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Cancer

Cover image for Cancer

1 July 2005

Volume 104, Issue 1

Pages 1–221

  1. Review Article

    1. Top of page
    2. Review Article
    3. Original Articles
    4. Communication
    5. Correspondence
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      5-hydroxytryptamine type-3 receptor antagonists for chemotherapy-induced and radiotherapy-induced nausea and emesis : Can we safely reduce the dose of administered agents? (pages 1–18)

      Matti Aapro and Peter Blower

      Article first published online: 31 MAY 2005 | DOI: 10.1002/cncr.21141

      Due to financial considerations, the 5-hydroxytryptamine type-3 receptor antagonist antiemetic agents are used at lower doses than recommended. Suboptimal dosing not only will be detrimental to the quality of life for patients with cancer but, ultimately, will prove counterproductive in terms of hospital resources, and it will add to the already significant socioeconomic burden associated with cancer therapy.

  2. Original Articles

    1. Top of page
    2. Review Article
    3. Original Articles
    4. Communication
    5. Correspondence
    1. Disease Site

      Breast Disease
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      Rapid immunohistochemistry enhances the intraoperative diagnosis of sentinel lymph node metastases in invasive lobular breast carcinoma (pages 14–19)

      Junnu P. Leikola, Terttu S. Toivonen, Leena A. Krogerus, Karl A. J. von Smitten and Marjut H. K. Leidenius

      Article first published online: 31 MAY 2005 | DOI: 10.1002/cncr.21133

      In the current study, rapid immunohistochemistry enhanced the intraoperative diagnosis of sentinel lymph node metastases in patients with invasive lobular carcinoma. It may also improve the diagnosis of micrometastases.

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      Improving local control with breast-conserving therapy : A 27-year single-institution experience (pages 20–29)

      Neslihan Cabioglu, Kelly K. Hunt, Thomas A. Buchholz, Nadeem Mirza, S. Eva Singletary, Henry M. Kuerer, Gildy V. Babiera, Frederick C. Ames, Aysegul A. Sahin and Funda Meric-Bernstam

      Article first published online: 23 MAY 2005 | DOI: 10.1002/cncr.21121

      The authors report a large single institution experience with breast-conserving therapy and report that ipsilateral breast tumor recurrence rate after breast conservation appears to be declining, especially among patients younger than age 50 years. The results reflect changes in surgical approaches, pathologic evaluations, and increasing use of systemic therapy.

    3. Genitourinary Disease
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      Increased plasma levels of angiogenin and the risk of bladder carcinoma : From initiation to recurrence (pages 30–35)

      Hua Zhao, H. Barton Grossman, George L. Delclos, Lu-yu Hwang, Catherine L. Troisi, Robert M. Chamberlain, Marsha A. Chenoweth, Huifeng Zhang, Margaret R. Spitz and Xifeng Wu

      Article first published online: 23 MAY 2005 | DOI: 10.1002/cncr.21136

      Patients with carcinoma of the urinary bladder had statistically higher plasma levels of angiogenin compared with a healthy control group. Patients who had bladder carcinoma with higher plasma levels of angiogenin had shorter recurrence-free survival and higher risk of recurrence compared with patients who had lower plasma levels of angiogenin.

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      Radical cystectomy in the elderly : Comparison of clinical outcomes between younger and older patients (pages 36–43)

      Peter E. Clark, John P. Stein, Susan G. Groshen, Jie Cai, Gus Miranda, Gary Lieskovsky and Donald G. Skinner

      Article first published online: 23 MAY 2005 | DOI: 10.1002/cncr.21126

      The current results indicated that it is safe to offer carefully selected elderly patients an orthotopic urinary diversion. Chronological age, per se, was not a contraindication for radical cystectomy in the setting of invasive bladder carcinoma.

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      CpG methylation at promoter site −140 inactivates TGFβ2 receptor gene in prostate cancer (pages 44–52)

      Hong Zhao, Hiroaki Shiina, Kirsten L. Greene, Long-Cheng Li, Yuichiro Tanaka, Hirofumi Kishi, Mikio Igawa, Christopher J. Kane, Peter Carroll and Rajvir Dahiya

      Article first published online: 13 MAY 2005 | DOI: 10.1002/cncr.21135

      The authors of the current study hypothesized that CpG methylation of the TβRII promoter at the Sp1 binding site −140 mediates loss of TβRII expression in prostate cancer compared to benign prostatic hypertrophy (BPH). The authors found lower TβRII mRNA and protein expression in prostate cancer compared to BPH and higher CpG promoter methylation using methylation-specific polymerase chain reaction and bisulfite sequencing.

