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Cancer

Cover image for Cancer

15 September 2006

Volume 107, Issue 6

Pages 1205–1421

  1. Listen to the Patient

    1. Top of page
    2. Listen to the Patient
    3. Review Article
    4. Original Articles
    5. Correspondence
    6. Errata
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  2. Review Article

    1. Top of page
    2. Listen to the Patient
    3. Review Article
    4. Original Articles
    5. Correspondence
    6. Errata
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      Clinical implications of the mechanism of epidermal growth factor receptor inhibitors (pages 1207–1218)

      John Marshall

      Version of Record online: 14 AUG 2006 | DOI: 10.1002/cncr.22133

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      Although both classes of antiepidermal growth factor receptor agents (monoclonal antibodies and small-molecule tyrosine kinase inhibitors) target the epidermal growth factor receptor, substantial distinctions regarding their mechanism significantly affect dosing requirements, toxicity profiles, and their use as combination agents.

  3. Original Articles

    1. Top of page
    2. Listen to the Patient
    3. Review Article
    4. Original Articles
    5. Correspondence
    6. Errata
    1. Disease Site

      Breast Disease
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      Treatment of pregnant breast cancer patients and outcomes of children exposed to chemotherapy in utero (pages 1219–1226)

      Karin M.E. Hahn, Peter H. Johnson, Nancy Gordon, Henry Kuerer, Lavinia Middleton, Mildred Ramirez, Wei Yang, George Perkins, Gabriel N. Hortobagyi and Richard L. Theriault

      Version of Record online: 7 AUG 2006 | DOI: 10.1002/cncr.22081

      In the largest prospective cohort of pregnant women with breast cancer treated with chemotherapy, anthracycline-based (FAC: 5-fluorouracil, doxorubicin, and cyclophosphamide), the majority of the children exposed to FAC in utero did not have significant short-term complications.

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      Excellent survival, cancer type, and Nottingham grade after atypical lobular hyperplasia on initial breast biopsy (pages 1227–1233)

      Bernadette K. McLaren, Peggy A. Schuyler, Melinda E. Sanders, Roy A. Jensen, Jean F. Simpson, William D. Dupont and David L. Page

      Version of Record online: 7 AUG 2006 | DOI: 10.1002/cncr.22113

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      In a long-term, longitudinal follow-up study of 252 women with confirmed atypical lobular hyperplasia, grade and survival of women with 48 subsequent invasive breast cancers were analyzed. Nearly half of the cancers were low or intermediate grade or special/variant type with excellent survival, suggesting that treatment of these women should be influenced by their modest elevation in breast cancer risk, good prognosis, and low mortality.

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      Significance of micrometastases on the survival of women with T1 breast cancer (pages 1234–1239)

      Douglas C. Maibenco, George W. Dombi, Tsui Y. Kau and Richard K. Severson

      Version of Record online: 9 AUG 2006 | DOI: 10.1002/cncr.22112

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      Lymph node micrometastases are associated with a modest survival disadvantage in the long-term survival of women with T1 breast cancer. The variable impact of micrometastases in subgroup analyses indicates that micrometastases are not determinants of survival.

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      The influence of family history on breast cancer risk in women with biopsy-confirmed benign breast disease : Results from the Nurses' Health Study (pages 1240–1247)

      Laura C. Collins, Heather J. Baer, Rulla M. Tamimi, James L. Connolly, Graham A. Colditz and Stuart J. Schnitt

      Version of Record online: 10 AUG 2006 | DOI: 10.1002/cncr.22136

      In a case–control study of benign breast disease and breast cancer risk nested within the Nurses' Health Study, a positive family history of breast cancer slightly increased the breast cancer risk among women who had proliferative lesions without atypia. The increase in risk of breast cancer associated with a positive family history was not significant among women who had atypical hyperplasia.

