You have free access to this content

Cancer

Cover image for Cancer

1 November 2006

Volume 107, Issue 9

Pages 2099–2315

  1. Review Articles

    1. Top of page
    2. Review Articles
    3. Original Articles
    4. Errata
    1. You have free access to this content
      Acute myeloid leukemia: Epidemiology and etiology (pages 2099–2107)

      Barbara Deschler and Michael Lübbert

      Version of Record online: 3 OCT 2006 | DOI: 10.1002/cncr.22233

      • original image
      • original image

      Despite rapid progress in basic science and clinical research, acute myeloid leukemias remain a leading cause of death due to cancer in the Western world. The current review presents facts concerning incidence and outcomes.

    2. You have free access to this content
      Primary malignant hepatic epithelioid hemangioendothelioma : A comprehensive review of the literature with emphasis on the surgical therapy (pages 2108–2121)

      Arianeb Mehrabi, Arash Kashfi, Hamidreza Fonouni, Peter Schemmer, Bruno M. Schmied, Peter Hallscheidt, Peter Schirmacher, Jurgen Weitz, Helmut Friess, Markus W. Buchler and Jan Schmidt

      Version of Record online: 3 OCT 2006 | DOI: 10.1002/cncr.22225

      • original image
      • original image
      • original image
      • original image

      Primary malignant hepatic epithelioid hemangioendothelioma (HEH) is a rare malignant tumor of vascular origin. In this review of the literature, the authors observed that liver resection has been the treatment of choice for patients who have resectable disease. However, liver transplantation has been proposed as the treatment of choice because of the hepatic multicentricity of HEH.

  2. Original Articles

    1. Top of page
    2. Review Articles
    3. Original Articles
    4. Errata
    1. Disease Site

      Breast Disease
      You have free access to this content
      In utero exposure to diethylstilbestrol (DES) does not increase genomic instability in normal or neoplastic breast epithelium (pages 2122–2126)

      Pamela S. Larson, Rosemarie A. Ungarelli, Antonio de las Morenas, L. Adrienne Cupples, Kathleen Rowlings, Julie R. Palmer and Carol L. Rosenberg

      Version of Record online: 22 SEP 2006 | DOI: 10.1002/cncr.22223

      • original image

      Measured by microsatellite instability and allele imbalance, in utero diethylstilbestrol exposure does not appear to significantly increase genomic instability in breast epithelium. Breast tissue may respond differently from that of the reproductive tract to in utero diethylstilbestrol exposure, with consequences of such exposure mediated by proliferative effects of estrogen.

    2. You have free access to this content
      Malignant phyllodes tumor of the female breast : Association of primary therapy with cause-specific survival from the Surveillance, Epidemiology, and End Results (SEER) program (pages 2127–2133)

      O. Kenneth Macdonald, Christopher M. Lee, Jonathan D. Tward, Craig D. Chappel and David K. Gaffney

      Version of Record online: 22 SEP 2006 | DOI: 10.1002/cncr.22228

      • original image
      • original image

      A large US population database was analyzed to identify predictors of cause-specific mortality after primary surgery, comparing mastectomy to wide excision (lumpectomy) in women with malignant phyllodes tumor of the breast. Breast conservation, or wide excision, is not associated with reduced cancer-specific mortality compared with mastectomy in malignant phyllodes tumor.

    3. Endocrine Disease
      You have free access to this content
      Prognosis of medullary thyroid carcinoma : Demographic, clinical, and pathologic predictors of survival in 1252 cases (pages 2134–2142)

      Sanziana Roman, Rong Lin and Julie Ann Sosa

      Version of Record online: 3 OCT 2006 | DOI: 10.1002/cncr.22244

      • original image
      • original image
      • original image

      A total of 1252 patients with medullary thyroid carcinoma were evaluated using the Surveillance, Epidemiology, and End Results (SEER) 1973–2002 database. Associations were assessed between demographic, clinical, and pathologic characteristics and survival. Stage of disease, age at diagnosis, and extent of surgery were found to be strong predictors; radiotherapy appeared to have a negative association.

    4. Gastrointestinal Disease
      You have free access to this content
      Significant regional variation in adequacy of lymph node assessment and survival in gastric cancer (pages 2143–2151)

      Natalie G. Coburn, Carol J. Swallow, Alex Kiss and Calvin Law

      Version of Record online: 25 SEP 2006 | DOI: 10.1002/cncr.22229

      • original image
      • original image
      • original image
      • original image

      In the overwhelming majority of patients undergoing resection for gastric cancer, lymph node assessment remained inadequate despite revised AJCC guidelines. Adequacy of lymph node assessment was associated with improved overall survival, with significant variation across SEER regions. Understaging due to inadequate lymph node assessment may affect eligibility for adjuvant therapy for early stage patients.

