You have free access to this content

Cancer

Cover image for Cancer

15 April 2004

Volume 100, Issue 8

Pages 1549–1769

  1. Editorial

    1. Top of page
    2. Editorial
    3. Review Article
    4. Original Articles
    5. Correspondence
    1. You have free access to this content
      The never-ending controversies of screening mammography : What is the appropriate callback rate for women undergoing screening mammographic examination? (pages 1549–1552)

      Rachel F. Brem

      Article first published online: 8 MAR 2004 | DOI: 10.1002/cncr.20148

      Controversies regarding the recommendations for screening mammography seen to be never ending. In this issue of Cancer, Gur et al. report their findings that breast cancer diagnosis improves with increasing recall rate above 10% in a study of experienced, high-volume radiologists. This editorial discusses the implication of this well designed and executed study with bold and important conclusions.

      See also pages 000–000.

    2. You have free access to this content
      Cancer screening and the periodic health examination (pages 1553–1557)

      Robert A. Smith and Richard C. Wender

      Article first published online: 8 MAR 2004 | DOI: 10.1002/cncr.20170

      In this issue of Cancer, Chen et al. report outcomes from an integrated model of multiphasic chronic disease screening in Taiwan. The design and outcomes of the Keelung Community-based Integrated Screening program are noteworthy for several reasons and should reopen the debate not only regarding the worth, but also the protocol for periodic preventive health examinations.

      See also pages 000–000.

  2. Review Article

    1. Top of page
    2. Editorial
    3. Review Article
    4. Original Articles
    5. Correspondence
    1. You have free access to this content
      New systemic frontline treatment for metastatic colorectal carcinoma (pages 1558–1577)

      Ada H. Braun, Wolf Achterrath, Hansjochen Wilke, Udo Vanhoefer, Andreas Harstrick and Peter Preusser

      Article first published online: 18 MAR 2004 | DOI: 10.1002/cncr.20154

      Colorectal carcinoma is a major cause of malignancy-related morbidity and mortality worldwide; however, treatment options have broadened considerably with the introduction of irinotecan, oxaliplatin, and 5-fluorouracil prodrugs, as well as new molecular targeted agents. This review updates current first-line chemotherapy strategies and future perspectives for patients with advanced disease.

    2. You have free access to this content
      Nuclear factor-KappaB modulation as a therapeutic approach in hematologic malignancies (pages 1578–1589)

      Amit Panwalkar, Srdan Verstovsek and Francis Giles

      Article first published online: 11 MAR 2004 | DOI: 10.1002/cncr.20182

      Nuclear factor-kappaB (NF-κB) is a collective term that refers to a small class of dimeric transcription factors for a number of cancer-related genes, including growth factors, angiogenesis modulators, cell-adhesion molecules, and antiapoptotic factors. NF-κB modulation is likely to be a therapeutic endeavor of increasing interest in coming years.

  3. Original Articles

    1. Top of page
    2. Editorial
    3. Review Article
    4. Original Articles
    5. Correspondence
    1. Disease Site

      Breast Disease
      You have free access to this content
      Recall and detection rates in screening mammography : A review of clinical experience: Implications for practice guidelines (pages 1590–1594)

      David Gur, Jules H. Sumkin, Lara A. Hardesty, Ronald J. Clearfield, Cathy S. Cohen, Marie A. Ganott, Christiane M. Hakim, Kathleen M. Harris, William R. Poller, Ratan Shah, Luisa P. Wallace and Howard E. Rockette

      Article first published online: 8 MAR 2004 | DOI: 10.1002/cncr.20053

      Mammographic recall rates are reported to be highly correlated with tumor detection rates. Earlier detection of breast carcinoma could be achieved if radiology practice guidelines were to allow for higher recall rates in screening mammography.

      See also pages 000–000.

    2. You have free access to this content
      Racial differences in diagnosis, treatment, and clinical delays in a population-based study of patients with newly diagnosed breast carcinoma (pages 1595–1604)

      Karin Gwyn, Melissa L. Bondy, Deborah S. Cohen, Mary Jo Lund, Jonathan M. Liff, Elaine W. Flagg, Louise A. Brinton, J. William Eley and Ralph J. Coates

      Article first published online: 8 MAR 2004 | DOI: 10.1002/cncr.20169

      The current population-based study examined differences in the delay in diagnosis as well as the delay in initiation of treatment between African American women and white women ages 20–54 years with newly diagnosed invasive breast carcinoma. Although access to care (as represented by method of detection and insurance status) and poverty accounted for some of the observed differences, racial differences remained even after adjustment for these factors.

