You have free access to this content

Cancer Cytopathology

Cover image for Cancer Cytopathology

25 April 2006

Volume 108, Issue 2

Pages 77–136

Currently known as: Cancer Cytopathology

  1. Original Articles

    1. Top of page
    2. Original Articles
    3. Correspondence
    1. Gynecologic Cytopathology

      You have free access to this content
      Cellular features of endometrial hyperplasia and well differentiated adenocarcinoma using the Endocyte sampler : Diagnostic criteria based on the cytoarchitecture of tissue fragments (pages 77–85)

      Yoshiaki Norimatsu, Keiko Shimizu, Tadao K. Kobayashi, Takuya Moriya, Choutatsu Tsukayama, Yasuyuki Miyake and Eiji Ohno

      Version of Record online: 6 FEB 2006 | DOI: 10.1002/cncr.21734

      • original image
      • original image
      • original image
      • original image
      • original image

      Because cellular atypia is often limited in endometrial hyperplasia and well-differentiated endometrial adenocarcinoma (WHO Grade 1 adenocarcinoma), diagnostic criteria for endometrial cytology have not been fully established. New diagnostic criteria based on the composition and architecture of tissue fragments (cytoarchitecture) in the smears were used in the present study. Cytologic features are of less importance because the distinction between endometrial hyperplasia and Grade 1 adenocarcinoma relies more on architectural features than cellular changes. Cell clumps of various size are usually collected abundantly with cytologic material using a disposable scraping device and it was noticed that those cell clumps reflected the histologic architecture. The purpose of the current study was to determine the form of the cytoarchitecture that reflects the histologic structure and to examine the cellular features in endometrial hyperplasia and Grade 1 adenocarcinoma.

    2. Non-Gynecologic Cytopathology

      You have free access to this content
      Cytopathologic features of olfactory neuroblastoma (pages 86–92)

      Sepi Mahooti and Paul E. Wakely Jr.

      Version of Record online: 2 FEB 2006 | DOI: 10.1002/cncr.21718

      • original image
      • original image
      • original image
      • original image

      The cytopathology of metastatic olfactory neuroblastoma (ONB) is nonspecific unless fibrillar neuropil is identified. Nonetheless, a cytopathologic diagnosis of metastatic ONB can be made with confidence in nearly all patients with a well documented history of ONB. Minus such a clinical context, metastatic ONB can be mistaken for malignant small round cell tumors such as small cell neuroendocrine carcinoma, Merkel cell carcinoma, and small cell non-Hodgkin lymphoma.

    3. Fine-Needle Aspiration

      You have free access to this content
      Probabilistic reporting of EUS-FNA cytology : Toward improved communication and better clinical decisions (pages 93–101)

      Isam A. Eltoum, Victor K. Chen, David C. Chhieng, Darshana Jhala, Nirag C. Jhala, Ralph Crowe, Shyam Varadarajulu and Mohamad A. Eloubeidi

      Version of Record online: 27 JAN 2006 | DOI: 10.1002/cncr.21719

      • original image
      • original image
      • original image
      • original image

      This article presents the first study of its kind to assess probabilistic reporting and threshold modeling of clinical decisions in cytodiagnosis.

    4. You have free access to this content
      Fine-needle aspiration biopsy of Hurthle cell lesions of the thyroid gland : A cytomorphologic study of 139 cases with statistical analysis (pages 102–109)

      Danielle D. Elliott, Martha B. Pitman, Leonard Bloom and William C. Faquin

      Version of Record online: 1 FEB 2006 | DOI: 10.1002/cncr.21716

      • original image
      • original image
      • original image
      • original image

      In this study, 139 fine-needle aspiration biopsies of Hurthle cell lesions of the thyroid gland were evaluated using morphology and statistical analysis. Four cytologic features were found to be helpful in the distinction between neoplastic and nonneoplastic nodules: nonmacrofollicular architecture, absence of background colloid, absence of chronic inflammation, and transgressing blood vessels.

    5. You have free access to this content
      The value of onsite adequacy assessment of thyroid fine-needle aspirations is a function of operator experience (pages 110–113)

      Mohiedean Ghofrani, Danita Beckman and David L. Rimm

      Version of Record online: 6 JAN 2006 | DOI: 10.1002/cncr.21715

      Review of thyroid fine-needle aspiration (FNA) samples has suggested that onsite assessment decreases the inadequacy rate, independent of the modality used (palpable vs. ultrasound-guided). However, experienced FNA operators using ultrasound demonstrate low inadequacy rates, even without onsite assessment.

    6. Immunocytochemistry

      You have free access to this content
      Immunocytochemical detection using CDX2 : An aid for discerning tumor involvement in ascites cytology (pages 114–118)

      Masako Kobayashi, Yuji Ueyama, Hayao Nakanishi, Hiroji Ishida, Emiko Takahashi, Shigeo Nakamura, Takashi Koshikawa and Yasushi Yatabe

      Version of Record online: 15 MAR 2006 | DOI: 10.1002/cncr.21840

      • original image
      • original image

      CDX2 immunostaining can serve as a specific and sensitive marker to detect gastrointestinal and pancreatic malignancies in ascites cytology.

    7. Immunocytopathology

      You have free access to this content
      Role of P16(INK4a) expression in identifying CIN2 or more severe lesions among HPV-positive patients referred for colposcopy after abnormal cytology (pages 119–123)

      Francesca Carozzi, Silvia Cecchini, Massimo Confortini, Virginia Becattini, Marcia Paola Cariaggi, Giovanni Pontenani, Cristina Sani and Stefano Ciatto

      Version of Record online: 12 JAN 2006 | DOI: 10.1002/cncr.21713

      Triage by HPV and p16 improves considerably the positive predictive value of diagnostic assessment but decreases > CIN2 detection rate and is associated with substantially higher costs.

    8. You have free access to this content
      The utility of GLUT-1 immunolocalization in cell blocks : An adjunct to the fine needle aspiration diagnosis of cystic squamous lesions of the head and neck (pages 124–128)

      Vishal. S. Chandan, William C. Faquin, David C. Wilbur and Kamal K. Khurana

      Version of Record online: 24 JAN 2006 | DOI: 10.1002/cncr.21714

      • original image
      • original image
      • original image

      Cytologic distinction of metastatic cystic squamous cell carcinoma (SCC) from benign squamous cell lesions can be diagnostically challenging. This study shows that GLUT-1 immunostaining is a useful adjunct in differentiating benign and malignant squamous lesions in cell-block material.

    9. Molecular Diagnostics

      You have free access to this content
      Methylation of RAS association domain family protein 1A as a biomarker of lung cancer (pages 129–134)

      Hans Juergen Grote, Viola Schmiemann, Helene Geddert, Alfred Bocking, Rainer Kappes, Helmut Erich Gabbert and Mario Sarbia

      Version of Record online: 27 JAN 2006 | DOI: 10.1002/cncr.21717

      • original image
      • original image

      Bronchial aspirates of patients with suspected lung cancer were investigated for the methylation status of the promoter region of RASSF1A by using a methylation-specific real-time PCR. RASSF1A hypermethylation appeared to be a useful biomarker for distinguishing patients with lung cancer from those with nonneoplastic lung disease.

  2. Correspondence

    1. Top of page
    2. Original Articles
    3. Correspondence
    1. You have free access to this content
    2. You have free access to this content
      Author reply (page 136)

      Yun Gong, Teresa Joseph and Nour Sneige

      Version of Record online: 6 JAN 2006 | DOI: 10.1002/cncr.21736

SEARCH

SEARCH BY CITATION