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Cancer

Cover image for Cancer

1 July 2004

Volume 101, Issue 1

Pages 1–210

  1. Listen to the Patient

    1. Top of page
    2. Listen to the Patient
    3. Commentary
    4. Review Article
    5. Review Articles
    6. Original Articles
    7. Correspondence
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      An unforgettable surgery (pages 1–2)

      Sharon Cowden

      Version of Record online: 13 MAY 2004 | DOI: 10.1002/cncr.20331

  2. Commentary

    1. Top of page
    2. Listen to the Patient
    3. Commentary
    4. Review Article
    5. Review Articles
    6. Original Articles
    7. Correspondence
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      Annual report to the nation on the status of cancer, 1975–2001, with a special feature regarding survival (pages 3–27)

      Ahmedin Jemal, Limin X. Clegg, Elizabeth Ward, Lynn A. G. Ries, Xiaocheng Wu, Patricia M. Jamison, Phyllis A. Wingo, Holly L. Howe, Robert N. Anderson and Brenda K. Edwards

      Version of Record online: 3 JUN 2004 | DOI: 10.1002/cncr.20288

      Cancer death rates have continued to decline since the early 1990s, whereas delay-adjusted incidence rates have stabilized. Relative survival rates have significantly improved for several malignancies over the last 20 years due, in part, to advances in detection and treatment. However, not all segments of the U.S. population have benefited equally from such advances.

  3. Review Article

    1. Top of page
    2. Listen to the Patient
    3. Commentary
    4. Review Article
    5. Review Articles
    6. Original Articles
    7. Correspondence
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      Dermatofibrosarcoma protuberans: A report on 29 patients treated by Mohs micrographic surgery with long-term follow-up and review of the literature (pages 28–38)

      Stephen N. Snow, Ellen M. Gordon, Paul O. Larson, Mohammed M. Bagheri, Michael L. Bentz and David B. Sable

      Version of Record online: 11 MAY 2004 | DOI: 10.1002/cncr.20316

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      The authors report on 29 patients with dermatofibrosarcoma protuberans (DFSP) who underwent Mohs micrographic surgery (MMS) and had more than 5 years of follow-up. In addition, they reviewed the medical literature to summarize the accumulated experience of MMS treatment in the management of DFSP.

  4. Review Articles

    1. Top of page
    2. Listen to the Patient
    3. Commentary
    4. Review Article
    5. Review Articles
    6. Original Articles
    7. Correspondence
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      Pediatric gastrointestinal stromal tumors and leiomyosarcoma : The St. Jude Children's Research Hospital experience and a review of the literature (pages 39–50)

      Monica S. Cypriano, Jesse J. Jenkins, Alberto S. Pappo, Bhaskar N. Rao and Najat C. Daw

      Version of Record online: 28 MAY 2004 | DOI: 10.1002/cncr.20352

      Gastrointestinal stromal tumors (GISTs) and leiomyosarcomas (LMSs) rarely affect pediatric patients. Surgery was the treatment of choice for both entities, and tumor resectability was a key prognostic factor. KIT staining helped to distinguish GISTs from LMSs.

  5. Original Articles

    1. Top of page
    2. Listen to the Patient
    3. Commentary
    4. Review Article
    5. Review Articles
    6. Original Articles
    7. Correspondence
    1. Disease Site

      Breast Disease
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      Breast carcinoma in men : A population-based study (pages 51–57)

      Sharon H. Giordano, Deborah S. Cohen, Aman U. Buzdar, George Perkins and Gabriel N. Hortobagyi

      Version of Record online: 24 MAY 2004 | DOI: 10.1002/cncr.20312

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      The current study used data from the Surveillance, Epidemiology, and End Results cancer registry to present epidemiologic data concerning 2537 cases of male breast carcinoma. Findings demonstrated that the incidence of breast carcinoma in men is increasing and that there are epidemiologic and biologic differences between men and women with breast carcinoma.

