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Cancer

Cover image for Cancer

1 March 2004

Volume 100, Issue 5

Pages 881–1106

  1. Editorial

    1. Top of page
    2. Editorial
    3. Commentary
    4. Review Articles
    5. Original Articles
    6. Correspondence
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      Believing is seeing : A new parameter to study cancer prevention and cancer treatment in older individuals (pages 881–882)

      Lodovico Balducci

      Version of Record online: 21 JAN 2004 | DOI: 10.1002/cncr.20086

      Health beliefs play an important role in the implementation of cancer prevention and treatment, and health beliefs may differ between older patients and younger patients. In their report in this issue, Clipp et al. make the case for assessing health beliefs in future clinical trials and correlating these beliefs with treatment outcome.

      See also pages 1085–94, this issue.

  2. Commentary

    1. Top of page
    2. Editorial
    3. Commentary
    4. Review Articles
    5. Original Articles
    6. Correspondence
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      National estimates of medical costs incurred by nonelderly cancer patients (pages 883–891)

      David H. Howard, Noelle-Angelique Molinari and Kenneth E. Thorpe

      Version of Record online: 26 JAN 2004 | DOI: 10.1002/cncr.20063

      Cancer-attributable spending as a percent of aggregate medical spending by nonelderly individuals is between 4.7% and 6.3%. A program to provide insurance coverage to nonelderly cancer patients would cost the government at least $30 billion, and possibly as much as $47 billion, annually.

  3. Review Articles

    1. Top of page
    2. Editorial
    3. Commentary
    4. Review Articles
    5. Original Articles
    6. Correspondence
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      Osteoporosis in men with prostate carcinoma receiving androgen-deprivation therapy : Recommendations for diagnosis and therapies (pages 892–899)

      Terrence H. Diamond, Celestia S. Higano, Matthew R. Smith, Theresa A. Guise and Frederick R. Singer

      Version of Record online: 19 JAN 2004 | DOI: 10.1002/cncr.20056

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      The authors address the current research, diagnostic methods, and treatment recommendations for bone loss and osteoporosis in men with prostate carcinoma who receive androgen-deprivation therapy (ADT). Their findings confirm that men who receive ADT are at risk for significant bone loss and that they have an increased risk of fracture.

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      Parathyroid carcinoma: Evaluation and interdisciplinary management (pages 900–905)

      Gary L. Clayman, Hernan E. Gonzalez, Adel El-Naggar and Rena Vassilopoulou-Sellin

      Version of Record online: 30 JAN 2004 | DOI: 10.1002/cncr.20089

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      The authors completed both a comprehensive literature review and a retrospective analysis of a 20-year history at The University of Texas M. D. Anderson Cancer Center in patients with of parathyroidism. Through this report, they were able to provide added pattern-specific information on the interdisciplinary evaluation and management of this disease, such as indications of local recurrence rates appearing lower if adjuvant radiation was applied after initial surgery, independent of the type of surgery or disease stage.

  4. Original Articles

    1. Top of page
    2. Editorial
    3. Commentary
    4. Review Articles
    5. Original Articles
    6. Correspondence
    1. Disease Site

      Breast Disease
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      Can the Gail model be useful in American Indian and Alaska Native populations? (pages 906–912)

      Judith Salmon Kaur, Marilyn A. Roubidoux, Jeff Sloan and Paul Novotny

      Version of Record online: 21 JAN 2004 | DOI: 10.1002/cncr.20047

      The current retrospective review of screening mammograms performed in 1458 American Indian and Alaska Native women found that if Gail model criteria were applied, breast carcinoma rates would increase significantly in this special population.

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      The replication error phenotype is associated with the development of distant metastases in hormonally treated patients with breast carcinoma (pages 913–919)

      Anees Chagpar, Anthony Magliocco, Annette Kerviche, Leonard Tan, Barbara Walley and John F. DeCoteau

      Version of Record online: 22 JAN 2004 | DOI: 10.1002/cncr.20084

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      The replication error phenotype has been studied well in hereditary nonpolypsis colon carcinoma, but to the authors' knowledge, its impact in breast carcinoma has not been elucidated. The authors demonstrate that this phenotype is associated with the development of distant metastases in women with early-stage breast carcinoma who are treated with hormonal therapy.

