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Cancer

Cover image for Cancer

15 March 2005

Volume 103, Issue 6

Pages 1097–1318

  1. A Note From History

    1. Top of page
    2. A Note From History
    3. Review Articles
    4. Original Articles
    5. Original Article
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Original Article
    10. Original Articles
    11. Original Article
    12. Original Articles
    13. Correspondence
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  2. Review Articles

    1. Top of page
    2. A Note From History
    3. Review Articles
    4. Original Articles
    5. Original Article
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Original Article
    10. Original Articles
    11. Original Article
    12. Original Articles
    13. Correspondence
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      Perspectives for the management of febrile neutropenic patients with cancer in the 21st century (pages 1103–1113)

      Nikolaos V. Sipsas, Gerald P. Bodey and Dimitrios P. Kontoyiannis

      Version of Record online: 21 JAN 2005 | DOI: 10.1002/cncr.20890

      Neutropenic patients with cancer are at risk for serious infections caused by a variety of pathogens. In this article, the authors review the predisposing factors, clinical features, microbiologic spectrum, and management issues in this patient population.

  3. Original Articles

    1. Top of page
    2. A Note From History
    3. Review Articles
    4. Original Articles
    5. Original Article
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Original Article
    10. Original Articles
    11. Original Article
    12. Original Articles
    13. Correspondence
    1. Disease Site

      Breast Disease
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      Tamoxifen-treated breast carcinoma patients and the risk of acute myocardial infarction and newly-diagnosed angina (pages 1114–1121)

      Brian D. Bradbury, Timothy L. Lash, James A. Kaye and Susan S. Jick

      Version of Record online: 14 FEB 2005 | DOI: 10.1002/cncr.20900

      Using a nested, matched, case–control study design and data collected in the General Practice Research Database, the authors assessed whether breast carcinoma patients who had been treated with tamoxifen were at reduced risk of having a first acute myocardial infarction (MI) or of developing angina. The results indicated that breast carcinoma patients who were treated with tamoxifen for up to 5 years were at reduced risk of having an acute MI or developing angina (adjusted odds ratio, 0.4; 95% confidence interval, 0.2–0.7) compared with other women who were not prescribed tamoxifen.

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      Thyroid hormone and breast carcinoma : Primary hypothyroidism is associated with a reduced incidence of primary breast carcinoma (pages 1122–1128)

      Massimo Cristofanilli, Yuko Yamamura, Shu-Wan Kau, Therese Bevers, Sara Strom, Modesto Patangan, Limin Hsu, Savitri Krishnamurthy, Richard L. Theriault and Gabriel N. Hortobagyi

      Version of Record online: 14 FEB 2005 | DOI: 10.1002/cncr.20881

      In this retrospective review, the authors investigated the role of primary hypothyroidism (HYPT) in breast carcinogenesis. The findings suggest a possible biologic role for thyroid hormone in the etiology of breast carcinoma and indicate areas of research for the prevention and treatment of breast carcinoma.

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      Reproducibility of cytologic atypia in repeat nipple duct lavage (pages 1129–1136)

      April Johnson-Maddux, Raheela Ashfaq, Leslie Cler, Elizabeth Naftalis, Ann Marilyn Leitch, Susan Hoover and David M. Euhus

      Version of Record online: 31 JAN 2005 | DOI: 10.1002/cncr.20884

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      Atypia diagnosed by nipple duct lavage was confirmed on repeat lavage in 48% of women and was associated with findings on magnetic resonance images in 13% of women. Lavage atypia may be physiologic or artifactual rather than pathologic in many instances.

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      Long-term outcome after breast-conservation treatment with radiation for mammographically detected ductal carcinoma in situ of the breast (pages 1137–1146)

      Lawrence J. Solin, Alain Fourquet, Frank A. Vicini, Marie Taylor, Ivo A. Olivotto, Bruce Haffty, Eric A. Strom, Lori J. Pierce, Lawrence B. Marks, Harry Bartelink, Marsha D. McNeese, Anuja Jhingran, Elaine Wai, Nina Bijker, Francois Campana and Wei-Ting Hwang

      Version of Record online: 26 JAN 2005 | DOI: 10.1002/cncr.20886

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      The outcome after breast-conservation treatment with radiation is presented for 1003 women who had mammographically detected ductal carcinoma in situ of the breast. Patient age ≥ 50 years and negative final pathology margins both were associated independently with a lower risk of local failure.