    2. Gastrointestinal Tract
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      Overexpression of synuclein-γ in pancreatic adenocarcinoma (pages 58–65)

      Zhongkui Li, Guido M. Sclabas, Bailu Peng, Kenneth R. Hess, James L. Abbruzzese, Douglas B. Evans and Paul J. Chiao

      Version of Record online: 19 MAY 2004 | DOI: 10.1002/cncr.20321

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      To achieve a better understanding of the clinical features of pancreatic carcinoma, such as locally aggressive growth, metastasis, and chemotherapy resistance, the authors conducted serial analyses of gene expression profiles and demonstrated that synuclein-γ was overexpressed in human pancreatic carcinoma. The overexpression of synuclein-γ may play a role in pancreatic carcinoma invasion.

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      Postsurgical disparity in survival between African Americans and Caucasians with colonic adenocarcinoma (pages 66–76)

      Dominik Alexander, Chakrapani Chatla, Ellen Funkhouser, Sreelatha Meleth, William E. Grizzle and Upender Manne

      Version of Record online: 24 MAY 2004 | DOI: 10.1002/cncr.20337

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      In the current report on racial differences in survival based on tumor location and tumor stage, the authors examined African-American patients and Caucasian patients who underwent surgery alone for colorectal adenocarcinoma. The results indicate decreased overall survival at 5 years and 10 years postsurgery for African-American patients who had Stage II colonic adenocarcinoma, but not for those who had rectal tumors. This disparity may not be attributable to tumor stage at diagnosis or treatment.

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      Circulating D-dimer levels are better predictors of overall survival and disease progression than carcinoembryonic antigen levels in patients with metastatic colorectal carcinoma (pages 77–82)

      Kimberly Blackwell, Herbert Hurẃitz, Grazyna Liebérman, William Novotny, Stacey Snyder, Mark Dewhirst and Charles Greenberg

      Version of Record online: 28 MAY 2004 | DOI: 10.1002/cncr.20336

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      The current study prospectively examined serial D-dimer levels in patients with metastatic colorectal carcinoma undergoing chemotherapy with or without bevacizumab. Initial D-dimer levels predicted overall survival, and increases in D-dimer levels predicted disease progression. These findings probably reflect the importance of coagulation in tumor angiogenesis, invasion, and metastasis.

    5. Genitourinary Disease
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      Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status (pages 83–89)

      Heng Hong, Chinghai Kao, Meei-Huey Jeng, John N. Eble, Michael O. Koch, Thomas A. Gardner, Shaobo Zhang, Lang Li, Chong-Xian Pan, Zhiqiang Hu, Gregory T. MacLennan and Liang Cheng

      Version of Record online: 28 MAY 2004 | DOI: 10.1002/cncr.20327

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      In the current study, overexpression of coactivator-associated arginine methyltransferase 1 (CARM1) was involved in the development of hormone-dependent prostate carcinoma as well as androgen-independent prostate carcinoma. The authors concluded that because CARM1 is functionally different from most other transcriptional coactivators of androgen receptor, it may serve as a new target for the treatment of hormone-independent prostate carcinoma.

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      Time to disease progression to evaluate a novel protein kinase C inhibitor, UCN-01, in renal cell carcinoma (pages 90–95)

      Brian I. Rini, Vivian Weinberg, Vanessa Shaw, Janet Scott, Robert Bok, John W. Park and Eric J. Small

      Version of Record online: 11 MAY 2004 | DOI: 10.1002/cncr.20313

      UCN-01 is a protein kinase C inhibitor with potential antitumor activity in renal cell carcinoma (RCC) via vascular endothelial growth factor inhibition. A novel endpoint of time to disease progression was employed to evaluate UCN-01 in RCC. No antitumor activity was observed.

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      Early prostate-specific antigen (PSA) kinetics following prostate carcinoma radiotherapy : Prognostic value of a time-and–PSA threshold model (pages 96–105)

      Sean X. Cavanaugh, Patrick A. Kupelian, Clifton D. Fuller, Chandana Reddy, Patrick Bradshaw, Brad H. Pollock and Martin Fuss

      Version of Record online: 21 MAY 2004 | DOI: 10.1002/cncr.20328

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      Using a time and prostate-specific antigen (PSA) threshold model, significant differences in long-term biochemical recurrence–free survival between cohorts were established as early as 90 days after external-beam radiotherapy for localized prostate carcinoma. Applying this new model involving a PSA-based early prognosticator of outcome after prostate carcinoma therapy may allow the scientific community to evaluate promising treatment concepts and technologies at a highly accelerated pace.