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      Inflammatory breast carcinoma: Outcomes with trimodality therapy for nonmetastatic disease (pages 920–928)

      Stanley L. Liauw, Rashmi K. Benda, Christopher G. Morris and Nancy Price Mendenhall

      Version of Record online: 30 JAN 2004 | DOI: 10.1002/cncr.20083

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      Inflammatory breast carcinoma is an aggressive disease that is treated effectively in select patients by multimodality therapy. Patient outcomes may be improved with therapies that result in better local and systemic control.

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      Immunohistochemically detected tumor cells in the sentinel lymph nodes of patients with breast carcinoma : Biologic metastasis or procedural artifact? (pages 929–934)

      Katrina H. Moore, Howard T. Thaler, Lee K. Tan, Patrick I. Borgen and Hiram S. Cody III

      Version of Record online: 14 JAN 2004 | DOI: 10.1002/cncr.20035

      In patients with breast carcinoma, the frequency of sentinel lymph node (SLN) positivity by cytokeratin staining alone 1) is unrelated to conventional predictors of lymph node positivity, 2) is increased after instrumentation of the tumor site, and 3) is increased approximately proportionate to the degree of manipulation. A proportion of cytokeratin-positive SLN are present before biopsy and therefore less likely to be artifactual.

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      Validation of axillary sentinel lymph node detection in the staging of early lobular invasive breast carcinoma : A prospective study (pages 935–941)

      Jean-Marc Classe, Delphine Loussouarn, Loïc Campion, Maryse Fiche, Chantal Curtet, François Dravet, Raphaëlle Pioud, Caroline Rousseau, Isabelle Resche and Christine Sagan

      Version of Record online: 30 JAN 2004 | DOI: 10.1002/cncr.20054

      Sentinel lymph node resection provides accurate axillary staging of early lobular invasive breast carcinoma.

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      Physician recommendations regarding tamoxifen and patient utilization of tamoxifen after surgery for ductal carcinoma in situ (pages 942–949)

      Tina W. F. Yen, Kelly K. Hunt, Nadeem Q. Mirza, Eva S. Thomas, S. Eva Singletary, Gildy V. Babiera, Funda Meric-Bernstam, Thomas A. Buchholz, Barry W. Feig, Merrick I. Ross, Frederick C. Ames, Richard L. Theriault and Henry M. Kuerer

      Version of Record online: 20 JAN 2004 | DOI: 10.1002/cncr.20085

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      The impact of the National Surgical Adjuvant Breast and Bowel Project B-24 study on the use of tamoxifen after surgery for ductal carcinoma in situ is not known. At a comprehensive cancer center between July 1999 and June 2002, the authors demonstrated that not all patients were offered tamoxifen after surgery for DCIS, approximately 50% patients who were offered tamoxifen declined, and complications and side effects related to tamoxifen use resulted in a high (21%) discontinuation rate.

    7. Endocrine Disease
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      Poorly differentiated carcinomas of the thyroid with trabecular, insular, and solid patterns : A clinicopathologic study of 183 patients (pages 950–957)

      Marco Volante, Stefania Landolfi, Luigi Chiusa, Nicola Palestini, Manuela Motta, Alessandra Codegone, Bruno Torchio and Mauro G. Papotti

      Version of Record online: 26 JAN 2004 | DOI: 10.1002/cncr.20087

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      Trabecular-insular-solid carcinomas of the thyroid are a heterogeneous, aggressive group of tumors, and patients with these tumors have a prognosis intermediate between the prognosis for patients with well differentiated papillary/follicular carcinomas and patients with anaplastic carcinoma. The statistical analysis of clinicopathologic parameters for 183 patients indicated that age, the presence of necrosis, and the mitotic count all were significantly predictive of the clinical aggressiveness of poorly differentiated carcinomas.

