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Cancer Cytopathology

Cover image for Cancer Cytopathology

25 October 2004

Volume 102, Issue 5

Pages 269–327

Currently known as: Cancer Cytopathology

  1. Original Articles

    1. Top of page
    2. Original Articles
    1. Gynecologic Cytopathology

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      Comparison of the Surepath™ liquid-based Papanicolaou smear with the conventional Papanicolaou smear in a multisite direct-to-vial study (pages 269–279)

      Maurice Fremont-Smith, James Marino, Bryan Griffin, Lynn Spencer and David Bolick

      Version of Record online: 31 AUG 2004 | DOI: 10.1002/cncr.20599

      A liquid-based Papanicolaou (Pap) smear was compared with the conventional Pap smear in a multisite direct-to-vial study. The SurePath™ Pap smear was found to outperform the conventional Pap smear in the detection of high-grade squamous intraepithelial and low-grade squamous intraepithelial cytologic lesions of the cervix (P < 0.00001 for each lesion) and reduced the number of unsatisfactory diagnoses (P < 0.00001).

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      Adenocarcinoma in situ of the uterine cervix : Screening and diagnostic errors in Papanicolaou smears (pages 280–287)

      Sukeerat Ruba, Meike Schoolland, Stephen Allpress and Gregory Sterrett

      Version of Record online: 16 SEP 2004 | DOI: 10.1002/cncr.20600

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      The main factors contributing to screening or diagnostic errors in the detection or diagnosis of adenocarcinoma in situ (AIS) of the uterine cervix in Papanicolaou smears were minimal, poorly preserved material and an overly conservative approach to the assessment of unusual large sheets of glandular cells. With regard to AIS combined with high-grade squamous intraepithelial lesions, the main source of error was insufficient appreciation of the significance of disorganized, crowded sheets of poorly preserved squamous epithelial cells.

    3. Fine Needle Aspiration

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      Microcystic adenoma of the pancreas : Clinical, radiologic, and cytologic features (pages 288–294)

      Aseem Lal, Eleni P. Bourtsos, Denise V. S. DeFrias, Albert A. Nemcek and Ritu Nayar

      Version of Record online: 13 AUG 2004 | DOI: 10.1002/cncr.20487

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      The aspiration cytology findings from 11 patients with microcystic adenoma (MCA) of the pancreas were correlated with immunohistochemical and radiologic studies. Correlating these various findings allows for a precise diagnosis of MCA based on specific criteria.

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      Adequacy evaluation of fine-needle aspiration biopsy in the breast health clinic setting (pages 295–301)

      Lydia P. Howell, Regina Gandour-Edwards, Katherine Folkins, Robin Davis, Shagufta Yasmeen and Alaa Afify

      Version of Record online: 31 AUG 2004 | DOI: 10.1002/cncr.20497

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      The 20% upper threshold for unsatisfactory breast fine-needle aspiration biopsies (FNABs) recommended by the National Cancer Institute is not appropriate for FNABs obtained from the breast health clinic setting, particularly if clinicians are the primary aspirators. The authors recommended that cytology laboratories that receive a large amount of clinician-performed FNABs from a community population, especially a breast health clinic, define their own unsatisfactory threshold above which they will investigate for technical or other problems.

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      Fine-needle aspiration cytology of solitary thyroid nodules : How far can we go in rendering differential cytologic diagnoses? (pages 302–307)

      Canan Ersöz, Pinar Firat, Aysun Uguz and Gamze Mocan Kuzey

      Version of Record online: 16 SEP 2004 | DOI: 10.1002/cncr.20610

      Differential cytologic diagnosis of solitary thyroid nodules using fine-needle aspiration cytology (FNAC) typically is challenging. With the goal of identifying findings that could improve predictions regarding the presence of neoplastic lesions, the authors retrospectively reviewed cases in which FNAC led to diagnoses of solitary cellular nodules or cellular microfollicular lesions. Based on this review, they concluded that data on nuclear size and pleomorphism, cellularity, the presence and prevalence of microfollicular structures, and background colloidal characteristics could assist in the tailoring of preoperative management strategies for patients with thyroid lesions.

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      Endoscopic ultrasound-guided fine-needle aspiration biopsy of the adrenal glands : Analysis of 24 patients (pages 308–314)

      Nirag C. Jhala, Darshana Jhala, Mohamad A. Eloubeidi, David C. Chhieng, D. Ralph Crowe, Janie Roberson and Isam Eltoum

      Version of Record online: 16 SEP 2004 | DOI: 10.1002/cncr.20498

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      The current analysis of 24 patients demonstrated that endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) biopsy is a powerful modality that collects adequate samples from adrenal glands. Furthermore, the study demonstrated not only that EUS-FNA biopsy of left adrenal glands is feasible but also, for the first time, that it may be possible to obtain samples from right adrenal glands in select patients. The authors also demonstrated that EUS-FNA biopsy is a highly specific and safe technique for confirming a diagnosis of metastatic disease in the adrenal glands. EUS imaging, along with cytology, is needed to support the diagnosis of adrenal adenoma.

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      Primary pancreatic lymphomas : A cytopathologic analysis of a rare malignancy (pages 315–321)

      Hassan Nayer, Edward G. Weir, Sheila Sheth and Syed Z. Ali

      Version of Record online: 31 AUG 2004 | DOI: 10.1002/cncr.20488

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      Primary pancreatic lymphomas are rare and may mimic, both clinicoradiologically and pathologically, the more common epithelial tumors. However, cytomorphology coupled with flow cytometry appears to furnish an accurate diagnosis.

    8. Molecular Diagnosis

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      Feasibility and utility of using chromosomal aneusomy to further define the cytologic categories in nipple aspirate fluid specimens : A preliminary study (pages 322–327)

      Savitri Krishnamurthy, Lian Zhao, Kimberly Hayes, Armand B. Glassman, Massimo Cristofanilli, S. Eva Singletary, Kelly K. Hunt, Henry M. Kuerer and Nour Sneige

      Version of Record online: 16 SEP 2004 | DOI: 10.1002/cncr.20558

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      In the current study, fluorescence in situ hybridization for chromosomal aneusomy was a valuable adjunct to conventional cytology for the definitive categorization of ductal epithelial cells in nipple aspirate fluid specimens.

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