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Cancer

Cover image for Cancer

1 May 2004

Volume 100, Issue 9

Pages 1771–1994

  1. EDITORIAL

    1. Top of page
    2. EDITORIAL
    3. Review Articles
    4. Review Article
    5. Review Articles
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Correspondence
    10. Erratum
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      The challenge of discrepancies in values among physicians, patients, and family members (pages 1771–1775)

      David W. Kissane

      Version of Record online: 29 MAR 2004 | DOI: 10.1002/cncr.20180

      Dignity, autonomy, integrity, and vulnerability constitute an excellent set of ethical principles fundamental to a conception of the human good upon which to consider questions of care for the terminally ill.

      See article by Oh et al, this issue.

  2. Review Articles

    1. Top of page
    2. EDITORIAL
    3. Review Articles
    4. Review Article
    5. Review Articles
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Correspondence
    10. Erratum
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      Diagnostic strategies for unknown primary cancer (pages 1776–1785)

      Gauri R. Varadhachary, James L. Abbruzzese and Renato Lenzi

      Version of Record online: 22 MAR 2004 | DOI: 10.1002/cncr.20202

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      The current article discusses the role of histochemical markers in the diagnosis of unknown primary cancer and the most recent data on the use of imaging and invasive diagnostic modalities and gene expression profiles.

  3. Review Article

    1. Top of page
    2. EDITORIAL
    3. Review Articles
    4. Review Article
    5. Review Articles
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Correspondence
    10. Erratum
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      Management of T1–T2 glottic carcinomas (pages 1786–1792)

      William M. Mendenhall, John W. Werning, Russell W. Hinerman, Robert J. Amdur and Douglas B. Villaret

      Version of Record online: 29 MAR 2004 | DOI: 10.1002/cncr.20181

      Well defined lesions suitable for transoral laser excision with a good functional outcome were treated with either laser or radiotherapy. Remaining T1–T2 tumors were optimally treated with radiotherapy. Open partial laryngectomy was reserved for salvage treatment of patients with locally recurrent tumors.

  4. Review Articles

    1. Top of page
    2. EDITORIAL
    3. Review Articles
    4. Review Article
    5. Review Articles
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Correspondence
    10. Erratum
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      Gemcitabine-related radiation recall preferentially involves internal tissue and organs (pages 1793–1799)

      Philip A. Friedlander, Roopa Bansal, Lawrence Schwartz, Raquel Wagman, Jerome Posner and Nancy Kemeny

      Version of Record online: 2 APR 2004 | DOI: 10.1002/cncr.20229

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      Radiation recall is a complication of certain chemotherapy (i.e., that administered after radiation). An analysis of the literature demonstrated that radiation recall attributed to gemcitabine manifests predominantly as inflammation of internal tissue and organs. This differs from other common agents, which mainly are reported to cause a dermatitis. The development of internal tissue inflammation appears to be correlated with a shorter interval from the completion of radiation therapy to the initiation of chemotherapy.

  5. Original Articles

    1. Top of page
    2. EDITORIAL
    3. Review Articles
    4. Review Article
    5. Review Articles
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Correspondence
    10. Erratum
    1. Disease Site

      Breast Disease
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      Acceptance of tamoxifen chemoprevention by physicians and women at risk (pages 1800–1806)

      Julia Tchou, Nanjiang Hou, Alfred Rademaker, V. Craig Jordan and Monica Morrow

      Version of Record online: 22 MAR 2004 | DOI: 10.1002/cncr.20205

      In the current study, tamoxifen chemoprevention was offered to 63% of 219 high-risk women, and was accepted by 57 of those who were offered the drug (42%; 26% overall acceptance rate). The presence of atypical hyperplasia or lobular carcinoma in situ were the strongest predictors of a patient being offered tamoxifen, and appeared to be the only significant predictors of tamoxifen acceptance.

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      The natural history of breast carcinoma in the elderly : Implications for screening and treatment (pages 1807–1813)

      Rachana Singh, Samuel Hellman and Ruth Heimann

      Version of Record online: 31 MAR 2004 | DOI: 10.1002/cncr.20206

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      Distant disease–free survival, virulence, and metastagenicity were analyzed in 2136 women who underwent mastectomy without adjuvant therapy between 1927 and 1987 to determine whether breast carcinoma was more indolent in women age > 70 years compared with younger women. Although fewer older women had positive lymph node status at presentation, the authors found no difference in the natural history of breast carcinoma in older women compared with women age ≤ 70 years. This finding supports the implementation of diagnostic and therapeutic approaches in older women that are similar to the approaches used in their younger counterparts.

