Disease Site Endocrine Disease You have free access to this content Microsatellite instability and gene mutations in transforming growth factor-beta type II receptor are absent in small bowel carcinoid tumors (pages 229–236)
Mark Kidd, Geeta Eick, Michael D. Shapiro, Robert L. Camp, Shrikant M. Mane and Irvin M. Modlin
Version of Record online: 14 DEC 2004 | DOI: 10.1002/cncr.20750
The authors showed that the common colorectal carcinoma molecular events of microsatellite instability and mutations in the transforming growth factor beta type II receptor gene do not occur in carcinoid tumors in the small bowel. They reported that the usually slow-growing and relatively nonaggressive nature of these carcinoid tumors may be associated with the retention of mismatch repair protein function and a microsatellite-stable phenotype.
Genitourinary Disease You have free access to this content Physician practices of bone density testing and drug prescribing to prevent or treat osteoporosis during androgen deprivation therapy [An erratum to this Article has been published in Cancer 2006;106(11):2530] (pages 237–241)
Version of Record online: 13 DEC 2004 | DOI: 10.1002/cncr.20766
The majority of patients with prostate carcinoma undergoing androgen deprivation therapy did not receive interventions to prevent or treat osteoporosis. Having other concurrent risk factors for osteoporosis was not predictive of receiving dual-energy X-ray absorptiometry scans, bisphosphonates, calcium or vitamin D supplements, calcitonin, or estrogen.
You have free access to this content Prostate carcinoma detection and increased prostate-specific antigen levels after 4 years in Dutch and Japanese males who had no evidence of disease at initial screening (pages 242–250)
Kazuto Ito, René Raaijmakers, Monique Roobol, Mark Wildhagen, Hidetoshi Yamanaka and Fritz H. Schröder
Version of Record online: 1 DEC 2004 | DOI: 10.1002/cncr.20739
In the current study, the authors investigated the relation between prostate-specific antigen (PSA) levels and the risk of newly developed prostate carcinoma in Dutch and Japanese men. The risk of developing prostate carcinoma within a given 4-year period was greater for Dutch males ages 55–69 years compared with their Japanese counterparts, although there appeared to be no significant difference in prostate carcinoma risk between Dutch and Japanese males within the same baseline PSA category.
You have free access to this content De novo renal cell carcinoma of native kidney in renal transplant recipients (pages 251–257)
Yann Neuzillet, Franck Lay, Aline Luccioni, Laurent Daniel, Yvon Berland, Christian Coulange and Eric Lechevallier
Version of Record online: 8 DEC 2004 | DOI: 10.1002/cncr.20745
Kidney transplant recipients appear to have an increased risk of developing high-grade and papillary malignancies in the native kidney. Consequently, systematic radiologic follow-up of native kidneys must be performed for kidney transplant recipients.
You have free access to this content Up-regulation of the interferon γ (IFN-γ)-inducible chemokines IFN-inducible T-cell α chemoattractant and monokine induced by IFN-γ and of their receptor CXC receptor 3 in human renal cell carcinoma (pages 258–267)
Takahito Suyama, Mitsuko Furuya, Mariko Nishiyama, Yoshitoshi Kasuya, Sadao Kimura, Tomohiko Ichikawa, Takeshi Ueda, Takashi Nikaido, Haruo Ito and Hiroshi Ishikura
Version of Record online: 1 DEC 2004 | DOI: 10.1002/cncr.20747
The antiangiogenic CXC chemokines interferon (IFN)-inducible T-cell chemoattractant (I-TAC) and monokine induced by IFN-γ (Mig) were up-regulated significantly in tissue samples from untreated patients with renal cell carcinoma (RCC). I-TAC was expressed exclusively in tumor vascular smooth muscle cells and pericytes, whereas Mig was expressed in tumor endothelial cells. These chemokines in tumor vessels may interact with CXCR3 expressed in tumor cells, with possible pathophysiologic significance in RCC progression.
Gynecologic Oncology You have free access to this content Mcl-1 expression in gestational trophoblastic disease correlates with clinical outcome : A differential expression study (pages 268–276)
Pui-Yee Fong, Wei-Cheng Xue, Hextan Y. S. Ngan, Kelvin Y. K. Chan, Ui-Soon Khoo, Siu-Wah Tsao, Pui-Man Chiu, Lai-Shan Man and Annie N. Y. Cheung
Version of Record online: 1 DEC 2004 | DOI: 10.1002/cncr.20767
The up-regulation of Mcl-1 in hydatidiform moles that subsequently developed into persistent disease and required chemotherapy was detected by apoptotic cyclic DNA array and was confirmed by quantitative RNA and immunohistochemistry studies. Mcl-1 may be a potential marker for adverse outcomes in patients with hydatidiform moles.
