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Cancer

Cover image for Cancer

15 July 2004

Volume 101, Issue 2

Pages 211–433

  1. Commentary

    1. Top of page
    2. Commentary
    3. Review Article
    4. Original Articles
    5. Correspondence
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      Controversies in the management of advanced laryngeal squamous cell carcinoma (pages 211–219)

      Randal S. Weber, Arlene Forastiere, David I. Rosenthal and Ollivier Laccourreye

      Article first published online: 9 JUN 2004 | DOI: 10.1002/cncr.20231

      The current treatment paradigm for patients with advanced laryngeal squamous cell carcinoma continues to evolve. The authors assembled a panel of experts from the fields of medical oncology, radiation oncology, and surgery to discuss treatment options and to defend their positions.

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      Establishing the multidisciplinary care of patients with cancer in the state of Delaware (pages 220–225)

      Nicholas J. Petrelli and Patrick A. Grusenmeyer

      Article first published online: 9 JUN 2004 | DOI: 10.1002/cncr.20371

      Delaware has the fifth highest cancer death rate in the U.S. As part of a comprehensive program to decrease the cancer mortality and incidence in the state, an infrastructure to establish the multidisciplinary care of patients with cancer was established. The current article reviews the continued success of this program in the state of Delaware in the effort to reduce the cancer incidence and mortality.

  2. Review Article

    1. Top of page
    2. Commentary
    3. Review Article
    4. Original Articles
    5. Correspondence
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      Novel therapies for myelodysplastic syndromes (pages 226–241)

      Stefan Faderl and Hagop M. Kantarjian

      Article first published online: 14 JUN 2004 | DOI: 10.1002/cncr.20381

      Myelodysplastic syndromes (MDS) constitute a heterogeneous group of disorders. In reviewing the literature on MDS, the authors found that, although progress has been made toward understanding the clinical manifestations and some of the molecular pathways that lead to ineffective hematopoiesis and leukemic transformation in MDS, current classification and prognostic schemes are not sufficient to take into consideration the significant biologic diversity of MDS. Intensive clinical and laboratory research continues.

  3. Original Articles

    1. Top of page
    2. Commentary
    3. Review Article
    4. Original Articles
    5. Correspondence
    1. Disease Site

      Breast Disease
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      Lobular neoplasia on core-needle biopsy—Clinical significance (pages 242–250)

      Grazia Arpino, D. Craig Allred, Syed Khalid Mohsin, Heidi L. Weiss, David Conrow and Richard M. Elledge

      Article first published online: 14 JUN 2004 | DOI: 10.1002/cncr.20318

      Malignant disease was found in a substantial percentage of excisional biopsy samples (14%) following the detection of lobular neoplasia on core biopsy. Thus, like patients with atypical ductal hyperplasia, patients with lobular neoplasia detected on core biopsy could be considered candidates for surgical excision, which would allow full assessment of breast carcinoma risk and thereby facilitate the planning of prevention strategies.

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      Genetic polymorphisms in the human growth hormone-1 gene (GH1) and the risk of breast carcinoma (pages 251–257)

      Zefang Ren, Qiuyin Cai, Xiao-Ou Shu, Hui Cai, Jia-Rong Cheng, Wan-Qing Wen, Yu-Tang Gao and Wei Zheng

      Article first published online: 14 JUN 2004 | DOI: 10.1002/cncr.20375

      Recent in vitro and in vivo experiments have shown that human growth hormone-1 (GH1) induces carcinogenesis. The authors investigated four common polymorphisms in the proximal region (A-75G, A-75G, G-57T, A-6G, and A69G) and one in intron 4 (T1169A) of the GH1 gene in relation to breast carcinoma risk in a large, population-based case–control study involving Chinese women. None of the polymorphisms, either alone or in combination, were associated with the risk of developing breast carcinoma. The results of the current study suggest that these polymorphisms may not be a major genetic susceptibility factor for breast carcinoma among Chinese women.