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      Breast carcinoma chemoprevention in the community setting : Estimating risks and benefits (pages 1147–1153)

      Abenaa M. Brewster, Dana K. Christo, Hong Lai and Kathy Helzlsouer

      Version of Record online: 26 JAN 2005 | DOI: 10.1002/cncr.20882

      The United States Preventive Services Task Force recommends that women who are at both high risk for breast carcinoma and low risk for adverse events should receive counseling about tamoxifen for chemoprevention. The authors analyzed a community-based cohort to estimate the prevalence of women who may be eligible for breast carcinoma chemoprevention and the baseline incidence of adverse health events that may affect the community-level risks and benefits of chemoprevention.

  4. Original Article

    1. Top of page
    2. A Note From History
    3. Review Articles
    4. Original Articles
    5. Original Article
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Original Article
    10. Original Articles
    11. Original Article
    12. Original Articles
    13. Correspondence
    1. Disease Site

      Endocrine Disease
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      Alteration of the E-cadherin/β-catenin cell adhesion system is common in pulmonary neuroendocrine tumors and is an independent predictor of lymph node metastasis in atypical carcinoids (pages 1154–1164)

      Giuseppe Pelosi, Aldo Scarpa, Giacomo Puppa, Giulia Veronesi, Lorenzo Spaggiari, Felice Pasini, Patrick Maisonneuve, Antonio Iannucci, Gianluigi Arrigoni and Giuseppe Viale

      Version of Record online: 14 FEB 2005 | DOI: 10.1002/cncr.20901

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      Changes in E-cadherin/β-catenin immunoreactivity patterns are common in lung neuroendocrine tumors, with either subcellular redistribution and/or down-regulation occurring according to tumor differentiation. In atypical carcinoids, such dysregulation of the E-cadherin/β-catenin adhesion complex was found to be an independent predictor of regional lymph node metastasis.

  5. Original Articles

    1. Top of page
    2. A Note From History
    3. Review Articles
    4. Original Articles
    5. Original Article
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Original Article
    10. Original Articles
    11. Original Article
    12. Original Articles
    13. Correspondence
    1. Disease Site

      Gastrointestinal Tract
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      Differences in toxicity between men and women treated with 5-fluorouracil therapy for colorectal carcinoma (pages 1165–1171)

      Kari Chansky, Jacqueline Benedetti and John S. Macdonald

      Version of Record online: 3 FEB 2005 | DOI: 10.1002/cncr.20878

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      In the current study, 1074 patients from 4 Southwest Oncology Group colorectal carcinoma trials with 5-fluorouracil (5-FU)-containing regimens were examined for toxicity differences between the genders, using the data from 2 trials for exploration and the other 2 trials for validation of findings. Regression and classification tree methods revealed that 5-FU toxicity was more frequent and of higher grade in women than in men. Differences were seen particularly for the hematologic toxicities and mucositis.

    2. Genitourinary Disease
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      Small cell carcinoma of the urinary bladder : The Mayo Clinic experience (pages 1172–1178)

      Nicholas W. W. Choong, J. Fernando Quevedo and Judith S. Kaur

      Version of Record online: 7 FEB 2005 | DOI: 10.1002/cncr.20903

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      Small cell carcinoma of the urinary bladder is an uncommon but aggressive tumor and should be treated with radical cystectomy, except when metastatic disease is present. In patients with metastases, systemic chemotherapy is indicated. Adjuvant treatment is not indicated for patients with Stage II disease after radical cystectomy but should be considered for patients with Stage III and IV disease.

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      Selecting patients for flexible sigmoidoscopy : Determinants of incomplete depth of insertion (pages 1179–1185)

      Kalyanakrishnan Ramakrishnan and Dewey C. Scheid

      Version of Record online: 26 JAN 2005 | DOI: 10.1002/cncr.20904

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      Many factors (older age, female gender, prior hysterectomy, poor bowel preparation, coexisting large bowel pathology) may contribute to incomplete flexible sigmoidoscopy (FS). A model based on age, gender, and prior hysterectomy was constructed that may predict incomplete FS, so that patients who have a high likelihood of undergone an incomplete FS may be offered the procedure under sedation or analgesia to minimize the risk of incomplete examination or may be referred for screening colonoscopy.