You have free access to this content Up-regulated expression of cytoplasmic clusterin in human ovarian carcinoma (pages 277–283)
Dan Xie, Sze Hang Lau, Jonathan S. T. Sham, Qiu-Liang Wu, Yan Fang, Li-Zhi Liang, Li-Hong Che, Yi-Xin Zeng and Xin-Yuan Guan
Version of Record online: 1 DEC 2004 | DOI: 10.1002/cncr.20765
To determine the potential tumorigenic role of the
clusterin gene in the development and progression of ovarian carcinoma, the authors investigated staining for clusterin in different ovarian tissues. The results indicated that the overexpression of cytoplasmic clusterin may represent an acquired malignant phenotypic feature of ovarian carcinoma and may be one of the important factors in determining the aggressive nature of ovarian carcinoma. Head and Neck Disease You have free access to this content Serum levels of folate, homocysteine, and vitamin B 12 in head and neck squamous cell carcinoma and in laryngeal leukoplakia (pages 284–292)
Giovanni Almadori, Francesco Bussu, Jacopo Galli, Gabriella Cadoni, Bruno Zappacosta, Silvia Persichilli, Angelo Minucci, Bruno Giardina and Maurizio Maurizi
Version of Record online: 8 DEC 2004 | DOI: 10.1002/cncr.20772
Serum folate and homocysteine status is impaired significantly in patients with head and neck squamous cell carcinoma. The data from this report suggest a role for hypofolatemia as a risk factor for head and neck carcinoma, opening intriguing perspectives for chemoprevention.
Hematologic Oncology You have free access to this content Lack of association of polyomavirus and herpesvirus types 6 and 7 in human lymphomas (pages 293–298)
Javier Hernández-Losa, Cesar Giovanni Fedele, Francisco Pozo, Antonio Tenorio, Victor Fernández, Josep Castellví, Carlos Parada and Santiago Ramón y Cajal
Version of Record online: 8 DEC 2004 | DOI: 10.1002/cncr.20801
The real role of viruses in human lymphomas remains very controversial; in fact, many contradictory reports have created great uncertainty. In this article, the authors report on their investigation into the presence of polyomaviruses and herpes viruses 6 and 7 in 83 human lymphomas and 52 normal lymphoid tissues. The results indicate that these viruses are not expressed specifically in lymphomas compared with normal lymphoid tissues, and the association of these viruses with human lymphomas is not supported.
Hepatobiliary Disease You have free access to this content Microsatellite distribution and indication for locoregional therapy in small hepatocellular carcinoma (pages 299–306)
Atsushi Sasaki, Seiichiro Kai, Yukio Iwashita, Seitaro Hirano, Masayuki Ohta and Seigo Kitano
Version of Record online: 1 DEC 2004 | DOI: 10.1002/cncr.20798
The distance of microsatellites from small (diameter ≤ 5 cm) HCC tumors correlated significantly with tumor size. Twenty-one of 22 patients with a microsatellite distance > 5 mm had a tumor ≥ 25 mm in greatest dimension, and all 21 tumors were high-grade (moderately to poorly differentiated) HCCs. Locoregional therapies were appropriate for patients with low-grade HCC tumors or with HCC tumors < 25 mm in dimension.
You have free access to this content Akt phosphorylation is a risk factor for early disease recurrence and poor prognosis in hepatocellular carcinoma (pages 307–312)
Kazuaki Nakanishi, Michiie Sakamoto, Susumu Yamasaki, Satoru Todo and Setsuo Hirohashi
Version of Record online: 8 DEC 2004 | DOI: 10.1002/cncr.20774
Thes current clinical study showed that Akt phosphorylation is one of the crucial factors for early disease recurrence and poor prognosis after hepatectomy for patients with hepatocellular carcinoma. The potential benefits of surgery should be assessed carefully in patients with any of these risk factors.
Melanoma You have free access to this content Postoperative radiotherapy for primary mucosal melanoma of the head and neck (pages 313–319)
Stephane Temam, Gerard Mamelle, Patrick Marandas, Pierre Wibault, Marie-France Avril, François Janot, Morbize Julieron, Guy Schwaab and Bernard Luboinski
Version of Record online: 1 DEC 2004 | DOI: 10.1002/cncr.20775
Primary mucosal melanoma of the head and neck has a poor prognosis and an associated low rate of local control. In the authors' retrospective study of 69 patients, postoperative radiotherapy improved local control rates independent of primary tumor size. Nevertheless, a high rate of distant metastasis (69%) and a poor 5-year overall survival rate of 20% was not influenced by radiotherapy treatment.
