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Cancer

Cover image for Cancer

1 November 2004

Volume 101, Issue 9

Pages 1923–2145

  1. Editorial

    1. Top of page
    2. Editorial
    3. Review Articles
    4. Original Articles
    5. Correspondence
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      What is ‘insignificant’ prostate carcinoma? (pages 1923–1925)

      Eric A. Klein

      Article first published online: 15 SEP 2004 | DOI: 10.1002/cncr.20584

      In the absence of clinical context, current definitions of insignificant prostate carcinoma are not useful in assessing the need for definitive treatment. Nonetheless, the findings of Bastian and colleagues, which are reported in the current issue of Cancer, strongly suggest that the Epstein criteria select for a subset of patients who may not require immediate therapy and who, at least initially, may be followed safely. The remaining challenge for the urologic community is to design clinical trials aimed at prospectively identifying individuals who require further intervention and determining when such intervention is necessary. Only after the completion of trials such as these can an accurate definition of ‘insignificant’ prostate carcinoma be put forth.

      See pages 2001–5.

  2. Review Articles

    1. Top of page
    2. Editorial
    3. Review Articles
    4. Original Articles
    5. Correspondence
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      Systematic review of adjuvant care for women with Stage I ovarian carcinoma (pages 1926–1935)

      Laurie Elit, Alexandra Chambers, Anthony Fyles, Allan Covens, Mark Carey and Michael Fung Kee Fung

      Article first published online: 27 SEP 2004 | DOI: 10.1002/cncr.20595

      A review of the current literature indicated that adjuvant platinum-based chemotherapy improved survival and reduced the risk of recurrent disease in women with Stage I ovarian carcinoma.

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      Acute graft-versus-host disease: Pathophysiology, clinical manifestations, and management (pages 1936–1946)

      Daniel Couriel, Humberto Caldera, Richard Champlin and Krishna Komanduri

      Article first published online: 15 SEP 2004 | DOI: 10.1002/cncr.20613

      Hematopoietic stem cell transplantation has evolved as a central treatment modality in the management of different hematologic malignancies. Despite adequate posttransplantation immunosuppressive therapy, acute graft-versus-host disease remains a major cause of morbidity and mortality in the hematopoietic stem cell transplantation setting.

  3. Original Articles

    1. Top of page
    2. Editorial
    3. Review Articles
    4. Original Articles
    5. Correspondence
    1. Disease Site

      Breast Disease
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      Anatomy of the nipple and breast ducts revisited (pages 1947–1957)

      Susan M. Love and Sanford H. Barsky

      Article first published online: 20 SEP 2004 | DOI: 10.1002/cncr.20559

      Using six different complementary in vivo and in vitro approaches, the authors determined the number, distribution, and anatomic properties of the ductal systems of the breast that extend from the nipple orifices to the terminal duct lobular units. More than 90% of all nipples examined contained 5–9 ductal orifices, which generally were arranged into a central group and a peripheral group. Each nipple orifice communicated with separate, nonanastomosing ductal systems, which extended to the terminal duct lobular units.

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      The management of ductal carcinoma in situ in North America and Europe : Results of a survey (pages 1958–1967)

      Elizabeth Ceilley, Reshma Jagsi, Saveli Goldberg, Lisa Kachnic, Simon Powell and Alphonse Taghian

      Article first published online: 23 SEP 2004 | DOI: 10.1002/cncr.20580

      The current study presented the results of a survey of radiation oncologists in North America and Europe regarding the treatment of ductal carcinoma in situ (DCIS). It quantified and highlighted areas of agreement and controversy regarding radiotherapy and tamoxifen in the treatment of low and high-grade DCIS.

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      The relationship between breast density and bone mineral density in postmenopausal women (pages 1968–1976)

      Diana S. M. Buist, Melissa L. Anderson, Stephen H. Taplin and Andrea Z. LaCroix

      Article first published online: 31 AUG 2004 | DOI: 10.1002/cncr.20565

      The current study did not show a positive relationship between bone mineral density (BMD) and breast density despite an expectation that both were reflective of estrogen exposure. This suggested that either breast density was not a good marker of lifetime estrogen exposure (if BMD is truly a good marker of lifetime estrogen exposure) or that organ-specific responses obscured the relation to cumulative exposure. BMD and breast density are both products of complex biology and each organ's unique response to estrogen appeared to leave these density measures unrelated to each other as indicators of estrogen exposure.