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      Pharmacoproteomic analysis of prechemotherapy and postchemotherapy plasma samples from patients receiving neoadjuvant or adjuvant chemotherapy for breast carcinoma (pages 1814–1822)

      Lajos Pusztai, Betsy W. Gregory, Keith A. Baggerly, Bo Peng, John Koomen, Henry M. Kuerer, Francisco J. Esteva, W. Fraser Symmans, Peter Wagner, Gabriel N. Hortobagyi, Christine Laronga, O. John Semmes, George L. Wright Jr., Richard R. Drake and Antonia Vlahou

      Version of Record online: 29 MAR 2004 | DOI: 10.1002/cncr.20203

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      Proteomic changes were examined in response to chemotherapy in patients with Stage I–III breast carcinoma, and plasma profiles from patients with breast carcinoma were compared with the profiles from healthy women to identify breast carcinoma-associated protein markers. Five mass peaks were identified that were absent in healthy women and one unique chemotherapy-induced peak. These peaks may represent markers that have the potential to detect and monitor micrometastatic disease after surgery.

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      Effect of margins on ipsilateral breast tumor recurrence after breast conservation therapy for lymph node-negative breast carcinoma (pages 1823–1832)

      Carson Leong, John Boyages, Upali W. Jayasinghe, Michael Bilous, Owen Ung, Boon Chua, Elizabeth Salisbury and Angela Y. Wong

      Version of Record online: 22 MAR 2004 | DOI: 10.1002/cncr.20153

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      In a study of the effect of the pathologic margin status on ipsilateral breast tumor recurrence (IBTR) rates in a cohort of women with lymph node-negative breast carcinoma who were treated with breast-conservative surgery and radiotherapy, higher IBTR rates were associated with positive or indeterminate margins compared with negative, pathologic margins. Young age (age < 35 years at the time of diagnosis) was found to be associated with the highest risk of IBTR regardless of margin status.

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      Initially metastatic breast carcinoma has a distinct disease pattern but an equivalent outcome compared with recurrent metastatic breast carcinoma (pages 1833–1842)

      Antonio Jimeno, María Luz Amador, Lucía González-Cortijo, María Victoria Tornamira, Santiago Ropero, Vicente Valentín, Javier Hornedo, Hernán Cortés-Funes and Ramón Colomer

      Version of Record online: 2 APR 2004 | DOI: 10.1002/cncr.20204

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      The authors compared the clinical features and outcomes of patients with initially metastatic breast carcinoma (IMBC) with the corresponding characteristics in patients with recurrent metastatic breast carcinoma (RBC). It was found that patients with IMBC and patients with RBC exhibited distinct histologic and clinical characteristics but had similar treatment efficacy results and survival outcomes.

    6. Gastrointestinal Tract
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      Primary care provider perceptions of barriers to and facilitators of colorectal cancer screening in a managed care setting (pages 1843–1852)

      Gareth S. Dulai, Melissa M. Farmer, Patricia A. Ganz, Coen A. Bernaards, Karen Qi, Allen J. Dietrich, Roshan Bastani, Michael J. Belman and Katherine L. Kahn

      Version of Record online: 22 MAR 2004 | DOI: 10.1002/cncr.20209

      A survey of 1340 randomly selected primary care providers in a statewide, network model health maintenance organization in California indicated that colorectal cancer screening tests remained underused in the year 2000. Potential targets for interventions aimed at increasing screening rates are identified and discussed.

  6. Original Article

    1. Top of page
    2. EDITORIAL
    3. Review Articles
    4. Review Article
    5. Review Articles
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Correspondence
    10. Erratum
    1. Disease Site

      Genitourinary Disease
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      Methyl-CpG-binding domain 2 : A protective role in bladder carcinoma (pages 1853–1858)

      Yong Zhu, Margaret R. Spitz, Hui Zhang, H. Barton Grossman, Marsha L. Frazier and Xifeng Wu

      Version of Record online: 29 MAR 2004 | DOI: 10.1002/cncr.20199

      In the current case–control study, the authors investigated the association between expression of the methyl-CpG-binding domain protein and bladder carcinoma risk. Although the underlying molecular mechanisms remain unclear, the data obtained represent the first evidence demonstrating a protective role against bladder carcinoma risk for MBD2 expression. MBD2 expression may prevent age-related, gender-affected, and smoking-induced hypermethylation, which are predisposing factors for tumor development.

