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Cancer Cytopathology

Cover image for Cancer Cytopathology

25 December 2004

Volume 102, Issue 6

Pages 329–388

Currently known as: Cancer Cytopathology

  1. Editorial

    1. Top of page
    2. Editorial
    3. Contemporary Issue
    4. Original Articles
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      State of the art symposium–prescreening and rescreening of cervical vaginal cytology specimens (pages 329–330)

      William J. Frable

      Version of Record online: 19 OCT 2004 | DOI: 10.1002/cncr.20723

      The effectiveness of prescreening and rescreening gynecologic cytology samples has been of importance to cytotechnologists and pathologists for some time and has resulted in technical advances that currently are being incorporated into an increasing number of cytology laboratories. This issue of Cancer Cytopathology contains four articles from the State of the Art Symposium presented at the annual meeting of the American Society of Cytopathology, which was held in Orlando, Florida, November 7–12, 2003

  2. Contemporary Issue

    1. Top of page
    2. Editorial
    3. Contemporary Issue
    4. Original Articles
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      State of the Art Symposium: Prescreening and rescreening (pages 331–333)

      Timothy J. O'Leary

      Version of Record online: 11 NOV 2004 | DOI: 10.1002/cncr.20719

      The effectiveness of prescreening and rescreening cervical cytology preparations, whether used as quality assurance measures or in an attempt to improve sensitivity, has engendered broad discussion within the cytology community. This article presents an introduction to some of the issues surrounding prescreening and rescreening in cervical cytology.

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      The FocalPoint system : FocalPoint Slide Profiler and FocalPoint GS (pages 334–339)

      Thomas F. Kardos

      Version of Record online: 17 NOV 2004 | DOI: 10.1002/cncr.20720

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      The FocalPoint system includes the U.S. Food and Drug Administration (FDA)-approved FocalPoint Slide Profiler, a computerized scanning device that performs analyses of cervicovaginal cytology samples, and the FocalPoint GS, a system that currently is under evaluation by the FDA and that adds location-guided screening capabilities to the FocalPoint Slide Profiler.

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      Can we change the way we screen?: The ThinPrep Imaging System® : Clinical trial data and early experience (pages 340–344)

      Andrea E. Dawson

      Version of Record online: 11 NOV 2004 | DOI: 10.1002/cncr.20721

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      A clinical trial of the ThinPrep Imaging System established at least equivalent results when compared with manual screening and appeared to improve the sensitivity and specificity for some diagnostic categories, while improving productivity

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      Quality assessment in the age of machine-aided cervical cytology screening : Changing art into science with prescreening (pages 345–347)

      Andrew A. Renshaw

      Version of Record online: 11 NOV 2004 | DOI: 10.1002/cncr.20722

      The shift toward machine-aided cytologic screening brings with it changing expectations from patients and clinicians. Although cytologists have long considered cytology to be both an art and a science, automated screening techniques bear the expectation of being evaluable using verifiable scientific methods, rather than artistic ones. At present, it appears that the optimal cervical cytologic screening method may combine the technical advances made in the United States with the quality assurance methods (e.g., prescreening of slides) used in Europe.

  3. Original Articles

    1. Top of page
    2. Editorial
    3. Contemporary Issue
    4. Original Articles
    1. Non-Gynecologic Cytopathology

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      Anthracotic index and DNA methylation status of sputum contents can be used for identifying the population at risk of lung carcinoma (pages 348–354)

      Sato Konno, Yukio Morishita, Masakatsu Fukasawa, Yujian Shu, Daye Wang, Ryota Tanaka, Yuko Minami, Tatsuo Iijima and Masayuki Noguchi

      Version of Record online: 12 OCT 2004 | DOI: 10.1002/cncr.20643

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      Anthracotic index (AI) and methylation status of the promoter regions of the p16, adenomatous polyposis coli, and retinoic acid receptor-beta genes were examined in sputum specimens. AI and abnormal methylation status were useful for identifying a population at risk of lung carcinoma using mass screening of cytology specimens.

    2. Fine-Needle Aspiration

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      Myoepithelial cell-rich neoplasms: Cytologic features of benign and malignant lesions (pages 355–361)

      Farbod Darvishian and Oscar Lin

      Version of Record online: 8 OCT 2004 | DOI: 10.1002/cncr.20642

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      Lesions that contain abundant myoepithelial cells may present as a diagnostic challenge in fine-needle aspiration (FNA) specimens due to morphologic heterogeneity and lack of established malignancy criteria. The presence of pleomorphism, coarse chromatin, prominent nucleoli, mitotic figures, and necrosis should raise the possibility of myoepithelial carcinoma in FNA specimens.

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      Results of the implementation of liquid-based cytology—SurePath in the Ontario screening program (pages 362–367)

      Terence J. Colgan, C. Meg McLachlin, Michelle Cotterchio, Robbi Howlett, Allan M. Seidenfeld and Verna M. Mai

      Version of Record online: 12 OCT 2004 | DOI: 10.1002/cncr.20656

      The Ontario implementation of the SurePath liquid-based cytology system for gynecologic screening was followed by improved adequacy and increased detection rates for ASC+ and LSIL+ and a trend of increased detection of HSIL+ relative to historical conventional practice. Sensitivity rates will only be available after the establishment of a correlative histopathologic database.

    4. Immunocytochemistry

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      Mammaglobin and CRxA-01 in pleural effusion cytology : Potential utility of distinguishing metastatic breast carcinomas from other cytokeratin 7–positive/cytokeratin 20–negative carcinomas (pages 368–372)

      Armando Ciampa, Gary Fanger, Ashraf Khan, Kenneth L. Rock and Bo Xu

      Version of Record online: 22 NOV 2004 | DOI: 10.1002/cncr.20627

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      The most common causes of malignant pleural effusions in women are metastatic lung carcinomas and breast carcinomas. It is often very difficult to distinguish between breast carcinomas and other metastatic carcinomas when they share a similar morphology and a similar cytokeratin profile (CK7-positive/CK20-negative). To better differentiate between metastatic mammary carcinomas and other metastatic carcinomas in pleural effusion cytology, the authors studied the potential use of a novel antibody, CRxA-01, which was identified by a cDNA subtraction library, together with a well characterized antibody against mammaglobin.

    5. Analytical and Quantitative Cytopathology

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      Identification of progressive cervical epithelial cell abnormalities using DNA image cytometry (pages 373–379)

      Hans Juergen Grote, Huy V. Q. Nguyen, Anand Gilbert Leick and Alfred Böcking

      Version of Record online: 3 NOV 2004 | DOI: 10.1002/cncr.20644

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      Results from the current prospective cohort study demonstrated that DNA image cytometry may improve the diagnostic accuracy of Papanicolaou tests significantly in women diagnosed with atypical squamous cells, low-grade squamous intraepithelial lesions, or atypical glandular cells.

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      Implementation of DNA cytometric measurements in fine-needle aspiration biopsy diagnostics of breast disease (pages 380–388)

      Adem Elzagheid, Teijo Kuopio and Yrjo Collan

      Version of Record online: 19 OCT 2004 | DOI: 10.1002/cncr.20641

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      DNA cytometry of fine-needle aspiration samples (when producing aneuploid histograms) of the breast was able to support a diagnosis of carcinoma in 95.2% of highly suspicious samples, but diploid histograms did not improve sensitivity. Benign lesions could produce abnormal histograms, but these potential-false positive samples could be distinguished as polyploid.

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