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Cancer

Cover image for Cancer

15 December 2004

Volume 101, Issue 12

Pages 2713–2903

  1. Original Articles

    1. Top of page
    2. Original Articles
    3. Communications
    4. Correspondence
    1. Disease Site

      Chest
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      Investigation of healthcare-associated transmission of Mycobacterium tuberculosis among patients with malignancies at three hospitals and at a residential facility (pages 2713–2721)

      Joseph L. Malone, Kashef Ijaz, Lauren Lambert, Louie Rosencrans, Lynelle Phillips, Victor Tomlinson, Michael Arbise, Ronald L. Moolenaar, Mark S. Dworkin and Eduardo J. Simoes

      Version of Record online: 16 NOV 2004 | DOI: 10.1002/cncr.20698

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      A delayed tuberculosis (TB) diagnosis in 2 patients with leukemia resulted in transmission of Mycobacterium tuberculosis infection to 5 employees, and possibly 14 other individuals at a total of 3 hospitals and a residential facility for patients with malignancies. Baseline TB screening and earlier clinical recognition of TB disease could reduce healthcare facility-associated transmission of M. tuberculosis among patients with malignant disease.

    2. Gastrointestinal Tract
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      Risk factors associated with earlier age of onset in familial pancreatic carcinoma (pages 2722–2726)

      Ted A. James, David G. Sheldon, Ashwani Rajput, Boris W. Kuvshinoff, Milind M. Javle, Hector R. Nava, Judy L. Smith and John F. Gibbs

      Version of Record online: 8 NOV 2004 | DOI: 10.1002/cncr.20700

      Patients with inherited pancreatic carcinoma tend to present at an earlier age and have a greater incidence of smoking compared with patients who have sporadic pancreatic carcinoma. Both environmental and genetic factors may play a role in the clinical presentation of familial pancreatic carcinoma.

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      Cytokines in pancreatic carcinoma : Correlation with phenotypic characteristics and prognosis (pages 2727–2736)

      Behnam Ebrahimi, Susan L. Tucker, Donghui Li, James L. Abbruzzese and Razelle Kurzrock

      Version of Record online: 3 NOV 2004 | DOI: 10.1002/cncr.20672

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      Circulating levels of several cytokines are high in patients with pancreatic carcinoma, and their association with weight loss and poor performance status suggests that they may be involved in these disease manifestations. Furthermore, serum cytokine levels, in particular interleukin-6, may be a useful prognostic marker.

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      Impact of functional support on health-related quality of life in patients with colorectal cancer (pages 2737–2743)

      Shahnaz Sultan, Deborah A. Fisher, Corrine I. Voils, Anita Y. Kinney, Robert S. Sandler and Dawn Provenzale

      Version of Record online: 9 NOV 2004 | DOI: 10.1002/cncr.20699

      Patients with colorectal cancer who receive instrumental and emotional support have better health-related quality of life, irrespective of the size of their social network.

    5. Genitourinary Disease
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      Inverse association between prostatic polyunsaturated fatty acid and risk of locally advanced prostate carcinoma (pages 2744–2754)

      Vincent L. Freeman, Mohsen Meydani, Kwan Hur and Robert C. Flanigan

      Version of Record online: 19 OCT 2004 | DOI: 10.1002/cncr.20676

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      Fatty acids influence the course of early-stage prostate carcinoma. In the current study, the authors demonstrated that their effects are likely mediated through the immune system.

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      Thromboembolic events with estramustine phosphate-based chemotherapy in patients with hormone-refractory prostate carcinoma : Results of a meta-analysis (pages 2755–2759)

      Gregory M. Lubiniecki, Jesse A. Berlin, Rachel B. Weinstein and David J. Vaughn

      Version of Record online: 9 NOV 2004 | DOI: 10.1002/cncr.20673

      The current meta-analysis demonstrated that the risk of thromboembolic events in men with hormone-refractory prostate carcinoma who were treated with estramustine-based chemotherapy was 6–7%. Patient age, baseline prostatic-specific antigen level, and dose of estramustine phosphate administered did not appear to affect this risk.