    3. You have free access to this content
      The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma : Correlations with clinical features (pages 1605–1614)

      Gulnur Guler, Aysegul Uner, Nilufer Guler, Shuang-Yin Han, Dimitrios Iliopoulos, Walter W. Hauck, Peter McCue and Kay Huebner

      Article first published online: 3 MAR 2004 | DOI: 10.1002/cncr.20137

      Two fragile genes, FHIT and WWOX, exhibit correlated protein expression in breast carcinoma. Reduced Fhit expression was associated with adverse prognostic factors. The results imply that, through an apparently complex pathway, the expression of Wwox is associated with the expression of steroid hormones and breast carcinogenesis.

    4. Gastrointestinal Tract
      You have free access to this content
      Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma : Relation to p27Kip1 and its Ubiquitin Ligase Subunit, S Phase Kinase Protein 2 (pages 1615–1621)

      Ma'anit Shapira, Ofer Ben-Izhak, Bishara Bishara, Boris Futerman, Ira Minkov, Michael M. Krausz, Michele Pagano and Dan D. Hershko

      Article first published online: 18 MAR 2004 | DOI: 10.1002/cncr.20172

      Increased levels of S phase kinase protein 2 (Skp2), a specific ubiquitin ligase subunit that targets p27Kip1 for degradation, are associated with high aggressiveness and poor prognosis in a variety of human cancers. The current study showed that the expression of cyclin kinase subunit 1, an essential accessory factor for Skp2-mediated degradation, was correlated with Skp2 expression and loss of tumor differentiation and was inversely related to the expression of p27Kip1 and overall survival.

    5. You have free access to this content
      Dysplasia in Barrett esophagus : Implications for chemoprevention (pages 1622–1627)

      Christopher D. Lao, Melanie Simmons, Sapna Syngal, Robert S. Bresalier, Laurie Fortlage, Daniel Normolle, Kent A. Griffith, Henry D. Appelman and Dean E. Brenner

      Article first published online: 11 MAR 2004 | DOI: 10.1002/cncr.20149

      Dysplasia in Barrett esophagus is a premalignant condition that has remained the focus of attention for esophageal adenocarcinoma prevention strategies and is the primary predictor of malignant progression. Review of the pathology archives of 3 institutions over a 5-year period revealed few cases of low-grade dysplasia (LGD) in Barrett esophagus. The low prevalence of cases of LGD will affect future clinical trial designs for chemopreventive interventions in Barrett esophagus.

    6. Genitourinary Disease
      You have free access to this content
      Radical retropubic prostatectomy in Hispanic patients (pages 1628–1632)

      Pablo Gomez, Muruqesan Manoharan, Paul Sved, Sandy S. Kim and Mark S. Soloway

      Article first published online: 3 MAR 2004 | DOI: 10.1002/cncr.20127

      In the current study, the authors found that Hispanic patients with prostate carcinoma managed with radical prostatectomy had similar presentation, pathologic findings, and outcome as white non-Hispanic patients.

    7. You have free access to this content
      Predictors of prostate-specific antigen progression among men with seminal vesicle invasion at the time of radical prostatectomy (pages 1633–1638)

      Stephen J. Freedland, William J. Aronson, Joseph C. Presti Jr.,, Christopher L. Amling, Martha K. Terris, Bruce Trock and Christopher J. Kane

      Article first published online: 18 MAR 2004 | DOI: 10.1002/cncr.20122

      Because most (but not all) men with seminal vesicle (SV) invasion at the time of radical prostatectomy (RP) develop biochemical recurrence, the authors sought to identify the subset of men with SV invasion who had long-term prostate-specific antigen (PSA) progression–free survival. Using multivariate analysis to determine the independent predictors of PSA progression–free survival, low pathologic Gleason score, negative surgical margins, and patient age ≥ 60 years were identified as favorable findings. Combining these factors, the authors identified a small group of men (n = 11; 8%) who, despite SV invasion, had a 100% 5-year PSA progression–free survival rate.

    8. You have free access to this content
      Phase III trial of methotrexate, vinblastine, doxorubicin, and cisplatin versus carboplatin and paclitaxel in patients with advanced carcinoma of the urothelium : A trial of the Eastern Cooperative Oncology Group (pages 1639–1645)

      Robert Dreicer, Judith Manola, Bruce J. Roth, William A. See, Steven Kuross, Martin J. Edelman, Gary R. Hudes and George Wilding

      Article first published online: 25 FEB 2004 | DOI: 10.1002/cncr.20123

      The combination regimen of methotrexate, vinblastine, doxorubicin, and cisplatin and that of carboplatin and paclitaxel are reported to have activity in advanced urothelial carcinoma. Nevertheless, the current study was underpowered and does not permit conclusions to be drawn regarding the comparable efficacy of these regimens.