    8. Gastrointestinal Tract
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      Improved prediction of recurrence after curative resection of colon carcinoma using tree-based risk stratification (pages 958–967)

      Martin Radespiel-Tröger, Werner Hohenberger and Bertram Reingruber

      Version of Record online: 26 JAN 2004 | DOI: 10.1002/cncr.20065

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      A tree-based analysis of disease-free survival was performed in 641 patients who underwent curative (R0) resection for colon carcinoma in the Surgical Department at the University of Erlangen-Nuernberg (Germany) between 1984 and 1996. The resulting prognostic tree, which contained the variables pathologic tumor stage, number of lymph node metastases, venous invasion, and emergency presentation, showed superior predictive accuracy in an independent sample compared with the most current International Union Against Cancer TNM staging system.

    9. Genitourinary Disease
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      Potentially advanced malignancies detected by screening for prostate carcinoma after an interval of 4 years (pages 968–975)

      Renske Postma, Monique Roobol, Fritz H. Schröder and Theodorus H. van der Kwast

      Version of Record online: 16 JAN 2004 | DOI: 10.1002/cncr.20048

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      During the second round of screening for prostate carcinoma after an interval of 4 years, malignancies with adverse features on sextant biopsy rarely are detected. Data suggest that a screening protocol based on measurements of serum prostate-specific antigen levels (with a 4-year interval between measurements) and sextant biopsy is effective in detecting most prostate malignancies when they are in a curable stage.

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      Gene expression profiling of renal medullary carcinoma : Potential clinical relevance (pages 976–985)

      Ximing J. Yang, Jun Sugimura, Maria S. Tretiakova, Kyle Furge, Gregory Zagaja, Mitchell Sokoloff, Michael Pins, Raymond Bergan, David J. Grignon, Walter M. Stadler, Nicholas J. Vogelzang and Bin Tean Teh

      Version of Record online: 14 JAN 2004 | DOI: 10.1002/cncr.20049

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      In the current study, the authors report what to their knowledge is the first gene profiling of renal medullary carcinoma, a rare but highly malignant kidney disease. The distinct genes expressed in this tumor were identified and compared with the genes expressed in other types of kidney tumors. The identification of these differentially expressed genes in renal medullary carcinoma may provide better insights into the pathogenesis of the disease and may lead to potential diagnostic and therapeutic innovation.

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      Screening computed tomography : Will it result in overdiagnosis of renal carcinoma? (pages 986–990)

      Joshua J. Fenton and Noel S. Weiss

      Version of Record online: 14 JAN 2004 | DOI: 10.1002/cncr.20055

      Screening sometimes detects cancers that otherwise would have remained silent clinically. Analyzing data from case series of computed tomography (CT) screening and regional cancer registries, the authors argue that CT screening is unlikely to be associated with substantial overdiagnosis of renal carcinoma.

    12. Head and Neck Disease
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      A Phase II study of docetaxel and carboplatin as neoadjuvant therapy for nasopharyngeal carcinoma with early T status and advanced N status (pages 991–998)

      Faye M. Johnson, Adam Garden, J. Lynn Palmer, Merrill Kies, Gary Clayman, Brenda Brumfield, Fadlo R. Khuri, William Morrison, Vassiliki Papadimitrakopoulou, Eduardo M. Diaz and Bonnie S. Glisson

      Version of Record online: 30 JAN 2004 | DOI: 10.1002/cncr.20079

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      The authors investigated a risk-based approach for patients with early T and advanced N stage nasopharyngeal carcinoma that incorporated evaluation of docetaxel and cisplatin as an induction regimen followed by radiation. The regimen was active and well-tolerated, though not likely more effective than standard cisplatin and 5-fluorouracil.

    13. Neuro-Oncology
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      Craniotomy for the resection of metastatic brain tumors in the U.S., 1988–2000 : Decreasing mortality and the effect of provider caseload (pages 999–1007)

      Fred G. Barker II

      Version of Record online: 14 JAN 2004 | DOI: 10.1002/cncr.20058

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      Better patient outcomes have been documented after complex medical and surgical care delivered by higher volume providers. The current analysis demonstrates lower rates of mortality and adverse outcome at the time of hospital discharge after resection of brain metastases by higher volume hospitals and surgeons. Mortality rates were found to decrease significantly during the study period.

