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Cancer

Cover image for Cancer

1 April 2005

Volume 103, Issue 7

Pages 1319–1536

  1. Original Articles

    1. Top of page
    2. Original Articles
    3. Retraction
    4. Original Articles
    1. Disease Site

      Breast Disease
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      Immunohistochemically detected lymph node metastases from breast carcinoma : Practical considerations about the New American Joint Committee on Cancer classification (pages 1319–1322)

      Isabelle de Mascarel, Isabelle Soubeyran, Gaetan MacGrogan, Véronique Picot and Simone Mathoulin-Pélissier

      Version of Record online: 17 FEB 2005 | DOI: 10.1002/cncr.20937

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      Using the sixth edition of the American Joint Committee classification system to classify isolated tumor cells (ITCs) detected by immunohistochemistry in a group of patients with breast carcinoma who had previously determined pathologically negative lymph node status, the authors found 2 categories of pN0(i+): measurable tumor cell deposits ≤ 0.2 mm, which were found exclusively in infiltrating ductal carcinoma; and nonmeasurable ITCs, which were found in infiltrating lobular carcinoma and rarely in infiltrating ductal carcinoma. The new classification system was difficult to apply to ITCs that were detected by immunohistochemistry in infiltrating lobular carcinomas.

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      Lower and central tumor location correlates with lymphoscintigraphy drainage to the internal mammary lymph nodes in breast carcinoma (pages 1323–1329)

      Karen H. Shahar, Thomas A. Buchholz, Ebrahim Delpassand, Aysegul A. Sahin, Merrick I. Ross, Fredrick C. Ames, Henry M. Kuerer, Barry W. Feig, Funda Meric-Bernstam, Gildy V. Babiera, S. Eva Singletary, Jeri S. Akins, Nadeem Q. Mirza and Kelly K. Hunt

      Version of Record online: 22 FEB 2005 | DOI: 10.1002/cncr.20914

      Patients with tumors in the lower or central breast and positive axillary sentinel lymph nodes have an increased incidence of drainage to the internal mammary chain. Lymphoscintigraphy helps to identify these extraaxillary drainage patterns so that appropriate patients can be targeted for treatment of the internal mammary chain.

    3. Endocrine Disease
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      Anaplastic thyroid carcinoma : Treatment outcome and prognostic factors (pages 1330–1335)

      Electron Kebebew, Francis S. Greenspan, Orlo H. Clark, Kenneth A. Woeber and Alex McMillan

      Version of Record online: 28 FEB 2005 | DOI: 10.1002/cncr.20936

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      Although most patients with anaplastic thyroid carcinoma (ATC) had a lethal clinical course, patients < 60 years old with intrathyroidal ATC had a better prognosis than older patients with distant metastasis. Surgical resection with external beam radiation in patients with ATC was associated with a lower cause-specific mortality.

    4. Gastrointestinal Tract
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      The prognostic impact of the ubiquitin ligase subunits Skp2 and Cks1 in colorectal carcinoma (pages 1336–1346)

      Ma'anit Shapira, Ofer Ben–Izhak, Shai Linn, Boris Futerman, Ira Minkov and Dan D. Hershko

      Version of Record online: 16 FEB 2005 | DOI: 10.1002/cncr.20917

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      The expression of S-phase kinase-associated protein 2 (Skp2) and cyclin kinase subunit 1 (Cks1), the specific ubiquitin ligase subunits that target p27Kip1 for degradation, are altered in various human cancers. It is shown in the current study that increased expression of Skp2 or Cks1 is strongly associated with poor prognosis and that their increased expression may be used as a prognostic marker for overall survival in colorectal carcinoma.

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      Posttherapy pathologic stage predicts survival in patients with esophageal carcinoma receiving preoperative chemoradiation (pages 1347–1355)

      Lucian R. Chirieac, Stephen G. Swisher, Jaffer A. Ajani, Ritsuko R. Komaki, Arlene M. Correa, Jeffrey S. Morris, Jack A. Roth, Asif Rashid, Stanley R. Hamilton and Tsung-Teh Wu

      Version of Record online: 17 FEB 2005 | DOI: 10.1002/cncr.20916

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      Posttherapy pathologic stage was the best available predictor of outcome for patients with locoregional carcinoma of the esophagus or esophagogastric junction who underwent chemoradiation therapy followed by esophagectomy. The findings in the current study supported the concept of downstaging by preoperative therapy.