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      The safety of breast-conserving surgery in patients who achieve a complete pathologic response after neoadjuvant chemotherapy (pages 1248–1254)

      Florentia Peintinger, W. Fraser Symmans, Ana M. Gonzalez-Angulo, Judy C. Boughey, Aman U. Buzdar, T. Kuan Yu, Kelly K. Hunt, S. Eva Singletary, Gildy V. Babiera, Anthony Lucci, Funda Meric-Bernstam and Henry M. Kuerer

      Version of Record online: 21 JUL 2006 | DOI: 10.1002/cncr.22111

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      Patients with breast cancer who had a pathologic complete response after neoadjuvant chemotherapy were at especially low risk for local recurrence. Extending the surgical resection volumes in this population is unlikely to lead to significant improvements in local control.

    6. Endocrine Disease
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      Follicular variant of papillary thyroid carcinoma : A clinicopathologic study of a problematic entity (pages 1255–1264)

      Jeffrey Liu, Bhuvanesh Singh, Giovanni Tallini, Diane L. Carlson, Nora Katabi, Ashok Shaha, R. Michael Tuttle and Ronald A. Ghossein

      Version of Record online: 9 AUG 2006 | DOI: 10.1002/cncr.22138

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      The follicular variant of papillary thyroid carcinoma appeared to be a heterogeneous disease composed of 2 distinct groups: an infiltrative/diffuse (nonencapsulated) subvariant, which resembles classic papillary carcinoma in its metastatic lymph node pattern and invasive growth, and an encapsulated form, which behaves more like follicular thyroid adenoma/carcinoma.

    7. Genitourinary Disease
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      Clinical and pathologic outcome after radical prostatectomy for prostate cancer patients with a preoperative Gleason sum of 8 to 10 (pages 1265–1272)

      Patrick J. Bastian, Mark L. Gonzalgo, William J. Aronson, Martha K. Terris, Christopher J. Kane, Christopher L. Amling, Joseph C. Presti Jr., Leslie A. Mangold, Elizabeth Humphreys, Jonathan I. Epstein, Alan W. Partin and Stephen J. Freedland

      Version of Record online: 9 AUG 2006 | DOI: 10.1002/cncr.22116

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      Men with prostate cancer and a biopsy Gleason sum of 8 to 10 are considered high-risk. The current study sought to identify whether there was a subset of men with high biopsy Gleason sums who would have a good pathologic and biochemical outcome with surgical monotherapy. The results from a tertiary care referral center and multiple equal-access medical centers demonstrate that the majority of men with a biopsy Gleason sum of ≥8 will have nonorgan-confined disease and experience a biochemical progression after radical prostatectomy. Even among men with organ-confined disease and negative surgical margins or pathologic Gleason sum <8, the majority of men experienced a prostate-specific antigen recurrence. The findings confirm the high-risk nature of these patients and suggest that these patients may be best served with multimodal therapy.

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      A phase II study of gemcitabine and capecitabine in metastatic renal cancer : A report of Cancer and Leukemia Group B protocol 90008 (pages 1273–1279)

      Walter M. Stadler, Susan Halabi, Brian Rini, Marc S. Ernstoff, Enrique Davila, Joel Picus, Robert Barrier, Eric J. Small and for Cancer and Leukemia Group B

      Version of Record online: 14 AUG 2006 | DOI: 10.1002/cncr.22117

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      The objective of this study was to verify previous reports of activity with gemcitabine plus a fluoropyrimidine in patients with metastatic renal cell cancer in a multiinstitutional setting. The results indicated that combined gemcitabine and capecitabine had modest activity in patients with metastatic renal cancer, although the degree of activity and its associated toxicity would not support further evaluation in a Phase III trial of unselected patients.

