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Cancer Cytopathology

Cover image for Cancer Cytopathology

25 August 2004

Volume 102, Issue 4

Pages 203–268

Currently known as: Cancer Cytopathology

  1. Editorial

    1. Top of page
    2. Editorial
    3. Commentary
    4. Original Articles
    5. Original Article
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      Endoscopic ultrasound-guided fine-needle aspiration : Time, diagnostic challenges, and clinical impact (pages 203–206)

      Mary R. Schwartz

      Version of Record online: 12 JUL 2004 | DOI: 10.1002/cncr.20486

      In this issue of Cancer Cytopathology, Jhala et al. report their experience with endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) of a variety of sites. The authors identify two factors that can increase the sensitivity of EUS-FNA: the presence of an on-site pathologist for immediate assessment of adequacy, and a higher number of passes. The impact of these factors on pathologists' time, the difficult diagnostic challenges of EUS-FNA, reimbursement issues, and the potential significant impact of the FNA diagnoses on major clinical decisions is discussed in this editorial.

      See also pages 239–46, this issue.

  2. Commentary

    1. Top of page
    2. Editorial
    3. Commentary
    4. Original Articles
    5. Original Article
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      Is c-kit (CD117) immunolocalization in cell block preparations useful in the differentiation of adenoid cystic carcinoma from pleomorphic adenoma? (pages 207–209)

      Vishal S. Chandan, David Wilbur, William C. Faquin and Kamal K. Khurana

      Version of Record online: 14 JUL 2004 | DOI: 10.1002/cncr.20301

      The authors examined the role of c-kit antigen expression in cell block material obtained by fine-needle aspiration in differentiating between adenoid cystic carcinoma and pleomorphic adenoma. It was found that c-kit expression was not restricted to adenoid cystic carcinomas; instead, c-kit was expressed in pleomorphic adenomas as well. Thus, c-kit was not useful in distinguishing between these two types of lesions.

  3. Original Articles

    1. Top of page
    2. Editorial
    3. Commentary
    4. Original Articles
    5. Original Article
    1. Gynecologic Cytopathology

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      Severe cervical glandular cell lesions and severe cervical combined lesions : Predictive value of the Papanicolaou smear (pages 210–217)

      Anniek J. M. van Aspert-van Erp, Frank M. M. Smedts and G. Peter Vooijs

      Version of Record online: 7 JUL 2004 | DOI: 10.1002/cncr.20473

      The establishment of well organized screening programs resulted in a considerable decrease in the incidence and mortality rates of cervical squamous cell carcinoma. However, in the last decades, several studies have reported an increase in the incidence of cervical adenocarcinoma. The purpose of the current study was to determine the sensitivity of cytologic examination for the diagnosis of severe cervical glandular cell lesions (with or without a coexistent squamous cell lesion) in the Netherlands, with the focus primarily directed toward the reporting of severely abnormal glandular cells on Papanicolaou smears.

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      Severe cervical glandular cell lesions with coexisting squamous cell lesions : A reevaluation of cytologic (and histologic) specimens (pages 218–227)

      Anniek J. M. Van Aspert-Van Erp, Frank M. M. Smedts and G. Peter Vooijs

      Version of Record online: 3 AUG 2004 | DOI: 10.1002/cncr.20474

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      The authors reevaluated 36 combined severe cervical lesions to assess whether knowledge of the specific cytologic characteristics of the cervical glandular cell component could have made the cytologic diagnosis of these combined lesions more accurate. In the 36 samples that were reevaluated, consideration of these cytologic features would have increased the accuracy of diagnosis from 55.6% to 75.0%. Furthermore, the presence of adenocarcinoma in situ (AIS) was predicted in the majority of cytologic specimens, and in most cases, the predominant subtype of AIS could be identified.

    3. Gynecologic Cytopathology

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      Prognosis and recurrence risk for patients with cervical squamous intraepithelial lesions diagnosed during pregnancy (pages 228–232)

      Keith J. Kaplan, Louis A. Dainty, Brad Dolinsky, G. Scott Rose, Jay Carlson, Michael McHale and John C. Elkas

      Version of Record online: 30 JUN 2004 | DOI: 10.1002/cncr.20428

      In the current retrospective review, the authors found that low-grade squamous intraepithelial lesions will regress or remain unchanged during pregnancy, whereas high-grade squamous intraepithelial lesions will advance into the puerperium and may progress to invasive carcinoma.

