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Cancer

Cover image for Cancer

1 July 2006

Volume 107, Issue 1

Pages 1–216

  1. Review Article

    1. Top of page
    2. Review Article
    3. Original Articles
    4. Correspondence
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      Adult survivors of childhood cancer and unemployment : A metaanalysis (pages 1–11)

      Anna G.E.M. de Boer, Jozef H.A.M. Verbeek and Franciscus J.H. van Dijk

      Article first published online: 22 MAY 2006 | DOI: 10.1002/cncr.21974

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      Results of this metaanalysis show that adult survivors of childhood cancer are twice as likely to be unemployed than healthy controls. Moreover, survivors of central nervous system and brain tumors are nearly 5 times more likely to be unemployed, and survivors living in the U.S. are 3 times more likely to be unemployed.

  2. Original Articles

    1. Top of page
    2. Review Article
    3. Original Articles
    4. Correspondence
    1. Disease Site

      Breast Disease
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      Adult weight gain and histopathologic characteristics of breast cancer among postmenopausal women (pages 12–21)

      Heather Spencer Feigelson, Alpa V. Patel, Lauren R. Teras, Ted Gansler, Michael J. Thun and Eugenia E. Calle

      Article first published online: 22 MAY 2006 | DOI: 10.1002/cncr.21965

      The authors examined histopathologic subtypes of breast cancer by categories of adult weight gain in 1200 postmenopausal women with invasive breast cancer from the American Cancer Society's Cancer Prevention Study II Nutrition Cohort. Excess adiposity is an important contributor to breast cancer risk among postmenopausal women, regardless of histologic type, and especially for tumors of advanced stage and high grade.

    2. Gastrointestinal Tract
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      Increased diagnostic yield of small bowel tumors with capsule endoscopy (pages 22–27)

      Gena M. Cobrin, Robert H. Pittman and Blair S. Lewis

      Article first published online: 30 MAY 2006 | DOI: 10.1002/cncr.21975

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      The incidence of small bowel tumors suggests an important role for capsule endoscopy in the algorithm for diagnostic work-up of suspected small bowel lesions. Capsule endoscopy may lead to earlier detection and treatment of small bowel tumors and an improved prognosis for patients with these neoplasms.

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      The metabolic syndrome and risk of incident colorectal cancer (pages 28–36)

      Rehana L. Ahmed, Kathryn H. Schmitz, Kristin E. Anderson, Wayne D. Rosamond and Aaron R. Folsom

      Article first published online: 23 MAY 2006 | DOI: 10.1002/cncr.21950

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      By using data from a multicenter prospective cohort study in men and women, the authors observed a dose-response association between colorectal cancer incidence and the number of metabolic syndrome components (0-5 components) that were present at baseline (P for trend = .006) after multivariate adjustment; the multivariate-adjusted association of metabolic syndrome (≥3 components) with colorectal cancer had borderline significance in men (relative risk, 1.78; 95% confidence interval, 1.0-3.6) and was absent in women (relative risk, 1.01; 95% confidence interval, 0.5-2.0).

    4. Genitourinary Disease
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      High expression levels of survivin protein independently predict a poor outcome for patients who undergo surgery for clear cell renal cell carcinoma (pages 37–45)

      Alexander S. Parker, Farhad Kosari, Christine M. Lohse, R. Houston Thompson, Eugene D. Kwon, Linda Murphy, Darren L. Riehle, Michael L. Blute, Bradley C. Leibovich, George Vasmatzis and John C. Cheville

      Article first published online: 30 MAY 2006 | DOI: 10.1002/cncr.21952

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      The results of this study indicated that survivin expression was an independent predictor of disease progression in patients with clear cell renal cell carcinoma (RCC) and of death from RCC. Survivin has the potential to offer additional prognostic information and may provide a novel target for the development of new adjuvant therapies.