    9. Gynecologic Oncology
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      Phase II trial of pulse dactinomycin as salvage therapy for failed low-risk gestational trophoblastic neoplasia : A Gynecologic Oncology Group study (pages 1280–1286)

      Allan Covens, Virginia L. Filiaci, Robert A. Burger, Raymond Osborne and M. Dwight Chen

      Version of Record online: 9 AUG 2006 | DOI: 10.1002/cncr.22118

      Up to one-third of patients with low-risk gestational trophoblastic neoplasia fail first-line treatment with methotrexate. Pulse dactinomycin as second-line therapy is active and produces an acceptable level of toxicity in this population.

    10. Head and Neck Disease
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      The risk of second primary tumors in patients with nasopharyngeal carcinoma after definitive radiotherapy (pages 1287–1293)

      Lin Kong, Jiade Jay Lu, Chaosu Hu, Xiaomao Guo, Yongru Wu and Youwang Zhang

      Version of Record online: 14 AUG 2006 | DOI: 10.1002/cncr.22119

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      The risk factors for second primary tumors (SPTs) were studied in patients with nasopharyngeal carcinoma (NPC). The results indicated that SPTs in patients with NPC occur preferentially in the upper aerodigestive tract and tend to develop within the irradiated field more than 5 years after radiation.

    11. Hematologic Malignancies
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      Hodgkin transformation of chronic lymphocytic leukemia : The M. D. Anderson Cancer Center experience (pages 1294–1302)

      Apostolia-Maria Tsimberidou, Susan O'Brien, Hagop M. Kantarjian, Charles Koller, Fredrick B. Hagemeister, Luis Fayad, Susan Lerner, Carlos E. Bueso-Ramos and Michael J. Keating

      Version of Record online: 10 AUG 2006 | DOI: 10.1002/cncr.22121

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      The authors report 18 patients who had Hodgkin transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The presenting characteristics shared same features with de novo Hodgkin lymphoma. The rates of response, survival, and failure-free survival (FFS) of patients with Hodgkin transformation of CLL/SLL were inferior to those reported in patients with de novo Hodgkin lymphoma and similar to those of patients with Richter syndrome (overall response rate, 44%; complete response rate, 19%; median survival, 0.8 years; median FFS, 0.4 years).

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      Metabolic syndrome and growth hormone deficiency in adult survivors of childhood acute lymphoblastic leukemia (pages 1303–1312)

      James G. Gurney, Kirsten K. Ness, Shalamar D. Sibley, Maura O'Leary, Donald R. Dengel, Joyce M. Lee, Nancy M. Youngren, Stephen P. Glasser and K. Scott Baker

      Version of Record online: 7 AUG 2006 | DOI: 10.1002/cncr.22120

      This clinical follow-up study of 75 adult survivors of childhood acute lymphoblastic leukemia revealed a pattern of dyslipidemia, abdominal obesity, and untreated growth hormone insufficiency that was strongly correlated with past treatment exposure to cranial irradiation, particularly in women.

    13. Lung Disease
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      Racial differences in doctors' information-giving and patients' participation (pages 1313–1320)

      Howard S. Gordon, Richard L. Street Jr., Barbara F. Sharf and Julianne Souchek

      Version of Record online: 14 AUG 2006 | DOI: 10.1002/cncr.22122

      At initial visits for confirmed lung cancer or a pulmonary nodule or mass requiring surgical diagnosis, the authors used audio recordings to evaluate doctor's information-giving and patient's active participation (asking questions, expressing concerns, and making assertions). The authors found that black patients used active participation behaviors less often than white patients, and as a result black patients received less information from doctors.

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      Toxicity and outcome of a phase II trial of taxane-based neoadjuvant chemotherapy and 3-dimensional, conformal, accelerated radiotherapy in locally advanced nonsmall cell lung cancer (pages 1321–1330)

      Ana M. Rojas, Basil E. Lyn, Elena M. Wilson, Frances J. Williams, Nihal Shah, Jeanette Dickson and Michele I. Saunders

      Version of Record online: 10 AUG 2006 | DOI: 10.1002/cncr.22123

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      Paclitaxel/carboplatin neoadjuvant chemotherapy followed by 3-dimensional, conformal,accelerated radiotherapy was feasible and was tolerated well in patients with locallyadvanced nonsmall cell lung cancer.

