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Cancer

Cover image for Cancer

1 May 2005

Volume 103, Issue 9

Pages 1761–1984

  1. Editorial

    1. Top of page
    2. Editorial
    3. Original Articles
    4. Correspondence
    5. Erratum
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      Carcinoma core distribution in patients with palpable and nonpalpable prostate tumors (pages 1761–1762)

      Javier Hernandez and Ian M. Thompson

      Version of Record online: 1 MAR 2005 | DOI: 10.1002/cncr.21019

      Introduction of prostate-specific antigen (PSA)–based screening for prostate carcinoma has led to a significant increase in the detection of prostate carcinoma. Prostate core needle biopsy remains the gold standard as a diagnostic tool with which to ascertain disease status. In this issue of Cancer, Demura et al. challenge some commonly accepted concepts regarding the zonal distribution of prostate carcinoma and explore the distribution of carcinoma cores within the prostate as well as the potential impact of a systematic, ultrasound-guided transperineal template biopsy in improving carcinoma detection rates.

  2. Original Articles

    1. Top of page
    2. Editorial
    3. Original Articles
    4. Correspondence
    5. Erratum
    1. Disease Site

      Breast Disease
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      Comparison of HER-2 status determined by fluorescence in situ hybridization in primary and metastatic breast carcinoma (pages 1763–1769)

      Yun Gong, Daniel J. Booser and Nour Sneige

      Version of Record online: 22 MAR 2005 | DOI: 10.1002/cncr.20987

      The HER-2 status in patients with breast carcinoma generally was stable during disease progression. The current results indicated that discrepancies in HER-2 status between metastases and primary tumors are very rare.

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      Coexpression of the type 1 growth factor receptor family members HER-1, HER-2, and HER-3 has a synergistic negative prognostic effect on breast carcinoma survival (pages 1770–1777)

      Sam M. Wiseman, Nikita Makretsov, Torsten O. Nielsen, Blake Gilks, Erika Yorida, Maggie Cheang, Dmitry Turbin, Karen Gelmon and David G. Huntsman

      Version of Record online: 15 MAR 2005 | DOI: 10.1002/cncr.20970

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      In a cohort of 242 patients diagnosed with invasive breast carcinoma, the authors observed type 1 growth factor (T1GFR) family member coexpression (HER-1, HER-2, and HER-3) to have a negative synergistic effect on patient outcome, independent of tumor size or lymph node status. Such patients may potentially benefit from therapy simultaneously targeting several TIGFR family members.

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      Outcome of patients with ductal carcinoma in situ untreated after diagnostic biopsy : Results from the Nurses' Health Study (pages 1778–1784)

      Laura C. Collins, Rulla M. Tamimi, Heather J. Baer, James L. Connolly, Graham A. Colditz and Stuart J. Schnitt

      Version of Record online: 15 MAR 2005 | DOI: 10.1002/cncr.20979

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      During a review of 1877 breast biopsy specimens in a nested case–control study of benign breast disease and breast carcinoma risk, the authors identified 13 biopsy specimens with ductal carcinoma in situ that were originally diagnosed as benign. When compared with specimens from women with nonproliferative lesions, the odds ratio (OR) for the development of invasive breast carcinoma (n = 6 cases) was 13.5 (95% confidence interval [CI], 3.7–49.7). The OR for the development of any subsequent invasive or in situ breast carcinoma event (n = 10 cases) was 20.1 (95% CI, 6.1–66.5).

    4. Endocrine Disease
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      Overexpressed in anaplastic thyroid carcinoma-1 (OEATC-1) as a novel gene responsible for anaplastic thyroid carcinoma (pages 1785–1790)

      Kazunori Mizutani, Masamitsu Onda, Shinichi Asaka, Junko Akaishi, Shizuyo Miyamoto, Akira Yoshida, Mitsuji Nagahama, Kouichi Ito and Mitsuru Emi

      Version of Record online: 23 MAR 2005 | DOI: 10.1002/cncr.20988

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      The overexpressed in anaplastic thyroid carcinoma-1 (OEATC-1) gene was overexpressed significantly in anaplastic thyroid carcinoma cell lines and was expressed less in normal thyroid tissues and in other normal human tissues. Gene silencing of OEATC-1 using small-interfering RNA caused cell growth suppression, suggesting an oncogenic function of OEATC-1 in anaplastic thyroid carcinoma.