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      Reclassification of patients with pT3 and pT4 renal cell carcinoma improves prognostic accuracy (pages 53–60)

      R. Houston Thompson, John C. Cheville, Christine M. Lohse, W. Scott Webster, Horst Zincke, Eugene D. Kwon, Igor Frank, Michael L. Blute and Bradley C. Leibovich

      Article first published online: 13 MAY 2005 | DOI: 10.1002/cncr.21125

      Over a 30-year period, 697 patients underwent nephrectomy for pT3 or pT4 renal cell carcinoma at a single institution. Incorporating perinephric fat invasion, direct ipsilateral adrenal invasion, and tumor thrombus level, the authors' proposed reclassification improved prognostic accuracy.

    7. Gynecologic Oncology
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      Socioeconomic status and the risk of cervical intraepithelial neoplasia grade 3 among oncogenic human papillomavirus DNA-positive women with equivocal or mildly abnormal cytology (pages 61–70)

      Michelle J. Khan, Edward E. Partridge, Sophia S. Wang, Mark Schiffman and Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesion Triage Study (ALTS) Group

      Article first published online: 11 MAY 2005 | DOI: 10.1002/cncr.21129

      In the Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesion Triage Study (ALTS) population, socioeconomic status and race were not associated with risk of infection with oncogenic human papillomavirus (HPV) once age, sexual variables, study center, and smoking were taken into account. However, among HPV-infected women, lower education levels were associated with increased risk for cervical intraepithelial neoplasia Grade 3 and carcinoma (≥ CIN3), and black and white/Hispanic race/ethnicity were associated with decreased risk for ≥ CIN3.

    8. Head and Neck Disease
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      Postoperative intensity-modulated radiotherapy in sinonasal carcinoma : Clinical results in 39 patients (pages 71–82)

      Wim Duthoy, Tom Boterberg, Filip Claus, Piet Ost, Luc Vakaet, Samuel Bral, Frederic Duprez, Marianne Van Landuyt, Hubert Vermeersch and Wilfried De Neve

      Article first published online: 24 MAY 2005 | DOI: 10.1002/cncr.21100

      Paranasal sinus carcinoma is a rare disease, mostly requiring surgery and radiotherapy (RT). A major adverse effect is RT-induced ocular toxicity. Intensity-modulated RT, a new RT technique, was able to spare the optic structures and lower the ocular toxicity without compromising local control.

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      Bisphosphonate-associated osteonecrosis of mandibular and maxillary bone : An emerging oral complication of supportive cancer therapy (pages 83–93)

      Cesar A. Migliorati, Mark M. Schubert, Douglas E. Peterson and Luis Marcelo Seneda

      Article first published online: 31 MAY 2005 | DOI: 10.1002/cncr.21130

      The current report presented the findings of 17 patients with cancer with skeletal metastasis and 1 patient with osteopenia, who received treatment with bisphosphonates. The patients developed osteonecrosis involving the mandible and maxilla. All patients with cancer had received chemotherapy while receiving bisphosphonates. The authors discussed diagnosis, patient management, and the pathologic mechanisms involved in the formation of this new oral complication of cancer therapy.

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      Metaanalysis of the significance of matrix metalloproteinases for lymph node disease in patients with head and neck squamous cell carcinoma (pages 94–100)

      Susanne Wiegand, Anja A. Dünne, Helge H. Müller, Robert Mandic, Peter Barth, Ronald K. Davis and Jochen A. Werner

      Article first published online: 23 MAY 2005 | DOI: 10.1002/cncr.21131

      The results of this metaanalysis revealed a significant lack of valid data with which to determine the prognostic relevance of immunohistochemical matrix metalloproteinase expression and lymph node status in patients with head and neck squamous cell carcinoma. To rectify this lack of data, the first step will require standardization of immunohistochemical staining procedures and evaluation protocols. The authors indicated that such standardization will be a prerequisite to achieving comparable results for further evaluation.