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      Lack of association between amplification of her-2 and response to preoperative taxanes in patients with breast carcinoma (pages 258–263)

      Ana M. Gonzalez-Angulo, Savitri Krishnamurthy, Yuko Yamamura, Kristine R. Broglio, Lajos Pusztai, Aman U. Buzdar, Gabriel N. Hortobagyi and Francisco J. Esteva

      Article first published online: 14 JUN 2004 | DOI: 10.1002/cncr.20348

      Her-2 amplification detected by fluorescence in situ hybridization is not predictive of pathologic response to preoperative taxanes in patients with early-stage breast carcinoma.

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      Estrogen-metabolizing gene polymorphisms in the assessment of breast carcinoma risk and fibroadenoma risk in Caucasian women (pages 264–269)

      Lukas A. Hefler, Clemens B. Tempfer, Christoph Grimm, Antje Lebrecht, Eva Ulbrich, Georg Heinze, Sepp Leodolter, Christian Schneeberger, Manfred W. Mueller, Axel Muendlein and Heinz Koelbl

      Article first published online: 14 JUN 2004 | DOI: 10.1002/cncr.20361

      In a case–control study involving 2486 patients, the authors assessed the association of breast diseases with 10 polymorphisms of genes encoding enzymes involved in estrogen metabolism. The authors obtained the first single-nucleotide polymorphism data indicating that the cytochrome P-450 (CYP) family 17 gene (CYP17) and CYP1A1-1 play a role in the pathogenesis of fibroadenoma. In addition, the current study provided evidence that CYP1A1 is a low-penetrance susceptibility gene with respect to breast carcinoma in a large series of Caucasian women.

    5. Gastrointestinal Tract
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      Human papillomavirus, smoking, and sexual practices in the etiology of anal cancer (pages 270–280)

      Janet R. Daling, Margaret M. Madeleine, Lisa Godefroy Johnson, Stephen M. Schwartz, Katherine A. Shera, Michelle A. Wurscher, Joseph J. Carter, Peggy L. Porter, Denise A. Galloway and James K. McDougall

      Article first published online: 2 JUN 2004 | DOI: 10.1002/cncr.20365

      Human papillomavirus DNA was found in all histologic types of anal cancer, at all tumor sites, and in invasive and in situ tumors. The risk of anal cancer for both men and women increased with the number of sexual partners, and both men and women who practiced anal intercourse had an increased risk of anal cancer. Current smokers among men and women were at particularly high risk of anal cancer independent of age and other risk factors for anal cancer.

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      Anal cancer incidence and survival: The Surveillance, Epidemiology, and End Results experience, 1973–2000 (pages 281–288)

      Lisa G. Johnson, Margaret M. Madeleine, Laura M. Newcomer, Stephen M. Schwartz and Janet R. Daling

      Article first published online: 14 JUN 2004 | DOI: 10.1002/cncr.20364

      In the United States, the incidence of anal cancer increased between 1973 and 2000, particularly among men. During this same period, the 5-year relative survival among patients with anal cancer improved for white women, remained constant for white men and black women, and decreased for black men.

    7. Genitourinary Disease
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      Adult Wilms' tumor: A monoinstitutional experience and a review of the literature (pages 289–293)

      Monica Terenziani, Filippo Spreafico, Paola Collini, Luigi Piva, Daniela Perotti, Marta Podda, Lorenza Gandola, Maura Massimino, Stefano Cereda, Graziella Cefalo, Roberto Luksch, Michela Casanova, Andrea Ferrari, Daniela Polastri, Pinuccia Valagussa and Franca Fossati-Bellani

      Article first published online: 9 JUN 2004 | DOI: 10.1002/cncr.20387

      Wilms' tumor is a rare disease in adults. In the current study, the authors found that poor compliance with specific therapeutic guidelines may contribute to the worse outcome in adults compared with children.

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      Prostate carcinoma among men with human immunodeficiency virus infection (pages 294–299)

      Nancy F. Crum, Craig R. Spencer and Christopher L. Amling

      Article first published online: 9 JUN 2004 | DOI: 10.1002/cncr.20389

      The current study demonstrated that prostate carcinoma is common among men with human immunodeficiency virus (HIV) infection and that it is correlated with both age and duration of HIV infection. Given the increasing life expectancy of men with HIV infection, the authors recommended routine prostate carcinoma screening among this population.