    14. Sarcoma
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      Low recurrence rate after surgery for dermatofibrosarcoma protuberans : A multidisciplinary approach from a single institution (pages 1008–1016)

      Derek DuBay, Vincent Cimmino, Lori Lowe, Timothy M. Johnson and Vernon K. Sondak

      Version of Record online: 21 JAN 2004 | DOI: 10.1002/cncr.20051

      Wide local excision with careful pathologic analysis of margins has a very low recurrence rate and is used for the majority of patients (68%) with dermatofibrosarcoma protuberans (DFSP) lesions at the authors' institution. Wide local excision, Mohs surgery, and, when necessary, a multidisciplinary combination approach all appear to be efficacious in the treatment of DFSP.

    15. Discipline

      Clinical Trials
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      Recruiting Black/African American men for research on prostate cancer prevention (pages 1017–1025)

      V. Diane Woods, Susanne B. Montgomery and R. Patti Herring

      Version of Record online: 21 JAN 2004 | DOI: 10.1002/cncr.20029

      Qualitative research methods were used to identify recruitment strategies for attracting black men to research programs on prostate cancer prevention and retaining them in these programs. Cultural sensitivity; attractive Afrocentric materials; a caring, professional, personalized ethnic approach; respect; participatory involvement; physician interest; and quality healthcare were key factors for engaging black males in the current study.

    16. Epidemiology
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      Dental X-rays and the risk of intracranial meningioma : A population-based case–control study (pages 1026–1034)

      W. T. Longstreth Jr., Leslie E. Phillips, Mark Drangsholt, Thomas D. Koepsell, Brian S. Custer, Jo-Ann Gehrels and Gerald van Belle

      Version of Record online: 16 JAN 2004 | DOI: 10.1002/cncr.20036

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      In a population-based case–control study, the investigators sought to identify associations between intracranial meningioma and past dental X-rays—specifically, posterior bitewings, full-mouth series, and lateral cephalometric and panoramic radiographs. The only significant associations involved full-mouth series obtained decades before diagnosis.

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      Cervical adenocarcinoma and squamous cell carcinoma incidence trends among white women and black women in the United States for 1976–2000 (pages 1035–1044)

      Sophia S. Wang, Mark E. Sherman, Allan Hildesheim, James V. Lacey Jr. and Susan Devesa

      Version of Record online: 30 JAN 2004 | DOI: 10.1002/cncr.20064

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      Cervical carcinoma incidence patterns in the U.S. vary by race, age, and stage. Changes in screening practices, endocervical sampling, and nomenclature and improvements in treatment resulted in an increasing incidence of in situ cervical squamous cell carcinoma (SCC) during the early 1990s and a corresponding decline in invasive SCC incidence. Despite the rising incidence of adenocarcinoma in situ (AIS), invasive adenocarcinoma rates have not yet been noted to have declined. In black women, AIS incidence remains low, and invasive cervical adenocarcinoma incidence continues to rise with age, reflecting either no effect from screening or a differential disease etiology.

    18. Gynecologic Oncology
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      Survival among women with borderline ovarian tumors and ovarian carcinoma : A population-based analysis (pages 1045–1052)

      Mark E. Sherman, Pamela J. Mink, Rochelle Curtis, Timothy R. Cote, Sandra Brooks, Patricia Hartge and Susan Devesa

      Version of Record online: 30 JAN 2004 | DOI: 10.1002/cncr.20080

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      Compared with tumor-free women, patients with localized ovarian tumors of low malignant potential (LMP) experienced similar survival, whereas survival was reduced among women with distant-stage tumors. Further studies are required to elucidate the causes of death among women who are diagnosed with tumors of LMP.

    19. Pediatric Oncology
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      The predictive potential of molecular detection in the nonmetastatic Ewing family of tumors (pages 1053–1058)

      Smadar Avigad, Ian J. Cohen, Julia Zilberstein, Ella Liberzon, Yacov Goshen, Shifra Ash, Isaac Meller, Yehuda Kollender, Josephine Issakov, Rina Zaizov and Isaac Yaniv

      Version of Record online: 16 JAN 2004 | DOI: 10.1002/cncr.20059

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      Occult tumor cells in the bone marrow and/or peripheral blood were evaluated as a potential prognostic parameter in 26 patients with localized Ewing sarcoma during a long follow-up period. The authors demonstrated that the presence of occult tumor cells is a strong predictor of recurrence.