    8. Gynecologic Oncology
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      Association between serum levels of soluble tumor necrosis factor receptors/CA 125 and disease progression in patients with epithelial ovarian malignancy : A Gynecologic Oncology Group study (pages 106–115)

      Robert A. Burger, Kathleen M. Darcy, Philip J. DiSaia, Bradley J. Monk, Elizabeth A. Grosen, Tetsuya Gatanaga, Gale A. Granger, Jianmin Wang, Chunqiao Tian, Parviz Hanjani and David E. Cohn

      Version of Record online: 25 MAY 2004 | DOI: 10.1002/cncr.20314

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      A prospective serum biomarker study was undertaken to determine the association of serum levels of soluble tumor necrosis factor receptors I (sTNFR-I) and II (sTNFR-II), alone or in association with CA 125, with clinical characteristics and outcomes in patients with epithelial ovarian malignancies. Results suggest that distinct relationships exist between pretreatment serum levels of sTNFR-I or sTNFR-II compared with CA 125 and historically important clinicopathologic variables. This study also provides compelling evidence of a more refined risk assessment model for ovarian cancer progression when serum concentrations of all three biomarkers are simultaneously included in Cox regression analyses.

    9. Head and Neck Disease
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      Tobacco use outcomes among patients with head and neck carcinoma treated for nicotine dependence : A matched-pair analysis (pages 116–124)

      Yolanda I. Garces, Darrell R. Schroeder, Liza M. Nirelli, Gary A. Croghan, Ivana T. Croghan, Robert L. Foote and Richard D. Hurt

      Version of Record online: 28 MAY 2004 | DOI: 10.1002/cncr.20350

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      Tobacco use outcomes among patients with head and neck carcinoma were compared with a group of matched controls from the general population of patients treated for nicotine dependence. The authors found that nicotine dependence treatments were effective among patients with head and neck carcinoma, particularly when delivered shortly after initial diagnosis and for those who received surgery as their primary treatment.

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      Smoking and drinking can induce p15 methylation in the upper aerodigestive tract of healthy individuals and patients with head and neck squamous cell carcinoma (pages 125–132)

      Hsiao Wen Chang, Guang Sheng Ling, William Ignace Wei and Anthony Po-Wing Yuen

      Version of Record online: 25 MAY 2004 | DOI: 10.1002/cncr.20323

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      The authors evaluated the effect of tobacco and alcohol use on p15 gene methylation in cells from mouth and throat samples of physically healthy individuals and patients with head and neck squamous cell carcinoma (HNSCC). The results suggested that p15 gene methylation can be induced by chronic smoking and drinking and may play a role in the very early stage of carcinogenesis in HNSCC.

    11. Hepatobiliary Disease
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      Pilot study of celecoxib and infusional 5-fluorouracil as second-line treatment for advanced pancreatic carcinoma (pages 133–138)

      Michele Milella, Alain Gelibter, Serena Di Cosimo, Emilio Bria, Enzo Maria Ruggeri, Paolo Carlini, Paola Malaguti, Mario Pellicciotta, Edmondo Terzoli and Francesco Cognetti

      Version of Record online: 19 MAY 2004 | DOI: 10.1002/cncr.20338

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      Combined celecoxib and infusional 5-fluorouracil may induce durable, clinically meaningful responses in a minority of patients with far advanced, gemcitabine-resistant/refractory pancreatic ductal adenocarcinoma despite negligible toxicity. Further exploration of cyclooxygenase-2 inhibition as a therapeutic strategy in this disease is warranted.

