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Cancer

Cover image for Cancer

15 September 2004

Volume 101, Issue 6

Pages 1261–1478

  1. Editorial

    1. Top of page
    2. Editorial
    3. Review Article
    4. Original Articles
    5. Correspondence
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      Breast carcinoma in African-American and White women : Application of molecular biology to understand outcome disparities (pages 1261–1263)

      Lisa A. Newman

      Article first published online: 9 AUG 2004 | DOI: 10.1002/cncr.20501

      The door to improved understanding of ethnicity-related variations in breast carcinoma risk and outcome has now been wedged open by the powerful tools of molecular biology. It is the responsibility of clinicians and investigators to accept the challenge of conducting the studies, collecting and interpreting the data, and validating the results.

      See also pages 1293–301.

  2. Review Article

    1. Top of page
    2. Editorial
    3. Review Article
    4. Original Articles
    5. Correspondence
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      Young age and outcome for women with early-stage invasive breast carcinoma (pages 1264–1274)

      Ping Zhou and Abram Recht

      Article first published online: 22 JUL 2004 | DOI: 10.1002/cncr.20523

      Although young patients with invasive breast carcinoma have a worse prognosis and higher local failure rates after breast-conserving therapy (BCT) compared with older patients, there are insufficient data to demonstrate that mastectomy provides superior long-term outcome compared with BCT. Although it is uncertain whether having truly uninvolved margins abrogates a patient's increased risk of local failure after BCT, the authors believe that young age at the time of diagnosis need not be a contraindication to BCT when meticulous attention is given to surgical techniques and margin status, together with the increasing use of systemic therapy.

  3. Original Articles

    1. Top of page
    2. Editorial
    3. Review Article
    4. Original Articles
    5. Correspondence
    1. Disease Site

      Breast Disease
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      Time interval to the development of breast carcinoma after treatment for Hodgkin disease (pages 1275–1282)

      Merideth M. M. Wendland, Alexander Tsodikov, Martha J. Glenn and David K. Gaffney

      Article first published online: 4 AUG 2004 | DOI: 10.1002/cncr.20516

      Population, cancer incidence, and survival data were extracted from nine Surveillance, Epidemiology, and End Results registries for women treated for Hodgkin disease (HD). Use of a flexible semiparametric survival methodology instrument, the PHPH model, indicated that the use of radiotherapy in the treatment of HD resulted in an increased long-term risk for the subsequent development of breast carcinoma, but conferred a short-term reduction.

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      Ductoscopic cytology and image analysis to detect breast carcinoma (pages 1283–1292)

      Edward R. Sauter, Andres Klein-Szanto, Hormoz Ehya and Brenda MacGibbon

      Article first published online: 4 AUG 2004 | DOI: 10.1002/cncr.20524

      Image analysis (IA; ploidy, S-phase fraction) and cytologic evaluation of fiberoptic ductoscopy (FD) breast specimens were feasible, and abnormal IA findings were related to the identification of malignant cytology and atypical papillomas. Omitting women with spontaneous nipple discharge improved the sensitivity and specificity of a breast carcinoma detection model that included IA, cytology, epithelial cell quantity, and visual findings from FD, suggesting that FD may ultimately prove useful, in combination with imaging studies, in early breast carcinoma detection.

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      African-American/White differences in breast carcinoma : p53 Alterations and other tumor characteristics (pages 1293–1301)

      Beth A. Jones, Stanislav V. Kasl, Christine L. Howe, Mary Lachman, Robert Dubrow, Mary McCrea Curnen, Hosanna Soler-Vila, Alicia Beeghly, Fenghai Duan and Patricia Owens

      Article first published online: 9 AUG 2004 | DOI: 10.1002/cncr.20500

      Data from this population-based breast carcinoma cohort confirmed that breast tumors in African-American women likely are more aggressive compared with breast tumors in white women and offer new evidence for possible racial/ethnic differences in p53 alterations.

      See also pages 1261–3.