    5. You have free access to this content
      Comparison of a brush-sampling fecal immunochemical test for hemoglobin with a sensitive guaiac-based fecal occult blood test in detection of colorectal neoplasia (pages 2152–2159)

      Alicia Smith, Graeme P. Young, Stephen R Cole and Peter Bampton

      Version of Record online: 22 SEP 2006 | DOI: 10.1002/cncr.22230

      A brush-sampling fecal immunochemical test for hemoglobin (FIT) was shown to be more sensitive for cancers and significant adenomas than a sensitive guaiac-based fecal occult blood test (GFOBT) in a paired comparison involving 2512 people who underwent screening or diagnostic colonoscopy. Such FIT should deliver greater reductions in colorectal cancer mortality and incidence than GFOBT.

    6. Gastrointestinal Tract
      You have free access to this content
      Gastroesophageal reflux symptoms in patients with adenocarcinoma of the esophagus or cardia (pages 2160–2166)

      Amitabh Chak, Ashley Faulx, Charis Eng, William Grady, Margaret Kinnard, Heather Ochs-Balcom and Gary Falk

      Version of Record online: 3 OCT 2006 | DOI: 10.1002/cncr.22245

      Current practice, which uses a screening strategy of performing endoscopy in patients with a history of >5 years of heartburn or regurgitation, can detect Barrett epithelium in only a limited proportion of those at risk for developing adenocarcinoma of the esophagus or adenocarcinoma of the cardia.

    7. Genitourinary Disease
      You have free access to this content
      Significance of intraoperative ureteral evaluation at radical cystectomy for urothelial cancer (pages 2167–2172)

      Ganesh V. Raj, Raanan Tal, Andrew Vickers, Bernard H. Bochner, Angel Serio, S. Machele Donat, Harry Herr, Semra Olgac and Guido Dalbagni

      Version of Record online: 21 SEP 2006 | DOI: 10.1002/cncr.22238

      Patients with pathologic evidence of involvement of the ureters with urothelial cancer during a radical cystectomy have a higher likelihood of upper tract recurrence. Intraoperative assessment of the ureters using frozen section analyses is accurate in identifying ureteral involvement, but even with sequential resection of ureters to a negative anastomotic ureteral margin, the risk of upper tract recurrence is not decreased. The data from the current study do not support routine intraoperative frozen sections to assess ureteral involvement.

    8. You have free access to this content
      Long-term outcome of hematuria home screening for bladder cancer in men (pages 2173–2179)

      Edward M. Messing, Ralph Madeb, Terry Young, Kennedy W. Gilchrist, Lora Bram, E. Barry Greenberg, John D. Wegenke, Laura Stephenson, Jason Gee and Changyong Feng

      Version of Record online: 6 OCT 2006 | DOI: 10.1002/cncr.22224

      • original image

      Repetitive home screening for hematuria in healthy men aged ≥50 years with chemical reagent strips reduced bladder cancer and overall mortality significantly during 14 years of follow-up compared with outcomes in a prospective, comparable, unscreened population with bladder cancer. Reduced bladder cancer mortality occurred because screening permitted the diagnosis of high-grade cancers at preinvasive stages far more frequently than standard clinical presentation.

    9. You have free access to this content
      Prostate-specific antigen recurrence and mortality after conventional dose radiation therapy in select men with low-risk prostate cancer (pages 2180–2185)

      Joshua H. Petit, Ming-Hui Chen, Marian Loffredo, Brenda Sussman, Andrew A. Renshaw and Anthony V. D'Amico

      Version of Record online: 28 SEP 2006 | DOI: 10.1002/cncr.22243

      • original image
      • original image
      • original image

      Despite a prostate-specific antigen (PSA) recurrence rate of 43% after conventional dose radiation therapy (RT) (70 Gy) in men age >70 years with low-risk prostate cancer and pretreatment PSA velocity ≤1.0 ng/mL/year, no prostate cancer death was observed. The value of RT dose escalation in this group on time to the initiation of salvage hormonal therapy, metastases, and cancer death should be studied in the setting of a prospective randomized trial.