    12. Neuro-Oncology
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      Immunochemotherapy with rituximab and temozolomide for central nervous system lymphomas (pages 139–145)

      Eric T. Wong, Roy Tishler, Loretta Barron and Julian K. Wu

      Version of Record online: 25 MAY 2004 | DOI: 10.1002/cncr.20339

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      The authors report their experience with an immunochemotherapy regimen, consisting of rituximab and temozolomide, that exhibited efficacy against recurrent PCNSL and against systemic non-Hodgkin lymphoma that had metastasized to the CNS. This immunochemotherapy combination may offer superior efficacy compared with either agent alone.

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      Supratentorial gangliogliomas: Histopathologic grading and tumor recurrence in 184 patients with a median follow-up of 8 years (pages 146–155)

      Cordelia Luyken, Ingmar Blümcke, Rolf Fimmers, Horst Urbach, Otmar D. Wiestler and Johannes Schramm

      Version of Record online: 28 MAY 2004 | DOI: 10.1002/cncr.20332

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      Over a median follow-up period of 8 years, tumor recurrence was identified in only 3% of 184 patients with supratentorial gangliogliomas. However, malignant progression (2%) and death (1%) also were encountered. A favorable prognosis was associated with Grade 1 disease according to the World Health Organization classification system. Tumor location within the temporal lobe, complete resection of the lesion, and chronic seizures were additional parameters that predicted a favorable outcome after neurosurgical therapy.

    14. Sarcoma
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      A phase II study of cisplatin, doxorubicin, and ifosfamide with peripheral blood stem cell support in patients with skeletal osteosarcoma and variant bone tumors with a poor prognosis (pages 156–163)

      Shreyaskumar R. Patel, Nicholas Papadopolous, A. Kevin Raymond, Michele Donato, Chu-Myong Seong, Alan W. Yasko, Valerae O. Lewis, Patrick P. Lin, Richard Champlin and Robert S. Benjamin

      Version of Record online: 13 MAY 2004 | DOI: 10.1002/cncr.20317

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      A dose-intensive combination of doxorubicin, ifosfamide, and cisplatin with peripheral blood stem cell support improved by ≥ 90% the necrosis rate in patients with bone osteosarcomas and variant bone tumors with a poor prognosis. However, the toxicity profile was significant and limited the duration of postoperative chemotherapy.

    15. Discipline

      Diagnostic Imaging
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      Positron emission tomography for unexplained elevation of serum squamous cell carcinoma antigen levels during follow-up for patients with cervical malignancies : A Phase II study (pages 164–171)

      Ting-Chang Chang, Kim-Seng Law, Ji-Hong Hong, Chyong-Huey Lai, Koon-Kwan Ng, Suei Hsueh, Lai-Chu See, Yu-Chen Chang, Chien-Sheng Tsai, Hung-Hsueh Chou, Kuan-Gen Huang, Jui-Der Liou, Cheng-Tao Lin, Angel Chao, Min-Yu Chen, Tzu-I Wu, Shih-Ya Ma and Tzu-Chen Yen

      Version of Record online: 28 MAY 2004 | DOI: 10.1002/cncr.20349

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      Elevation of serum squamous cell carcinoma antigen levels on follow-up without detectable recurrence in patients with cervical carcinoma presents a diagnostic and therapeutic challenge. Fluorine-18-labeled fluoro-2-deoxy-D-glucose positron emission tomography expedited the detection of disease recurrence in this setting and thereby allowed earlier intervention, which may have a positive impact on outcome.

    16. Epidemiology
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      Association of colonic and endometrial carcinomas in Portuguese families with hereditary nonpolyposis colorectal carcinoma significantly increases the probability of detecting a pathogenic mutation in mismatch repair genes, primarily the MSH2 gene (pages 172–177)

      Pedro A. Lage, Cristina Albuquerque, Rita G. Sousa, Marilia L. Cravo, Maria Salazar, Inês Francisco, Lara Maia, Isabel Claro, Alexandra Suspiro, Paula Rodrigues, Hélder Raposo, Paulo A. Fidalgo and Carlos Nobre-Leitão

      Version of Record online: 25 MAY 2004 | DOI: 10.1002/cncr.20320

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      Hereditary nonpolyposis colorectal carcinoma (HNPCC) is an autosomic disease that carries a high risk of developing colorectal carcinoma as well as other extracolonic tumors, including endometrial carcinoma. Mutations in MLH1 and MSH2 are found in a significant number of families. In the current study, the authors found that the presence of endometrial carcinoma in families with HNPCC conferred a significantly greater probability of detecting a pathogenic mutation, which may have important implications when referring patients for genetic testing.