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      Breast carcinoma in elderly women : Features of disease presentation, choice of local and systemic treatments compared with younger postmenopausal patients (pages 1302–1310)

      Roberto Gennari, Giuseppe Curigliano, Nicole Rotmensz, Chris Robertson, Marco Colleoni, Stefano Zurrida, Franco Nolè, Filippo de Braud, Laura Orlando, Maria Cristina Leonardi, Viviana Galimberti, Mattia Intra, Paolo Veronesi, Giuseppe Renne, Saverio Cinieri, Riccardo A. Audisio, Alberto Luini, Roberto Orecchia, Giuseppe Viale and Aron Goldhirsch

      Article first published online: 4 AUG 2004 | DOI: 10.1002/cncr.20535

      Older patients had tumors with more favorable biologic characteristics, when compared with younger postmenopausal patients. Reluctance to prescribe systemic treatments for older patients was due to the complexity of evaluation. The authors individualized care on the basis of biologic characteristics, comorbidity, functional status, and patient preferences.

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      Benefit and projected cost-effectiveness of anastrozole versus tamoxifen as initial adjuvant therapy for patients with early-stage estrogen receptor–positive breast cancer (pages 1311–1322)

      Bruce E. Hillner

      Article first published online: 6 AUG 2004 | DOI: 10.1002/cncr.20492

      The results of a computer simulation based on ATAC (‘Arimidex, Tamoxifen Alone or in Combination’) trial data suggest that in the adjuvant treatment of early-stage estrogen receptor–positive breast cancer, anastrozole will provide substantial long-term benefit in terms of disease-free survival (DFS). If this DFS benefit were to ultimately lead to a survival benefit, then anastrozole would have an acceptable incremental cost per life year gained for women with a life expectancy of > 12 years from the start of treatment.

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      Decentralization of breast cancer surgery in the United States (pages 1323–1329)

      Joan M. Neuner, Mary Ann Gilligan, Rodney Sparapani, Purushottam W. Laud, David Haggstrom and Ann B. Nattinger

      Article first published online: 9 AUG 2004 | DOI: 10.1002/cncr.20490

      In a study of physician volume of breast cancer operations among Medicare patients in six areas in the Surveillance, Epidemiology and End Results tumor registry, the authors found that surgeons had low volumes on average and estimated that few patients in the United States are treated by surgeons who perform at least the 30 annual operations previously shown to be associated with lower mortality. Individual physician characteristics (female gender, general surgery board certification, and academic affiliation) were associated with only modestly higher volumes, but higher volume was associated with differences in surgical processes of care.

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      Intramammary lymph node metastases are an independent predictor of poor outcome in patients with breast carcinoma (pages 1330–1337)

      Jeannie Shen, Kelly K. Hunt, Nadeem Q. Mirza, Savitri Krishnamurthy, S. Eva Singletary, Henry M. Kuerer, Funda Meric-Bernstam, Barry Feig, Merrick I. Ross, Frederick C. Ames and Gildy V. Babiera

      Article first published online: 6 AUG 2004 | DOI: 10.1002/cncr.20515

      The clinical significance of intramammary lymph node (intraMLN) metastases is not well characterized. In the current study, the authors found that the presence of intraMLN metastases was an independent predictor of poor outcome in patients with breast carcinoma.

    8. Gastrointestinal Tract
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      Adjuvant postoperative radiotherapy for colon carcinoma (pages 1338–1344)

      William M. Mendenhall, E. Henry Amos, W. Robert Rout, Robert A. Zlotecki, Steven N. Hochwald and William G. Cance

      Article first published online: 6 AUG 2004 | DOI: 10.1002/cncr.20526

      Adjuvant postoperative radiotherapy probably improves locoregional control and survival for patients with T4 colon carcinoma. The benefit for patients with T3N1–N2 disease is equivocal.