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      Mononuclear cell infiltration in clear-cell renal cell carcinoma independently predicts patient survival (pages 46–53)

      W. Scott Webster, Christine M. Lohse, R. Houston Thompson, Haidong Dong, Xavier Frigola, Demetrius L. Dicks, Shomik Sengupta, Igor Frank, Bradley C. Leibovich, Michael L. Blute, John C. Cheville and Eugene D. Kwon

      Article first published online: 17 MAY 2006 | DOI: 10.1002/cncr.21951

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      In the current study, the authors evaluated the associations between mononuclear cell infiltration in routinely prepared paraffin-embedded specimens with survival in patients with clear-cell renal cell carcinoma (RCC). After adjusting for the Mayo Clinic SSIGN (stage, size, grade, and necrosis) score, it was determined that patients with specimens that had mononuclear cell infiltration exhibited a significantly increased likelihood of dying from RCC compared with patients whose specimens had no mononuclear cell infiltration (risk ratio, 1.61; P = .028). Therefore, routine documentation of mononuclear cell infiltration is recommended during the pathologic assessment of RCC.

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      Impact of fellowship training on pathologic outcomes and complication rates of radical prostatectomy (pages 54–59)

      Charles J. Rosser, Ashish M. Kamat, John Pendleton, Tracy L. Robinson, Louis L. Pisters, David A. Swanson and Richard J. Babaian

      Article first published online: 17 MAY 2006 | DOI: 10.1002/cncr.21955

      This study was conducted to assess the results of radical prostatectomy (RP) performed by fellowship-trained surgeons in the first year of independent practice. Results of RP performed by fellowship-trained surgeons in their first year of practice compared favorably with results reported by more experienced surgeons. Being trained in an environment where an experienced surgeon serves as first assistant to the trainee may abbreviate the learning curve for this procedure.

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      Prospective evaluation of the prognostic relevance of molecular staging for urothelial carcinoma (pages 60–66)

      Hillary L. Copp, Joseph L. Chin, Mark Conaway and Dan Theodorescu

      Article first published online: 11 MAY 2006 | DOI: 10.1002/cncr.21953

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      Lymph node metastases portend a poor prognosis in patients with urothelial carcinoma, and 50% of patients with lymph node-negative but invasive cancers recur after radical surgery. Thus, we hypothesized that occult local or lymph node disease may be present in many of these cases, although undetectable by current approaches. In a prospective trial reverse-transcriptase polymerase chain reaction showed that detectable mRNA of Uroplakin II (UPII), a urothelial-specific gene mRNA, in perivesical and lymph node samples removed at radical surgery, is an independent predictor of clinical recurrence.

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      Combination immunotherapy with prostatic acid phosphatase pulsed antigen-presenting cells (provenge) plus bevacizumab in patients with serologic progression of prostate cancer after definitive local therapy (pages 67–74)

      Brian I. Rini, Vivian Weinberg, Lawrence Fong, Shauna Conry, Robert M. Hershberg and Eric J. Small

      Article first published online: 30 MAY 2006 | DOI: 10.1002/cncr.21956

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      APC8015 and bevacizumab were given to patients with biochemically recurrent prostate cancer. Generation of an immune response and prostate-specific antigen-modulating effects were observed.

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      African-American men with nonpalpable prostate cancer exhibit greater tumor volume than matched white men (pages 75–82)

      Ricardo F. Sanchez-Ortiz, Patricia Troncoso, Richard J. Babaian, Josep Lloreta, Dennis A. Johnston and Curtis A. Pettaway

      Article first published online: 30 MAY 2006 | DOI: 10.1002/cncr.21954

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      The authors compared the clinicopathologic characteristics of a consecutive series of African-American men who underwent radical prostatectomy for clinical Stage T1c prostate cancer with a matched cohort of white patients. Despite similar clinical stage, serum prostate-specific antigen (PSA) levels, biopsy strategy, biopsy Gleason score, and year of surgery, African-American patients exhibited significantly greater prostatectomy tumor volumes. These data support the need for early prostate cancer detection among African-American males using lower serum PSA thresholds for biopsy recommendation.

    10. Gynecologic Oncology
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      Bevacizumab combination therapy in recurrent, platinum-refractory, epithelial ovarian carcinoma : A retrospective analysis (pages 83–89)

      Jason D. Wright, Andrea Hagemann, Janet S. Rader, Dana Viviano, Randall K. Gibb, Lori Norris, David G. Mutch and Matthew A. Powell

      Article first published online: 30 MAY 2006 | DOI: 10.1002/cncr.21969

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      Combination bevacizumab therapy demonstrates activity in heavily pretreated women with platinum-refractory ovarian cancer. Life-threatening gastrointestinal perforations were identified in 9% of the subjects.