    10. You have free access to this content
      Long-term quality of life among Dutch prostate cancer survivors : Results of a population-based study (pages 2186–2196)

      Floortje Mols, L. V. van de Poll-Franse, A. J. J. M. Vingerhoets, A. Hendrikx, N. K. Aaronson, S. Houterman, J. W. W. Coebergh and M. L. Essink-Bot

      Version of Record online: 29 SEP 2006 | DOI: 10.1002/cncr.22231

      • original image
      • original image
      • original image

      Unselected long-term prostate cancer survivors reported comparable health-related quality of life (HRQL) but worse General Health Perceptions and better Mental Health scores than an age-matched norm population. Patients who underwent radical prostatectomy had the best physical HRQL; whereas, in general, patients who received treatment primarily with hormone therapy had the worst physical HRQL.

      Corrected by:

      Information Item: Erratum: Long-term quality of life among Dutch prostate cancer survivors

      Vol. 122, Issue 6, 974, Version of Record online: 30 DEC 2015

    11. Gynecologic Oncology
      You have free access to this content
      Racial disparity in survival among patients with advanced/recurrent endometrial adenocarcinoma : A Gynecologic Oncology Group study (pages 2197–2205)

      G. Larry Maxwell, Chunqiao Tian, John Risinger, Carol L. Brown, G. Scott Rose, J. Tate Thigpen, Gini F. Fleming, Holly H. Gallion and Wendy R. Brewster

      Version of Record online: 25 SEP 2006 | DOI: 10.1002/cncr.22232

      • original image
      • original image
      • original image
      • original image

      In an analysis of 4 clinical trials of women with advanced/recurrent endometrial cancer that were conducted by the Gynecologic Oncology Group, the authors observed a worse survival for black women compared with white women in a clinical trial setting, even after controlling for confounding variables that may affect outcome (hazards ratio, 1.26, 95% confidence interval, 1.06–1.51; P = .010).

    12. Hematologic Malignancies
      You have free access to this content
      JAK2 (V617F) as an acquired somatic mutation and a secondary genetic event associated with disease progression in familial myeloproliferative disorders (pages 2206–2211)

      Elisa Rumi, Francesco Passamonti, Daniela Pietra, Matteo G. Della Porta, Luca Arcaini, Sabrina Boggi, Chiara Elena, Emanuela Boveri, Cristiana Pascutto, Mario Lazzarino and Mario Cazzola

      Version of Record online: 22 SEP 2006 | DOI: 10.1002/cncr.22240

      • original image
      • original image
      • original image

      The authors identified 20 pedigrees with familial chronic myeloproliferative disorders through a family history investigation of patients with sporadic myeloproliferative disorders. Studies of these families showed that the Janus kinase 2 gene (JAK2) (V617F) mutation represents an acquired somatic mutation in both familial and sporadic chronic myeloproliferative disorders and that JAK2 (V617F) probably occurs as a secondary genetic event in the background of preexisting clonal hematopoiesis.

    13. Hepatobiliary Disease
      You have free access to this content
      Thrombocytopenia as a surrogate for cirrhosis and a marker for the identification of patients at high-risk for hepatocellular carcinoma (pages 2212–2222)

      Sheng-Nan Lu, Jing-Houng Wang, Shiann-Long Liu, Chao-Hung Hung, Chien-Hung Chen, Hung-Da Tung, Tsung-Ming Chen, Wu-Shiung Huang, Chuan-Mo Lee, Chia-Cheng Chen and Chi-Sin Changchien

      Version of Record online: 3 OCT 2006 | DOI: 10.1002/cncr.22242

      • original image
      • original image
      • original image
      • original image
      • original image

      Thrombocytopenia is a valid surrogate of cirrhosis and is a marker for the identification of high-risk patients with hepatocellular carcinoma, especially in areas with prevalent high hepatitis C virus infection.

    14. Neuro-Oncology
      You have free access to this content
      Capillary physiology of human medulloblastoma : Impact on chemotherapy (pages 2223–2227)

      Peter C. Warnke, Klaus Kopitzki, Jens Timmer and Christoph B. Ostertag

      Version of Record online: 22 SEP 2006 | DOI: 10.1002/cncr.22212

      • original image

      Advances in the treatment of medulloblastoma have largely been attributed to the introduction of chemotherapy, although Phase III trials have shown advantages for chemotherapy only in subgroups. Because the efficacy of chemotherapy depends on tumor vascularization, the vascular physiology of human medulloblastomas was evaluated.