    7. Gynecologic Oncology
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      Human ovarian carcinoma cells: Histone deacetylase inhibitors exhibit antiproliferative activity and potently induce apoptosis (pages 2760–2770)

      Noriyuki Takai, Norihiko Kawamata, Dorina Gui, Jonathan W. Said, Isao Miyakawa and H. Phillip Koeffler

      Version of Record online: 9 NOV 2004 | DOI: 10.1002/cncr.20709

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      The authors demonstrated that histone deacetylase inhibitors (HDACIs) were effective in inhibiting the growth of ovarian carcinoma cells in vitro and in vivo. These findings suggest that HDACIs may be particularly effective in the treatment of ovarian carcinomas.

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      Successful human ovarian autotransplantation to the upper arm (pages 2771–2778)

      Carina G. Hilders, Andrzej G. Baranski, Lex Peters, Andre Ramkhelawan and J. Baptist Trimbos

      Version of Record online: 8 NOV 2004 | DOI: 10.1002/cncr.20715

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      The authors reported on the first successful heterotopic autotransplantation to the upper arm in a young patient with cervical carcinoma. This surgical technique has the potential to be implemented in the treatment of young patients with cancer to prevent gonadal damage.

    9. Head and Neck Disease
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      Prognostic factors in oral cavity and oropharyngeal squamous cell carcinoma : The impact of tumor-associated macrophages (pages 2779–2787)

      Benjamin Marcus, Douglas Arenberg, Julia Lee, Celina Kleer, Douglas B. Chepeha, Cecelia E. Schmalbach, Mozaffarul Islam, Supriti Paul, Quintin Pan, Samir Hanash, Rork Kuick, Sofia D. Merajver and Theodoros N. Teknos

      Version of Record online: 15 NOV 2004 | DOI: 10.1002/cncr.20701

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      Reliable and clinically applicable markers of tumor aggressiveness have not been identified for patients with head and neck squamous cell carcinoma (HNSCC), and the survival of patients with HNSCC has not improved despite recent advances. The authors found that primary tumor macrophage content was a strong predictor of tumor aggressiveness in HNSCC.

    10. Hematologic Malignancies
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      Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia (pages 2788–2801)

      Hagop Kantarjian, Deborah Thomas, Susan O'Brien, Jorge Cortes, Francis Giles, Sima Jeha, Carlos E. Bueso-Ramos, Sherry Pierce, Jianqin Shan, Charles Koller, Miloslav Beran, Michael Keating and Emil J. Freireich

      Version of Record online: 12 OCT 2004 | DOI: 10.1002/cncr.20668

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      Modern intensive chemotherapy regimens have improved the prognosis for patients with adult acute lymphocytic leukemia. With these regimens, the complete response rates are now reported to be > 80%, and the long-term survival rates range from 30% to 45%. The current analysis updated the long-term results with the original hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone program, with a median follow-up time of 63 months.

    11. Lung Disease
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      The SOD2 Val/Val genotype enhances the risk of nonsmall cell lung carcinoma by p53 and XRCC1 polymorphisms (pages 2802–2808)

      Geoffrey Liu, Wei Zhou, Sohee Park, Lisa I. Wang, David P. Miller, John C. Wain, Thomas J. Lynch, Li Su and David C. Christiani

      Version of Record online: 8 NOV 2004 | DOI: 10.1002/cncr.20716

      Manganese superoxide dismutase (SOD2), X-ray cross-complementing group 1 XRCC1, and p53 all are related indirectly to modulating damage from reactive oxygen species. The SOD2 Val16Val genotype increases the risk of nonsmall cell lung carcinoma carried by XRCC1 Arg399Gln and p53 Arg72Pro polymorphisms, particularly in lung adenocarcinomas.

    12. Melanoma
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      Heterogeneity of risk for melanoma and pancreatic and digestive malignancies : A melanoma case–control study (pages 2809–2816)

      Joni L. Rutter, Christina M. Bromley, Alisa M. Goldstein, David E. Elder, Elizabeth A. Holly, DuPont Guerry IV, Patricia Hartge, Jeffery P. Struewing, David Hogg, Allan Halpern, Richard W. Sagebiel and Margaret A. Tucker

      Version of Record online: 4 NOV 2004 | DOI: 10.1002/cncr.20669

      The authors assessed melanoma risk according to family history of melanoma and other melanoma-associated malignancies and evaluated the familial heterogeneity of melanomas, pancreatic malignancies, and gastrointestinal malignancies.