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      Contralateral prophylactic mastectomy : Predictors of significant histologic findings (pages 1977–1986)

      Katja Goldflam, Kelly K. Hunt, Jeffrey E. Gershenwald, S. Eva Singletary, Nadeem Mirza, Henry M. Kuerer, Gildy V. Babiera, Frederick C. Ames, Merrick I. Ross, Barry W. Feig, Aysegul A. Sahin, Banu Arun and Funda Meric-Bernstam

      Article first published online: 23 SEP 2004 | DOI: 10.1002/cncr.20617

      This retrospective analysis demonstrated that contralateral prophylactic mastectomy was associated with a low risk of subsequent development of breast carcinoma. Histologic findings in the ipsilateral breast, such as invasive lobular histology and estrogen and progesterone receptor positivity, and additional ipsilateral moderate to high-risk pathology may help to predict the likelihood of significant disease in the contralateral breast and assist in risk stratification.

    5. Endocrine Disease
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      Iodine-131 metaiodobenzylguanidine treatment for metastatic carcinoid : Results in 98 patients (pages 1987–1993)

      Shawn D. Safford, R. Edward Coleman, Jon P. Gockerman, Joseph Moore, Jerome Feldman, Mark W. Onaitis, Douglas S. Tyler and John A. Olson Jr.

      Article first published online: 28 SEP 2004 | DOI: 10.1002/cncr.20592

      The authors performed a retrospective review of 98 patients with metastatic carcinoid who were treated with iodine-131 metaiodobenzylguanidine (131I-MIBG) over a 15-year period. Symptomatic responses to 131I-MIBG treatment were associated with improved survival. The data from this study support 131I-MIBG treatment in select patients with metastatic carcinoid.

    6. Gastrointestinal Tract
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      CD147 and matrix metalloproteinase-2 protein expression as significant prognostic factors in esophageal squamous cell carcinoma (pages 1994–2000)

      Yoshio Ishibashi, Tomoe Matsumoto, Mikio Niwa, Yutaka Suzuki, Nobuo Omura, Nobuyoshi Hanyu, Koji Nakada, Katsuhiko Yanaga, Kyosuke Yamada, Kiyoshi Ohkawa, Makio Kawakami and Mitsuyoshi Urashima

      Article first published online: 15 SEP 2004 | DOI: 10.1002/cncr.20593

      The presence of matrix metalloproteinase-2 (MMP-2) and its inducer, CD147, in cancerous esophageal lesions and surrounding tissue was investigated to determine if they are prognostic factors. Data were drawn from tissue samples from 101 patients with esophageal squamous cell carcinoma. Measurement of CD147 and MMP-2 expression may enhance understanding of the pathophysiology of invading tumor cells and, when used with cancer staging, may increase the ability of investigators to predict prognosis in patients with esophageal squamous cell carcinoma.

    7. Genitourinary Disease
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      Characteristics of insignificant clinical T1c prostate tumors : A contemporary analysis (pages 2001–2005)

      Patrick J. Bastian, Leslie A. Mangold, Jonathan I. Epstein and Alan W. Partin

      Article first published online: 15 SEP 2004 | DOI: 10.1002/cncr.20586

      The Epstein criteria were developed in 1994 to facilitate the identification of insignificant prostate carcinoma. In the current contemporary analysis, the authors verify that the Epstein criteria remain a useful tool in the process of making decisions regarding prostate carcinoma treatment.

      See pages 1923–5.