    15. Melanoma
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      The incidence and mortality of cutaneous melanoma in southern Germany : Trends by anatomic site and pathologic characteristics, 1976 to 2003 (pages 1331–1339)

      Konstantinos G. Lasithiotakis, Ulrike Leiter, Roman Gorkievicz, Thomas Eigentler, Helmut Breuninger, Gisela Metzler, Waltraud Strobel and Claus Garbe

      Version of Record online: 14 AUG 2006 | DOI: 10.1002/cncr.22126

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      During the past 3 decades, the incidence of cutaneous melanoma in Southern Germany tripled, but the mortality from this tumor decreased as a result of its earlier detection. Current preventive strategies should be intensified to include older age groups and particularly males, who continue to present with melanomas that have a worse prognosis.

    16. Neuro-Oncology
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      Role of spinal MRI in the follow-up of children treated for medulloblastoma (pages 1340–1347)

      Ute Bartels, Manohar Shroff, Lillian Sung, Ugo Dag-Ellams, Normand Laperriere, James Rutka and Eric Bouffet

      Version of Record online: 7 AUG 2006 | DOI: 10.1002/cncr.22129

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      The current retrospective study evaluated the relevance of systematic spinal magnetic resonance imaging (MRI) in the follow-up of children treated for medulloblastoma. The findings suggest that surveillance spinal MRI does not improve the detection of recurrences in children who underwent craniospinal radiation as part of their initial treatment.

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      Phase I study of capecitabine in combination with temozolomide in the treatment of patients with brain metastases from breast carcinoma (pages 1348–1354)

      Edgardo Rivera, Christina Meyers, Morris Groves, Vicente Valero, Deborah Francis, Banu Arun, Kristine Broglio, Guosheng Yin, Gabriel N. Hortobagyi and Thomas Buchholz

      Version of Record online: 14 AUG 2006 | DOI: 10.1002/cncr.22127

      The combination of temozolomide and capecitabine is an active, well-tolerated regimen. The observed antitumor activity warrants further evaluation of this combination as an alternative to or in combination with whole-brain radiation therapy for the treatment of multiple brain metastases.

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      Linear accelerator radiosurgery for pituitary macroadenomas : A 7-Year Follow-Up Study (pages 1355–1364)

      Juergen Voges, Martin Kocher, Matthias Runge, Jorg Poggenborg, Ralph Lehrke, Doris Lenartz, Mohammad Maarouf, Ioanna Gouni-Berthold, Wilhelm Krone, Rolf-Peter Muller and Volker Sturm

      Version of Record online: 7 AUG 2006 | DOI: 10.1002/cncr.22128

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      The authors present 142 consecutive patients with pituitary macroadenomas with a mean (± standard deviation) follow-up of 81.9 ± 37.2 months in a prospective clinical study who underwent linear accelerator-based radiosurgery (RS) and received a prescribed therapeutic dose that was limited to 20 grays. Compared with RS studies that used higher radiation doses, the local tumor control and cure rates of hormone hypersecretion achieved were comparable in the current study, whereas the time from RS to cure was longer.

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      Increased expression of avian erythroblastosis virus E26 oncogene homolog 1 in World Health Organization grade 1 meningiomas is associated with an elevated risk of recurrence and is correlated with the expression of its target genes matrix metalloproteinase-2 and MMP-9 (pages 1365–1372)

      Ali Fuat Okuducu, Ulrich Zils, Silke A. M. Michaelis, Christian Mawrin and Andreas von Deimling

      Version of Record online: 7 AUG 2006 | DOI: 10.1002/cncr.22130

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      The transcription factor avian erythroblastosis virus E26 oncogene homolog 1 (Ets-1) was up-regulated together with its target genes matrix metalloproteinase-2 (MMP-2) and MMP-9 in patients with recurrent of Grade 1 meningioma. Ets-1 may be involved in meningioma recurrence by up-regulating the expression MMP-2 and MMP-9.