    5. Gastrointestinal Tract
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      Health-related quality of life during neoadjuvant treatment and surgery for localized esophageal carcinoma (pages 1791–1799)

      Jane M. Blazeby, Emma Sanford, Stephen J. Falk, Derek Alderson and Jenny L. Donovan

      Version of Record online: 18 MAR 2005 | DOI: 10.1002/cncr.20980

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      Chemotherapy or chemoradiotherapy treatment before esophagectomy reduced health-related quality of life. Recovery from esophagectomy was not hampered by preoperative treatment.

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      Chemosensitization by STI571 targeting the platelet-derived growth factor/platelet-derived growth factor receptor-signaling pathway in the tumor progression and angiogenesis of gastric carcinoma (pages 1800–1809)

      Ryungsa Kim, Manabu Emi, Koji Arihiro, Kazuaki Tanabe, Yoko Uchida and Tetsuya Toge

      Version of Record online: 22 MAR 2005 | DOI: 10.1002/cncr.20973

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      STI571 was an effective chemosensitizer of antitumor drugs, such as 5-fluorouracil and paclitaxel, for gastric carcinoma, targeting the platelet-derived growth factor (PDGF)/PDGF receptor-signaling pathway of tumor and stromal cells in disease progression and angiogenesis.

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      Serum parathyroid hormone-related peptide is associated with systemic inflammation and adverse prognosis in gastroesophageal carcinoma (pages 1810–1818)

      Chris Deans, Stephen Wigmore, Simon Paterson-Brown, James Black, James Ross and Kenneth C. H. Fearon

      Version of Record online: 30 MAR 2005 | DOI: 10.1002/cncr.20972

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      Serum parathyroid hormone-related peptide (PTHrP) levels were elevated in a proportion of patients who had gastroesophageal carcinoma without hypercalcemia. Elevated PTHrP levels were associated with markers of systemic inflammation and with an adverse prognosis.

    8. Genitourinary Disease
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      Marriage and ethnicity predict treatment in localized prostate carcinoma (pages 1819–1825)

      Thomas D. Denberg, Brenda L. Beaty, Fernando J. Kim and John F. Steiner

      Version of Record online: 28 MAR 2005 | DOI: 10.1002/cncr.20982

      Marriage was positively associated with curative treatment in general, and with prostatectomy specifically. Blacks received prostatectomy less often than whites, although they did not receive less curative treatment overall. Latinos received prostatectomy more often than whites. Clinicians should recognize the importance of cultural and social forces as well as biomedical factors in decisions regarding treatment of patients with early-stage prostate carcinoma.

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      Differences in tumor core distribution between palpable and nonpalpable prostate tumors in patients diagnosed using extensive transperineal ultrasound-guided template prostate biopsy (pages 1826–1832)

      Takayoshi Demura, Takaya Hioka, Tsuyoshi Furuno, Tatsuo Kaneta, Hiroko Gotoda, Shunji Muraoka, Toshihiro Sato, Tsutomu Mochizuki, Satoshi Nagamori and Nobuo Shinohara

      Version of Record online: 8 MAR 2005 | DOI: 10.1002/cncr.21020

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      In the current study, carcinoma-positive cores obtained with extensive transperineal ultrasound-guided template prostate biopsy were found to be distributed in the prostate in such a manner as to suggest that nonpalpable prostate carcinoma grows equally within the prostate and palpable carcinoma grows mainly in the peripheral zone. Many of the tumor foci in the anterior prostate may be missed when transrectal sextant biopsy is used.

      See also pages 1761–2.

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      Postprostatectomy adjuvant versus salvage radiotherapy : A complication-adjusted number-needed-to-treat analysis (pages 1833–1842)

      Ashesh B. Jani and Johnny Kao

      Version of Record online: 8 MAR 2005 | DOI: 10.1002/cncr.20949

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      Using the number-needed-to-treat methodology for quantitative analysis, immediate/adjuvant postprostatectomy adjuvant radiotherapy (RT) was advantageous compared with delayed/salvage RT if the side effects of RT were estimated to be negligible. However, with moderate incidence/severity of RT side effects, salvage RT was advantageous.