    9. Head and Neck Disease
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      Lung metastasis alone in nasopharyngeal carcinoma: A relatively favorable prognostic group : A study by the Hong Kong Nasopharyngeal Carcinoma Study Group (pages 300–306)

      Edwin P. Hui, Sing F. Leung, Joseph S. K. Au, Benny Zee, Stewart Tung, Daniel Chua, Wai M. Sze, Chun K. Law, To W. Leung and Anthony T. C. Chan

      Article first published online: 26 MAY 2004 | DOI: 10.1002/cncr.20358

      Despite the poor overall survival of patients with distant metastatic nasopharyngeal carcinoma (NPC), those patients with lung metastasis alone were found to represent a distinctive group that was associated with a significantly better overall survival. An aggressive treatment approach in the management of metastatic NPC, especially if the metastasis is confined to the lungs, should be considered.

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      Prognostic impact of hemoglobin levels on treatment outcome in patients with nasopharyngeal carcinoma treated with sequential chemoradiotherapy or radiotherapy alone (pages 307–316)

      Daniel T. T. Chua, Jonathan S. T. Sham and Damon T. K. Choy

      Article first published online: 14 JUN 2004 | DOI: 10.1002/cncr.20366

      The authors reviewed data from a randomized trial comparing induction chemotherapy plus radiotherapy with radiotherapy alone in patients with nasopharyngeal carcinoma. They found that low hemoglobin levels during radiation were predictive of local disease recurrence and malignancy-related death.

    11. Hematologic Oncology
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      Malignancy-related causes of death in human immunodeficiency virus–infected patients in the era of highly active antiretroviral therapy (pages 317–324)

      Fabrice Bonnet, Charlotte Lewden, Thierry May, Laurence Heripret, Eric Jougla, Sibylle Bevilacqua, Dominique Costagliola, Dominique Salmon, Geneviève Chêne and Philippe Morlat

      Article first published online: 14 JUN 2004 | DOI: 10.1002/cncr.20354

      Malignancies accounted for 28% of all deaths in a national prospective study involving human immunodeficiency virus–infected patients during the highly active antiretroviral therapy era. Hemopathies often are associated with advanced immunosuppression, and lethal solid tumors may occur in individuals with controlled immunologic parameters.

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      The benefit of induction chemotherapy in patients age ≥ 75 years : A retrospective study of 110 patients from a single institution (pages 325–331)

      Norbert Vey, Diane Coso, Valerie-Jeanne Bardou, Anne-Marie Stoppa, Anne-Chantal Braud, Reda Bouabdallah, Daniele Sainty, Marie-Joelle Mozziconacci, Marina Lafage, Gandhi Damaj, Didier Blaise, Jean-Albert Gastaut and Dominique Maraninchi

      Article first published online: 7 JUN 2004 | DOI: 10.1002/cncr.20353

      In this retrospective study of 110 patients age ≥ 75 years who received different treatments for newly diagnosed acute myeloid leukemia, the authors evaluated the benefits of intensive treatment approaches. The results showed that selected elderly patients can benefit from induction chemotherapy and that a complete response translates into improved survival, as it does in younger patients.

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      Imatinib mesylate therapy reduces bone marrow fibrosis in patients with chronic myelogenous leukemia (pages 332–336)

      Carlos E. Bueso-Ramos, Jorge Cortes, Moshe Talpaz, Susan O'Brien, Francis Giles, Mary Beth Rios, L. Jeffrey Medeiros and Hagop Kantarjian

      Article first published online: 26 MAY 2004 | DOI: 10.1002/cncr.20380

      Significant resolution of bone marrow fibrosis was observed in 61% of patients with Philadelphia chromosome-positive, chronic-phase chronic myelogenous leukemia (CML) who were treated with imatinib mesylate after failure with interferon-α. This finding may improve further the prognosis of patients with CML.

    14. Hepatobiliary Disease
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      Transjugular intrahepatic portosystemic shunts: Experience in the oncology setting (pages 337–345)

      Michael J. Wallace, David C. Madoff, Kamran Ahrar and Carla L. Warneke

      Article first published online: 24 MAY 2004 | DOI: 10.1002/cncr.20367

      Transjugular intrahepatic portosystemic shunt placement for patients with cancer can be performed safely without high rates of procedure-related complications. Patients with malignancy and ascites, primary hepatic malignancy, or model for end-stage liver disease scores ≥ 12 had the lowest 90-day survival rates.