    6. Genitourinary Disease
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      Detection of bladder carcinoma by combined testing of urine for hyaluronidase and cytokeratin 20 RNAs (pages 1356–1362)

      Sanaa Eissa, Samar K. Kassim, Randa Ali Labib, Inas M. El-Khouly, Taghreed M. Ghaffer, Mohamed Sadek, Omar Abdel Razek and Omar El-Ahmady

      Version of Record online: 16 FEB 2005 | DOI: 10.1002/cncr.20902

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      HAase RNA is a promising noninvasive test with high sensitivity and specificity in bladder carcinoma detection.

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      Resistance to caspase-dependent, hypoxia-induced apoptosis is not hypoxia-inducible factor-1 alpha mediated in prostate carcinoma cells (pages 1363–1374)

      Ronan N. T. Coffey, Colm Morrissey, Cormac T. Taylor, John M. Fitzpatrick and R. William G. Watson

      Version of Record online: 17 FEB 2005 | DOI: 10.1002/cncr.20918

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      Apoptotic resistance is already established in cells that survive an hypoxic insult, and, although increased HIF-1α activity may be essential for the development of a more aggressive cancer phenotype, it is not initially responsible for the selection of an apoptotic resistance phenotype.

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      Estimated impact of the Prostate Cancer Prevention Trial on population mortality (pages 1375–1380)

      Joseph M. Unger, Ian M. Thompson Jr., Michael LeBlanc, John J. Crowley, Phyllis J. Goodman, Leslie G. Ford and Charles A. Coltman Jr.

      Version of Record online: 28 FEB 2005 | DOI: 10.1002/cncr.20919

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      The results of the Prostate Cancer Prevention Trial, which showed a reduction in the period prevalence of prostate cancer but also showed an increase in the rate of high-grade prostate cancers, sparked debate regarding the potential public health impact of finasteride. In the current analysis, the authors showed that finasteride may have a major impact on population mortality from prostate cancer if it is applied clinically and that the potential detrimental effects of an increased rate of patients with high-grade Gleason score would be outweighed by a reduction in incidence.

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      Estradiol and cognition during androgen deprivation in men with prostate carcinoma (pages 1381–1387)

      Eeva K. Salminen, R.I. Portin, A.I. Koskinen, H.Y.M. Helenius and M.J. Nurmi

      Version of Record online: 16 FEB 2005 | DOI: 10.1002/cncr.20962

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      Estradiol decline is associated with cognitive changes during androgen deprivation in prostate carcinoma patients.

    10. Gynecologic Oncology
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      Sequential topotecan and oral etoposide in recurrent ovarian carcinoma pretreated with platinum-taxane : Results from a multicenter Phase I/II study (pages 1388–1396)

      Bo Gronlund, Svend A. Engelholm, György Horvath, Johanna Mäenpää and Mona Ridderheim

      Version of Record online: 17 FEB 2005 | DOI: 10.1002/cncr.20921

      Because of the results from this study, the authors could not recommend topotecan plus oral etoposide for future trials in patients with recurrent ovarian carcinoma due to unpredictable hematologic toxicity. However, the high objective response rate achieved highlighted the effect of topoisomerase I and II inhibitors.

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      The clinical significance of malignant pleural effusions in patients with optimally debulked ovarian carcinoma (pages 1397–1401)

      Ram Eitan, Douglas A. Levine, Nadeem Abu-Rustum, Yukio Sonoda, Jae N. Huh, Corinna C. Franklin, Tobey A. Stevens, Richard R. Barakat and Dennis S. Chi

      Version of Record online: 22 FEB 2005 | DOI: 10.1002/cncr.20920

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      Optimally debulked patients who were diagnosed with International Federation of Gynecology and Obstetrics (FIGO) Stage IV ovarian carcinoma based on malignant pleural effusion had a worse prognosis than optimally debulked patients with Stage IIIC disease.

    12. Hepatobiliary Disease
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      Phase II study of hepatic intraarterial epirubicin and cisplatin, with systemic 5-fluorouracil in patients with unresectable biliary tract tumors (pages 1402–1407)

      Maurizio Cantore, Andrea Mambrini, Giammaria Fiorentini, Carla Rabbi, Donatella Zamagni, Roberto Caudana, Cristina Pennucci, Franco Sanguinetti, Mirko Lombardi and Nicola Nicoli

      Version of Record online: 22 FEB 2005 | DOI: 10.1002/cncr.20964

      The activity of standard chemotherapy in the treatment of advanced biliary tract carcinomas is reported to be very low. The authors evaluated a novel combined intraarterial and systemic chemotherapic approach.