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      Major histocompatibility antigens and antigen-processing molecules in retinoblastoma (pages 1059–1069)

      Subramanian Krishnakumar, Amirthalakshmi Sundaram, Dhiraj Abhyankar, Vanitha Krishnamurthy, Mahesh Palanivelu Shanmugam, Lingam Gopal, Tarun Sharma and Jyotirmay Biswas

      Version of Record online: 26 JAN 2004 | DOI: 10.1002/cncr.20062

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      Retinoblastomas are immunogenic tumors. Decreased expression of human leukocyte antigens and antigen-processing molecules are seen in tumors with invasion of the choroid and optic nerve. This preliminary observation deserves further investigation, which may shed more light on the immune escape mechanisms of this tumor and thus enable novel therapeutic strategies.

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      Birth characteristics and hepatoblastoma risk in young children (pages 1070–1076)

      Peggy Reynolds, Kevin Y. Urayama, Julie Von Behren and James Feusner

      Version of Record online: 30 JAN 2004 | DOI: 10.1002/cncr.20061

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      The authors conducted a case–control study of hepatoblastoma in California children, ages birth–4 years, who were diagnosed between 1988 and 1997. In what to the authors' knowledge is the largest case–control study published to date, a dramatically increased hepatoblastoma risk was found among children with very low birth weight, and the authors provide evidence to suggest differing etiologies between children with very low birth weight and children with normal birth weight.

    22. Psychological Oncology
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      Effects of media information on cancer patients' opinions, feelings, decision-making process and physician-patient communication (pages 1077–1084)

      Rodolfo Passalacqua, Caterina Caminiti, Stefania Salvagni, Sandro Barni, Giordano D. Beretta, Paolo Carlini, Antonio Contu, Francesco Di Costanzo, Lucia Toscano and Francesco Campione

      Version of Record online: 16 JAN 2004 | DOI: 10.1002/cncr.20050

      To determine the influence of media information on the opinions and feelings of patients with cancer and to measure the factors that affect the decision-making process and physician-patient communication, the authors measured the changes in patients' opinions and attitudes at the peak of a media campaign promoting an unproven cancer treatment method and after the publicized demonstration of its ineffectiveness.

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      Age-related vulnerabilities of older adults with colon adenomas : Evidence from project prevent (pages 1085–1094)

      Elizabeth C. Clipp, Elizabeth H. Carver, Kathryn I. Pollak, Elaine Puleo, Karen M. Emmons, Jane Onken, Francis A. Farraye and Colleen M. McBride

      Version of Record online: 21 JAN 2004 | DOI: 10.1002/cncr.20082

      This report examines how well established age-related vulnerabilities affect colorectal carcinoma risk perceptions and behaviors among older adults after they undergo the removal of one or more adenomatous polyps. Results indicate that certain subgroups of vulnerable older patients may benefit from behavior change interventions that account for impaired functional status, inadequate social support, and lower income.

      See also pages 881–2.

    24. Translational Research
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      Redirected T-cell cytotoxicity to epithelial cell adhesion molecule-overexpressing adenocarcinomas by a novel recombinant antibody, E3Bi, in vitro and in an animal model (pages 1095–1103)

      Lifen Ren-Heidenreich, Pamela A. Davol, Nicola M. Kouttab, Gerald J. Elfenbein and Lawrence G. Lum

      Version of Record online: 26 JAN 2004 | DOI: 10.1002/cncr.20060

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      A novel, recombinant, chimeric-bispecific antibody, E3Bi, was developed in the authors' laboratory. In both in vitro and in vivo experiments, E3Bi demonstrated specific and effective antitumor effects in eradicating tumors that carried the tumor-associated antigen, epithelial cell adhesion molecule.

  5. Correspondence

    1. Top of page
    2. Editorial
    3. Commentary
    4. Review Articles
    5. Original Articles
    6. Correspondence
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      Author reply (pages 1105–1106)

      Varsha I. Shah and Usha Raju

      Version of Record online: 26 JAN 2004 | DOI: 10.1002/cncr.20078

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      Global TNM advisory group (page 1106)

      Leslie H. Sobin and Frederick L. Greene

      Version of Record online: 8 JAN 2004 | DOI: 10.1002/cncr.20037

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