    15. You have free access to this content
      Focal and craniospinal irradiation for patients with intracranial germinoma and patterns of failure (pages 2228–2236)

      Quynh-Nhu Nguyen, Eric L. Chang, Pamela K. Allen, Moshe H. Maor, Joann L. Ater, Anita Mahajan, Johannes E. A. Wolff, Jeffrey S. Weinberg and Shiao Y. Woo

      Version of Record online: 3 OCT 2006 | DOI: 10.1002/cncr.22246

      • original image
      • original image

      The objective of this study was to compare the patterns of failure in patients with central nervous system germinomas who received either chemotherapy and focal irradiation or craniospinal irradiation therapy alone. The results indicated that focal irradiation with chemotherapy may be associated with increased rates of failure in the brain and spine.

    16. Sarcoma
      You have free access to this content
      Correlation of immunophenotype with progression-free survival in patients with gastrointestinal stromal tumors treated with imatinib mesylate (pages 2237–2244)

      Lucian R. Chirieac, Jonathan C. Trent, Dejka M. Steinert, Haesun Choi, Ying Yang, Jiexin Zhang, Shreyaskumar R. Patel, Robert S. Benjamin and A. Kevin Raymond

      Version of Record online: 22 SEP 2006 | DOI: 10.1002/cncr.22226

      • original image
      • original image
      • original image

      Patients with advanced gastrointestinal stromal tumors (GISTs) benefit from therapy with imatinib mesylate (IM) regardless of the level of KIT expression or the presence of CD34, smooth muscle actin, desmin, or S-100 protein as determined by immunohistochemistry. Therefore, GIST patients should not be denied therapy with IM due to weak KIT expression.

    17. Discipline

      Epidemiology
      You have free access to this content
      Promoter polymorphism (−786t>C) in the endothelial nitric oxide synthase gene is associated with risk of sporadic breast cancer in non-Hispanic white women age younger than 55 years (pages 2245–2253)

      Jiachun Lu, Qingyi Wei, Melissa L. Bondy, Tse-Kuan Yu, Donghui Li, Abenaa Brewster, Sanjay Shete, Aysegul Sahin, Funda Meric-Bernstam and Li-E. Wang

      Version of Record online: 24 OCT 2006 | DOI: 10.1002/cncr.22269

      Nitric oxide (NO) is constitutively synthesized in the endothelium by endothelial nitric oxide synthase (eNOS) and acts as a pleiotropic regulator involved in carcinogenesis. Most breast cancers develop from mammary epithelial cells and therefore NO may play a role in their development. It was hypothesized that eNOS polymorphisms are associated with risk of breast cancer.

    18. Medical Oncology
      You have free access to this content
      Improved tolerability and quality of life with maintained efficacy using twice-daily low-dose interferon-α-2b : Results of a randomized phase II trial of low-dose versus intermediate-dose interferon-α-2b in patients with metastatic renal cell carcinoma (pages 2254–2261)

      Nizar M. Tannir, Lorenzo Cohen, Xuemei Wang, Peter Thall, Paul F. Mathew, Eric Jonasch, Arlene Siefker-Radtke, Lance C. Pagliaro, Chaan S. Ng and Christopher Logothetis

      Version of Record online: 6 OCT 2006 | DOI: 10.1002/cncr.22253

      • original image

      In a randomized Phase II trial conducted in 118 patients with metastatic renal cell cancer, it was shown that interferon-alpha-2b at a dose of 0.5 million units (MU) twice daily is neither more nor less effective but is less toxic with a better reported quality of life compared with interferon-α-2b at a dose of 5 MU daily. The results may have implications for the design of combination regimens incorporating interferon-α with targeted agents.

    19. Pathology
      You have free access to this content
      Extrapulmonary small cell cancer : A Canadian province's experience (pages 2262–2269)

      Kamal Haider, Rabia K. Shahid, Daygen Finch, Amer Sami, Imran Ahmad, Sunil Yadav, Riaz Alvi, David Popkin and Shahid Ahmed

      Version of Record online: 22 SEP 2006 | DOI: 10.1002/cncr.22235

      • original image
      • original image

      Extrapulmonary small cell carcinoma is a rare and distinct clinicopathologic entity. It affects various anatomic sites, and the prognosis for patients with extrapulmonary small cell carcinoma varies according to the primary disease site. In this study, the authors determined that an abnormal white blood cell count, a poor performance status, and the extent of disease were important factors in predicting survival.