    9. You have free access to this content
      Biochemical failure after radical prostatectomy in men with pathologic organ-confined disease: pT2a versus pT2b (pages 1646–1649)

      Stephen J. Freedland, Alan W. Partin, Jonathan I. Epstein and Patrick C. Walsh

      Article first published online: 18 MAR 2004 | DOI: 10.1002/cncr.20145

      There were no differences in prostate-specific antigen (PSA) recurrence rates between men with pT2aN0 versus pT2bN0 tumors. In men with organ-confined disease, radical prostatectomy provided excellent 10-year PSA progression-free survival regardless of tumor burden (pT2a vs. pT2b). Consideration should be given to modifying the TNM staging system to eliminate substratification of pT2 tumors.

    10. Gynecologic Oncology
      You have free access to this content
      Laparoscopic fluorescence detection of ovarian carcinoma metastases using 5-aminolevulinic acid-induced protoporphyrin IX (pages 1650–1656)

      Martin Löning, Heyke Diddens, Wolfgang Küpker, Klaus Diedrich and Gereon Hüttmann

      Article first published online: 15 MAR 2004 | DOI: 10.1002/cncr.20155

      After intraperitoneal application of 5-aminolevulinic acid in patients with ovarian carcinoma, laparoscopic fluorescence imaging allowed the very early detection of intraperitoneal micrometastases with high sensitivity and specificity.

    11. Head and Neck Disease
      You have free access to this content
      Primary mucosal melanoma of the head and neck : A proposal for microstaging localized, Stage I (lymph node-negative) tumors (pages 1657–1664)

      Manju L. Prasad, Snehal G. Patel, Andrew G. Huvos, Jatin P. Shah and Klaus J. Busam

      Article first published online: 11 MAR 2004 | DOI: 10.1002/cncr.20201

      In the current study, the authors propose a prognostically significant histologic microstaging system for localized, lymph node-negative (Stage I), primary mucosal melanoma of the head and neck.

    12. Lung Disease
      You have free access to this content
      Increased expression of collagen XVIII and its prognostic value in nonsmall cell lung carcinoma (pages 1665–1672)

      Hao Chang, Toshihiko Iizasa, Kiyoshi Shibuya, Akira Iyoda, Makoto Suzuki, Yasumitsu Moriya, Tian-Ling Liu, Takaki Hiwasa, Kenzo Hiroshima and Takehiko Fujisawa

      Article first published online: 18 MAR 2004 | DOI: 10.1002/cncr.20156

      The authors investigated the expression of collagen XVIII in 221 patients using immunohistochemical methods. Low collagen XVIII expression levels were found in 75 tumor specimens, while high expression levels were noted in 87 tumor specimens. The overexpression of collagen XVIII was found to be associated with the progression of nonsmall cell lung carcinoma and with poor prognosis.

    13. You have free access to this content
      p53 apoptotic pathway molecules are frequently and simultaneously altered in nonsmall cell lung carcinoma (pages 1673–1682)

      Shoichi Mori, Genshi Ito, Noriyasu Usami, Hiromu Yoshioka, Yuichi Ueda, Yoshinori Kodama, Masahide Takahashi, Kwun M. Fong, Kaoru Shimokata and Yoshitaka Sekido

      Article first published online: 18 MAR 2004 | DOI: 10.1002/cncr.20164

      The authors performed a comprehensive analysis of the p53 apoptotic pathway in 118 patients with nonsmall cell lung carcinoma (NSCLCs) to study whether this pathway is inactivated in tumors without mutation in p53 itself. Two or more p53 pathway components were found to be frequently altered, with > 90% of the alterations resulting from abnormalities of p53, p14ARF, or HDM2. The data indicated that inactivation of the p53 pathway is a prerequisite for the development of most NSCLCs.

    14. Melanoma
      You have free access to this content
      Sentinel lymph nodes in malignant melanoma : Extended histopathologic evaluation improves diagnostic precision (pages 1683–1691)

      Helene Nortvig Abrahamsen, Stephen J. Hamilton-Dutoit, Jørn Larsen and Torben Steiniche

      Article first published online: 18 MAR 2004 | DOI: 10.1002/cncr.20179

      An extensive histopathologic protocol was used to examine sentinel lymph nodes from 100 patients with cutaneous malignant melanoma that measured 1–4 mm in thickness. The protocol resulted in substantial increases in the detection rates for micrometastases and benign nevus inclusions approaching the detection rates reported for molecular techniques.