Neuro-Oncology You have free access to this content Prediction of survival in patients with metastases in the spinal column : Results based on a randomized trial of radiotherapy (pages 320–328)
Yvette M. van der Linden, Sander P. D. S. Dijkstra, Ernest J. A. Vonk, Corrie A. M. Marijnen, Jan Willem H. Leer and for The Dutch Bone Metastasis Study Group
Version of Record online: 8 DEC 2004 | DOI: 10.1002/cncr.20756
For patients with painful spinal metastases, radiotherapy often is an adequate palliative treatment, as demonstrated in a large, randomized trial. When conditions deteriorate, however, surgical intervention maybe needed in these patients with an overall limited prognosis. A scoring system was developed to predict overall survival and to use as a tool for deciding on treatment.
You have free access to this content Phase II trial of irinotecan plus celecoxib in adults with recurrent malignant glioma (pages 329–338)
David A. Reardon, Jennifer A. Quinn, James Vredenburgh, Jeremy N. Rich, Sridharan Gururangan, Michael Badruddoja, James E. Herndon II, Jeannette M. Dowell, Allan H. Friedman and Henry S. Friedman
Version of Record online: 22 NOV 2004 | DOI: 10.1002/cncr.20776
Recurrence is nearly universal for patients with malignant glioma (MG) after conventional therapy comprised of surgical debulking, external beam radiotherapy, and chemotherapy, and typically is accompanied by progressive physical and mental debilitation, culminating in death. Available salvage therapies after disease progression are reported to be ineffective. The role of chemotherapy for patients with MG remains controversial. In the current study, the authors report a Phase II trial of irinotecan, a topoisomerase I inhibitor active against MG, with celecoxib, a selective COX-2 inhibitor, among MG patients with recurrent disease.
Discipline Diagnostic Imaging You have free access to this content Use of positron emission tomography in localized extremity soft tissue sarcoma treated with neoadjuvant chemotherapy (pages 339–348)
Scott M. Schuetze, Brian P. Rubin, Cheryl Vernon, Douglas S. Hawkins, James D. Bruckner, Ernest U. Conrad III and Janet F. Eary
Version of Record online: 1 DEC 2004 | DOI: 10.1002/cncr.20769
Fluorodeoxyglucose uptake measured by positron emission tomography correlated with soft tissue sarcoma recurrence after chemotherapy. Patients with extremity sarcomas who had a metabolic response had a significantly lower risk of disease recurrence and improved survival.
Epidemiology You have free access to this content Risk of pancreatic adenocarcinoma : Disparity between African Americans and other race/ethnic groups (pages 349–357)
Kenneth J. Chang, Gulshan Parasher, Catherine Christie, Joan Largent and Hoda Anton-Culver
Version of Record online: 8 DEC 2004 | DOI: 10.1002/cncr.20771
African Americans in California had a higher incidence rate of pancreatic adenocarcinoma, had a slightly higher risk of presenting with advanced-stage disease and with nonresectable tumors (i.e., tumors located in the body or tail of the pancreas), and underwent less surgical treatment than all other race/ethnicities. Younger females in all race/ethnic groups had a survival advantage over males of the same age.
Pathology You have free access to this content Improving the reproducibility of diagnosing micrometastases and isolated tumor cells (pages 358–367)
Gábor Cserni, Simonetta Bianchi, Werner Boecker, Thomas Decker, Manuela Lacerda, Fritz Rank, Clive A. Wells and for The European Working Group for Breast Screening Pathology
Version of Record online: 8 DEC 2004 | DOI: 10.1002/cncr.20760
The diagnoses of micrometastasis and isolated tumor cells in axillary lymph nodes from patients with breast cancer were poorly reproducible in this study by the European Working Group for Breast Screening Pathology. The definitions available for these categories did not appear to permit a consistent distinction between the two entities; therefore, refinements are required and suggested.
Pediatric Oncology You have free access to this content Bone marrow recurrence after initial intensive treatment for childhood acute lymphoblastic leukemia (pages 368–376)
Gaston K. Rivera, Yinmei Zhou, Michael L. Hancock, Amar Gajjar, Jeffrey Rubnitz, Raul C. Ribeiro, John T. Sandlund, Melissa Hudson, Mary Relling, William E. Evans and Ching-Hon Pui
Version of Record online: 14 DEC 2004 | DOI: 10.1002/cncr.20743
In the current study, the authors studied the clinical outcome of 106 children with acute lymphoblastic leukemia (ALL) after first bone marrow recurrence. The 5-year survival probability among all patients was 24.2% ± 4.2% (standard error), signaling a poor outcome despite intensive retrieval therapy.