    15. Discipline

      Diagnostic Imaging
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      The utility of computed tomography scans in predicting suboptimal cytoreductive surgery in women with advanced ovarian carcinoma (pages 346–352)

      Sean C. Dowdy, Sally A. Mullany, Kathy R. Brandt, Bonnie J. Huppert and William A. Cliby

      Article first published online: 2 JUN 2004 | DOI: 10.1002/cncr.20376

      The presence of diffuse peritoneal thickening and large-volume ascites on preoperative computed tomography scans of patients with ovarian carcinoma was associated with a very low rate of optimal cytoreduction in a surgical practice. Patients with these characteristics may be more appropriately treated with neoadjuvant chemotherapy followed by surgical cytoreduction.

    16. Epidemiology
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      Reproductive factors and risk of breast carcinoma in a study of white and African-American women (pages 353–362)

      Giske Ursin, Leslie Bernstein, Yaping Wang, Sarah J. Lord, Dennis Deapen, Jonathan M. Liff, Sandra A. Norman, Linda K. Weiss, Janet R. Daling, Polly A. Marchbanks, Kathleen E. Malone, Suzanne G. Folger, Jill A. McDonald, Ronald T. Burkman, Michael S. Simon, Brian L. Strom and Robert Spirtas

      Article first published online: 7 JUN 2004 | DOI: 10.1002/cncr.20373

      Overall, parity and lactation had similar effects on breast carcinoma risk in white and African-American women. If younger African-American women now are giving birth to fewer children than in the past, without a substantial increase in breastfeeding, breast carcinoma rates may continue to increase at a more rapid rate among these women compared with white women.

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      Familial risk and clustering of nasopharyngeal carcinoma in Guangdong, China (pages 363–369)

      Wei-Hua Jia, Bing-Jian Feng, Zong-Li Xu, Xiao-Shi Zhang, Ping Huang, Li-Xi Huang, Xing-Juan Yu, Qi-Sheng Feng, Ming-Hong Yao, Yin Yao Shugart and Yi-Xin Zeng

      Article first published online: 14 JUN 2004 | DOI: 10.1002/cncr.20372

      Families with multiple cases of nasopharyngeal carcinoma (NPC) are distributed predominantly among Cantonese-speaking high-risk subgroups in Guangdong Province, China. A significantly elevated risk for NPC was observed in first-degree relatives of probands with early age of onset (< 40 years; standardized incidence ratio, 9.01 [95% confidence interval, 6.10–13.30]).

    18. Medical Oncology
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      Phase II study of high-dose fish oil capsules for patients with cancer-related cachexia : A Cancer and Leukemia Group B study (pages 370–378)

      C. Patrick Burns, Susan Halabi, Gerald Clamon, Ellen Kaplan, Raymond J. Hohl, James N. Atkins, Michael A. Schwartz, Brett A. Wagner and Electra Paskett

      Article first published online: 14 JUN 2004 | DOI: 10.1002/cncr.20362

      If a suitable dose of omega-3 fish oil fatty acid capsules used to supplement the diet can be tolerated, a subset of patients with malignancy-related cachexia should experience increased or stabilized body weight.

    19. Pathology
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      Clinical utility of serum amyloid A and macrophage migration inhibitory factor as serum biomarkers for the detection of nonsmall cell lung carcinoma (pages 379–384)

      Nayela Khan, Charles J. Cromer, Michael Campa and Edward F. Patz Jr.

      Article first published online: 14 JUN 2004 | DOI: 10.1002/cncr.20377

      The current study evaluated the clinical utility of serum amyloid A (SAA) and macrophage migration inhibitory factor (MIF) as diagnostic serum markers for lung carcinoma. SAA has potential utility as part of a panel of serum biomarkers, whereas serum levels of MIF could not be used to differentiate between patients with lung carcinoma and patients with other diseases.

