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Cancer Cytopathology

Cover image for Cancer Cytopathology

25 June 2005

Volume 105, Issue 3

Pages 119–183

Currently known as: Cancer Cytopathology

  1. Editorial

    1. Top of page
    2. Editorial
    3. Commentary
    4. Original Articles
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      Proficiency testing for cytologists : Where science, biology, and government regulations collide (pages 119–123)

      William J. Frable

      Article first published online: 13 APR 2005 | DOI: 10.1002/cncr.21096

      By the time this editorial is published, proficiency testing for those professionals involved in the screening and/or interpretation of gynecologic smears will be underway. In this editorial, Dr. Frable asks how did the field of cytopathology arrive at this point and what may be the implications.

      See also pages 124–5, this issue.

  2. Commentary

    1. Top of page
    2. Editorial
    3. Commentary
    4. Original Articles
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      Proficiency testing: Planning for the future (pages 124–125)

      Andrew A. Renshaw

      Article first published online: 13 APR 2005 | DOI: 10.1002/cncr.21097

      Proficiency testing (PT) for professionals involved in the screening and/or interpretation of gynecologic smears makes sense to the centers for Medicare & Medicaid Services, the public, and other government officials. However, imposing PT on the field may have unintended consequences.

      See also pages 119–23, this issue.

  3. Original Articles

    1. Top of page
    2. Editorial
    3. Commentary
    4. Original Articles
    1. Gynecologic Cytopathology

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      Age-related performance of human papillomavirus testing used as an adjunct to cytology for cervical carcinoma screening in a population with a low incidence of cervical carcinoma (pages 126–132)

      Patrick Petignat, Daniel Faltin, Frederic Goffin, Marie-Helene Billieux, David Stucki, Stefan Sporri and Pierre Vassilakos

      Article first published online: 8 APR 2005 | DOI: 10.1002/cncr.21060

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      To assess the age-specific prevalence of high-risk human papillomavirus (HR-HPV) infection and the correlation between HR-HPV status and cytologic diagnosis, cervical samples were collected in 7254 women using liquid-based cytology to perform both Papanicolaou smears and HR-HPV testing. The results of this cross-sectional study showed that the prevalence of HR-HPV was age-dependent, with the strongest correlation between HR-HPV positivity and disease observed among older women, who potentially may derive the most benefit.

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      Does the interval between papanicolaou tests influence the quality of cytology? (pages 133–138)

      Jose Jeronimo, Michelle J. Khan, Mark Schiffman, Diane Solomon and ALTS Group

      Article first published online: 8 APR 2005 | DOI: 10.1002/cncr.21065

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      A short time interval to repeat cervical cytology does not appear to influence its sensitivity for detecting grade 3 cervical intraepithelial neoplasia or adjunctive human papillomavirus DNA testing.

    3. Non-Gynecologic Cytopathology

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      Cytologic features of plasmablastic lymphoma : Report of four cases (pages 139–144)

      Oscar Lin, Rene Gerhard, Maria C. N. Zerbini and Julie Teruya-Feldstein

      Article first published online: 31 MAR 2005 | DOI: 10.1002/cncr.21036

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      Plasmablastic lymphoma is a variant of large cell lymphoma with heterogeneous cytologic findings but with a distinct immunophenotype. Knowledge of the cytomorphologic spectrum of plasmablastic lymphoma and detection of CD138 expression by flow cytometry is helpful in achieving a correct diagnosis.

    4. Fine-Needle Aspiration

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      Angiosarcoma after breast-conserving therapy: Fine-needle aspiration biopsy, immunocytochemistry, and clinicopathologic correlates (pages 145–151)

      Giorgio Gherardi, Stefania Rossi, Silvia Perrone and Alberto Scanni

      Article first published online: 20 APR 2005 | DOI: 10.1002/cncr.21035

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      Angiosarcoma of breast skin and/or subcutaneous fat is a rare but significant complication of breast-conserving therapy and irradiation for breast carcinoma. The authors studied the fine-needle aspiration cytologic features of three patients with this tumor and examined potential diagnostic pitfalls.

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      Analysis of morphologic patterns of fine-needle aspiration of the breast to reduce false-negative results in breast cytology (pages 152–157)

      Paolo Bulgaresi, Maria Paola Cariaggi, Lucia Bonardi, Maria Francesca Carozzi, Massimo Confortini, Laura Galanti, Cristina Maddau, Marzia Matucci, Tiziana Rubeca, Patricia Turco, Stefano Ciatto and Guido Miccinesi

      Article first published online: 28 APR 2005 | DOI: 10.1002/cncr.21059

      A blind review of 41 false-negative and 49 true-negative breast aspiration samples was performed by 10 expert cytologists, who provided a final report and classified the samples according to classic morphologic parameters. The majority final report sensitivity was 54% (range, 19–61%) and the specificity was 73% (range, 65–92%). The results of the current study confirm that false-negative breast cytology results are at least partially due to the underreporting of abnormalities that may be noted at review. Detailed analysis of single morphologic characteristics was found to be of limited diagnostic value, suggesting that operators do perceive abnormalities but cannot translate these findings into distinct morphologic categories.

    6. Immunocytochemistry

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      Validation of commonly used immunostains on cell-transferred cytologic specimens (pages 158–164)

      Yun Gong, Teresa Joseph and Nour Sneige

      Article first published online: 25 APR 2005 | DOI: 10.1002/cncr.21063

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      Immunocytochemical staining can be reliably performed on cell-transferred tissue specimens for most immunomarkers commonly used in cytologic diagnosis.

    7. Molecular Diagnostics

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      c-KIT mutation analysis for diagnosis of gastrointestinal stromal tumors in fine needle aspiration specimens (pages 165–170)

      Carlynn Willmore-Payne, Lester J. Layfield and Joseph A. Holden

      Article first published online: 8 APR 2005 | DOI: 10.1002/cncr.21064

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      C-KIT mutations are found in the majority of gastrointestinal stromal tumors and their presence indicates a probable response to imatinib therapy. C-KIT mutations can be identified by high resolution amplicon melting analysis performed on fine needle aspiration material.

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      Human papillomavirus genome detection by in situ hybridization in fine-needle aspirates of metastatic lesions from head and neck squamous cell carcinomas (pages 171–177)

      Haldun Umudum, Turkan Rezanko, Filiz Dag and Tugba Dogruluk

      Article first published online: 8 APR 2005 | DOI: 10.1002/cncr.21027

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      Human papillomavirus DNA integration on host cell nuclei was associated with the absence of keratinization in metastases from head and neck squamous cell carcinoma.

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      Cytologic findings and protein expression profiles associated with ductal carcinoma of the breast in ductal lavage specimens using surface-enhanced laser desorption and ionization-time of flight mass spectrometry (pages 178–183)

      Savvas Mendrinos, John David L. Nolen, Toncred Styblo, Grant Carlson, Jan Pohl, Melinda Lewis and James Ritchie

      Article first published online: 8 APR 2005 | DOI: 10.1002/cncr.21052

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      The authors described the enhancement of the accuracy of conventional ductal lavage (DL) cytology with surface-enhanced laser desorption and ionization-time of flight mass spectrometry in patients with unilateral breast carcinoma. Twelve of 16 DL samples (75%) from breasts that contained malignant neoplasms had unique protein peak patterns compared with the DL samples from unaffected breasts in the same patients. Only 5 of 16 DL samples (31%) from the malignant breasts contained malignant cells.

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