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Cancer Cytopathology

Cover image for Cancer Cytopathology

25 December 2005

Volume 105, Issue 6

Pages 429–497

Currently known as: Cancer Cytopathology

  1. Editorial

    1. Top of page
    2. Editorial
    3. Contemporary Issue
    4. Original Articles
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      Modern approach to lymphoma diagnosis by fine-needle aspiration : Restoring respect to a valuable procedure (pages 429–431)

      Ruth L. Katz

      Article first published online: 12 OCT 2005 | DOI: 10.1002/cncr.21499

      For fine-needle aspiration (FNA) biopsy to become established as a first-line procedure, it has to be perceived by the oncology community as yielding accurate and diagnostically useful information on which to base therapy. The articles submitted for this State of the Art Symposium regarding the diagnosis of lymphoma by FNA describe a minimalist but powerful approach, requiring the synthesis of morphology, phenotyping, and cytogenetic information on a small quantity of tissue.

  2. Contemporary Issue

    1. Top of page
    2. Editorial
    3. Contemporary Issue
    4. Original Articles
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      Strategies to diagnose lymphoproliferative disorders by fine-needle aspiration by using ancillary studies (pages 432–442)

      Nancy P. Caraway

      Article first published online: 12 OCT 2005 | DOI: 10.1002/cncr.21452

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      This article outlines a multiparameter approach to diagnosing lymphoproliferative disorders by fine-needle aspiration.

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      State of the Art Symposium: Flow cytometry in the diagnosis of lymphoproliferative disorders by fine-needle aspiration (pages 443–451)

      Jeffrey L. Jorgensen

      Article first published online: 9 SEP 2005 | DOI: 10.1002/cncr.21455

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      Immunophenotyping is an essential component of the diagnosis of lymphoma using fine-needle aspiration (FNA) and flow cytometry is a powerful technique that is well suited to FNA material. The current article addresses basic principles of flow cytometry data collection and interpretation, presents a differential diagnosis of common lymphomas based on immunophenotype, and discusses potential pitfalls in the interpretation of flow cytometry data.

  3. Original Articles

    1. Top of page
    2. Editorial
    3. Contemporary Issue
    4. Original Articles
    1. Gynecologic Cytopathology

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      Reflex high-risk human papillomavirus DNA testing (Hybrid Capture 2) of bloody ThinPrep specimens with atypical squamous cells of undetermined significance interpretation : Does pretreatment with Acetic Acid Affect Test Performance? (pages 452–456)

      Jining Feng and Mujtaba Husain

      Article first published online: 3 AUG 2005 | DOI: 10.1002/cncr.21349

      Pretreatment of bloody gynecologic ThinPrep specimens with glacial acetic acid has been shown to reduce the rate of an unsatisfactory interpretation. The current study further demonstrated that such treated specimens are also suitable for reflex high-risk human papillomavirus DNA testing using the Hybrid Capture 2 test.

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      Should women with atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion, receive reflex human papillomavirus-DNA testing? (pages 457–460)

      Agnes K. Liman, Ellen J. Giampoli and Thomas A. Bonfiglio

      Article first published online: 15 AUG 2005 | DOI: 10.1002/cncr.21387

      The results from this study showed that a negative high-risk human papillomavirus (HPV) result was an excellent predictor of the absence of high-grade squamous intraepithelial lesion (HSIL) in subsequent follow-up biopsy. The authors propose that HPV-DNA testing for triage for patients with atypical squamous cells, cannot exclude HSIL is a feasible, cost-effective alternative to colposcopic examination.

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      Evaluation of a nuclear score for p16INK4a-stained cervical squamous cells in liquid-based cytology samples (pages 461–467)

      Nicolas Wentzensen, Christine Bergeron, Frederic Cas, Denise Eschenbach, Svetlana Vinokurova and Magnus von Knebel Doeberitz

      Article first published online: 22 AUG 2005 | DOI: 10.1002/cncr.21378

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      Two hundred ten liquid-based cytology specimens, including 108 normal samples, 52 samples with low-grade squamous intraepithelial lesions, and 50 samples with high-grade squamous intraepithelial lesions, were used to compare the standard Papanicolaou stain with p16INK4a immunocytochemistry to identify samples with abnormal cells. The results revealed that p16INK4a can be used to identify potentially abnormal cells (locator function) in cytology and that the degree of abnormality can be determined by applying standard morphologic criteria for the nucleus.

    4. Non-Gynecologic Cytopathology

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      Analysis of atypical urine cytology in a tertiary care center (pages 468–475)

      Vikram Deshpande and Grace T. McKee

      Article first published online: 3 AUG 2005 | DOI: 10.1002/cncr.21317

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      The atypical category continues to be clinically relevant in voided urine cytology, and attention to cytomorphology, clinical results, and imaging results will serve further to refine this group.

    5. Analytical and Quantitative Cytopathology

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      S-phase fraction as an independent prognostic factor of long-term overall survival in patients with early-stage or locally advanced invasive breast carcinoma (pages 476–482)

      Philippe Vielh, Mathieu Carton, Eliane Padoy, Yann de Rycke, Jerzy Klijanienko, Adel K. El-Naggar and Bernard Asselain

      Article first published online: 22 AUG 2005 | DOI: 10.1002/cncr.21348

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      The current study showed the prognostic relevance of S-phase fraction measurement in predicting the long-term overall survival of patients with early-stage or locally advanced invasive breast carcinoma.

    6. Molecular Diagnostics

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      Manual exfoliation of fresh tissue obviates the need for frozen sections for molecular profiling (pages 483–491)

      Wilfrido D. Mojica, Amy V. Rapkiewicz, Lance A. Liotta and Virginia Espina

      Article first published online: 13 JUL 2005 | DOI: 10.1002/cncr.21347

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      A simple and rapid cytology-based tissue procurement method was designed for procuring pure cell populations while preserving macromolecules without the need for preparing tissue cryosections. High-quality nucleic acids and proteins are recoverable as evidenced by DNA, RNA, and protein quality, thereby identifying this technique as a promising approach for translational research studies.

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      Telomerase activity in “suspicious” thyroid cytology (pages 492–497)

      Enrique Lerma, Josefina Mora and Thyroid Study Group

      Article first published online: 15 AUG 2005 | DOI: 10.1002/cncr.21380

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      Telomerase activity may help in the diagnosis of thyroid fine-needle aspirates when the cytologic diagnosis is nonconclusive.

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