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      p53 and p21 expression levels predict organ preservation and survival in invasive bladder carcinoma treated with a combined-modality approach (pages 1859–1867)

      Xavier Garcia del Muro, Enric Condom, Francesc Vigués, Xavier Castellsagué, Agnès Figueras, Josep Muñoz, Judit Solá, Teresa Soler, Gabriel Capellà and Josep R. Germà

      Version of Record online: 29 MAR 2004 | DOI: 10.1002/cncr.20200

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      Expression levels of p53 and p21 were independent predictors of long-term bladder preservation and survival in patients with invasive bladder carcinoma treated with a combined-modality approach. These predictive effects were especially apparent when both markers were assessed simultaneously.

  7. Original Articles

    1. Top of page
    2. EDITORIAL
    3. Review Articles
    4. Review Article
    5. Review Articles
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Correspondence
    10. Erratum
    1. Disease Site

      Genitourinary Disease
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      High-dose calcitriol, zoledronate, and dexamethasone for the treatment of progressive prostate carcinoma (pages 1868–1875)

      Michael J. Morris, Oren Smaletz, David Solit, W. Kevin Kelly, Susan Slovin, Carlos Flombaum, Tracy Curley, Anthony Delacruz, Lawrence Schwartz, Martin Fleisher, Andrew Zhu, Meghan Diani, Mary Fallon and Howard I. Scher

      Version of Record online: 31 MAR 2004 | DOI: 10.1002/cncr.20185

      In the current Phase I study, the authors examined the use of dose-escalated calcitriol (1,25-dihydroxycholecalciferol) with zoledronate and dexamethasone for the treatment of patients with progressive prostate carcinoma. The regimen was well tolerated, even at calcitriol doses as high as 30 μg 3 times per week; however, it was cumbersome to administer and had minimal activity.

    2. Head and Neck Disease
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      Diagnostic accuracy of fine-needle aspiration cytology and frozen section in primary parotid carcinoma (pages 1876–1883)

      Peter Zbären, Michel Nuyens, Heinz Loosli and Edouard Stauffer

      Version of Record online: 29 MAR 2004 | DOI: 10.1002/cncr.20186

      The diagnostic value of fine-needle aspiration cytology (FNAC) and frozen sections (FS) were analyzed in 101 primary parotid carcinomas. The authors' institutional experience demonstrated the superiority of FS compared with FNAC in detecting, typing, and grading primary parotid carcinomas. Nevertheless, FNAC and FS should not compete but rather should complement one another.

    3. Hematologic Malignancies
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      Soluble vascular endothelial growth factor receptor 1, and not receptor 2, is an independent prognostic factor in acute myeloid leukemia and myelodysplastic syndromes (pages 1884–1891)

      Qinglong Hu, Amanda L. Dey, Ying Yang, Yu Shen, Iman B. Jilani, Elihu H. Estey, Hagop M. Kantarjian, Francis J. Giles and Maher Albitar

      Version of Record online: 29 MAR 2004 | DOI: 10.1002/cncr.20187

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      The authors measured plasma concentrations of soluble vascular endothelial growth factor receptor 1 (sVEGFR1) and sVEGFR2. The findings indicate that concentrations of sVEGFR1 and sVEGFR2 in plasma should be considered a significant factor in guiding antiangiogenic therapy for patients with acute myeloid leukemia and myelodysplastic syndromes, and they also may play a role in the pharmacodynamics of therapeutic agents that are supposed to bind directly to these receptors.

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      Adoptive immunotherapy with allogeneic Epstein–Barr virus (EBV)-specific cytotoxic T-lymphocytes for recurrent, EBV-positive Hodgkin disease (pages 1892–1901)

      Kenneth G. Lucas, Donna Salzman, Alejandro Garcia and Qi Sun

      Version of Record online: 24 MAR 2004 | DOI: 10.1002/cncr.20188

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      Adoptive immunotherapy with allogeneic, Epstein–Barr virus (EBV)-specific cytotoxic T-lymphocytes (CTL) for patients with recurrent, refractory, EBV-positive Hodgkin disease was safe and resulted in disease regression without the establishment of donor CTL chimerism. Although recipients of immunosuppressive chemotherapy did not have detectable CTL against donor cells, the patients did not have donor CTL chimerism postinfusion or improved clinical outcome.