Psychological Oncology You have free access to this content The correlation between fatigue, physical function, the systemic inflammatory response, and psychological distress in patients with advanced lung cancer (pages 377–382)
Duncan J. F. Brown, Donald C. McMillan and Robert Milroy
Version of Record online: 22 NOV 2004 | DOI: 10.1002/cncr.20777
Objective physical function in patients with advanced lung cancer is poorer with increasing fatigue. Fatigue is not primarily a result of weight loss or anemia but is related to Karnofsky performance status and psychological distress.
Radiation Oncology You have free access to this content Estimating the optimal utilization rates of radiotherapy for hematologic malignancies from a review of the evidence : Part I—Lymphoma (pages 383–392)
Carolyn Featherstone, Geoff Delaney, Susannah Jacob and Michael Barton
Version of Record online: 14 DEC 2004 | DOI: 10.1002/cncr.20754
The authors developed an evidence-based benchmark for the proportion of patients with lymphoma that should receive radiotherapy at least once by reviewing treatment guidelines and merging the indications for radiotherapy with epidemiological data. The resulting optimal radiotherapy utilization rates were then compared with actual radiotherapy utilization rates recorded in clinical practice.
You have free access to this content Estimating the optimal utilization rates of radiotherapy for hematologic malignancies from a review of the evidence : Part II—Leukemia and myeloma (pages 393–401)
Carolyn Featherstone, Geoff Delaney, Susannah Jacob and Michael Barton
Version of Record online: 8 DEC 2004 | DOI: 10.1002/cncr.20755
The authors developed an evidence-based benchmark for the proportions of patients with leukemia and myeloma who should receive radiotherapy at least once by reviewing treatment guidelines and merging the indications for radiotherapy with epidemiological data. The resulting optimal radiotherapy utilization rates were then compared with actual radiotherapy utilization rates recorded in clinical practice.
Sarcoma You have free access to this content Validation and adaptation of a nomogram for predicting the survival of patients with extremity soft tissue sarcoma using a three-grade system (pages 402–408)
Luigi Mariani, Rosalba Miceli, Michael W. Kattan, Murray F. Brennan, Maurizio Colecchia, Marco Fiore, Paolo G. Casali and Alessandro Gronchi
Version of Record online: 1 DEC 2004 | DOI: 10.1002/cncr.20778
The performance of the Memorial Sloan-Kettering Cancer Center (MSKCC) nomogram in predicting long term tumor-specific death of soft tissue sarcoma (STS) was assessed in an independent series of patients with extremity STS. The MSKCC nomogram was shown to be a valuable tool for individual prognostic assessment and could be improved by incorporating a three-level histologic grade classification.
You have free access to this content Deep-seated, well differentiated lipomatous tumors of the chest wall and extremities : The role of cytogenetics in classification and prognostication (pages 409–416)
Mikelle D. Bassett, Scott M. Schuetze, Christine Disteche, Thomas H. Norwood, Karen Swisshelm, Xiaoqin Chen, James Bruckner, Ernest U. Conrad III and Brian P. Rubin
Version of Record online: 8 DEC 2004 | DOI: 10.1002/cncr.20779
A combined approach of histology and cytogenetics was used to stratify patients with deep-seated, well-differentiated lipomatous tumors of the chest wall and extremities into intramuscular lipoma and atypical lipomatous tumor. The diagnosis of atypical lipomatous tumor correlated with local disease recurrence (
P = 0.006). The authors advocate this combined approach to better stratify patients for treatment and follow-up strategies. You have free access to this content Weekly docetaxel is safe and effective in the treatment of advanced-stage acquired immunodeficiency syndrome-related Kaposi sarcoma (pages 417–421)
Soon Thye Lim, Anil Tupule, Byron M. Espina and Alexandra M. Levine
Version of Record online: 1 DEC 2004 | DOI: 10.1002/cncr.20780
A Phase II trial was conducted with weekly docetaxel in patients with advanced-stage Kaposi sarcoma (KS) to assess the drug's safety and antitumor activity. The authors found that weekly docetaxel was safe, with reasonable antitumor activity in patients with advanced-stage, recurrent, or refractory acquired immunodeficiency syndrome-related KS.
Translational Research You have free access to this content Ethanol stimulates tumor progression and expression of vascular endothelial growth factor in chick embryos (pages 422–431)
Jian-Wei Gu, Amelia Purser Bailey, Amanda Sartin, Ian Makey and Ann L. Brady
Version of Record online: 13 DEC 2004 | DOI: 10.1002/cncr.20781
A chick embryo chorioallantoic membrane model that bore human fibrosarcoma was used to demonstrate that the administration of physiologically relevant doses of ethanol cause significant increases in both tumor size and intratumoral vascular volume density accompanied by the up-regulation of vascular endothelial growth factor (VEGF) tumor expression. These findings support the hypothesis that the induction of angiogenesis and VEGF expression by ethanol represents an important mechanism of cancer progression associated with alcoholic beverage consumption.