoma (pages 507–517)

      Zhiyuang Zhou, Alberto Redaelli, Olof Johnell, Richard J. Willke and Giorgio Massimini

      Version of Record online: 12 DEC 2003 | DOI: 10.1002/cncr.11917

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      This study is the first retrospective, prevalence-based research on the costs of bone fracture in older women with early-stage breast carcinoma. The high direct costs from bone fracture in this cohort present a significant economic burden for the health care system in the U.S. because of increased morbidity (for example, pain and decreased activity), which often requires hospitalization or long-term care. The potential economic magnitude of bone fracture in women with early-stage breast carcinoma deserves complementary, incidence-based research that measures the benefit of a preventive intervention in terms of fractures avoided.

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      Should decisions on internal mammary lymph node irradiation be based on current lymphoscintigraphy techniques for sentinel lymph node identification? (pages 518–523)

      Rashmi K. Benda, Juan C. Cendan, Edward M. Copeland, Robert J. Feezor, D. Scott Lind, Christopher G. Morris and Nancy Price Mendenhall

      Version of Record online: 12 DEC 2003 | DOI: 10.1002/cncr.11918

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      Despite the well documented prognostic significance of internal mammary lymph node (IMN) metastases, treatment of IMN remains controversial because of potential treatment-related morbidity and questionable efficacy. In the absence of histopathologic information, treatment decisions should be based on clinical information that is known to be correlated with occult involvement of IMNs. The findings of the current study suggest that IMN flow may not always be identified by lymphoscintigraphy.

    9. Gastrointestinal Tract
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      Association of ampullary and colorectal malignancies (pages 524–530)

      Ananya Das, Alfred I. Neugut, Gregory S. Cooper and Amitabh Chak

      Version of Record online: 19 DEC 2003 | DOI: 10.1002/cncr.11943

      Using the Surveillance, Epidemiology, and End Results database, the authors observed that white patients with ampullary cancer had an increased risk of developing second primary colorectal malignancies and that white patients with colorectal cancer had an increased risk of developing second primary ampullary malignancies.

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      Treatment of advanced colorectal carcinoma with oxaliplatin and capecitabine : A Phase II trial (pages 531–537)

      Anthony F. Shields, Mark M. Zalupski, John L. Marshall and Neal J. Meropol

      Version of Record online: 12 DEC 2003 | DOI: 10.1002/cncr.11925

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      Patients with advanced colorectal carcinoma were treated on a Phase II trial of oxaliplatin given every 3 weeks and capecitabine given for 14 days. The partial response rate was 37.1% with an estimated median progression-free survival of 6.9 months.

    11. Genitourinary Disease
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      The relationship of increasing radiotherapy dose to reduced distant metastases and mortality in men with prostate cancer (pages 538–543)

      Rojymon Jacob, Alexandra L. Hanlon, Eric M. Horwitz, Benjamin Movsas, Robert G. Uzzo and Alan Pollack

      Version of Record online: 18 DEC 2003 | DOI: 10.1002/cncr.11927

      For patients with prostate cancer treated with conformal radiotherapy alone, increasing radiation dose was significantly associated with reductions in biochemical failure, distant metastases, and overall mortality. Inclusion of the year of treatment as a covariate to account for time-related changes may confound such associations.

    12. Gynecologic Oncology
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      Restaging of recurrent cervical carcinoma with dual-phase [18F]fluoro-2-deoxy-D-glucose positron emission tomography (pages 544–552)

      Chyong-Huey Lai, Kuan-Gen Huang, Lai-Chu See, Tzu-Chen Yen, Chien-Sheng Tsai, Ting-Chang Chang, Hung-Hsueh Chou, Koon-Kwan Ng, Swei Hsueh and Ji-Hong Hong

      Version of Record online: 18 DEC 2003 | DOI: 10.1002/cncr.11928

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      Dual-phase [18F]fluoro-2-deoxy-D-glucose positron emission tomography (PET) is superior to computed tomography/magnetic resonance imaging in the restaging of recurrent cervical carcinoma. Restaging with PET provides benefit by allowing the physician to offer optimal management of recurrent cervical carcinoma.

    13. Head and Neck Disease
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      Prognostic significance of intratumoral lymphangiogenesis in squamous cell carcinoma of the oral cavity : A study of the early stages (pages 553–560)

      Mario Fernando Muñoz-Guerra, Eva G. Marazuela, Esther Martín-Villar, Miguel Quintanilla and Carlos Gamallo

      Version of Record online: 23 DEC 2003 | DOI: 10.1002/cncr.11933

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      Using the new immunohistochemical marker, PA2.26, the authors studied retrospectively the effect of intratumoral lymphangiogenesis on prognosis in early-stage oral carcinoma. This morphologic feature had independent prognostic significance and may be helpful for assigning patients to risk-oriented complementary treatments.