    9. Genitourinary Disease
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      Up-regulation of Wnt-1 and β-catenin production in patients with advanced metastatic prostate carcinoma : Potential pathogenetic and prognostic implications (pages 1345–1356)

      Gaoping Chen, Nicholas Shukeir, Anil Potti, Kanishka Sircar, Armen Aprikian, David Goltzman and Shafaat A. Rabbani

      Article first published online: 4 AUG 2004 | DOI: 10.1002/cncr.20518

      Expression levels of Wnt-1 and β-catenin were correlated with disease stage in patients with prostate carcinoma.

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      Squamous cell carcinoma of the penis : Evaluation of data from the Surveillance, Epidemiology, and End Results program (pages 1357–1363)

      Jonathan M. Rippentrop, Sue A. Joslyn and Badrinath R. Konety

      Article first published online: 29 JUL 2004 | DOI: 10.1002/cncr.20519

      An analysis of Surveillance, Epidemiology, and End Results program data concerning penile squamous cell carcinoma revealed that African-American men presented at a younger age with a higher stage of disease, whereas previously or currently married men of all races presented at an earlier stage and sought more aggressive treatment.

    11. Gynecologic Oncology
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      Vascular endothelial growth factor C and vascular endothelial growth factor receptor 2 are related closely to the prognosis of patients with ovarian carcinoma (pages 1364–1374)

      Naoyo Nishida, Hirohisa Yano, Kan Komai, Takashi Nishida, Toshiharu Kamura and Masamichi Kojiro

      Article first published online: 9 JUL 2004 | DOI: 10.1002/cncr.20449

      Vascular endothelial growth factor C (VEGF-C) and VEGF receptor 2 expression levels were correlated with the peritoneal spread of ovarian carcinoma; thus, they may be regarded as prognostic factors.

    12. Head and Neck Disease
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      Squamous cell carcinoma in situ at oropharyngeal and hypopharyngeal mucosal sites (pages 1375–1381)

      Manabu Muto, Mari Nakane, Chikatoshi Katada, Yasushi Sano, Atsushi Ohtsu, Hiroyasu Esumi, Satoshi Ebihara and Shigeaki Yoshida

      Article first published online: 27 JUL 2004 | DOI: 10.1002/cncr.20482

      Earlier detection of lesions at head and neck mucosal sites would be of great benefit to patients. The authors showed that carcinoma in situ at oropharyngeal and hypopharyngeal mucosal sites can be clinically recognized by narrowband imaging (NBI) endoscopy with a magnifying observation. NBI is a promising and potentially powerful tool for identifying carcinomas at an earlier stage at head and neck mucosal sites during routine endoscopic examination.

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      Value of routine follow-up for patients cured of laryngeal carcinoma (pages 1382–1389)

      Savitri C. Ritoe, Paul F. M. Krabbe, Johannes H. A. M. Kaanders, Frank J. A. van den Hoogen, André L. M. Verbeek and Henri A. M. Marres

      Article first published online: 13 AUG 2004 | DOI: 10.1002/cncr.20536

      Routine follow-up was offered to patients with laryngeal carcinoma in The Netherlands without sufficient proof of survival benefit or reduction of cancer-specific mortality rates for asymptomatic patients. The current study showed that the follow-up program used in The Netherlands did not achieve improved survival benefit or cancer-specific mortality rates for asymptomatic patients with laryngeal carcinoma.

    14. Hematologic Malignancies
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      Inhibition of bcr-abl and/or c-abl gene expression by small interfering, double-stranded RNAs : Cross-talk with cell proliferation factors and other oncogenes (pages 1390–1403)

      Hideki Ohba, Zhivko Zhelev, Rumiana Bakalova, Ashraf Ewis, Toshiro Omori, Mitsuru Ishikawa, Yasuo Shinohara and Yoshinobu Baba

      Article first published online: 22 JUL 2004 | DOI: 10.1002/cncr.20468

      The results of this microarray analysis demonstrated that short, 21-mer, double-stranded RNA (ds/siRNA) interference of bcr-abl expression is involved in cross-talk with many other factors that are responsible for the development of apoptosis or restoration of the proliferation and immortalization of siRNA-treated cells.