    11. Hematologic Malignancies
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      Increase in platelet count in older, poor-risk patients with acute myeloid leukemia or myelodysplastic syndrome treated with valproic acid and all-trans retinoic acid (pages 101–109)

      Chiara Pilatrino, Daniela Cilloni, Emanuela Messa, Alessandro Morotti, Emilia Giugliano, Marisa Pautasso, Ubaldo Familiari, Susanna Cappia, Pier Giuseppe Pelicci, Francesco Lo Coco, Giuseppe Saglio and Angelo Guerrasio

      Article first published online: 13 MAY 2005 | DOI: 10.1002/cncr.21132

      Differentiation therapy with the histone deacetylase inhibitors valproic acid and all-trans retinoic acid induced hematologic improvement, according to World Health Organization criteria, in 30% of older, poor-risk patients with acute myeloid leukemia/myelodysplastic syndrome.

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      Acute leukemia during pregnancy : A report on 37 patients and a review of the literature (pages 110–117)

      Youcef Chelghoum, Norbert Vey, Emmanuel Raffoux, Françoise Huguet, Arnaud Pigneux, Brigitte Witz, Cécile Pautas, Stéphane de Botton, Denis Guyotat, Bruno Lioure, Nathalie Fegueux, Frédéric Garban, Hussam Saad and Xavier Thomas

      Article first published online: 23 MAY 2005 | DOI: 10.1002/cncr.21137

      Among women with acute leukemia (AL) who required cytotoxic treatment during pregnancy, chemotherapy treatment with fetal surveillance and monitoring for adequate growth during the second and third trimesters did not always require termination, and remission of AL and delivery of a normal infant were likely.

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      Zoledronic acid down-regulates adhesion molecules of bone marrow stromal cells in multiple myeloma : A possible mechanism for its antitumor effect (pages 118–125)

      Alessandro Corso, Eleonora Ferretti, Monia Lunghi, Patrizia Zappasodi, Silvia Mangiacavalli, Mara De Amici, Chiara Rusconi, Marzia Varettoni and Mario Lazzarino

      Article first published online: 13 MAY 2005 | DOI: 10.1002/cncr.21104

      Antitumor activity has been hypothesized for bisphonates in multiple meloma. The current study demonstrated that zoledronic acid interfered with myeloma bone marrow stromal cells (BMSCs) by reducing proliferation, increasing apoptosis, and modifying the pattern of expression of adhesion molecules, especially those involved in plasma cell binding (CD106, CD54, and CD49d). These effects on BMSCs might explain the antitumor activity of zoledronic acid.

    14. Neuro-Oncology
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      Lack of benefit of spinal irradiation in the primary treatment of intracranial germinoma : A multiinstitutional, retrospective review of 180 patients (pages 126–134)

      Naoto Shikama, Kazuhiko Ogawa, Shiro Tanaka, Takafumi Toita, Katsumasa Nakamura, Takashi Uno, Hiroshi Ohnishi, Jun Itami, Tsuyoshi Tada and Naokatsu Saeki

      Article first published online: 13 MAY 2005 | DOI: 10.1002/cncr.21169

      Eight-year overall and event-free survival rates of all of 180 patients with intracranial germinoma were 91% and 89%, respectively. Spinal irradiation did not contribute to favorable event-free survival in these patients.

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      Recurrent central neurocytomas (pages 135–142)

      Alexander Bertalanffy, Karl Roessler, Oskar Koperek, Ellen Gelpi, Daniela Prayer and Engelbert Knosp

      Article first published online: 4 MAY 2005 | DOI: 10.1002/cncr.21109

      Central neurocytomas (CNs) are well differentiated benign tumors of neuronal or neuroglial origin. They first were recognized as a new entity with a typical immunohistochemical profile and ultrastructural features of neuronal differentiation but currently are believed to originate from precursor cells of the subependymal plate of the lateral ventricles, an embryonal matrix cell layer that maintains a limited proliferative potential to differentiate in either neuronal and glial cells. Therefore, CNs are not considered to be neuronal tumors but rather neuroectodermal tumors with predominant neuronal differentiation. In the current study, the authors retrospectively reported on a series of 14 CN patients treated at the study institution with special emphasis on the biologic behavior of the tumors and the incidence of disease recurrence during long-term follow-up and found a surprisingly high recurrence rate.