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      Expression of epithelial membrane protein-2 is associated with endometrial adenocarcinoma of unfavorable outcome (pages 90–98)

      Madhuri Wadehra, Sathima Natarajan, David B. Seligson, Carmen J. Williams, Amanda J. Hummer, Cyrus Hedvat, Jonathan Braun and Robert A. Soslow

      Article first published online: 30 MAY 2006 | DOI: 10.1002/cncr.21957

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      Epithelial membrane protein-2 (EMP2) is an estrus-regulated tetraspan protein that controls surface levels of several classes of integrin and other cell-interaction molecules and is required for endometrial competence in blastocyst implantation. To determine the prevalence of EMP2 expression in endometrial neoplasms and its clinical significance, the authors studied 99 endometrial cancers of various types, grades, and stages. A multivariate analysis of disease-free survival demonstrated independent negative prognostic significance for EMP2 expression, high stage, and high-risk histologic subtypes.

    12. Head and Neck Disease
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      Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry serum protein profiling to identify nasopharyngeal carcinoma (pages 99–107)

      David Wing Yuen Ho, Zhen Fan Yang, Birgitta Yee-Hang Wong, Dora Lai-Wan Kwong, Jonathan Shun-Tong Sham, William Ignace Wei and Anthony Po Wing Yuen

      Article first published online: 17 MAY 2006 | DOI: 10.1002/cncr.21970

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      Detection of nasopharyngeal carcinoma (NPC) at an early stage improves the outcome of patients. Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) serum protein profiles in combination with the classification tree algorithm detected NPC with an overall sensitivity and specificity of 83% and 82%, respectively.

    13. Hematologic Malignancies
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      The risk of secondary malignancies over 30 years after the treatment of non-Hodgkin lymphoma (pages 108–115)

      Jonathan D. Tward, Merideth M. M. Wendland, Dennis C. Shrieve, Aniko Szabo and David K. Gaffney

      Article first published online: 17 MAY 2006 | DOI: 10.1002/cncr.21971

      The authors studied the risk of secondary cancers in non-Hodgkin lymphoma (NHL) survivors over 30 years of follow-up. The results indicated that the overall risk of secondary malignancies is increased for NHL survivors and varies by age at NHL diagnosis, gender, and treatment.

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      High-dose cytosine arabinoside in the treatment of acute myeloid leukemia : Review of three randomized trials (pages 116–124)

      Wolfgang Kern and Elihu H. Estey

      Article first published online: 23 MAY 2006 | DOI: 10.1002/cncr.21543

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      High-dose cytosine arabinoside resulted in improved event-free and overall survival among patients with acute myeloid leukemia who were age < 60 years in this review of randomized trials.

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      Outcomes in patients with splenic marginal zone lymphoma and marginal zone lymphoma treated with rituximab with or without chemotherapy or chemotherapy alone (pages 125–135)

      Apostolia M. Tsimberidou, Daniel Catovsky, Ellen Schlette, Susan O'Brien, William G. Wierda, Hagop Kantarjian, Guillermo Garcia-Manero, Sijin Wen, Kim-Anh Do, Susan Lerner and Michael J. Keating

      Article first published online: 12 MAY 2006 | DOI: 10.1002/cncr.21931

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      Characteristics and clinical outcomes in 70 sequential patients with splenic marginal zone lymphoma/marginal zone lymphoma (SMZL) were reviewed. Treatments with rituximab resulted in higher rates of response, survival, and failure-free survival compared with chemotherapy. Rituximab alone resulted in disappearance of splenomegaly in 92% of patients and normalization of absolute lymphocyte counts. Rituximab should be the treatment of choice, at least in older patients with SMZL who have comorbid diseases.

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      Epsilon aminocaproic acid reduces transfusion requirements in patients with thrombocytopenic hemorrhage (pages 136–140)

      Sujith Kalmadi, Ramon Tiu, Christopher Lowe, Tao Jin and Matt Kalaycio

      Article first published online: 17 MAY 2006 | DOI: 10.1002/cncr.21958

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      Epsilon aminocaproic acid may be a valuable adjunctive therapy in the treatment of patients with thrombocytopenic hemorrhage.