    17. Medical Oncology
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      Reducing the time interval between cycles using standard doses of docetaxel and lenogastrim support : A feasibility study (pages 178–182)

      Stéphane Culine, Gilles Romieu, Michel Fabbro, Catherine Becht, Didier Cupissol, Catherine Guillemare, Jean-Pierre Bleuse, Véronique Lotz and Sophie Gourgou

      Version of Record online: 25 MAY 2004 | DOI: 10.1002/cncr.20351

      In the current study, the introduction of granulocyte–colony-stimulating factor (lenograstim) as primary prophylaxis allowed the administration of a standard dose of docetaxel every 14 days with manageable toxicities.

    18. Pathology
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      Laser capture microdissection analysis reveals frequent allelic losses in papillary urothelial neoplasm of low malignant potential of the urinary bladder (pages 183–188)

      Liang Cheng, Gregory T. MacLennan, Shaobo Zhang, Mingsheng Wang, Chong-Xian Pan and Michael O. Koch

      Version of Record online: 21 MAY 2004 | DOI: 10.1002/cncr.20343

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      In the current study, the authors performed loss of heterozygosity (LOH) analysis on 26 patients with a diagnosis of papillary urothelial neoplasm of low malignant potential (PUNLMP). Genomic DNA was extracted from formalin-fixed slides using laser capture microdissection. Eighty-one percent of patients with PUNLMP tumors had allelic loss in at least 1 of the DNA loci studied. The high frequency of LOH at various loci suggested that PUNLMP tumors share similar genetic instability with advanced stage (≥ pT2) bladder carcinoma.

    19. Translational Research
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      The cost-effectiveness of aspirin versus cyclooxygenase-2-selective inhibitors for colorectal carcinoma chemoprevention in healthy individuals (pages 189–197)

      Chin Hur, Lee S. Simon and G. Scott Gazelle

      Version of Record online: 7 MAY 2004 | DOI: 10.1002/cncr.20329

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      A cost-effectiveness analysis showed that aspirin was more effective and less costly than cyclooxygenase-2-selective inhibitors when used for colorectal carcinoma chemoprevention.

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      Role of the aging vasculature and Erb B-2 signaling in epidermal growth factor-dependent intravasion of breast carcinoma cells (pages 198–205)

      Daniel J. Price, Shalom Avraham, Shuxian Jiang, Yigong Fu and Hava Karsenty Avraham

      Version of Record online: 25 MAY 2004 | DOI: 10.1002/cncr.20340

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      These studies indicated that aging of endothelium may contribute to the invasive phenotype of breast carcinoma cells. Furthermore, “cross-talk” between Erb B-2 and epidermal growth factor receptor is required for the intravasion of these cells into the surrounding vasculature.

  6. Correspondence

    1. Top of page
    2. Listen to the Patient
    3. Commentary
    4. Review Article
    5. Review Articles
    6. Original Articles
    7. Correspondence
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      Prolonged survival after complete resection of metastases from intraocular melanoma (pages 207–208)

      Michel Rivoire, Laurent Kodjikian and Sylvie Négrier

      Version of Record online: 19 MAY 2004 | DOI: 10.1002/cncr.20324

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      Author reply (page 208)

      Eddy C. Hsueh and Donald L. Morton

      Version of Record online: 19 MAY 2004 | DOI: 10.1002/cncr.20333

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      Author reply (pages 209–210)

      Edward Gelmann and Andrew Glass

      Version of Record online: 11 MAY 2004 | DOI: 10.1002/cncr.20334

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      Birth characteristics and hepatoblastoma risk in young children (page 210)

      Giuseppe Latini, Francesco Gallo and Claudio De Felice

      Version of Record online: 14 MAY 2004 | DOI: 10.1002/cncr.20357

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