    13. Sarcoma
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      Rhabdomyosarcoma: Value of myogenin expression analysis and molecular testing in diagnosing the alveolar subtype : An analysis of 109 paraffin-embedded specimens (pages 2817–2824)

      Isabelle Hostein, Marie Andraud-Fregeville, Louis Guillou, Marie-José Terrier-Lacombe, Colette Deminière, Dominique Ranchère, Catherine Lussan, Elisabeth Longavenne, Nguyen Binh Bui, Olivier Delattre and Jean-Michel Coindre

      Version of Record online: 9 NOV 2004 | DOI: 10.1002/cncr.20711

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      The authors set out to assess the value of myogenin expression analysis and molecular testing in diagnosing alveolar rhabdomyosarcoma (ARMS). Using fixed embedded tissue from a series of 109 rhabdomyosarcomas, myogenin expression was evaluated immunohistochemically and also via real-time polymerase chain reaction analysis of PAX3 and PAX7 transcripts. Although molecular testing held no apparent diagnostic value for tumors containing < 50% myogenin-positive cells, it was quite useful in the diagnosis of tumors in which > 50% of all cell nuclei were positive for myogenin expression.

    14. Discipline

      Cancer Biology
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      α1-Acid glycoprotein fucosylation as a marker of carcinoma progression and prognosis (pages 2825–2836)

      Shinji Hashimoto, Takayuki Asao, Junko Takahashi, Yuko Yagihashi, Toyo Nishimura, Abby R. Saniabadi, Dennis C. W. Poland, Willem van Dijk, Hiroyuki Kuwano, Naohisa Kochibe and Shin Yazawa

      Version of Record online: 9 NOV 2004 | DOI: 10.1002/cncr.20713

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      Serum α1-acid glycoprotein (AGP) levels were evaluated in patients with malignant disease and were compared with the levels in a healthy control group. The results indicated that variations in the relative distribution of serum AGP glycoforms were appropriate markers of disease progression and prognosis in patients with various types of carcinoma.

    15. Epidemiology
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      Longitudinal study of smoking patterns in relation to the development of smoking-related secondary primary tumors in patients with upper aerodigestive tract malignancies (pages 2837–2842)

      Kim-Anh Do, Marcella M. Johnson, J. Jack Lee, Xi Feng Wu, Qiong Dong, Waun K. Hong, Fadlo R. Khuri and Margaret R. Spitz

      Version of Record online: 9 NOV 2004 | DOI: 10.1002/cncr.20714

      The authors assessed the correlation between smoking-related second primary tumor (SPT) development and cigarette smoking habits after diagnosis and definitive treatment in patients with early-stage head and neck squamous cell carcinoma. It was found that patients who continued to smoke after successful treatment of their index head and neck malignancies had a substantially higher risk of smoking-related SPT development.

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      Trends in mortality from major cancers in the European Union, including acceding countries, in 2004 (pages 2843–2850)

      Fabio Levi, Franca Lucchini, Eva Negri and Carlo La Vecchia

      Version of Record online: 3 NOV 2004 | DOI: 10.1002/cncr.20666

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      Because 10 additional countries joined the European Union (EU) in 2004, the authors updated mortality data concerning major cancers in various countries and analyzed trends for the current population of the EU. The priority for further reduction of cancer mortality in the EU remains tobacco control together with widespread adoption of modern and effective diagnostic and therapeutic procedures.

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      Colorectal carcinoma mortality among Appalachian men and women, 1969–1999 (pages 2851–2858)

      Lori R. Armstrong, Trevor Thompson, H. Irene Hall, Steven S. Coughlin, Brooke Steele and Joe D. Rogers

      Version of Record online: 3 NOV 2004 | DOI: 10.1002/cncr.20667

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      Colorectal carcinoma screening can reduce mortality, but residents of poor or medically underserved areas may face barriers to screening. The current study assessed colorectal carcinoma mortality in Appalachia, a historically underserved area, from 1969 to 1999.

    18. Medical Oncology
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      Impact of high-dose granulocyte transfusions in patients with cancer with candidemia : Retrospective case–control analysis of 491 episodes of Candida species bloodstream infections (pages 2859–2865)

      Amar Safdar, Hend A. Hanna, Maha Boktour, Dimitrios P. Kontoyiannis, Ray Hachem, Benjamin Lichtiger, Emil J. Freireich and Issam I. Raad

      Version of Record online: 4 NOV 2004 | DOI: 10.1002/cncr.20710

      The efficacy and feasibility of donor granulocyte transfusion therapy (GTX) have changed considerably over the past four decades. The authors sought to determine the impact of high-dose GTX (approximately 5.5 × 1010 cells) in patients with candidemia.