    17. Hepatobiliary Disease
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      The model for end-stage liver disease-based Japan Integrated Scoring system may have a better predictive ability for patients with hepatocellular carcinoma undergoing locoregional therapy (pages 141–148)

      Teh-Ia Huo, Han-Chieh Lin, Yi-Hsiang Huang, Jaw-Ching Wu, Jen-Huei Chiang, Pui-Ching Lee and Shou-Dong Lee

      Article first published online: 17 MAY 2006 | DOI: 10.1002/cncr.21972

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      The Japan Integrated Scoring (JIS) system, which is based on the combination of the TNM classification system and the Child–Turcotte–Pugh class, is a useful model for staging patients with hepatocellular carcinoma. In this report, the authors showed that the replacement of the Child–Turcotte–Pugh class with the model for end-stage liver disease in the JIS system may improve its prognostic ability further.

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      Pattern of carcinoembryonic antigen drop after laparoscopic radiofrequency ablation of liver metastasis from colorectal carcinoma (pages 149–153)

      Mohammed Ghanamah, Eren Berber and Allan Siperstein

      Article first published online: 30 MAY 2006 | DOI: 10.1002/cncr.21959

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      Laparoscopic radiofrequency ablation (RFA) is being increasingly used for local control of hepatic metastasis from colorectal carcinoma. After surgical resection of colorectal liver metastasis, carcinoembryonic antigen (CEA) values fall within 2 weeks, making this a useful parameter to follow shortly after surgery. Little is known, however, about the expected pattern of the CEA drop after RFA. Unlike resection patients, those undergoing ablation show an initial rise in CEA, probably due to release from the ablated tissue. Although heating of RFA would be expected to destroy CEA, the initial rise and slow drop postoperatively argue for a release of immunoreactive CEA from the ablated zone. This slow decline in CEA indicates that several months should pass before assessing the extent of potential residual disease.

    19. Lung Disease
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      Overexpression of jun activation domain-binding protein 1 in nonsmall cell lung cancer and its significance in p27 expression and clinical features (pages 154–161)

      Atsushi Osoegawa, Ichiro Yoshino, Takuro Kometani, Masafumi Yamaguchi, Toshifumi Kameyama, Tomofumi Yohena and Yoshihiko Maehara

      Article first published online: 23 MAY 2006 | DOI: 10.1002/cncr.21961

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      To examine the clinical significance of Jun activation domain-binding protein 1 (Jab1) in nonsmall cell lung cancer (NSCLC), the protein expression of Jab1 in tumor tissues was investigated in reference to the expression levels of p27 and S-phase kinase interacting protein 2. The results indicated for the first time that high Jab1 protein expression is related to poor outcome in patients NSCLC and that this protein may be a target of therapy.

    20. Neuro-Oncology
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      Histopathologic assessment of hot-spot microvessel density and vascular patterns in glioblastoma: Poor observer agreement limits clinical utility as prognostic factors : A translational research project of the European Organization for Research and Treatment of Cancer Rrain Tumor Group (pages 162–170)

      Matthias Preusser, Harald Heinzl, Ellen Gelpi, Katharina Schonegger, Christine Haberler, Peter Birner, Christine Marosi, Monika Hegi, Thierry Gorlia and Johannes A. Hainfellner

      Article first published online: 23 MAY 2006 | DOI: 10.1002/cncr.21973

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      The results of this investigation revealed that poor observer agreement limits the clinical utility of histopathologically assessed hot-spot microvessel density and vascular patterns as prognostic factors in patients with glioblastoma. Improved methodologies for morphologic assessment of glioblastoma vascularization need to be identified.

    21. Discipline

      Clinical Trials
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      Transdisciplinary studies of surgical oncology trial accrual : A National Institutes of Health/National Cancer Institute Roadmap-Affiliated Project Update (pages 171–174)

      Terrance L. Albrecht, Henry Kuerer, John C. Ruckdeschel, Jane Mendez and Felicity Harper

      Article first published online: 23 MAY 2006 | DOI: 10.1002/cncr.21966

      Recognizing an opportunity to focus on the growing problem of low accrual to cancer surgical trials, the authors organized a multidisciplinary network of 21 clinical researchers and social/behavioral scientists to meet, review the issues, and organize working groups to study the problem. The authors, as representatives of the Karmanos Cancer Institute (Detroit, MI) and the American College of Surgeons Oncology Group, were awarded a Roadmap-affiliated grant from the National Cancer Institute under the “Meetings and Networks for Methodological Development in Interdisciplinary Research” funding mechanism.