    20. Discipline

      Diagnostic Imaging
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      Noninvasive magnetic resonance thermography of soft tissue sarcomas during regional hyperthermia : Correlation with response and direct thermometry (pages 1373–1382)

      Johanna Gellermann, Bert Hildebrandt, Rolf Issels, Hildegard Ganter, Waldemar Wlodarczyk, Volker Budach, Roland Felix, Per-Ulf Tunn, Peter Reichardt and Peter Wust

      Version of Record online: 10 AUG 2006 | DOI: 10.1002/cncr.22114

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      The authors evaluated the suitability of noninvasive magnetic resonance (MR) thermography for the monitoring of regional hyperthermia in patients with soft tissue sarcomas of the lower extremities and pelvis. The results indicated that noninvasive MR thermography of soft tissue sarcoma is feasible and suitable for validating the quality of heating.

    21. Medical Oncology
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      Phase I study to determine the safety and pharmacokinetics of oral administration of TAS-102 in patients with solid tumors (pages 1383–1390)

      David S. Hong, James L. Abbruzzese, Karla Bogaard, Yvonne Lassere, Masakazu Fukushima, Akira Mita, Keizo Kuwata and Paulo M. Hoff

      Version of Record online: 10 AUG 2006 | DOI: 10.1002/cncr.22125

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      TAS-102, a novel nucleoside formed by the combination of α,α,α-trifluorothymidine (FTD) and a thymidine phosphorylase inhibitor (TPI: 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione) is tolerated at 50 mg/m2 and is the recommended Phase II dose.

    22. Pediatric Oncology
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      Telomere length is a prognostic factor in neuroblastoma (pages 1391–1399)

      Anat Ohali, Smadar Avigad, Shifra Ash, Yacov Goshen, Drorit Luria, Meora Feinmesser, Rina Zaizov and Isaac Yaniv

      Version of Record online: 17 AUG 2006 | DOI: 10.1002/cncr.22132

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      Telomere length was the most significant prognostic factor in patients with neuroblastoma, and telomere elongation was correlated with an adverse prognosis. Within the high-risk group, shortening of telomeres could identify a favorable subgroup. The results of the current investigation suggested that telomere stabilization may be critical for disease progression in patients with neuroblastoma.

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      Oral outpatient chemotherapy medication errors in children with acute lymphoblastic leukemia (pages 1400–1406)

      James A. Taylor, Laura Winter, Leah J. Geyer and Douglas S. Hawkins

      Version of Record online: 14 AUG 2006 | DOI: 10.1002/cncr.22131

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      One or more medication errors occurred in nearly 10% of oral outpatient medications indicated for children receiving treatment for acute lymphoblastic leukemia. Errors occurred both during the prescribing and administration phases of treatment.

    24. Translational Research
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      Interleukin-13 receptor α2 chain : A potential biomarker and molecular target for ovarian cancer therapy (pages 1407–1418)

      Mitomu Kioi, Mariko Kawakami, Takeshi Shimamura, Syed R. Husain and Raj K. Puri

      Version of Record online: 10 AUG 2006 | DOI: 10.1002/cncr.22134

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      Interleukin-13 receptorα2 (IL-13Rα2) is a promising target for ovarian cancer therapy.

  4. Correspondence

    1. Top of page
    2. Listen to the Patient
    3. Review Article
    4. Original Articles
    5. Correspondence
    6. Errata
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      Author reply (page 1420)

      Maurie Markman

      Version of Record online: 21 JUL 2006 | DOI: 10.1002/cncr.22141

  5. Errata

    1. Top of page
    2. Listen to the Patient
    3. Review Article
    4. Original Articles
    5. Correspondence
    6. Errata
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