    4. Non-Gynecologic Cytopathology

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      Diagnostic value of nipple cytology : Study of 466 cases (pages 233–238)

      Bobbi Pritt, Yijun Pang, Marybeth Kellogg, Timothy St. John and Abdelmonem Elhosseiny

      Version of Record online: 12 JUL 2004 | DOI: 10.1002/cncr.20379

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      The cytology of nipple discharge/nipple scraping was evaluated in 466 cases. Cytology was found to be highly specific and sensitive in the detection of carcinoma when applied to patients with either unilateral serosanguinous nipple discharge or an eczematous nipple lesion.

    5. Fine Needle Aspiration

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      Endoscopic ultrasound-guided fine-needle aspiration biopsy: A powerful tool to obtain samples from small lesions (pages 239–246)

      Nirag C. Jhala, Darshana Jhala, Isam Eltoum, Selwyn M. Vickers, C. Mel Wilcox, David C. Chhieng and Mohamad A. Eloubeidi

      Version of Record online: 30 JUN 2004 | DOI: 10.1002/cncr.20451

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      The current article showed that endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) is a powerful modality with which to obtain samples from small (≤ 25 mm) and large lesions with no difference in yield of samples (96 % vs. 96%) from the two groups. Most of the adequate samples for diagnosis of small lesions can be obtained within five passes irrespective of the organ site. The overall sensitivity (96% vs. 96%), specificity (100% vs. 100%), positive predictive value (100% vs. 100%), negative predictive value (96% vs. 91%), and diagnostic accuracy (98% vs. 97%) remained comparable regardless of whether the lesion was small or large. The results showed that EUS-FNAB is a highly accurate modality to obtain samples from small lesions irrespective of the anatomic location.

      See also pages 203–6, this issue.

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      Cytopathologic grading of hepatocellular carcinoma on fine-needle aspiration (pages 247–252)

      Piotr Kulesza, Michael Torbenson, Sheila Sheth, Yener S. Erozan and Syed Z. Ali

      Version of Record online: 30 JUN 2004 | DOI: 10.1002/cncr.20409

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      Cytopathologic grading of hepatocellular carcinoma on fine-needle aspiration is a useful prognostic test. The grading is clinically relevant because a correlation is known to exist between the carcinoma grade and other useful parameters such as vascular invasion and long-term survival.

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      Endoscopic ultrasound-guided fine-needle aspiration in the diagnosis of foregut duplication cysts: The value of demonstrating detached ciliary tufts in cyst fluid (pages 253–258)

      Mohamad A. Eloubeidi, Michael Cohn, Robert J. Cerfolio, David C. Chhieng, Nirag Jhala, Darshana Jhala and Isam A. Eltoum

      Version of Record online: 7 JUL 2004 | DOI: 10.1002/cncr.20369

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      Endoscopic ultrasound-guided fine-needle aspiration is safe and accurate in the diagnosis of foregut duplication cysts. The demonstration of detached ciliary tufts in cyst fluid and the absence of malignant cells confirm the benign nature of these lesions, allowing conservative and expectant management in these patients.

  4. Original Article

    1. Top of page
    2. Editorial
    3. Commentary
    4. Original Articles
    5. Original Article
    1. Molecular Diagnostics

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      DNA methylation profiling of cervical squamous intraepithelial lesions using liquid-based cytology specimens : An approach that utilizes receiver-operating characteristic analysis (pages 259–268)

      Karen S. Gustafson, Emma E. Furth, Daniel F. Heitjan, Zoya B. Fansler and Douglas P. Clark

      Version of Record online: 14 JUL 2004 | DOI: 10.1002/cncr.20425

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      DNA methylation profiling of multiple tumor suppressor genes in squamous intraepithelial lesions (SILs) of the cervix using liquid-based cytology samples revealed that there was a significant trend toward increased methylation with the increased severity of squamous lesions. Using area under the receiver-operating characteristic curve as a measure of test performance, the methylation of IGSF4 and DAPK1 had areas that were significantly greater than 0.5; thus, each had the ability to distinguish high-grade SIL samples from combined low-grade SIL/negative samples.

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