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      A multicenter retrospective study of chemotherapy for recurrent intracranial ependymal tumors in adults by the Gruppo Italiano Cooperativo di Neuro-Oncologia (pages 143–148)

      Alba A. Brandes, Giovanna Cavallo, Michele Reni, Alicia Tosoni, Linda Nicolardi, Luciano Scopece, Enrico Franceschi, Guido Sotti, Andrea Talacchi, Sergio Turazzi and Mario Ermani

      Article first published online: 23 MAY 2005 | DOI: 10.1002/cncr.21110

      Cisplatin-based chemotherapy achieved a higher response rate, but did not prolong disease progression-free or overall survival.. More active regimens for the salvage treatment of ependymal tumors have yet to be found.

    17. Sarcoma
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      Chondrosarcoma of the scapula : Long-term oncologic outcome (pages 149–158)

      Rajeev Pant, Alan W. Yasko, Valerae O. Lewis, Kevin Raymond and Patrick P. Lin

      Article first published online: 13 MAY 2005 | DOI: 10.1002/cncr.21114

      In contrast to chondrosarcomas of the pelvic girdle, and despite their central location, chondrosarcomas of the scapula were associated with a relatively favorable long-term prognosis in patients who underwent limb-sparing surgical resection.

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      9p21 locus analysis in high-risk gastrointestinal stromal tumors characterized for c-kit and platelet-derived growth factor receptor α gene alterations (pages 159–169)

      Federica Perrone, Elena Tamborini, Gian Paolo Dagrada, Federica Colombo, Lorena Bonadiman, Veronica Albertini, Maria Stefania Lagonigro, Elisa Gabanti, Stefano Caramuta, Angela Greco, Gabriella Della Torre, Alessandro Gronchi, Marco Alessandro Pierotti and Silvana Pilotti

      Article first published online: 31 MAY 2005 | DOI: 10.1002/cncr.21113

      The authors undertook a molecular and cytogenetic study of the 9p21 locus in a series of 22 pre-Gleevec era, cryopreserved, high-risk gastrointestinal stromal tumors that had been characterized previously. The investigation revealed cumulative alterations in the 9p21 locus in 54% of tumors in the series, represented mainly by the loss of tumor suppressor gene expression. The p16INK4a deletion, which always was coupled with p14ARF gene loss, seemed to be the most common 9p21 inactivation mechanism.

    19. Skin
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      Basosquamous carcinoma : Treatment with Mohs micrographic surgery (pages 170–175)

      Igal Leibovitch, Shyamala C. Huilgol, Dinesh Selva, Shawn Richards and Robert Paver

      Article first published online: 31 MAY 2005 | DOI: 10.1002/cncr.21143

      Basosquamous carcinoma was treated successfully with Mohs micrographic surgery in 178 patients. The 5-year disease recurrence rate was 4.1% in 98 patients.

    20. Discipline

      Integrative Medicine
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      Evaluation of shark cartilage in patients with advanced cancer : A North Central Cancer Treatment Group trial (pages 176–182)

      Charles L. Loprinzi, Ralph Levitt, Debra L. Barton, Jeff A. Sloan, Pam J. Atherton, Denise J. Smith, Shaker R. Dakhil, Dennis F. Moore Jr., James E. Krook, Kendrith M. Rowland Jr., Miroslaw A. Mazurczak, Alan R. Berg and George P. Kim

      Article first published online: 23 MAY 2005 | DOI: 10.1002/cncr.21107

      A randomized, placebo-controlled, double-blinded, clinical trial of shark cartilage did not suggest any benefit to patients with metastatic cancer.

    21. Pediatric Oncology
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      Outcomes and prognostic factors after recurrence in children and adolescents with nonmetastatic rhabdomyosarcoma (pages 183–190)

      Stefano Mazzoleni, Gianni Bisogno, Alberto Garaventa, Giovanni Cecchetto, Andrea Ferrari, Guido Sotti, Alberto Donfrancesco, Enrico Madon, Letizia Casula, Modesto Carli and Associazione Italiana di Ematologia e Oncologia Pediatrica Soft Tissue Sarcoma Committee

      Article first published online: 13 MAY 2005 | DOI: 10.1002/cncr.21138

      A retrospective analysis on 125 children with localized rhabdomyosarcoma who experienced a recurrence showed that groups of patients with a different prognosis can be identified. Favorable histology subtype and tumor site, local recurrence, and recurrence off therapy identified patients who had a second chance of cure. Patients with no or only one risk factor and those with a nonalveolar histology benefited more from salvage therapy if they had not received radiotherapy for their initial treatment.