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      Gamma radiation sensitivity and risk of malignant and benign salivary gland tumors : A pilot case–control analysis (pages 561–567)

      Rong Zheng, Li-E Wang, Melissa L. Bondy, Qingyi Wei and Erich M. Sturgis

      Version of Record online: 15 DEC 2003 | DOI: 10.1002/cncr.11944

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      Exposure to gamma radiation is a risk factor contributing to the etiology of both malignant (MSTs) and benign salivary gland tumors (BSTs). In a pilot study, the authors found that high levels of chromatid breaks in lymphocytes induced by in vitro gamma irradiation were an independent risk factor for MSTs and also may be associated with risk for BSTs.

    15. Hematologic Malignancies
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      Intravenous itraconazole for prophylaxis of systemic fungal infections in patients with acute myelogenous leukemia and high-risk myelodysplastic syndrome undergoing induction chemotherapy (pages 568–573)

      Gloria N. Mattiuzzi, Hagop Kantarjian, Susan O'Brien, Dimitrios P. Kontoyiannis, Francis Giles, Xian Zhou, JoAnn Lim, B. Nebiyou Bekele, Stefan Faderl, Jorge Cortes, Sherry Pierce, Gerhard J. Leitz, Issam Raad and Elihu Estey

      Version of Record online: 12 DEC 2003 | DOI: 10.1002/cncr.11930

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      Systemic fungal infections remain the leading cause of mortality in patients with newly diagnosed acute myelogenous leukemia and high-risk myelodysplastic syndrome. In the current study, the authors attempted to determine whether intravenous itraconazole reduced the incidence of probable/proven fungal infections in this group of patients and compared the results with those of a historic control group that was treated with fluconazole plus itraconazole capsules.

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      Activity of interferon-α and isotretinoin in patients with advanced, refractory lymphoid malignancies (pages 574–580)

      Apostolia-Maria Tsimberidou, Francis Giles, Jorge Romaguera, Madeleine Duvic and Razelle Kurzrock

      Version of Record online: 12 DEC 2003 | DOI: 10.1002/cncr.20009

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      Interferon-α (IFN-α) in combination with isotretinoin was administered to patients with lymphoid malignancies who had been heavily pretreated (a median of four previous treatments). IFN-α and isotretinoin were found to have antitumor activity in patients with cutaneous and peripheral T-cell lymphomas and Hodgkin disease (response rate of 39%) and were well tolerated.

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      Amphotericin B lipid complex as prophylaxis of invasive fungal infections in patients with acute myelogenous leukemia and myelodysplastic syndrome undergoing induction chemotherapy (pages 581–589)

      Gloria N. Mattiuzzi, Hagop Kantarjian, Stefan Faderl, JoAnn Lim, Dimitrios Kontoyiannis, Deborah Thomas, William Wierda, Isaam Raad, Guillermo Garcia-Manero, Xian Zhou, Alexandra Ferrajoli, Nebiyou Bekele and Elihu Estey

      Version of Record online: 18 DEC 2003 | DOI: 10.1002/cncr.11936

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      A prospective historical control study evaluated the efficacy and safety of amphotericin B lipid complex as antifungal prophylaxis in patients with acute myelogenous leukemia or high-risk myelodysplastic syndrome who were undergoing induction chemotherapy. A comparison of liposomal amphotericin B and amphotericin B lipid complex revealed similar tolerability and protection against the development of documented or suspected fungal infections in these patients.

    18. Hepatobiliary Disease
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      Prophylactic hepatic arterial infusion chemotherapy for the prevention of liver metastasis in patients with colon carcinoma : A randomized controlled trial (pages 590–597)

      Sotaro Sadahiro, Toshiyuki Suzuki, Kenji Ishikawa, Seiei Yasuda, Tomoo Tajima, Hiroyasu Makuuchi, Takuro Saitoh and Chieko Murayama

      Version of Record online: 12 DEC 2003 | DOI: 10.1002/cncr.11945

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      A randomized controlled study evaluated the effects of prophylactic hepatic arterial infusion (HAI) chemotherapy for the prevention of liver metastasis in patients with TNM Stage II or Stage III colon carcinoma who did not have liver metastasis. The use of 3-week HAI of 5-fluorouracil appeared to contribute significantly to a reduction in the frequency of liver metastases and was associated with an improved disease-free survival and overall survival.

      See also pages 437–40.

    19. Melanoma
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      Desmoplastic and neurotropic melanoma : Analysis of 33 patients with lymphatic mapping and sentinel lymph node biopsy (pages 598–604)

      Lyndon D. Su, Douglas R. Fullen, Lori Lowe, Timothy S. Wang, Jennifer L. Schwartz, Vincent M. Cimmino, Vernon K. Sondak and Timothy M. Johnson

      Version of Record online: 15 DEC 2003 | DOI: 10.1002/cncr.11947

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      Desmoplastic and neurotropic melanoma can metastasize to regional lymph nodes, and sentinel lymph node biopsy may detect early subclinical metastases.