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      Immunophenotypic and molecular features, clinical outcomes, treatments, and prognostic factors associated with subcutaneous panniculitis-like T-cell lymphoma : A systematic analysis of 156 patients reported in the literature (pages 1404–1413)

      Ronald S. Go and Susan M. Wester

      Article first published online: 13 AUG 2004 | DOI: 10.1002/cncr.20502

      In patients with subcutaneous panniculitis-like T-cell lymphoma, the presence of hemophagocytic syndrome or expression of γ/δ-type T-cell receptor by the tumor may predict a poorer outcome. A subgroup of patients can have long-term disease remission induced by anthracycline-based initial therapy or subsequent high-dose therapy and stem cell transplantation.

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      Idarubicin and standard-dose cytosine arabinoside in adults with recurrent and refractory acute lymphocytic leukemia (pages 1414–1419)

      Merat Karbasian-Esfahani, Peter H. Wiernik, Yelena Novik, Elisabeth Paietta and Janice P. Dutcher

      Article first published online: 27 JUL 2004 | DOI: 10.1002/cncr.20494

      The response rate of the regimen of idarubicin and cytosine arabinoside in patients with recurrent or refractory acute lymphocytic leukemia compared favorably with other regimens with acceptable toxicity.

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      Adult de novo acute myeloid leukemia with t(6;11)(q27;q23) : Results from Cancer and Leukemia Group B study 8461 and review of the literature (pages 1420–1427)

      William Blum, Krzysztof Mrózek, Amy S. Ruppert, Andrew J. Carroll, Kathleen W. Rao, Mark J. Pettenati, John Anastasi, Richard A. Larson and Clara D. Bloomfield

      Article first published online: 29 JUL 2004 | DOI: 10.1002/cncr.20489

      Acute myeloid leukemia (AML) with t(6;11)(q27;q23) is a well established but rare entity associated with poor clinical outcome. The authors suggested that investigational approaches, including allogeneic transplantation, be considered for adults with t(6;11) AML.

    18. Lung Disease
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      Lung adenocarcinoma and human papillomavirus infection (pages 1428–1436)

      Yen-Ching Chen, Jen-Hau Chen, Kradin Richard, Pao-Yang Chen and David C. Christiani

      Article first published online: 13 AUG 2004 | DOI: 10.1002/cncr.20538

      Human papillomavirus (HPV) infection is a known risk factor for the development of squamous cell carcinoma (SCC), but it has not been thoroughly assessed as a potential risk factor for the development of pulmonary adenocarcinoma. In the current report, the authors review the existing body of knowledge regarding the role of HPV in pulmonary neoplasia, with specific emphasis on the potential link between HPV infection and the development of pulmonary adenocarcinoma.

    19. Neuro-Oncology
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      Combination chemotherapy (cyclophosphamide, doxorubicin, and vincristine with continuous-infusion cisplatin and etoposide) and radiotherapy with stem cell support can be beneficial for adolescents and adults with estheisoneuroblastoma (pages 1437–1444)

      Yuko Mishima, Eijiro Nagasaki, Yasuhito Terui, Tetsuya Irie, Shunji Takahashi, Yoshinori Ito, Masahiko Oguchi, Kazuyoshi Kawabata, Shinetsu Kamata and Kiyohiko Hatake

      Article first published online: 27 JUL 2004 | DOI: 10.1002/cncr.20471

      A combined chemotherapy regimen of cyclophosphamide, doxorubicin, and vincristine plus continuous-infusion cisplatin and etoposide was very effective for adolescent-onset and adult-onset esthesioneuroblastoma. The combination of chemotherapy with radiotherapy and peripheral blood stem cell transplantation is a feasible multidisciplinary approach and may lead to complete remission without facial disfigurement.