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      Familial aggregation of Hodgkin lymphoma and related tumors (pages 1902–1908)

      Lynn R. Goldin, Ruth M. Pfeiffer, Gloria Gridley, Mitchell H. Gail, Xinjun Li, Lene Mellemkjaer, Jørgen H. Olsen, Kari Hemminki and Martha S. Linet

      Version of Record online: 29 MAR 2004 | DOI: 10.1002/cncr.20189

      Based on population data, the authors demonstrated that first-degree relatives of patients with Hodgkin lymphoma are at significantly increased risk for Hodgkin lymphoma and are also higher at risk for non-Hodgkin lymphoma and chronic lymphocytic leukemia. Familial risk was higher in males, in siblings, and in relatives of patients with early-onset disease.

    6. Lung Disease
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      Skip metastasis in nonsmall cell lung carcinoma : Predictive markers and isolated tumor cells in N1 lymph nodes (pages 1909–1917)

      Klaus L. Prenzel, Stephan E. Baldus, Stefan P. Mönig, Daniela Tack, Jan M. Sinning, Christian A. Gutschow, Guido Grass, Paul M. Schneider, Hans P. Dienes and Arnulf H. Hölscher

      Version of Record online: 18 MAR 2004 | DOI: 10.1002/cncr.20165

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      N2 skip metastases were misdiagnosed in 17.6% of patients with nonsmall cell lung carcinoma because of the spread of isolated tumor cells to regional N1 lymph nodes. Patients with N2 skip metastases had a favorable prognosis compared with patients with continuous N2 metastasis. In a set of immunohistochemical analyses, Bcl-2 and p21 were found to be related to the presence of skip metastases.

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      Recurrent chromosomal imbalances in nonsmall cell lung carcinoma : The association between 1q amplification and tumor recurrence (pages 1918–1927)

      Amy L. S. Tai, Wen-Sheng Yan, Yan Fang, Dan Xie, Jonathan S. T. Sham and Xin-Yuan Guan

      Version of Record online: 22 MAR 2004 | DOI: 10.1002/cncr.20190

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      Lung carcinoma is a leading cause of cancer deaths worldwide. To better understand this disease, the authors studied genetic alterations in patients with nonsmall cell lung carcinoma and the association between genetic changes and clinical features.

    8. Sarcoma
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      Outcome after local recurrence of osteosarcoma : The St. Jude Children's Research Hospital experience (1970–2000) (pages 1928–1935)

      Carlos Rodriguez-Galindo, Nirali Shah, M. Beth McCarville, Catherine A. Billups, Michael N. Neel, Bhaskar N. Rao and Najat C. Daw

      Version of Record online: 22 MAR 2004 | DOI: 10.1002/cncr.20214

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      In the current study, the authors analyzed factors believed to be predictive of survival in patients with local recurrence of osteosarcoma. Complete surgical resection at the time of recurrence is essential for survival. Positive margins at the time of the initial surgical resection and early recurrence were found to be poor prognostic factors.

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      Evaluation of P-glycoprotein, HER-2/ErbB-2, p53, and Bcl-2 in primary tumor and metachronous lung metastases in patients with high-grade osteosarcoma (pages 1936–1942)

      Stefano Ferrari, Franco Bertoni, Licciana Zanella, Elisabetta Setola, Patrizia Bacchini, Marco Alberghini, Michela Versari and Gaetano Bacci

      Version of Record online: 18 MAR 2004 | DOI: 10.1002/cncr.20151

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      Expression levels of P-glycoprotein, ErbB-2, p53, and Bcl-2 were evaluated in primary tumor and metachronous pulmonary metastases in patients with high-grade osteosarcoma. For most patients, the expression profiles of P-glycoprotein, ErbB-2, and Bcl-2 were different in recurrent pulmonary metastases compared with primary tumor, with expression levels increased in the former. In addition, altered p53 expression in lung metastases was related to postrecurrence survival probability.