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      Establishing a germ cell origin for metastatic tumors using OCT4 immunohistochemistry (pages 2006–2010)

      Liang Cheng

      Article first published online: 24 AUG 2004 | DOI: 10.1002/cncr.20566

      At times, it is difficult for pathologists and oncologists to ascertain the histogenesis and origin of certain neoplasms. The determination of tumor type is critical for patient management, and it is especially important when the differential diagnosis includes metastatic germ cell tumor, which is a highly treatable condition. Current data indicate that immunohistochemical detection of OCT4 is highly sensitive and specific for the diagnosis of metastatic seminoma and embryonal carcinoma.

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      Cross-sectional and longitudinal comparisons of health-related quality of life between patients with prostate carcinoma and matched controls (pages 2011–2019)

      Richard M. Hoffman, Frank D. Gilliland, David F. Penson, S. Noell Stone, William C. Hunt and Arnold L. Potosky

      Article first published online: 27 SEP 2004 | DOI: 10.1002/cncr.20608

      Men with localized prostate carcinoma had substantial declines in sexual and urinary function compared with an age-matched and ethnicity-matched control group. Bowel function and general health-related quality of life remained stable.

    10. Head and Neck Disease
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      Lymphoepithelial carcinoma versus large cell undifferentiated carcinoma of the major salivary glands (pages 2020–2027)

      Cheng-Ping Wang, Yih-Leong Chang, Jenq-Yuh Ko, Pei-Jen Lou, Chun-Fong Yeh and Tzung-Shiahn Sheen

      Article first published online: 23 SEP 2004 | DOI: 10.1002/cncr.20614

      The clinicopathologic features of lymphoepithelial carcinoma (LEC) and large cell undifferentiated carcinoma (LCUC) of the major salivary glands differed significantly. LEC was associated with Epstein–Barr virus, and patients who had LEC had a much better prognosis compared with patients who had LCUC.

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      Is routine triple endoscopy for head and neck carcinoma patients necessary in light of a negative chest computed tomography scan? (pages 2028–2033)

      Emmanuel Guardiola, Xavier Pivot, Olivier Dassonville, Gilles Poissonnet, Pierre-Yves Marcy, Josiane Otto, Michel Poudenx, Eric Francois, René-Jean Bensadoun, Antoine Thyss, François Demard and Maurice Schneider

      Article first published online: 1 SEP 2004 | DOI: 10.1002/cncr.20623

      The role of bronchoscopy and esophagoscopy in the presence of a normal thoracic computed tomography scan has been questioned because of the relatively low incidence of a second esophageal and/or lung primary tumor. The objective of the current study was to analyze the results obtained by triple endoscopy during the initial evaluation of patients with a primary carcinoma of the head and neck.

    12. Hematologic Malignancies
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      Phase II study of paclitaxel and estramustine in patients with recurrent and refractory non-Hodgkin lymphoma (pages 2034–2041)

      Hossein Borghaei, Michael Millenson, Russell Schilder, Mitchell Alden, Andre Rogatko, Hao Wang, Kristin Padavic-Shaller and Mitchell R. Smith

      Article first published online: 28 SEP 2004 | DOI: 10.1002/cncr.20616

      Patients with aggressive non-Hodgkin lymphoma (NHL) who fail to respond to or develop a disease recurrence after initial chemotherapy require second-line therapy. High-dose therapy with peripheral blood stem cell support reportedly offers overall prolonged disease-free survival rates of approximately 25%. However, many patients are not candidates for high-dose therapy because of several factors. The current study was conducted to evaluate the efficacy of paclitaxel in combination with oral estramustine phosphate in patients with recurrent or refractory, aggressive NHL.

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      A new model for predicting infectious complications during fludarabine-based combination chemotherapy among patients with indolent lymphoid malignancies (pages 2042–2049)

      Constantine S. Tam, Max M. Wolf, E. Henry Januszewicz, Andrew P. Grigg, H. Miles Prince, David Westerman and John F. Seymour

      Article first published online: 15 SEP 2004 | DOI: 10.1002/cncr.20615

      Baseline variables for 92 patients with indolent lymphoid malignancies treated with fludarabine-based combination chemotherapy were analyzed for their association with infectious complications. A predictive model based on six baseline variables identified patients at high risk of infections during such therapy.