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      Medullomyoblastoma: A radiographic and clinicopathologic analysis of six cases and review of the literature (pages 1445–1454)

      Kathleen J. Helton, Maryam Fouladi, Frederick A. Boop, Arie Perry, James Dalton, Larry Kun and Christine Fuller

      Article first published online: 16 JUL 2004 | DOI: 10.1002/cncr.20450

      The authors report on the radiographic and pathologic characteristics, treatment, and clinical outcomes of six children with medullomyoblastoma (MMB). The results of the current investigation demonstrated the frequent correlation of biphasic nodularity (as determined by magnetic resonance or computed tomographic imaging) with discrete rhabdomyoblastic and primitive neuroectodermal islands (as identified by microscopy) in MMB, supporting the view that MMB and medulloblastoma may have common tumorigenic origins, given their similar histologic and molecular features.

    21. Sarcoma
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      Tissue microarray immunohistochemical expression of estrogen, progesterone, and androgen receptors in uterine leiomyomata and leiomyosarcoma (pages 1455–1462)

      Mario M. Leitao, Robert A. Soslow, Daisuke Nonaka, Adam B. Olshen, Carol Aghajanian, Paul Sabbatini, Jakob Dupont, Martee Hensley, Yukio Sonoda, Richard R. Barakat and Sibyl Anderson

      Article first published online: 27 JUL 2004 | DOI: 10.1002/cncr.20521

      The rate of estrogen receptor and progesterone receptor expression was found to be significantly less in uterine leiomyosarcoma compared with benign leiomyomata, and androgen receptor was found to be similarly expressed in both. The expression of progesterone and androgen receptors suggests a lower risk of recurrence; however, no association with survival was observed.

    22. Discipline

      Pediatric Oncology
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      XRCC1 and glutathione-S-transferase gene polymorphisms and susceptibility to radiotherapy-related malignancies in survivors of Hodgkin disease : A report from the Childhood Cancer Survivor Study (pages 1463–1472)

      Ann C. Mertens, Pauline A. Mitby, Gretchen Radloff, Irene M. Jones, John Perentesis, William R. Kiffmeyer, Joseph P. Neglia, Anna Meadows, John D. Potter, Debra Friedman, Yutaka Yasui, Leslie L. Robison and Stella M. Davies

      Article first published online: 13 AUG 2004 | DOI: 10.1002/cncr.20520

      In the current study, the authors investigated the association between polymorphisms in 3 genes—glutathione-S-transferase M1 (GSTM1), glutathione-S-transferase T1 (GSTT1), and XRCC1, with roles in protection from a variety of DNA-damaging agents—and the risk of subsequent malignancy in 650 survivors of Hodgkin disease enrolled in the Childhood Cancer Survivor Study who had received radiotherapy. Individuals lacking GSTM1 but not GSTT1 were at increased risk of any subsequent malignancy, and for subsequent cancer within the radiation field. A nonsignificant increased risk of thyroid carcinoma was observed in individuals lacking either GSTM1 or GSTT1. Individuals having the genotype of the arginine/glutamine polymorphism at codon 399 in the XRCC1 gene (R399) showed a nonsignificant increased risk of breast carcinoma compared with those without, and a nonsignificant decreased risk against a subsequent thyroid carcinoma.

    23. Symptom Control and Palliative Care
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      Patterns of high-dose morphine use in a home-care hospice service : Should we be afraid of it? (pages 1473–1477)

      Michaela Bercovitch and Abraham Adunsky

      Article first published online: 27 JUL 2004 | DOI: 10.1002/cncr.20485

      The use of morphine by patients in a home-care hospice setting was found to be safe, even with high doses, and was not associated with shorter survival. The use of high-dose morphine should not be a barrier to providing palliative terminal care for outpatients with advanced-stage cancer.

  4. Correspondence

    1. Top of page
    2. Editorial
    3. Review Article
    4. Original Articles
    5. Correspondence
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    2. You have free access to this content
      Author reply (page 1478)

      Francis J. Giles

      Article first published online: 10 AUG 2004 | DOI: 10.1002/cncr.20496

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