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      Hyperthermic intraperitoneal intraoperative chemotherapy after cytoreductive surgery for the treatment of abdominal sarcomatosis : Clinical outcome and prognostic factors in 60 consecutive patients (pages 1943–1950)

      Carlo Riccardo Rossi, Marcello Deraco, Michele De Simone, Simone Mocellin, Pierluigi Pilati, Mirto Foletto, Francesco Cavaliere, Shigeki Kusamura, Alessandro Gronchi and Mario Lise

      Version of Record online: 22 MAR 2004 | DOI: 10.1002/cncr.20192

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      Abdominal sarcomatosis is a rare nosologic entity with a poor prognosis. After a Phase I study on cytoreductive surgery combined with hyperthermic intraperitoneal intraoperative chemotherapy, the authors reported the results of the treatment of 60 patients using this novel multimodal approach.

    11. Discipline

      Pathology
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      P53 and K-ras mutations are frequent events in microscopically negative surgical margins from patients with nonsmall cell lung carcinoma (pages 1951–1960)

      Jacek Jassem, Ewa Jassem, Joanna Jakóbkiewicz-Banecka, Witold Rzyman, Andrzej Badzio, Rafał Dziadziuszko, Grażyna Kobierska-Gulida, Amelia Szymanowska, Marcin Skrzypski and Maciej Żylicz

      Version of Record online: 2 APR 2004 | DOI: 10.1002/cncr.20191

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      To determine whether tumor cells that harbor P53 and K-ras mutations could be detected in histopathologically tumor-free surgical margins, the authors obtained DNA from primary tumors and surgical margins in patients with nonsmall cell lung carcinoma for molecular analysis. The results demonstrated the frequent occurrence of P53 and K-ras mutations in surgical margins that were determined to be tumor free on light microscopy.

    12. Psychological Oncology
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      Discrepancies among patients, family members, and physicians in Korea in terms of values regarding the withholding of treatment from patients with terminal malignancies (pages 1961–1966)

      Do-Youn Oh, Jee-Eun Kim, Chee-Hun Lee, Jae-Sung Lim, Kyung-Hye Jung, Dae Seog Heo, Yung-Jue Bang and Noe Kyeong Kim

      Version of Record online: 29 MAR 2004 | DOI: 10.1002/cncr.20184

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      Values held on issues such as therapeutic decision-making and the withholding of life-sustaining treatments from patients with terminal malignancies are discordant between physicians and family members. To resolve controversies regarding the role of the physician in end-of-life decisions, the values of physicians, patients, and family members should be considered in the final decision-making process.

      See also pages 1771–5.

    13. Symptom Control and Palliative Care
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      Palliative nutritional intervention in addition to cyclooxygenase and erythropoietin treatment for patients with malignant disease: Effects on survival, metabolism, and function : A randomized prospective study (pages 1967–1977)

      Kent Lundholm, Peter Daneryd, Ingvar Bosaeus, Ulla Körner and Elisabet Lindholm

      Version of Record online: 24 MAR 2004 | DOI: 10.1002/cncr.20160

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      The authors investigated whether specialized, nutrition-focused patient care administered in conjunction with cyclooxygenase and epoetin treatment improved metabolic function and outcome in patients with malignant disease who were experiencing cachexia. The results of the current study strongly support that nutrition is a limiting factor influencing outcome in patients receiving palliative treatment.

    14. Translational Research
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      Characterization of FAMPAC, a newly identified human pancreatic carcinoma cell line with a hereditary background (pages 1978–1986)

      Sven Eisold, Eduard Ryschich, Michael Linnebacher, Thomas Giese, Dirk Nauheimer, Anja Wild, Detlef K. Bartsch, Markus W. Büchler and Jan Schmidt

      Version of Record online: 31 MAR 2004 | DOI: 10.1002/cncr.20193

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      The authors have characterized a newly established pancreatic carcinoma cell line, FAMPAC, in a patient with a familial history of pancreatic carcinoma. FAMPAC is a rapidly growing, tumorigenic cell line that exhibits genetic alterations in the tumor suppressor genes p53 and p16.

  8. Correspondence

    1. Top of page
    2. EDITORIAL
    3. Review Articles
    4. Review Article
    5. Review Articles
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Correspondence
    10. Erratum
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      Author reply (page 1988)

      Allan Lipton

      Version of Record online: 18 MAR 2004 | DOI: 10.1002/cncr.20196

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      Author reply (page 1990)

      Mark Garzotto, Tomasz M. Beer and Motomi Mori

      Version of Record online: 29 MAR 2004 | DOI: 10.1002/cncr.20197

  9. Erratum

    1. Top of page
    2. EDITORIAL
    3. Review Articles
    4. Review Article
    5. Review Articles
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Correspondence
    10. Erratum
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