  6. Original Article

    1. Top of page
    2. A Note From History
    3. Review Articles
    4. Original Articles
    5. Original Article
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Original Article
    10. Original Articles
    11. Original Article
    12. Original Articles
    13. Correspondence
    1. Disease Site

      Genitourinary Disease
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      Combined c-Myc and caveolin-1 expression in human prostate carcinoma predicts prostate carcinoma progression (pages 1186–1194)

      Guang Yang, Terry L. Timme, Anna Frolov, Thomas M. Wheeler and Timothy C. Thompson

      Version of Record online: 14 FEB 2005 | DOI: 10.1002/cncr.20905

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      The combined expression of c-Myc and caveolin-1 had prognostic significance in patients with clinically confined, lymph node negative, prostate carcinoma.

  7. Original Articles

    1. Top of page
    2. A Note From History
    3. Review Articles
    4. Original Articles
    5. Original Article
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Original Article
    10. Original Articles
    11. Original Article
    12. Original Articles
    13. Correspondence
    1. Disease Site

      Hematologic Malignancies
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      Bortezomib in recurrent and/or refractory multiple myeloma : Initial clinical experience in patients with impaired renal function (pages 1195–1200)

      Sundar Jagannath, Bart Barlogie, James R. Berenson, Seema Singhal, Raymond Alexanian, Gordan Srkalovic, Robert Z. Orlowski, Paul G. Richardson, Jessica Anderson, Darrell Nix, Dixie L. Esseltine and Kenneth C. Anderson

      Version of Record online: 2 FEB 2005 | DOI: 10.1002/cncr.20888

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      Clinical experience in a limited number of patients with multiple myeloma and severely impaired renal function suggested that the proteasome inhibitor bortezomib provides clinical benefit with manageable toxicity in this high-risk population. Although the inhibition and recovery of proteasome activity in whole blood, as measured in an ex vivo assay, was independent of baseline creatinine clearance, formal pharmacokinetic and pharmacodynamic studies are needed.

    2. Hepatobiliary Disease
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      Percutaneous radiofrequency ablation for hepatocellular carcinoma : An analysis of 1000 cases (pages 1201–1209)

      Ryosuke Tateishi, Shuichiro Shiina, Takuma Teratani, Shuntaro Obi, Shinpei Sato, Yukihiro Koike, Tomonori Fujishima, Haruhiko Yoshida, Takao Kawabe and Masao Omata

      Version of Record online: 2 FEB 2005 | DOI: 10.1002/cncr.20892

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      The authors performed 1000 treatments of radiofrequency ablation (RFA) to 2140 hepatocellular carcinoma nodules in 664 patients with a cooled-tip electrode. RFA was feasible in all cases with a major complication rate of 4.0% per treatment and a 5-year survival rate of 54.3% among 319 naive patients.

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      Impact of ductal resection margin status on long-term survival in patients undergoing resection for extrahepatic cholangiocarcinoma (pages 1210–1216)

      Toshifumi Wakai, Yoshio Shirai, Tetsuya Moroda, Naoyuki Yokoyama and Katsuyoshi Hatakeyama

      Version of Record online: 31 JAN 2005 | DOI: 10.1002/cncr.20906

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      After surgical resection for extrahepatic cholangiocarcinoma, invasive carcinoma at ductal resection margins appears to have a strong adverse effect on survival, whereas residual carcinoma in situ does not. Therefore, when ductal resection margins are positive on frozen-section examination, it is clinically important to discriminate between carcinoma in situ and invasive carcinoma.

  8. Original Article

    1. Top of page
    2. A Note From History
    3. Review Articles
    4. Original Articles
    5. Original Article
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Original Article
    10. Original Articles
    11. Original Article
    12. Original Articles
    13. Correspondence
    1. Disease Site

      Melanoma
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      Malignant melanoma in pregnancy : A population-based evaluation (pages 1217–1226)

      Anne T. O'Meara, Rosemary Cress, Guibo Xing, Beate Danielsen and Lloyd H. Smith

      Version of Record online: 14 FEB 2005 | DOI: 10.1002/cncr.20925

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      Four hundred twelve women with pregnancy-associated malignant melanoma in California from 1991 to 1999 were identified through statewide comprehensive databases and were compared with a control group. No differences were found in stage of disease, tumor thickness, survival, lymph node assessment, or neonatal or maternal outcome.