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      Use of tamoxifen in advanced-stage hepatocellular carcinoma : A systematic review (pages 1408–1414)

      Anna K. Nowak, Martin R. Stockler, Pierce K. H. Chow and Michael Findlay

      Version of Record online: 2 MAR 2005 | DOI: 10.1002/cncr.20963

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    14. Lung Disease
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      The expression of Bcl-2 family proteins differs between nonsmall cell lung carcinoma subtypes (pages 1415–1419)

      Helen K. Berrieman, Laura Smith, Sara L. O'Kane, Anne Campbell, Michael J. Lind and Lynn Cawkwell

      Version of Record online: 7 FEB 2005 | DOI: 10.1002/cncr.20907

      Immunohistochemical analysis of apoptosis-related proteins identified differences between adenocarcinoma and squamous cell carcinoma subtypes in nonsmall cell lung carcinoma.

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      Racial differences in exposure and glucuronidation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) (pages 1420–1426)

      Joshua E. Muscat, Mirjana V. Djordjevic, Stephen Colosimo, Steven D. Stellman and John P. Richie Jr

      Version of Record online: 22 FEB 2005 | DOI: 10.1002/cncr.20953

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      In a community-based study of cigarette smokers, the urinary concentration of tobacco smoke biomarkers was higher in Black men than in White men per cigarette smoked.

    16. Neuro-Oncology
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      Cerebrospinal fluid-disseminated meningioma (pages 1427–1430)

      Marc C. Chamberlain and Michael J. Glantz

      Version of Record online: 2 FEB 2005 | DOI: 10.1002/cncr.20926

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      The treatment of eight patients with metastatic meningioma who had cerebrospinal fluid dissemination was difficult because the majority of patients had failed prior surgery and radiotherapy. Treatment was associated with a poor outcome notwithstanding a multimodal approach (both systemic and regional chemotherapy).

    17. Sarcoma
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      A multicenter Phase II study of bortezomib in recurrent or metastatic sarcomas (pages 1431–1438)

      Robert G. Maki, Andrew S. Kraft, Kelly Scheu, Jennifer Yamada, Scott Wadler, Cristina R. Antonescu, John J. Wright and Gary K. Schwartz

      Version of Record online: 28 FEB 2005 | DOI: 10.1002/cncr.20968

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      Bortezomib was examined in a Phase II study of patients with previously untreated metastatic soft tissue sarcomas. One of 21 evaluable patients responded, indicating limited activity of this single agent.

    18. Discipline

      Pathology
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      Clinicopathologic and protein expression differences between cardia carcinoma and noncardia carcinoma of the stomach (pages 1439–1446)

      Min A Kim, Hye Seung Lee, Han-Kwang Yang and Woo Ho Kim

      Version of Record online: 22 FEB 2005 | DOI: 10.1002/cncr.20966

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      According to data from the author's institute, cardia carcinomas and noncardia carcinomas differ in their clinicopathologic characteristics and in the alterations of gene expression, as evaluated by immunohistochemistry. The current results support the hypothesis that cardia carcinoma forms a specific category of gastric carcinoma that is distinct from noncardia carcinoma.

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      Interobserver agreement in the interpretation of anal intraepithelial neoplasia (pages 1447–1456)

      Alice Lytwyn, Irving E. Salit, Janet Raboud, William Chapman, Teresa Darragh, Barbara Winkler, Jill Tinmouth, James B. Mahony and Marie Sano

      Version of Record online: 22 FEB 2005 | DOI: 10.1002/cncr.20927

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      In the current study, reliability for cytologic and histologic interpretation of premalignant anal lesions ranged from moderate to substantial. Occurrence of only moderate agreement supported the need for alternate disease indicators with high and more uniform interobserver reliability.

    20. Pediatric Oncology
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      International Classification of Childhood Cancer, third edition (pages 1457–1467)

      Eva Steliarova-Foucher, Charles Stiller, Brigitte Lacour and Peter Kaatsch

      Version of Record online: 14 FEB 2005 | DOI: 10.1002/cncr.20910

      The new third edition of the International Classification of Childhood Cancer (ICCC-3) classifies tumors that were coded according to the most recent edition of the International Classification for Diseases. A three-level, hierarchical categorization allows both continuity with previous schemes and flexibility in cross-grouping of neoplasms. ICCC-3 is proposed for standardized presentation of population-based cancer incidence and survival studies in childhood.

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      Osteosarcoma of the pelvis in children and young adults: The St. Jude Children's Research Hospital experience (pages 1468–1474)

      Raya Saab, Bhaskar N. Rao, Carlos Rodriguez-Galindo, Catherine A. Billups, Tamra N. Fortenberry and Najat C. Daw

      Version of Record online: 28 FEB 2005 | DOI: 10.1002/cncr.20959

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      Pelvic osteosarcomas often are large and unresectable. In a reviewed the records of patients with pelvic osteosarcoma treated at their institution, the authors found that a high propensity for metastasis contributed to the poor outcome of patients with pelvic osteosarcoma.