    20. Pediatric Oncology
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      Long-term results of the first Italian Association of Pediatric Hematology and Oncology protocol for the treatment of pediatric B-cell non-Hodgkin lymphoma (AIEOP LNH92) (pages 385–394)

      Marta Pillon, Maria Teresa Di Tullio, Alberto Garaventa, Simone Cesaro, Maria Caterina Putti, Claudio Favre, Alma Lippi, Gianmarco Surico, Andrea Di Cataldo, Emanuele D'Amore, Luigi Zanesco and Angelo Rosolen

      Article first published online: 14 JUN 2004 | DOI: 10.1002/cncr.20382

      Between November 1992 and October 1997, 163 children who had B-cell lymphoma (B-NHL) were treated in a prospective national trial conducted by the Italian Association of Pediatric Hematology and Oncology. Treatment was assigned on the basis of risk group, which took into account disease stage and resectability as well as serum lactate dehydrogenase levels. Long-term follow-up confirmed the observation of a favorable outcome for patients with B-NHL treated with short, intensive chemotherapy and suggested that non-Burkitt or non-Burkitt-like histology and age ≥ 10 years may have negative prognostic value for patients with B-NHL.

    21. Psychological Oncology
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      Psychologic distress after disclosure of genetic test results regarding hereditary nonpolyposis colorectal carcinoma : A preliminary report (pages 395–403)

      Yoshie Murakami, Hitoshi Okamura, Kokichi Sugano, Teruhiko Yoshida, Keiko Kazuma, Tatsuo Akechi and Yosuke Uchitomi

      Article first published online: 24 MAY 2004 | DOI: 10.1002/cncr.20363

      The authors evaluated the prevalence rates and predictors of psychologic distress and evaluated the feelings of guilt at 1 month after the disclosure of test results for hereditary nonpolyposis colorectal carcinoma in Japanese probands and unaffected relatives.

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      Prospective assessment of emotional distress, cognitive function, and quality of life in patients with cancer treated with chemotherapy (pages 404–411)

      Gregoris Iconomou, Vasiliki Mega, Angelos Koutras, Alexander V. Iconomou and Haralabos P. Kalofonos

      Article first published online: 11 JUN 2004 | DOI: 10.1002/cncr.20385

      The current study, performed prospectively, showed that nearly one-third of Greek patients with cancer treated with adjuvant or first-line chemotherapy experienced intense anxiety and depression throughout treatment and that depression was the leading predictor of global quality of life. Cognitive dysfunction was very low at baseline and no significant changes were observed over time.

    23. Radiation Oncology
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      Intensity-modulated radiotherapy and the Internet : Evaluation of the content and quality of patient-oriented information (pages 412–420)

      David A. Schomas, Michael T. Milano, John C. Roeske, Loren K. Mell and Arno J. Mundt

      Article first published online: 14 JUN 2004 | DOI: 10.1002/cncr.20359

      In general, the content and quality of patient-oriented information regarding intensity-modulated radiotherapy on the Internet are poor. Patients and their physicians need to be aware of these problems when selecting treatment courses.

    24. Symptom Control and Palliative Care
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      Predictors of place of death for Japanese patients with advanced-stage malignant disease in home care settings: A nationwide survey (pages 421–429)

      Sakiko Fukui, Naoshi Fukui and Hiromi Kawagoe

      Article first published online: 14 JUN 2004 | DOI: 10.1002/cncr.20383

      In a nationwide survey, the authors investigated predictors of place of death involving patient demographics and clinical factors, the roles and status of family caregivers, and the support provided by the healthcare system and medical professionals throughout the three phases of home palliative care in Japan. The current report is the first in which the predictors of death at home were assessed systematically for patients with advanced malignancy who received home care.

  4. Correspondence

    1. Top of page
    2. Commentary
    3. Review Article
    4. Original Articles
    5. Correspondence
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    2. You have full text access to this OnlineOpen article
      Author reply (page 431)

      Ute Kettritz

      Article first published online: 14 JUN 2004 | DOI: 10.1002/cncr.20356

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      Author Reply (pages 432–433)

      Ferdinando De Vita, Michele Orditura, Gennaro Galizia, Fortunato Ciardiello and Giuseppe Catalano

      Article first published online: 9 JUN 2004 | DOI: 10.1002/cncr.20345

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