    22. Diagnostic Imaging
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      Role of fluorine-18 fluoro-deoxyglucose positron emission tomography scan in the evaluation and follow-up of patients with low-grade lymphomas (pages 175–183)

      Maroun Karam, Leon Novak, Jomol Cyriac, Ameera Ali, Tipu Nazeer and Francis Nugent

      Article first published online: 23 MAY 2006 | DOI: 10.1002/cncr.21967

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      The usefulness of positron emission tomography in staging low-grade lymphomas varies depending on histology. Sensitivity is excellent in follicular lymphomas, good in marginal zone lymphomas, and limited in B-cell small lymphocytic lymphoma. In all low-grade lymphomas the emergence of foci of intense uptake should raise suspicion of conversion to high-grade disease.

    23. Epidemiology
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      Low rates of colorectal, cervical, and breast cancer screening in Asian Americans compared with non-Hispanic whites : Cultural influences or access to care? (pages 184–192)

      Namratha R. Kandula, Ming Wen, Elizabeth A. Jacobs and Diane S. Lauderdale

      Article first published online: 23 MAY 2006 | DOI: 10.1002/cncr.21968

      In a large, population-based sample, Asian Americans had lower rates of colorectal, cervical, and breast cancer screening compared with non-Hispanic whites even after adjusting for socioeconomic status and access to care. Adjusting for nativity, years in the United States, and English language use at home attenuated these racial/ethnic cancer-screening disparities. Foreign-born Asian Americans were more likely than non-Hispanic whites to cite an absence of symptoms as the reason they were not screened, suggesting that interventions must address the cultural and linguistic factors that influence cancer screening beliefs and behaviors in Asian Americans.

    24. Pathology
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      Sensitivity and specificity of confocal laser-scanning microscopy for in vivo diagnosis of malignant skin tumors (pages 193–200)

      Armin Gerger, Silvia Koller, Wolfgang Weger, Erika Richtig, Helmut Kerl, Hellmut Samonigg, Peter Krippl and Josef Smolle

      Article first published online: 13 APR 2006 | DOI: 10.1002/cncr.21910

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      Confocal laser-scanning microscopy (CLSM) facilitates in vivo examination of the skin at a level that allows viewing microanatomic structures and individual cells. The authors examined 162 skin tumors and found that CLSM achieved significantly greater diagnostic accuracy than the accuracy reported for epiluminescence microscopy, which currently is applied in routine skin tumor screening.

    25. Pediatric Oncology
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      Ewing sarcoma-family tumors that arise after treatment of primary childhood cancer (pages 201–206)

      Sheri L. Spunt, Carlos Rodriguez-Galindo, Christine E. Fuller, JoAnn Harper, Matthew J. Krasin, Catherine A. Billups and Joseph D. Khoury

      Article first published online: 23 MAY 2006 | DOI: 10.1002/cncr.21962

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      The Ewing sarcoma family of tumors (ESFT) occurs rarely as a second malignant neoplasm after treatment of a primary cancer during childhood, and it does not appear to be related to radiation in most cases. Long-term survival can be achieved in some patients; therefore, secondary ESFT should be treated with curative intent.

    26. Symptom Control and Palliative Care
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      Brief cognitive-behavioral audiotape interventions for cancer-related pain : Immediate but not long-term effectiveness (pages 207–214)

      Karen O. Anderson, Marlene Z. Cohen, Tito R. Mendoza, Hong Guo, Margaret T. Harle and Charles S. Cleeland

      Article first published online: 17 MAY 2006 | DOI: 10.1002/cncr.21964

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      A randomized clinical trial evaluated the effectiveness of 3 brief cognitive-behavioral audiotape techniques for relief of chronic cancer-related pain: relaxation, distraction, and positive mood. Relaxation and distraction interventions produced immediate pain reductions but not longer-term pain relief.

  3. Correspondence

    1. Top of page
    2. Review Article
    3. Original Articles
    4. Correspondence
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    2. You have free access to this content
      Author reply (pages 215–216)

      Maurizio Belfiglio, Miriam Valentini and Antonio Nicolucci

      Article first published online: 11 MAY 2006 | DOI: 10.1002/cncr.21963

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