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Cancer Cytopathology

Cover image for Cancer Cytopathology

25 June 2006

Volume 108, Issue 3

Pages 137–204

Currently known as: Cancer Cytopathology

  1. Original Articles

    1. Top of page
    2. Original Articles
    1. Gynecologic Cytopathology

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      The PapSpin: A reasonable alternative to other, more expensive liquid-based papanicolaou tests (pages 137–143)

      Dorothy L. Rosenthal, Susan Geddes, Cornelia L. Trimble, Kathryn A. Carson and Patricia M. Alli

      Article first published online: 20 APR 2006 | DOI: 10.1002/cncr.21843

      The PapSpin is a legitimate and inexpensive alternative to the conventional Papanicolaou smear for the detection of cervical intraepithelial neoplasia and resulted in better preservation and improved cell detection in the current study. The liquid residual enables human papillomavirus-DNA or polymerase chain reaction testing, allowing small and medium-sized laboratories to offer this capability to their patients.

    2. Non-Gynecologic Cytopathology

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      Comparison of ThinPrep and cytospin preparations in the evaluation of exfoliative cytology specimens (pages 144–149)

      Tarik M. Elsheikh, Joseph L. Kirkpatrick and Howard H. Wu

      Article first published online: 20 MAR 2006 | DOI: 10.1002/cncr.21841

      ThinPrep is superior to conventional cytospins in the evaluation of nongynecologic exfoliative cytology specimens. In selected suspicious cases, however, the application of both methods may maximize the diagnostic yield.

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      Core imprint cytology of screen-detected breast lesions is predictive of the histologic results (pages 150–156)

      Gelareh Farshid and Steve Pieterse

      Article first published online: 21 APR 2006 | DOI: 10.1002/cncr.21939

      Review of core imprint cytology of 567 screen-detected breast lesions shows sensitivity and specificity exceeding 80% with a positive predictive value of 98.2% and a negative predictive value of 77.8%. Overall, 40% of malignant cores had immediate positive imprint results.

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      Detection of malignant hematopoietic cells in cerebral spinal fluid previously diagnosed as atypical or suspicious (pages 157–162)

      Malcolm Schinstine, Armando C. Filie, Wyndham Wilson, Maryalice Stetler-Stevenson and Andrea Abati

      Article first published online: 28 APR 2006 | DOI: 10.1002/cncr.21915

      A diagnosis of cerebrospinal fluid (CSF) malignancy will eventually be rendered by the 1-year mark in approximately 59% of patients with a previously known diagnosis of a hematopoietic malignancy and a CSF cytology initially diagnosed as “atypical” or “suspicious.” The combination of flow cytometry and cytology leads to a more expedient recognition of a malignant cellular population.

    5. Fine Needle Aspiration

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      Intraductal papillary mucinous neoplasm of the pancreas : Cytologic features predict histologic grade (pages 163–173)

      Paul J. Michaels, Elena F. Brachtel, Brenna C. Bounds, William R. Brugge and Martha Bishop Pitman

      Article first published online: 20 MAR 2006 | DOI: 10.1002/cncr.21838

      Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is increasingly encountered on endoscopic ultrasound-guided fine-needle aspiration biopsy. Analysis of 34 specimens from 25 patients with histologically confirmed IPMNs revealed cytologic features that correlated with histologic grade.

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      Diagnostic accuracy of follicular variant of papillary thyroid carcinoma in fine-needle aspirates processed by ultrafast Papanicolaou stain : Histologic follow-up of 125 cases (pages 174–179)

      Grace C. H. Yang, Doreen Liebeskind and Albert V. Messina

      Article first published online: 15 MAR 2006 | DOI: 10.1002/cncr.21837

      Over a 11-year period, 125 histologic follow-ups were available for fine-needle aspirations reported as suspicious for follicular variant (FV) of papillary carcinoma (PC), based on follicles with “grape-like” watery clear nuclei in Ultrafast Papanicolaou stain. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy in the detection of PC were 93.6%, 94.9%, 93.6%, 94.9%, and 94.3%, respectively, when follicular adenomas containing atypical nuclei were counted as encapsulated FVPC; and were 92.6%, 85.6%, 80%, 94.9%, and 88.3%, respectively, when follicular adenomas containing atypical nuclei were counted as benign.

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      Fine-needle aspiration biopsy of hepatic lesions : Computerized tomographic-guided versus endoscopic ultrasound-guided FNA (pages 180–185)

      D. Ralph Crowe, Mohamad A. Eloubeidi, David C. Chhieng, Nirag C. Jhala, Darshana Jhala and Isam A. Eltoum

      Article first published online: 21 APR 2006 | DOI: 10.1002/cncr.21912

      Early experience with endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) of liver lesions shows it comparable to traditional computerized tomographic (CT)-guided FNA, while conferring several advantages and some disadvantages. Recognition of gut epithelial cells—frequently present in EUS-FNA specimens—will avoid a significant potential pitfall of the new technique.

    8. Immunocytochemistry

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      Diagnostic utility of mucin profile in fine-needle aspiration specimens of the pancreas : An immunohistochemical study with surgical pathology correlation (pages 186–197)

      Tamar A. Giorgadze, Heather Peterman, Zubair W. Baloch, Emma E. Furth, Theresa Pasha, Natsuko Shiina, Paul J. Zhang and Prabodh K. Gupta

      Article first published online: 20 APR 2006 | DOI: 10.1002/cncr.21913

      The diagnostic utility of a panel of 4 mucin markers (MUC1, 2, 5AC, and 6) on the cell block preparations of the endoscopic ultrasound-guided fine-needle aspirations (EUS-FNA) and follow-up surgical pathology specimens of different pancreatic lesions was evaluated. This immunohistochemical panel is useful in the diagnosis of pancreatic ductal adenocarcinoma, as well as in differentiating inadvertently sampled normal/reactive duodenal and gastric epithelium from neoplastic pancreatic tissue and perhaps subclassifying pancreatic neoplasms in the EUS-FNA specimens.

    9. Molecular Diagnostics

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      FISH detection of t(14;18) in follicular lymphoma on Papanicolaou-stained archival cytology slides (pages 198–204)

      Jeffrey Richmond, Ronald Bryant, Winifred Trotman, Barbara Beatty and John Lunde

      Article first published online: 2 MAY 2006 | DOI: 10.1002/cncr.21917

      The authors proposed the use of fluorescence in situ hybridization (FISH) for detection of t(14;18)(q32;q21)in follicular lymphoma (FL) using Papanicolaou-stained archival cytology material. Among 60 cases including a variety of small B-cell non-Hodgkin lymphomas and reactive lymph nodes, FISH was 81% sensitive and 100% specific for FL. This practical technique will allow cytopathology and molecular diagnostic laboratories to utilize previously stained cytology slides for FISH evaluation.

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