    15. You have free access to this content
      Mature results of a phase III randomized trial of bacillus Calmette–Guerin (BCG) versus observation and BCG plus dacarbazine versus BCG in the adjuvant therapy of American Joint Committee on Cancer Stage I–III melanoma (E1673) : A trial of the Eastern Cooperative Oncology Group (pages 1692–1698)

      Sanjiv S. Agarwala, Donna Neuberg, Yuhyun Park and John M. Kirkwood

      Article first published online: 18 MAR 2004 | DOI: 10.1002/cncr.20166

      No benefit for bacillus Calmette–Guerin (BCG) was observed for patients with American Joint Committee on Cancer Stage I–III disease. The mature results projected to 30 years confirmed the negative results of previous smaller studies utilizing BCG.

    16. You have free access to this content
      A Phase II trial of vinorelbine tartrate in patients with disseminated malignant melanoma and one prior systemic therapy : A Southwest Oncology Group study (pages 1699–1704)

      Robert P. Whitehead, James Moon, S. Spence McCachren, Evan M. Hersh, Wolfram E. Samlowski, J. Thaddeus Beck, Nerses S. Tchekmedyian and Vernon K. Sondak

      Article first published online: 9 MAR 2004 | DOI: 10.1002/cncr.20183

      Single-agent chemotherapy with dacarbazine continues to be the standard of care for the treatment of metastatic melanoma. However, there is a large population of patients who have failed first-line therapy and might benefit from additional treatment. The Southwest Oncology Group evaluated the activity of vinorelbine in patients with advanced melanoma who had previously failed at least one prior systemic therapy.

    17. Neuro-Oncology
      You have free access to this content
      Stereotactic radiosurgery for multiple brain metastases from breast carcinoma : Feasibility and outcome of a local treatment concept (pages 1705–1711)

      Alexander Muacevic, Friedrich W. Kreth, Jörg-Christian Tonn and Berndt Wowra

      Article first published online: 15 MAR 2004 | DOI: 10.1002/cncr.20167

      Outpatient stereotactic radiosurgery can achieve high local tumor control rates for selected patients with multiple brain metastases from breast carcinoma. The number of brain metastases has no prognostic relevance.

    18. You have free access to this content
      Phase II study of neoadjuvant 1, 3-bis (2-chloroethyl)-1-nitrosourea and temozolomide for newly diagnosed anaplastic glioma : A North American Brain Tumor Consortium trial (pages 1712–1716)

      Susan M. Chang, Michael D. Prados, W. K. Alfred Yung, Howard Fine, Larry Junck, Harry Greenberg, H. Ian Robins, Minesh Mehta, Karen L. Fink, Kurt A. Jaeckle, John Kuhn, Kenneth Hess and Clifford Schold

      Article first published online: 8 MAR 2004 | DOI: 10.1002/cncr.20157

      The current Phase II neoadjuvant study of the combination of 1, 3-bis (2-chloroethyl)-1-nitrosourea and temozolomide before radiotherapy for newly diagnosed anaplastic glioma was associated with significant myelosuppression and a modest response rate. Further studies of this combination of agents would require a different dose schedule.

    19. You have free access to this content
      ABO blood group is a potent risk factor for venous thromboembolism in patients with malignant gliomas (pages 1717–1723)

      Michael B. Streiff, Jodi Segal, Stuart A. Grossman, Thomas S. Kickler and Edward G. Weir

      Article first published online: 11 MAR 2004 | DOI: 10.1002/cncr.20150

      Venous thromboembolism (VTE) is a common cause of morbidity and mortality among patients with malignant gliomas. To investigate the pathogenesis of VTE and facilitate targeted prophylaxis strategies, the authors aimed to characterize VTE risk factors in these patients.

    20. Sarcoma
      You have free access to this content
      High-dose methotrexate pharmacokinetics and outcome of children and young adults with osteosarcoma (pages 1724–1733)

      Kristine R. Crews, Tiebin Liu, Carlos Rodriguez-Galindo, Ming Tan, William H. Meyer, J. Carl Panetta, Michael P. Link and Najat C. Daw

      Article first published online: 3 MAR 2004 | DOI: 10.1002/cncr.20152

      High-dose methotrexate (given at a dose of 12 g/m2) resulted in peak plasma methotrexate concentrations of ≥ 1000 μM in 96% of patients with osteosarcoma; methotrexate clearance was decreased after the administration of cisplatin, cisplatin and ifosfamide, and methotrexate. When high-dose methotrexate is used with multiagent therapy, very high exposures are associated with poorer outcome.