  9. Original Articles

    1. Top of page
    2. A Note From History
    3. Review Articles
    4. Original Articles
    5. Original Article
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Original Article
    10. Original Articles
    11. Original Article
    12. Original Articles
    13. Correspondence
    1. Disease Site

      Neuro-Oncology
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      Survival rates in patients with low-grade glioma after intraoperative magnetic resonance image guidance (pages 1227–1233)

      Elizabeth B. Claus, Andres Horlacher, Liangge Hsu, Richard B. Schwartz, Donna Dello-Iacono, Florian Talos, Ferenc A. Jolesz and Peter M. Black

      Version of Record online: 2 FEB 2005 | DOI: 10.1002/cncr.20867

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      Patients with low-grade glioma who underwent subtotal resection under intraoperative magnetic resonance image (MRI) guidance were at 1.4 times the risk of recurrence (95% confidence interval [95% CI], 0.7–3.1) and at 4.9 times the risk of death (95% CI, 0.61–40.0) relative to patients who underwent gross total resection. The data presented in this report suggest a possible association between surgical resection and survival for neurosurgical patients who undergo surgery for low-grade glioma under intraoperative MRI guidance.

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      Is older age associated with a worse prognosis due to different patterns of care? : A long-term study of 1346 patients with glioblastomas or brain metastases (pages 1234–1244)

      Johannes Lutterbach, Susanne Bartelt, Felix Momm, Gerhild Becker, Hermann Frommhold and Christoph Ostertag

      Version of Record online: 21 JAN 2005 | DOI: 10.1002/cncr.20895

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      The objective of this study, which included 1346 patients, was to find out whether the access to essential steps of the treatment process in patients with primary or metastatic brain tumors depends on age. The results indicated that older age did not limit access to state-of-the-art diagnostic or therapeutic procedures. The worse prognosis of elderly patients could not be attributed to age-related differences in patterns of care.

    3. Sarcoma
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      A proposed explanation for female predominance in alveolar soft part sarcoma : Noninactivation of X; Autosome translocation fusion gene? (pages 1245–1253)

      Xiangdong Bu and Leslie Bernstein

      Version of Record online: 3 FEB 2005 | DOI: 10.1002/cncr.20899

      Alveolar soft part sarcoma (ASPS), a rare malignant soft tissue tumor with a predilection for females, was recently found to have a nonreciprocal der(17)t(X;17) translocation. A statistical association between the female predominance observed for ASPS and females' possession of an extra X-chromosome/noninactivation of the ASPS X;autosome translocation fusion gene was found.

    4. Skin
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      Impact of radiographic findings on prognosis for skin carcinoma with clinical perineural invasion (pages 1254–1257)

      Thomas J. Galloway, Christopher G. Morris, Anthony A. Mancuso, Robert J. Amdur and William M. Mendenhall

      Version of Record online: 3 FEB 2005 | DOI: 10.1002/cncr.20913

      Patients with imaging-negative clinical perineural invasion had an excellent outcome after radiotherapy alone or combined with surgery. Those with radiographic evidence of perineural invasion had a local control rate of approximately 25–57%, depending on extent of disease, and a 5-year survival rate of 56–61%.

    5. Discipline

      Epidemiology
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      Mortality trends for cervical squamous and adenocarcinoma in the United States : Relation to incidence and survival (pages 1258–1264)

      Mark E. Sherman, Sophia S. Wang, Joseph Carreon and Susan S. Devesa

      Version of Record online: 3 FEB 2005 | DOI: 10.1002/cncr.20877

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      Increased reporting of cervical carcinoma in situ in the Surveillance, Epidemiology, and End Results program seemed disproportionate to improvements in mortality rates attributable to squamous carcinoma (1986–2000). Declines in mortality rates related to cervical adenocarcinoma have not been demonstrated conclusively.