    19. Symptom Control and Palliative Care
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      Opioid switching from transdermal fentanyl to oral methadone in patients with cancer pain (pages 2866–2873)

      Miguel Angel Benítez-Rosario, Manuel Feria, Antonio Salinas-Martín, Luis Pedro Martínez-Castillo and José Javier Martín-Ortega

      Version of Record online: 4 NOV 2004 | DOI: 10.1002/cncr.20712

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      The efficacy and safety of a protocol for opioid switching from transdermal fentanyl to methadone was established in 17 cancer patients. Opioid rotation was fully and partially effective for controlling somatic pain in 80% and 20% of patients, respectively. Delirium and myoclonus were reverted in 80% and 100% of patients, respectively, after opioid switching.

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      The equivalence and difference between the English and Chinese versions of two major, cancer-specific, health-related quality-of-life questionnaires (pages 2874–2880)

      Yin-Bun Cheung, Julian Thumboo, Cynthia Goh, Kei-Siong Khoo, William Che and Joseph Wee

      Version of Record online: 4 NOV 2004 | DOI: 10.1002/cncr.20681

      Scores on the English and Chinese versions of the Total, Emotional, and Functional Well Being Scales of the Functional Assessment of Cancer Therapy-General and the Physical Functioning and Emotional Functioning Scales of the European Organization for the Research and Treatment of Cancer Core Quality-of-Life Questionnaire C30 were equivalent. Scores on versions of other scales in the two questionnaires, at most, had clinically small differences.

    21. Translational Research
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      2-Chloroethyl-3-sarcosinamide-1-nitrosourea (SarCNU) inhibits prostate carcinoma cell growth via p53-dependent and p53-independent pathways (pages 2881–2891)

      Hung Huynh, Thanh Hung Nguyen, Lawrence Panasci and PhucTien Do

      Version of Record online: 4 NOV 2004 | DOI: 10.1002/cncr.20670

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      2-Chloroethyl-3-sarcosinamide-1-nitrosourea (SarCNU) was found to induce growth arrest in human prostate carcinoma cells both in vitro and in vivo via p53-dependent upregulation of p21Cip1/Waf1 and p53-independent phosphorylation of Cdc-2 at Tyr15. These findings suggest a potential role forSarCNU in the treatment of prostate malignancies.

  2. Communications

    1. Top of page
    2. Original Articles
    3. Communications
    4. Correspondence
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      Palliative radiation therapy for painful vertebral metastases : A practice survey (pages 2892–2896)

      Tejpal Gupta and Rajiv Sarin

      Version of Record online: 8 NOV 2004 | DOI: 10.1002/cncr.20706

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      External beam radiation therapy reportedly provides excellent palliation for painful vertebral metastases. However, to the authors' knowledge, the optimal prescription parameters are not well established with widespread heterogeneity. The authors' survey assessed the patterns of practice for palliative spinal irradiation that were most prevalent among radiation oncologists in India in general and compared them with the practice patterns at Tata Memorial Hospital.

  3. Correspondence

    1. Top of page
    2. Original Articles
    3. Communications
    4. Correspondence
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      Author reply (pages 2898–2899)

      Olivier-L Chinot

      Version of Record online: 3 NOV 2004 | DOI: 10.1002/cncr.20708

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      Author reply (page 2900)

      Upender Manne, Dominik Alexander and Chakrapani Chatla

      Version of Record online: 19 OCT 2004 | DOI: 10.1002/cncr.20703

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      Immunochemotherapy with rituximab and temozolomide for central nervous system lymphomas (pages 2900–2901)

      Vincenzo Pitini, Carmela Arrigo and Maria Righi

      Version of Record online: 4 NOV 2004 | DOI: 10.1002/cncr.20704

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      Author reply (pages 2901–2902)

      Eric T. Wong

      Version of Record online: 4 NOV 2004 | DOI: 10.1002/cncr.20705

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      Author reply (page 2903)

      Grazia Arpino, D. Craig Allred and Richard M. Elledge

      Version of Record online: 12 OCT 2004 | DOI: 10.1002/cncr.20684

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