    21. You have free access to this content
      Community-based multiple screening model : Design, implementation, and analysis of 42,387 participants Taiwan community-based integrated screening group (pages 1734–1743)

      Tony Hsiu-Hsi Chen, Yueh-Hsia Chiu, Dih-Ling Luh, Ming-Fang Yen, Hui-Min Wu, Li-Sheng Chen, Tao-Hsin Tung, Chih-Chung Huang, Chang-Chuan Chan, Ming-Neng Shiu, Yen-Po Yeh, Horng-Huei Liou, Chao-Sheng Liao, Hsin-Chih Lai, Chun-Pin Chiang, Hui-Ling Peng, Chuen-Den Tseng, Ming-Shyen Yen, Wei-Chih Hsu and Chih-Hung Chen

      Article first published online: 3 MAR 2004 | DOI: 10.1002/cncr.20171

      An innovative community-based multiple disease screening model was created. The success of this model includes the enhancement of the attendance rate, the detection of a large proportion of asymptomatic neoplastic diseases and nonneoplastic chronic diseases, and the elucidation of the relations between certain neoplasms and nonneoplastic chronic disease.

    22. Discipline

      Epidemiology
      You have free access to this content
      Cigarette advertising and female smoking prevalence in Spain, 1982–1997 : Case studies in International Tobacco Surveillance (pages 1744–1749)

      Omar Shafey, Esteve Fernández, Michael Thun, Anna Schiaffino, Suzanne Dolwick and Vilma Cokkinides

      Article first published online: 3 MAR 2004 | DOI: 10.1002/cncr.20147

      The authors examined the correlation between the explosive increase in female smoking prevalence and tobacco industry cigarette marketing practices in Spain during a period of rapid social liberalization. Their findings indicate that strong cultural and traditional prohibitions against female smoking are not sufficient to withstand aggressive tobacco marketing in the context of social liberalization.

    23. Pediatric Oncology
      You have free access to this content
      Oral topotecan in children with recurrent or progressive high-grade glioma : A Phase I/II study by the German Society for Pediatric Oncology and Hematology (pages 1750–1757)

      Sabine Wagner, Bernhard Erdlenbruch, Alfred Längler, Astrid Gnekow, Joachim Kühl, Michael Albani, Sigrid Völpel, Peter Bucsky, Angela Emser, Ove Peters and Johannes E. A. Wolff

      Article first published online: 11 MAR 2004 | DOI: 10.1002/cncr.20168

      In children with recurrent high-grade glioma, oral topotecan (median dose, 0.9 mg/m2 per day) administered once daily was well tolerated, with a response rate (complete clinical remission, partial response, or stable disease) of 71.3%. The primary dose-limiting toxicity was hematotoxicity.

    24. You have free access to this content
      Soft tissue sarcoma as a second malignant neoplasm in the pediatric age group (pages 1758–1765)

      Gianni Bisogno, Guido Sotti, Yohann Nowicki, Andrea Ferrari, Alberto Garaventa, Ilaria Zanetti, Claudio Favre, Amalia Schiavetti, Paolo Tamaro and Modesto Carli

      Article first published online: 18 MAR 2004 | DOI: 10.1002/cncr.20159

      The experience of the Italian Cooperative Group showed that children who developed soft tissue sarcomas as a second malignancy had a less dismal prognosis than reported previously and could be treated with the same strategies used in the treatment of children with de novo pediatric sarcomas.

  4. Correspondence

    1. Top of page
    2. Editorial
    3. Review Article
    4. Original Articles
    5. Correspondence
    1. You have free access to this content
    2. You have free access to this content
      Author reply (page 1767)

      Matthew M. Poggi

      Article first published online: 8 MAR 2004 | DOI: 10.1002/cncr.20176

    3. You have free access to this content
      Familial sarcoma: challenging pedigrees (pages 1767–1768)

      Justo Lorenzo Bermejo and Kari Hemminki

      Article first published online: 3 MAR 2004 | DOI: 10.1002/cncr.20174

    4. You have free access to this content
      Author reply (page 1768)

      Henry T. Lynch and Jane F. Lynch

      Article first published online: 3 MAR 2004 | DOI: 10.1002/cncr.20177

    5. You have free access to this content
    6. You have free access to this content
      Author reply (page 1769)

      Peggy Manders, Vivianne C. G. Tjan-Heijnen and C. (Fred) G. J. Sweep

      Article first published online: 25 FEB 2004 | DOI: 10.1002/cncr.20178

SEARCH

SEARCH BY CITATION