Analysis of morphologic patterns of fine-needle aspiration of the breast to reduce false-negative results in breast cytology (pages 152–157)
Paolo Bulgaresi, Maria Paola Cariaggi, Lucia Bonardi, Maria Francesca Carozzi, Massimo Confortini, Laura Galanti, Cristina Maddau, Marzia Matucci, Tiziana Rubeca, Patricia Turco, Stefano Ciatto and Guido Miccinesi
Article first published online: 28 APR 2005 | DOI: 10.1002/cncr.21059
A blind review of 41 false-negative and 49 true-negative breast aspiration samples was performed by 10 expert cytologists, who provided a final report and classified the samples according to classic morphologic parameters. The majority final report sensitivity was 54% (range, 19–61%) and the specificity was 73% (range, 65–92%). The results of the current study confirm that false-negative breast cytology results are at least partially due to the underreporting of abnormalities that may be noted at review. Detailed analysis of single morphologic characteristics was found to be of limited diagnostic value, suggesting that operators do perceive abnormalities but cannot translate these findings into distinct morphologic categories.