    20. You have free access to this content
      Cost savings associated with the use of fine-needle aspiration biopsy (FNAB) for the diagnosis of palpable masses in a community hospital-based FNAB clinic (pages 2270–2281)

      Barbara D. Florentine, Barry Staymates, Munif Rabadi, Nayibe Sarda, John Barstis and Alexander Black

      Version of Record online: 6 OCT 2006 | DOI: 10.1002/cncr.22234

      • original image
      • original image

      Community-based specialty fine-needle aspiration biopsy clinic services provided accurate diagnoses of palpable masses, spared patients surgery, and cost approximately 80% less than open diagnostic surgical biopsy.

    21. You have free access to this content
      Virologic, hematologic, and immunologic risk factors for classic Kaposi sarcoma (pages 2282–2290)

      Elizabeth E. Brown, Denise Whitby, Francesco Vitale, Vickie Marshall, Georgina Mbisa, Christine Gamache, Carmela Lauria, Anthony J. Alberg, Diego Serraino, Paola Cordiali-Fei, Angelo Messina and James J. Goedert

      Version of Record online: 22 SEP 2006 | DOI: 10.1002/cncr.22236

      • original image
      • original image

      Classic Kaposi sarcoma (CKS) is an inflammatory-mediated neoplasm that develops in the presence of KS-associated herpesvirus (KSHV) and immune perturbation. Using a case–control approach, the findings of the current study appear to corroborate the specificity of KSHV dysregulation and highlight the hematologic and immunologic correlates involved in CKS pathogenesis, including markers of immune activation and suppression.

    22. Pediatric Oncology
      You have free access to this content
      Phase II study of oxaliplatin in children with recurrent or refractory medulloblastoma, supratentorial primitive neuroectodermal tumors, and atypical teratoid rhabdoid tumors : A pediatric brain tumor consortium study (pages 2291–2297)

      Maryam Fouladi, Susan M. Blaney, Tina Young Poussaint, Burgess B. Freeman III, Roger McLendon, Christine Fuller, Adekunle M. Adesina, Michael L. Hancock, Mary K. Danks, Clinton Stewart, James M. Boyett and Amar Gajjar

      Version of Record online: 3 OCT 2006 | DOI: 10.1002/cncr.22241

      • original image

      The current Phase II study of oxaliplatin in children with recurrent or refractory medulloblastoma (MB), supratentorial primitive neuroectodermal tumors (SPNET), and atypical teratoid rhabdoid tumor (ATRT) demonstrated that oxaliplatin was relatively well tolerated in children at 130 mg/m2/dose every 3 weeks, with myelosuppression and sensory neuropathy as the main Grade 3 and 4 toxicities. However, oxaliplatin had limited activity in children with recurrent central nervous system embryonal tumors previously treated with platinum compounds.

    23. You have free access to this content
      Ovarian small cell carcinoma of the hypercalcemic type in children and adolescents : A prognostically unfavorable but curable disease (pages 2298–2306)

      Felix Distelmaier, Gabriele Calaminus, Dieter Harms, Ronald Sträter, Uwe Kordes, Gudrun Fleischhack, Ulrich Göbel and Dominik T. Schneider

      Version of Record online: 22 SEP 2006 | DOI: 10.1002/cncr.22213

      • original image

      Ovarian small cell carcinoma of the hypercalcemic type constitutes a rare tumor entity that is considered to be associated with an almost invariably fatal outcome. Based on the analysis of 11 patients and a comprehensive review of the current literature, the authors propose an innovative concept for the treatment of ovarian small cell carcinoma that incorporates conservative surgical tumor resection, cisplatin-based chemotherapy, and consolidating high-dose chemotherapy and that resulted in continuous complete remission in 5 of 11 patients.

    24. Translational Research
      You have free access to this content
      Identification of high-grade cervical dysplasia by the detection of p16INK4a in cell lysates obtained from cervical samples (pages 2307–2313)

      Nicolas Wentzensen, Monika Hampl, Matthias Herkert, Anja Reichert, Marcus J. Trunk, Christopher Poremba, Ruediger Ridder and Magnus von Knebel Doeberitz

      Version of Record online: 6 OCT 2006 | DOI: 10.1002/cncr.22247

      • original image
      • original image

      The p16INK4a protein is up-regulated strongly in high-grade lesions of the uterine cervix. In this study, a novel p16INK4a enzyme-linked immunosorbent assay showed high sensitivity for detecting high-grade cervical lesions in a disease-enriched population.

  3. Errata

    1. Top of page
    2. Review Articles
    3. Original Articles
    4. Errata
    1. You have free access to this content
    2. You have free access to this content
    3. You have free access to this content
    4. You have free access to this content

SEARCH

SEARCH BY CITATION