    11. Head and Neck Disease
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      Tongue and tonsil carcinoma : Increasing trends in the U.S. population ages 20–44 years (pages 1843–1849)

      Caroline H. Shiboski, Brian L. Schmidt and Richard C. K. Jordan

      Version of Record online: 16 MAR 2005 | DOI: 10.1002/cncr.20998

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      The current analysis of Surveillance, Epidemiology and End Results program data revealed that despite a decrease in the incidence of oral cavity and pharyngeal (nasopharynx excluded) squamous cell carcinoma (SCC) among adults of all ages from 1973 to 2001, there was a significant increase in tongue and tonsil SCC incidence among younger whites ages 20–44 years. This increase was in contrast to SCC rates for all other oral cavity and pharyngeal sites, which either decreased or stayed constant over time.

    12. Hematologic Malignancies
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      Phase I/II trial of adding semisynthetic homoharringtonine in chronic myeloid leukemia patients who have achieved partial or complete cytogenetic response on imatinib (pages 1850–1855)

      David Marin, Jaspal S. Kaeda, Catharina Andreasson, Sue M. Saunders, Marco Bua, Eduardo Olavarria, John M. Goldman and Jane F. Apperley

      Version of Record online: 22 MAR 2005 | DOI: 10.1002/cncr.20975

      In a Phase I/II trial the addition of semisynthetic homoharringtonine to imatinib in patients with chronic myloid leukemia who had achieved a stable level in BCR-ABL transcripts on imatinib alone induced a further reduction of 1 log or more in 5 of 10 patients treated.

    13. Hepatobiliary Disease
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      The impact of preoperative serum C-reactive protein on the prognosis of patients with hepatocellular carcinoma (pages 1856–1864)

      Koji Hashimoto, Yasuharu Ikeda, Daisuke Korenaga, Kazuo Tanoue, Motoharu Hamatake, Katsumi Kawasaki, Terutoshi Yamaoka, Yasue Iwatani, Kohei Akazawa and Kenji Takenaka

      Version of Record online: 18 MAR 2005 | DOI: 10.1002/cncr.20976

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      The preoperative serum C-reactive protein (CRP) level proved to be an independent and significant predictor of poor prognosis and early recurrence in patients with hepatocellular carcinoma. A new CRP-based prognostic scoring system offers reliable prognostic information regarding survival.

    14. Lung Disease
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      Association of HER-2 overexpression with prognosis in nonsmall cell lung carcinoma: A metaanalysis (pages 1865–1873)

      Haruhiko Nakamura, Norihito Kawasaki, Masahiko Taguchi and Kazuyuki Kabasawa

      Version of Record online: 15 MAR 2005 | DOI: 10.1002/cncr.20957

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      In this metaanalysis of published studies, the effects of HER-2 overexpression on survival were reviewed among patients with nonsmall cell lung carcinoma. The results indicated that patients who had tumors that were positive for HER-2 overexpression had unfavorable survival. Positive rates differed according to histologic type.

    15. Neuro-Oncology
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      Medulloblastoma in the second decade of life: A specific group with respect to toxicity and management : A Canadian Pediatric Brain Tumor Consortium Study (pages 1874–1880)

      Uri Tabori, Lillian Sung, Juliette Hukin, Normand Laperriere, Bruce Crooks, Anne-Sophie Carret, Mariana Silva, Isaac Odame, Chris Mpofu, Douglas Strother, Beverly Wilson, Yvan Samson, Eric Bouffet and Canadian Pediatric Brain Tumor Consortium

      Version of Record online: 15 MAR 2005 | DOI: 10.1002/cncr.21003

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      In this study of 72 teenagers with medulloblastoma, patients were evaluated retrospectively for treatment toxicity and outcome. The high rate of toxicity and treatment modifications observed in this population suggested that current pediatric protocols may not be applicable to adolescents with medulloblastoma.

