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Cancer Cytopathology

Cover image for Cancer Cytopathology

25 April 2005

Volume 105, Issue 2

Pages 53–118

Currently known as: Cancer Cytopathology

  1. Commentary

    1. Top of page
    2. Commentary
    3. Original Articles
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      Blinded review of Papanicolaou smears (pages 53–55)

      Gary W. Gill

      Version of Record online: 20 JAN 2005 | DOI: 10.1002/cncr.20874

      The author reported that cytotechnologists and pathologists should not be held accountable for the local outcome consequences of global process shortcomings. Even if all identifiable process control factors were addressed and implemented, errors still would occur. False-negative Papanicolaou smears arise from the nature of the process, not the negligence of the practitioner. Respected cancer advocacy organizations should educate the public regarding the limitations of Papanicolaou test performance.

  2. Original Articles

    1. Top of page
    2. Commentary
    3. Original Articles
    1. Gynecologic Cytopathology

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      Study on the morphology and reproducibility of the diagnosis of endometrial lesions utilizing liquid-based cytology (pages 56–64)

      Maria Papaefthimiou, Hera Symiakaki, Panagiota Mentzelopoulou, Ageliki Tsiveleka, Aspasia Kyroudes, Zannis Voulgaris, Anastasia Tzonou and Petros Karakitsos

      Version of Record online: 4 MAR 2005 | DOI: 10.1002/cncr.21025

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      Liquid-based cytology offers the possibility of not only the standardized and reproducible preparation of endometrial slides, but also the application of common diagnostic criteria among cytopathologists.

    2. Non-Gynecologic Cytopathology

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      Atypical teratoid/rhabdoid tumor of the brain : Cytopathologic characteristics and differential diagnosis (pages 65–70)

      Anil V. Parwani, Edward B. Stelow, Stefan E. Pambuccian, Peter C. Burger and Syed Z. Ali

      Version of Record online: 2 FEB 2005 | DOI: 10.1002/cncr.20872

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      Atypical teratoid/rhabdoid tumor is a rare and aggressive brain neoplasm. The cytomorphologic features are unique and lead to an accurate diagnosis in the right clinicoradiologic context.

    3. Fine-Needle Aspiration

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      “Atypical” cells in fine-needle aspiration biopsy specimens of benign thyroid cysts (pages 71–79)

      William C. Faquin, Edmund S. Cibas and Andrew A. Renshaw

      Version of Record online: 20 JAN 2005 | DOI: 10.1002/cncr.20832

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      Fine-needle aspiration biopsy specimens from benign cysts of the thyroid occasionally contain “atypical” cells that raise the possibility of a malignant neoplasm. In the current study, the authors present evidence that, in many cases, these cells are altered follicular cells lining the cyst. An appreciation of their characteristic morphologic features may allow for more accurate classification of these cells and, in some cases, prevent unnecessary thyroid surgery.

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      Pineal gland lesions : A cytopathologic study of 20 specimens (pages 80–86)

      Anil V. Parwani, Blaire L. Baisden, Yener S. Erozan, Peter C. Burger and Syed Z. Ali

      Version of Record online: 20 JAN 2005 | DOI: 10.1002/cncr.20849

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      Pineal gland lesions are rare and cytopathologic evaluation often presents diagnostic challenges. Although the majority of the lesions in the current study were benign or malignant tumors, nonneoplastic cystic lesions were encountered as well.

    5. Immunocytochemistry

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      Immunocytochemical evaluation of thyroid neoplasms on thin-layer smears from fine-needle aspiration biopsies (pages 87–95)

      Esther D. Rossi, Marco Raffaelli, Corrado Minimo, Antonino Mule, Celestino P. Lombardi, Fabio M. Vecchio and Guido Fadda

      Version of Record online: 1 MAR 2005 | DOI: 10.1002/cncr.21026

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      A combined panel of antibodies together with nuclear features of thyrocytes were effectively used to diagnose thyroid nodules that had been judged to be candidates for surgery by preoperative fine-needle biopsy. Immunocytochemistry may be performed on thin-layer cytology with the same accuracy as that provided by conventional smears.

    6. Analytical and Quantitative Cytopathology

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      Aberrant, highly hyperdiploid cells in human papillomavirus-positive, abnormal cytologic samples are associated with progressive lesions of the uterine cervix (pages 96–100)

      Reinhard Bollmann, Gábor Méhes, Norbert Speich, Christoph Schmitt and Magdolna Bollmann

      Version of Record online: 20 JAN 2005 | DOI: 10.1002/cncr.20848

      In this study of cervical cytologic samples with positive diagnoses, the authors sought to demonstrate that oncogenic-type human papillomavirus and the occurrence of cells with abnormally high DNA content together help to predict neoplastic progression in the broad range of cytologic dysplasia.

    7. Molecular Diagnostics

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      Classification of human tumors using gene expression profiles obtained after microarray analysis of fine-needle aspiration biopsy samples (pages 101–109)

      Barbara A. Centeno, Steven A. Enkemann, Domenico Coppola, Shane Huntsman, Gregory Bloom and Timothy J. Yeatman

      Version of Record online: 10 JAN 2005 | DOI: 10.1002/cncr.20737

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      Gene expression profiling using gene-discovery, high-density microarray technologies is a powerful tool that is used to develop tumor classifiers that predict the site of origin. However, to be clinically relevant, it must be applicable to tumor biopsy samples. The current study demonstrated that fine-needle aspiration biopsy produced adequate material for microarray analysis and generated interpretable gene expression profiles that can be matched accurately with a tumor classifier established on tissue specimens.

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      The utility of interphase fluorescence in situ hybridization for the detection of the translocation t(11;14)(q13;q32) in the diagnosis of mantle cell lymphoma on fine-needle aspiration specimens (pages 110–118)

      Nancy P. Caraway, Jun Gu, Pei Lin, Jorge E. Romaguera, Armand Glassman and Ruth Katz

      Version of Record online: 11 FEB 2005 | DOI: 10.1002/cncr.20923

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      Interphase fluorescence in situ hybridization (FISH) was used to detect the t(11;14) translocation on FNA specimens in mantle cell and nonmantle cell lymphomas. In an initial diagnosis of mantle cell lymphoma, significant double-fusion FISH signals should be identified, because single-fusion signals can be seen in nonmantle cell lymphomas.

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