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      Long-term survival probabilities for childhood rhabdomyosarcoma : A population-based evaluation (pages 1475–1483)

      Judith A. Punyko, Ann C. Mertens, K. Scott Baker, Kirsten K. Ness, Leslie L. Robison and James G. Gurney

      Version of Record online: 11 FEB 2005 | DOI: 10.1002/cncr.20929

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      This analysis of population-based data from the national Surveillance, Epidemiology, and End Results (SEER) database demonstrated that survival of childhood rhabdomyosarcoma varies widely by factors such as age at diagnosis, tumor site, and histologic subtype. Poor prognosis was associated with diagnosis during infancy or adolescence; metastatic disease at the time of presentation; alveolar histology; and tumors of the extremities, retroperitoneum, and trunk. However, overall trends in survival appear to be improving, and children who survive the first 5 years after diagnosis have an excellent long-term prognosis.

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      Disturbed root development of permanent teeth after pediatric stem cell transplantation : Dental root development after SCT (pages 1484–1493)

      Päivi Hölttä, Liisa Hovi, Ulla M. Saarinen-Pihkala, Jaakko Peltola and Satu Alaluusua

      Version of Record online: 28 FEB 2005 | DOI: 10.1002/cncr.20967

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      Pediatric recipients of stem cell transplantation (SCT) had root-crown ratios outside ±2 standard deviation scores in almost 80% of their permanent teeth. High-dose chemotherapy alone intensely harmed root growth but total body irradiation further increased the adverse effects that were most extensive in patients 3.1–5.0 years at SCT.

    24. Pyschological Oncology
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      Screening for psychologic distress in ambulatory cancer patients : A multicenter evaluation of the Distress Thermometer (pages 1494–1502)

      Paul B. Jacobsen, Kristine A. Donovan, Peter C. Trask, Stewart B. Fleishman, James Zabora, Frank Baker and Jimmie C. Holland

      Version of Record online: 22 FEB 2005 | DOI: 10.1002/cncr.20940

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      Findings confirmed that the single-item Distress Thermometer compares favorably with longer measures used to screen for distress in cancer patients. A Distress Thermometer cutoff score of 4 yielded optimal sensitivity and specificity in a general cancer population relative to established cutoff scores on longer measures. The use of this cutoff score identified patients with a range of problems likely to reflect psychologic distress.

  2. Retraction

    1. Top of page
    2. Original Articles
    3. Retraction
    4. Original Articles
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      Retracted: Tumor necrosis factor enhances SN38-mediated apoptosis in mesothelioma cells : The role of nuclear factor-κB pathway activation (pages 1503–1518)

      Patrizia Russo, Alessia Catassi, Davide Malacarne, Stefano Margaritora, Alfredo Cesario, Luigi Festi, Antonino Mulé, Luigi Ferri and Pierluigi Granone

      Version of Record online: 7 FEB 2005 | DOI: 10.1002/cncr.20924

  3. Original Articles

    1. Top of page
    2. Original Articles
    3. Retraction
    4. Original Articles
    1. Discipline

      Translational Research
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      Preparation of murine B7.1-glycosylphosphatidylinositol and transmembrane-anchored staphylococcal enterotoxin : A dual-anchored tumor cell vaccine and its antitumor effect (pages 1519–1528)

      Pingyong Yi, Hai Yu, Wenxue Ma, Qingqing Wang and Boris R. Minev

      Version of Record online: 28 FEB 2005 | DOI: 10.1002/cncr.20943

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      The current study validated the novel approach for preparing tumor cell vaccines modified with dual immune active molecules using the protein transfer technique, and supported the feasibility and effectiveness of the dual-modified tumor cell vaccine.

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      Geranylgeranylacetone inhibits lysophosphatidic acid-induced invasion of human ovarian carcinoma cells in vitro (pages 1529–1536)

      Kae Hashimoto, Ken-ichirou Morishige, Kenjiro Sawada, Masahiro Tahara, Shoko Shimizu, Masahiro Sakata, Keiichi Tasaka and Yuji Murata

      Version of Record online: 28 FEB 2005 | DOI: 10.1002/cncr.20941

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      Lysophosphatidic acid (LPA) induced cancer cell invasion by promoting Rho/Rho-associated kinase signaling in ovarian carcinoma. Geranylgeranylacetone inhibited the LPA-induced invasion, at least in part, through suppressing the geranylgeranylation of Rho.

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