American founder mutation for Lynch syndrome : Prevalence estimates and implications (pages 448–452)
Henry T. Lynch, Albert de la Chapelle, Heather Hampel, Anja Wagner, Riccardo Fodde, Jane F. Lynch, Ross Okimoto, Mary Beth Clark, Stephanie Coronel, Abdon Trowonou, Yun-Xin Fu, Gleb R. Haynatzki and Gordon Gong
Version of Record online: 13 DEC 2005 | DOI: 10.1002/cncr.21624
Based on pedigree data and published epidemiology data, an estimated 19,000 expected carriers of the American Founder Mutation for Lynch syndrome were identified. The great number of a founder mutation for colorectal carcinoma bears significant implications for cancer control.