    16. Sarcoma
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      Expression of epidermal growth factor receptor, ERBB2 and KIT in adult soft tissue sarcomas : A clinicopathologic study of 281 cases (pages 1881–1890)

      Osamu Sato, Takuro Wada, Akira Kawai, Umio Yamaguchi, Atsushi Makimoto, Yasuo Kokai, Toshihiko Yamashita, Hirokazu Chuman, Yasuo Beppu, Yoichi Tani and Tadashi Hasegawa

      Version of Record online: 16 MAR 2005 | DOI: 10.1002/cncr.20986

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      An increased level of epidermal growth factor receptor was detected in 60% of adult soft tissue sarcomas. This negative prognostic factor was closely correlated with histologic grade. In contrast, positive staining of ERBB2 and KIT were very limited.

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      National survival trends of young adults with sarcoma : Lack of progress is associated with lack of clinical trial participation (pages 1891–1897)

      Archie Bleyer, Michael Montello, Troy Budd and Scott Saxman

      Version of Record online: 28 MAR 2005 | DOI: 10.1002/cncr.20995

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      During the past quarter century, Americans between age 15 years and age 45 years with bone and soft-tissue sarcomas have experienced less survival improvement than either younger patients or older patients. Because the age-dependent survival improvement and clinical-trial accrual patterns are correlated directly, the deficit may be related to the relative lack of participation of this group in clinical trials.

    18. Discipline

      Diagnostic Imaging
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      Screening women at high risk for breast cancer with mammography and magnetic resonance imaging (pages 1898–1905)

      Constance D. Lehman, Jeffrey D. Blume, Paul Weatherall, David Thickman, Nola Hylton, Ellen Warner, Etta Pisano, Stuart J. Schnitt, Constantine Gatsonis, Mitchell Schnall and for the International Breast MRI Consortium Working Group

      Version of Record online: 30 MAR 2005 | DOI: 10.1002/cncr.20971

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      The objective of this study was to compare the performance of screening mammography versus magnetic resonance imaging (MRI) in women at genetically high risk for breast cancer. Screening MRI in high-risk women was capable of detecting mammographically and clinically occult breast cancer.

    19. Epidemiology
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      A cohort study of cancer risk in relation to family histories of cancer in the Utah population database (pages 1906–1915)

      Richard A. Kerber and Elizabeth O'Brien

      Version of Record online: 18 MAR 2005 | DOI: 10.1002/cncr.20989

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      A study of familial incidence of 40 types of cancer in a cohort of 662,515 Utahans showed that both the proportions and the numbers of cancers that were attributable to family history peaked in the group ages 65–84 years and remained fairly high even in the group age ≥ 85 years.

    20. Medical Oncology
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      Incidence, cost, and mortality of neutropenia hospitalization associated with chemotherapy (pages 1916–1924)

      Vincent Caggiano, Richard V. Weiss, Timothy S. Rickert and Walter T. Linde-Zwirble

      Version of Record online: 4 MAR 2005 | DOI: 10.1002/cncr.20983

      Each year in the United States, > 60,000 patients with cancer will be hospitalized for chemotherapy-associated neutropenia. The average cost for neutropenia hospitalization is estimated at $13,372 per stay, and the associated mortality rate is projected to be 6.8%.

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      Phase I dose-escalation study of tezacitabine in combination with 5-fluorouracil in patients with advanced solid tumors (pages 1925–1931)

      Johanna C. Bendell, Joseph P. Eder, Jeffrey W. Clark, Panagiotis Fidias, Thomas J. Lynch, Michael V. Seiden and David P. Ryan

      Version of Record online: 16 MAR 2005 | DOI: 10.1002/cncr.21002

      The current Phase I study of tezacitabine and continuous infusion 5-fluorouracil (CI 5-FU) found the maximum tolerated dose to be tezacitabine, 200 mg/m2, with CI 5-FU, 200 mg/m2 per day. This combination was relatively well tolerated and had clinical activity in patients with advanced solid tumors, particularly in patients with esophageal and other gastrointestinal carcinomas.