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      Splenic marginal zone lymphoma with or without villous lymphocytes : Hematologic findings and outcomes in a series of 57 patients (pages 2050–2057)

      Emilio Iannitto, Achille Ambrosetti, Emanuele Ammatuna, Maura Colosio, Ada M. Florena, Claudio Tripodo, Viviana Minardi, Giuseppina Calvaruso, Maria Enza Mitra, Giovanni Pizzolo, Fabio Menestrina and Vito Franco

      Article first published online: 23 SEP 2004 | DOI: 10.1002/cncr.20596

      Splenic marginal zone lymphoma with or without villous lymphocytes is an indolent neoplasm, and up to 20% of patients require no therapy on diagnosis. The disease always involves bone marrow, although the infiltration may be very fine and exclusively intrasinusoidal. Bone marrow examination, coupled with the morphologic and immunophenotypic evaluation of peripheral blood, can lead to the correct diagnosis.

    15. Lung Disease
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      Pulmonary adenocarcinoma is associated with poor long-term survival after surgical resection : Effect of allogeneic blood transfusion (pages 2058–2066)

      Sudip Ghosh, Kamran Ahmed, David N. Hopkinson and Roger Vaughan

      Article first published online: 28 SEP 2004 | DOI: 10.1002/cncr.20590

      The authors demonstrated that long-term survival for patients with lung adenocarcinoma was significantly worse compared with patients with squamous cell carcinoma but was independent of allogeneic perioperative blood transfusion. The current study reaffirmed the importance of tumor invasion and lymph node involvement in the overall poor prognosis of patients with lung adenocarcinoma.

    16. Melanoma
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      Invasive cutaneous malignant melanoma in Sweden, 1990–1999 : A prospective, population-based study of survival and prognostic factors (pages 2067–2078)

      Christer Lindholm, Ronny Andersson, Monika Dufmats, Johan Hansson, Christian Ingvar, Torgil Möller, Helena Sjödin, Ulrika Stierner, Gunnar Wagenius and for the Swedish Melanoma Study Group

      Article first published online: 15 SEP 2004 | DOI: 10.1002/cncr.20602

      During the period from 1990 to 1999, the incidence rate of cutaneous melanoma in Sweden was unchanged. Favorable histopathologic factors compared with earlier decades in Sweden led to an improved relative 5-year survival rate of 91.5%. Multivariate analyses of prognostic factors were in agreement with the 2002 findings of the American Joint Committee on Cancer.

    17. Neuro-Oncology
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      Efficacy and feasibility of standard procarbazine, lomustine, and vincristine chemotherapy in anaplastic oligodendroglioma and oligoastrocytoma recurrent after radiotherapy : A phase II study (pages 2079–2085)

      Alba Ariela Brandes, Alicia Tosoni, Francesca Vastola, Lara Maria Pasetto, Bartolomea Coria, Daniela Danieli, Paolo Iuzzolino, Marina Gardiman, Andrea Talacchi and Mario Ermani

      Article first published online: 15 SEP 2004 | DOI: 10.1002/cncr.20611

      In patients with recurrent anaplastic oligodendroglioma, the response rate was reported to be high and time to disease progression was prolonged after chemotherapy with procarbazine, lomustine, and vincristine. However, toxicity, even if not severe, was persistent.

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      Imatinib mesylate in chordoma (pages 2086–2097)

      Paolo G. Casali, Antonella Messina, Silvia Stacchiotti, Elena Tamborini, Flavio Crippa, Alessandro Gronchi, Rosaria Orlandi, Carla Ripamonti, Carlo Spreafico, Raffaello Bertieri, Rossella Bertulli, Maurizio Colecchia, Elena Fumagalli, Angela Greco, Federica Grosso, Patrizia Olmi, Marco A. Pierotti and Silvana Pilotti

      Article first published online: 15 SEP 2004 | DOI: 10.1002/cncr.20618

      In the current study, six patients with advanced chordoma showed signs of tumor response to treatment with imatinib mesylate. This response may be mediated by the tyrosine kinase platelet-derived growth factor receptor-β.

