Prognostic factors in oral cavity and oropharyngeal squamous cell carcinoma : The impact of tumor-associated macrophages (pages 2779–2787)
Benjamin Marcus, Douglas Arenberg, Julia Lee, Celina Kleer, Douglas B. Chepeha, Cecelia E. Schmalbach, Mozaffarul Islam, Supriti Paul, Quintin Pan, Samir Hanash, Rork Kuick, Sofia D. Merajver and Theodoros N. Teknos
Version of Record online: 15 NOV 2004 | DOI: 10.1002/cncr.20701
Reliable and clinically applicable markers of tumor aggressiveness have not been identified for patients with head and neck squamous cell carcinoma (HNSCC), and the survival of patients with HNSCC has not improved despite recent advances. The authors found that primary tumor macrophage content was a strong predictor of tumor aggressiveness in HNSCC.