    20. Neuro-Oncology
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      Temozolomide in the treatment of recurrent malignant glioma (pages 605–611)

      Susan M. Chang, Philip Theodosopoulos, Kathleen Lamborn, Mary Malec, Jane Rabbitt, Margaretta Page and Michael D. Prados

      Version of Record online: 19 DEC 2003 | DOI: 10.1002/cncr.11949

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      Temozolomide possesses activity in patients with recurrent malignant glioma even at the time of multiple recurrences. In the patient population examined in the current study, the therapy was well tolerated.

    21. Sarcoma
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      High-dose tamoxifen and sulindac as first-line treatment for desmoid tumors (pages 612–620)

      Anika Hansmann, Claudia Adolph, Tilmann Vogel, Andreas Unger and Gabriela Moeslein

      Version of Record online: 19 DEC 2003 | DOI: 10.1002/cncr.11937

      The current study describes the clinical course of 25 patients with familial adenomatous polyposis-associated and sporadic desmoid tumors who were treated with high-dose tamoxifen and sulindac.

    22. Discipline

      Epidemiology
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      Survival experience of black patients and white patients with bladder carcinoma (pages 621–630)

      George R. Prout Jr., Margaret N. Wesley, Peter G. McCarron, Vivien W. Chen, Raymond S. Greenberg, Robert M. Mayberry and Brenda K. Edwards

      Version of Record online: 19 DEC 2003 | DOI: 10.1002/cncr.11942

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      In a study of racial differences in survival from bladder carcinoma, black patients with pure urothelial cancers were more likely to present with greater extent of disease than white patients, and histologically aggressive tumors also were more common in black patients. With regard to T classification, the survival of black patients was similar compared with white patients with Ta and T1 tumors and with T4, N+, or M+ tumors but was worse for patients with T2 and T3 tumors, leading to poorer overall survival among black patients. Future clinical research should focus on the role of comorbidity and supportive care among black patients and white patients with muscle-invasive carcinomas.

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      The cancer screening practices of adult survivors of childhood cancer : A report from the Childhood Cancer Survivor Study (pages 631–640)

      Mark W. Yeazel, Kevin C. Oeffinger, James G. Gurney, Ann C. Mertens, Melissa M. Hudson, Karen M. Emmons, Hegang Chen and Leslie L. Robison

      Version of Record online: 15 DEC 2003 | DOI: 10.1002/cncr.20008

      An increasing number of survivors of childhood cancer are at risk for a variety of long-term late effects of cancer and its treatment, including recurrence of the original malignancy or the development of subsequent malignancies. A survey exploring the cancer screening practices of 9434 long-term survivors of childhood cancer found below optimal screening levels.

  4. Communication

    1. Top of page
    2. Editorial
    3. Review Articles
    4. Original Articles
    5. Communication
    6. Book Review
    7. Correspondence
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      Radiofrequency ablation : The experts weigh in (pages 641–650)

      Kenneth K. Tanabe, Steven A. Curley, Gerald D. Dodd, Allan E. Siperstein and S. Nahum Goldberg

      Version of Record online: 19 DEC 2003 | DOI: 10.1002/cncr.11919

      Dr. Kenneth K. Tanabe solicited opinions from two interventional radiologists and two surgeons who have made groundbreaking innovations in the field of radiofrequency ablation. He asked each to address four questions, and the responses succinctly describe the current state and the future of radiofrequency ablation.

  5. Book Review

    1. Top of page
    2. Editorial
    3. Review Articles
    4. Original Articles
    5. Communication
    6. Book Review
    7. Correspondence
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      Color atlas of oral diseases : George Laskaris (page 651)

      Mark S. Chambers

      Version of Record online: 12 DEC 2003 | DOI: 10.1002/cncr.11924

  6. Correspondence

    1. Top of page
    2. Editorial
    3. Review Articles
    4. Original Articles
    5. Communication
    6. Book Review
    7. Correspondence
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      Fourteen-gauge needle core biopsy of mammographically evident radial scars : Is excision necessary? (pages 652–653)

      Caroline Brodie, Ann O'Doherty and Cecily Quinn

      Version of Record online: 12 DEC 2003 | DOI: 10.1002/cncr.11951

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      Author reply (pages 653–654)

      Jennifer N. Cawson, Prue Hill and Michael Henderson

      Version of Record online: 12 DEC 2003 | DOI: 10.1002/cncr.11953

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      Author reply (pages 655–656)

      Johan S. Rietman, Jan H. B. Geertzen and Jakob de Vries

      Version of Record online: 12 DEC 2003 | DOI: 10.1002/cncr.11948

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