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      Can we afford to add chemotherapy to radiotherapy for glioblastoma multiforme? Cost-identification analysis of concomitant and adjuvant treatment with temozolomide until patient death (pages 2098–2105)

      Jean-Blaise Wasserfallen, Sandrine Ostermann, Alessia Pica, René-Olivier Mirimanoff, Serge Leyvraz, Jean-Guy Villemure and Roger Stupp

      Article first published online: 23 SEP 2004 | DOI: 10.1002/cncr.20619

      The current analysis revealed that addition of temozolomide (TMZ) to standard radiotherapy as first-line treatment for glioma prolonged survival but increased costs eightfold compared with radiotherapy alone. TMZ acquisition costs amounted to 53% of the total cost of treatment.

    20. Discipline

      Pediatric Oncology
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      Autoregulation of the N-myc gene is operative in neuroblastoma and involves histone deacetylase 2 (pages 2106–2115)

      Marianne K. H. Kim and William L. Carroll

      Article first published online: 20 SEP 2004 | DOI: 10.1002/cncr.20626

      The autoregulatory circuit of the myc gene family was intact in both amplified and single-copy neuroblastoma cell lines. Furthermore, myc gene autoregulation occurred through histone deacetylation.

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      Parent proxy–reported health-related quality of life and fatigue in pediatric patients diagnosed with brain tumors and acute lymphoblastic leukemia (pages 2116–2125)

      Kathleen Meeske, Ernest R. Katz, Stephanie N. Palmer, Tasha Burwinkle and James W. Varni

      Article first published online: 23 SEP 2004 | DOI: 10.1002/cncr.20609

      Parents of children ages 2–18 years who were diagnosed with brain tumors (BT) or acute lymphoblastic leukemia (ALL) evaluated their children's health-related quality of life (HRQOL) over the previous week using the parent proxy versions of the Pediatric Quality of Life Inventory (PedsQL™) 4.0 Generic Core scales, the PedsQL™ 3.0 Acute Cancer Module, and the PedsQL™ Multidimensional Fatigue scales. Pediatric patients and survivors of BT experienced more fatigue and HRQOL problems than patients with ALL, and HRQOL differed by treatment status.

    22. Radiation Oncology
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      Unexpectedly frequent hepatitis B reactivation by chemoradiation in postgastrectomy patients (pages 2126–2133)

      Jason Chia-Hsien Cheng, Mei-Ching Liu, Stella Y. Tsai, Wei-Tse Fang, James Jer-Min Jian and Juei-Low Sung

      Article first published online: 23 SEP 2004 | DOI: 10.1002/cncr.20591

      Hepatitis B virus (HBV) carriers had a higher incidence of chemoradiation-induced liver disease (CRILD) after postgastrectomy adjuvant, concomitant chemoradiotherapy, probably related to HBV reactivation. Dosimetric parameters modulated the risk of CRILD in noncarriers, but not in carriers.

    23. Symptom Control and Palliative Care
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      Bacteremia caused by Achromobacter and Alcaligenes species in 46 patients with cancer (1989–2003) (pages 2134–2140)

      Gabriel Aisenberg, Kenneth V. Rolston and Amar Safdar

      Article first published online: 23 SEP 2004 | DOI: 10.1002/cncr.20604

      In the current retrospective study, the authors sought to determine the incidence and characteristics of bloodstream infections caused by two gram-negative bacterial organisms, Achromobacter and Alcaligenes, in immunosuppressed patients at a tertiary care comprehensive cancer center over the last 14.5 years.

  4. Correspondence

    1. Top of page
    2. Editorial
    3. Review Articles
    4. Original Articles
    5. Correspondence
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    2. You have free access to this content
      Author reply (pages 2142–2143)

      Helene Nortvig Abrahamsen, Stephen J. Hamilton-Dutoit and Torben Steiniche

      Article first published online: 15 SEP 2004 | DOI: 10.1002/cncr.20576

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      Author reply (pages 2144–2145)

      Jeffrey S. Wefel, Christina A. Meyers and Robert N. Davis

      Article first published online: 20 SEP 2004 | DOI: 10.1002/cncr.20603

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