    22. Psychological Oncology
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      Partnership status influences quality of life in low-income, uninsured men with prostate cancer (pages 191–198)

      John L. Gore, Tracey Krupski, Lorna Kwan, Sally Maliski and Mark S. Litwin

      Article first published online: 23 MAY 2005 | DOI: 10.1002/cncr.21139

      Among low-income, uninsured men with prostate cancer, being in a marital relationship was associated with significantly better health-related quality of life. Partnered patients had better mental health, less urinary bother, lower symptom distress, and higher spirituality compared with single men.

    23. Symptom Control and Palliative Care
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      Immunomodulation with interferon-gamma and colony-stimulating factors for refractory fungal infections in patients with leukemia (pages 199–204)

      M. Cecilia Dignani, John H. Rex, Ka-Wah Chan, Gordon Dow, Margarida deMagalhaes-Silverman, AnneMarie Maddox, Thomas Walsh and Elias Anaissie

      Article first published online: 31 MAY 2005 | DOI: 10.1002/cncr.21142

      Cytokines were administered for 1.5–5 months with clinical success and without significant toxicity. The data in the current study suggested a potential role for immunomodulation in patients with leukemia with refractory invasive fungal infections.

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      Risk factors for infections with multidrug-resistant Pseudomonas aeruginosa in patients with cancer (pages 205–212)

      Norio Ohmagari, Hend Hanna, Linda Graviss, Brenda Hackett, Cheryl Perego, Virginia Gonzalez, Tanya Dvorak, Holly Hogan, Ray Hachem, Kenneth Rolston and Issam Raad

      Article first published online: 4 MAY 2005 | DOI: 10.1002/cncr.21115

      In this case–control study, the authors found that risk factors for infection caused by multidrug-resistant Pseudomonas aeruginosa in hospitalized patients with cancer included a history of P. aeruginosa infection during the prior year, a history of chronic obstructive pulmonary disease, and carbapenems used as first-line empiric therapy. Broad-spectrum antibiotics need to be used judiciously in febrile neutropenic patients with cancer who require hospitalization.

  3. Communication

    1. Top of page
    2. Review Article
    3. Original Articles
    4. Communication
    5. Correspondence
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      Red cell mass and plasma volume measurements in polycythemia: : Evaluation of performance and practical utility (pages 213–215)

      Shireen Sirhan, Virgil F. Fairbanks and Ayalew Tefferi

      Article first published online: 11 MAY 2005 | DOI: 10.1002/cncr.21105

      A retrospective analysis was performed on a consecutive series of 105 patients who underwent blood volume measurements for evaluation of polycythemia.

  4. Correspondence

    1. Top of page
    2. Review Article
    3. Original Articles
    4. Communication
    5. Correspondence
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      Vascular targeting therapies for treatment of malignant disease (pages 216–217)

      Stephen L. Brown, Andrew Kolozsvary and Jae Ho Kim

      Article first published online: 13 MAY 2005 | DOI: 10.1002/cncr.21120

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      Author reply (page 217)

      Dietmar W. Siemann, David J. Chaplin and Michael R. Horsman

      Article first published online: 13 MAY 2005 | DOI: 10.1002/cncr.21117

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      Author reply (pages 218–219)

      Michael F. Sarosdy

      Article first published online: 28 APR 2005 | DOI: 10.1002/cncr.21103

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      Efficacy of radiotherapy for ovarian ablation : Results of a breast intergroup study (page 220)

      József Bódis, Miklós Koppán and Katalin Németh

      Article first published online: 24 MAY 2005 | DOI: 10.1002/cncr.21080

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      Author reply (pages 220–221)

      Lorie L. Hughes

      Article first published online: 24 MAY 2005 | DOI: 10.1002/cncr.21079

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