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      A Phase I clinical trial of ixabepilone (BMS-247550), an epothilone B analog, administered intravenously on a daily schedule for 3 days (pages 1932–1938)

      Sen H. Zhuang, Manish Agrawal, Maureen Edgerly, Susan Bakke, Herb Kotz, Paul Thambi, Ann Rutt, Frank M. Balis, Susan Bates and Tito Fojo

      Version of Record online: 30 MAR 2005 | DOI: 10.1002/cncr.20977

      The authors conducted a Phase I study on the efficacy of ixabepilone (BMS-247550) as a 1-hour intravenous infusion daily for 3 consecutive days every 21 days. Prolonged disease stabilization occurred in patients with mesothelioma, ovarian carcinoma, and renal cell carcinoma.

    23. Pediatric Oncology
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      Congenital abnormalities and childhood cancer : A cohort record-linkage study (pages 1939–1948)

      Mohammad M. Agha, Jack I. Williams, Loraine Marrett, Teresa To, Alvin Zipursky and Linda Dodds

      Version of Record online: 15 MAR 2005 | DOI: 10.1002/cncr.20985

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      There is evidence of an increased risk of cancer in children with gene disorders. Specific characteristics of neoplasms in children suggest that a significant proportion of pediatric malignancies are attributable to genetic mutation or genetic predisposition. Congenital abnormalities could provide essential information in the mapping of predisposing lesions in children with cancer. Using a cohort approach, the current study compared the occurrence of childhood cancer in two large cohorts of children with and without congenital abnormalities.

    24. Psychological Oncology
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      Usefulness of the nurse-assisted screening and psychiatric referral program (pages 1949–1956)

      Ken Shimizu, Tatsuo Akechi, Masako Okamura, Akira Oba, Maiko Fujimori, Nobuya Akizuki and Yosuke Uchitomi

      Version of Record online: 15 MAR 2005 | DOI: 10.1002/cncr.20992

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      The nurse-assisted screening and psychiatric referral program was introduced to identify major depression and adjustment disorders in patients with cancer and to implement their psychiatric treatment.

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      The needs of terminally ill cancer patients versus those of caregivers for information regarding prognosis and end-of-life issues (pages 1957–1964)

      Josephine M. Clayton, Phyllis N. Butow and Martin H. N. Tattersall

      Version of Record online: 23 MAR 2005 | DOI: 10.1002/cncr.21010

      In the current study, the authors provide evidence that the informational needs of caregivers differ from those of terminally ill cancer patients. Strategies to ensure that adequate information is provided to both parties are presented.

      See also pages 1965–75.

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      Fostering coping and nurturing hope when discussing the future with terminally ill cancer patients and their caregivers (pages 1965–1975)

      Josephine M. Clayton, Phyllis N. Butow, Robert M. Arnold and Martin H. N. Tattersall

      Version of Record online: 23 MAR 2005 | DOI: 10.1002/cncr.21011

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      Patients with a limited life expectancy need help to cope with their situation and maintain hope. Participants, including terminally ill cancer patients, their caregivers, and relevant health professionals, identified several means by which health professionals can facilitate hope and coping when discussing prognosis and end-of-life issues with patients.

      See also pages 1957–64.

    27. Radiation Oncology
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      Evaluation of the quality of radiotherapy randomized trials for painful bone metastases : Implications for future research design and reporting (pages 1976–1981)

      Thomas P. Shakespeare, Anuradha Thiagarajan and Val Gebski

      Version of Record online: 16 MAR 2005 | DOI: 10.1002/cncr.20993

      The authors evaluated the quality of published randomized evidence comparing the efficacy of fractionation schedules for the palliation of bone metastases. Research quality was poor in 94% of the 17 studies evaluated. As a result of the potential biases present, the authors found that subjective end points cannot be reliably evaluated. The authors reported that greater efforts are required by radiation oncology trial groups to improve quality, with a particular focus on developing methods of allocation concealment and comprehensively reporting results.

  3. Correspondence

    1. Top of page
    2. Editorial
    3. Original Articles
    4. Correspondence
    5. Erratum
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      Author reply (page 1983)

      Carina G. Hilders and J. Baptist Trimbos

      Version of Record online: 22 MAR 2005 | DOI: 10.1002/cncr.20994

  4. Erratum

    1. Top of page
    2. Editorial
    3. Original Articles
    4. Correspondence
    5. Erratum
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