  10. Original Article

    1. Top of page
    2. A Note From History
    3. Review Articles
    4. Original Articles
    5. Original Article
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Original Article
    10. Original Articles
    11. Original Article
    12. Original Articles
    13. Correspondence
    1. Discipline

      Pathology
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      Protein overexpression and gene amplification of epidermal growth factor receptor in nonsmall cell lung carcinomas : An immunohistochemical and fluorescence in situ hybridization study (pages 1265–1273)

      Shioto Suzuki, Yoh Dobashi, Hiroyuki Sakurai, Keiichi Nishikawa, Mitsuhiko Hanawa and Akishi Ooi

      Version of Record online: 14 FEB 2005 | DOI: 10.1002/cncr.20909

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      Overexpression of epidermal growth factor receptor (EGFR) in nonsmall cell lung carcinoma (NSCLC) is accompanied predominantly, but not exclusively, by gene amplification. It is important to evaluate not only protein overexpression but also the EGFR status to design adjuvant therapies for patients with NSCLC, because specimens that exhibit both protein overexpression and gene amplification may predict eventual lymph node metastasis and, possibly, aggressive tumor behavior.

  11. Original Articles

    1. Top of page
    2. A Note From History
    3. Review Articles
    4. Original Articles
    5. Original Article
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Original Article
    10. Original Articles
    11. Original Article
    12. Original Articles
    13. Correspondence
    1. Discipline

      Pediatric Oncology
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      Detection of recurrence in childhood solid tumors (pages 1274–1279)

      Lisa Howell, Adjoa Mensah, Bernadette Brennan and Guy Makin

      Version of Record online: 26 JAN 2005 | DOI: 10.1002/cncr.20896

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      The authors conducted a retrospective study in a group of children with solid tumors to determine the value of follow-up in detecting disease recurrence. The results indicated that many current practices with regard to follow-up lead to large numbers of surveillance investigations and clinic visits.

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      Results of a phase I study utilizing monocyte-derived dendritic cells pulsed with tumor RNA in children with stage 4 neuroblastoma (pages 1280–1291)

      Denise A. Caruso, Lisa M. Orme, Gerlinda M. Amor, Alana M. Neale, Fiona J. Radcliff, Peter Downie, Mimi L. K. Tang and David M. Ashley

      Version of Record online: 3 FEB 2005 | DOI: 10.1002/cncr.20911

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      An antitumor dendritic cell vaccine that used tumor RNA as the antigen source was both safe and feasible in children with Stage 4 neuroblastoma. Children with neuroblastoma were immunosuppressed profoundly, even though they received lymphocyte-sparing chemotherapy and had normal numbers of lymphocytes 6 weeks after they finished chemotherapy.

    3. Disease Site

      Psychological Oncology
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      Employment pathways in a large cohort of adult cancer survivors (pages 1292–1301)

      Pamela Farley Short, Joseph J. Vasey and Kaan Tunceli

      Version of Record online: 7 FEB 2005 | DOI: 10.1002/cncr.20912

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      In a cohort of cancer survivors, cancer survival sometimes had long-term effects on employment and ability to work that extended beyond the first year of survivorship, when most survivors returned to work from treatment. The risks of cancer-related disability and withdrawal from work varied according to clinical and patient characteristics.

    4. Discipline

      Translational Research
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      Nitroxide tempo, a small molecule, induces apoptosis in prostate carcinoma cells and suppresses tumor growth in athymic mice (pages 1302–1313)

      Simeng Suy, James B. Mitchell, Ayelet Samuni, Susette Mueller and Usha Kasid

      Version of Record online: 31 JAN 2005 | DOI: 10.1002/cncr.20898

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      Tempo, a small molecule, induced apoptosis in human prostate carcinoma cells. The antitumor effect of tempo in a human prostate tumor xenograft model in athymic mice suggested that tempo is a potential therapeutic agent.

  12. Correspondence

    1. Top of page
    2. A Note From History
    3. Review Articles
    4. Original Articles
    5. Original Article
    6. Original Articles
    7. Original Article
    8. Original Articles
    9. Original Article
    10. Original Articles
    11. Original Article
    12. Original Articles
    13. Correspondence
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      Author reply (page 1315)

      Rose Lai and Lauren E. Abrey

      Version of Record online: 26 JAN 2005 | DOI: 10.1002/cncr.20897

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      Author reply (pages 1316–1317)

      William Blum, Krzysztof Mrózek, Amy S. Ruppert and Clara D. Bloomfield

      Version of Record online: 7 FEB 2005 | DOI: 10.1002/cncr.20933

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      Author reply (page 1318)

      James I. Geller, Joseph D. Khoury and Jeffrey S. Dome

      Version of Record online: 26 JAN 2005 | DOI: 10.1002/cncr.20932

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