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Cancer Cytopathology

Cover image for Cancer Cytopathology

25 October 2006

Volume 108, Issue 5

Pages 271–336

Currently known as: Cancer Cytopathology

  1. Original Articles

    1. Top of page
    2. Original Articles
    1. Gynecologic Cytopathology

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      Applicability of the Bethesda System 2001 to a public health setting (pages 271–276)

      Sonia Prandi, Donatella Beccati, Graziella De Aloysio, Patrizia Fulgenzi, Marzio Gabrielli, Carla Ghirardini, Francesco Rivasi, Luca Saragoni, Priscilla Sassoli de Bianchi and Lauro Bucchi

      Article first published online: 31 AUG 2006 | DOI: 10.1002/cncr.22167

      In the current multicenter study from northern Italy, the Bethesda System 2001 (TBS 2001) showed no adverse effect on major feasibility parameters of an organized, population-based screening program. TBS 2001 is applicable to a public health setting.

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      The significance of “low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion” as a distinct squamous abnormality category in Papanicolaou tests (pages 277–281)

      Tarik M. Elsheikh, Joseph L. Kirkpatrick and Howard H. Wu

      Article first published online: 25 AUG 2006 | DOI: 10.1002/cncr.22169

      The results of this study indicated that a cytologic diagnosis of low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion (LSIL-H) had an intermediate risk of harboring histopathologic high-grade squamous intraepithelial lesion (HSIL) or worse. This risk was similar to that for atypical squamous cells, cannot exclude HSIL but fell between the low risk of atypical squamous cells of undermined significance and LSIL and the high risk of HSIL. The authors concluded that LSIL-H should be considered a cytologic diagnostic category that is separate from LSIL and HSIL.

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      Clinical implications of the diagnosis “atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion” in pregnant women (pages 282–287)

      Kazuya Onuma, Reda S. Saad, Amal Kanbour-Shakir, Anisa I. Kanbour and David J. Dabbs

      Article first published online: 21 SEP 2006 | DOI: 10.1002/cncr.22170

      The results of this study demonstrated a lower predictive value of the diagnosis of atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H) for an underlying squamous intraepithelial lesion in pregnant women compared with the general population, reflecting a more difficult interpretation of ASC-H in pregnancy. High-risk human papillomavirus (HPV) testing appeared to be useful for ruling out an underlying high-grade squamous intraepithelial lesion (HSIL). More conservative management with an adjunctive HPV testing may be reasonable for ASC-H in pregnant women.

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      Comparison of human papillomavirus distribution in cytologic subgroups of low-grade squamous intraepithelial lesion (pages 288–297)

      Rosemary E. Zuna, Sophia S. Wang, Mark Schiffman, Diane Solomon and for the Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesion Triage Study Group

      Article first published online: 1 SEP 2006 | DOI: 10.1002/cncr.22168

      Human papillomavirus (HPV) cellular changes and Grade 1 cervical intraepithelial neoplasia (CIN1) are morphologic patterns that jointly define low-grade squamous intraepithelial lesion (LSIL) in the Bethesda System terminology. In a comparison of the distribution of HPV types in these 2 morphologic patterns among patients in the in Atypical Squamous Cells of Unknown Significance/Low-Grade Squamous Intraepithelial Lesion Triage Study, subtle differences with considerable overlap were observed, justifying their combination as LSIL.

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      Cervical cytology of atypical squamous cells–cannot exclude high-grade squamous intraepithelial lesion (ASC-H) : Characteristics and histologic outcomes (pages 298–305)

      Mark E. Sherman, Philip E. Castle, Diane Solomon and The ASCUS LSIL Triage Group

      Article first published online: 16 MAR 2006 | DOI: 10.1002/cncr.21844

      Analysis of 2 years of follow-up demonstrated that positive human papillomavirus (HPV) tests and diagnoses of cervical intraepithelial neoplasia (CIN) 2a and CIN3a were more common among women with atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion compared with atypical squamous cells of undetermined significance, but the highest frequencies were found to be associated with high-grade squamous intraepithelial lesion. Women with atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion age 35 years or older were significantly less likely to test positive for HPV compared with younger women.

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      Correlation of cytotechnologists' parameters with their performance in rapid prescreening of papanicolaou smears (pages 306–310)

      Amina Djemli, Karim Khetani, Bruce W. Case and Manon Auger

      Article first published online: 31 AUG 2006 | DOI: 10.1002/cncr.22166

      The performance of individual screeners with the rapid prescreening (RPS) method was evaluated in a study involving 12 cytotechnologists and 8364 Papanicolaou smears. Although there was considerable variability in the sensitivity of the individual screeners in RPS, there was no correlation of their sensitivity in RPS with either their sensitivity in full screening or their years of experience as cytotechnologists.

    7. Fine-Needle Aspiration

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      Fine-needle aspiration biopsy of non-Hodgkin lymphoma for use in expression microarray analysis (pages 311–318)

      Carl Morrison, Jeff Palatini, Judy Riggenbach, Michael Radmacher and Pierluigi Porcu

      Article first published online: 30 AUG 2006 | DOI: 10.1002/cncr.22174

      The gene expression profiles from patients with non-Hodgkin lymphoma derived from material acquired by fine-needle aspiration (FNA) biopsy were comparable to the results obtained from surgically excised specimens. RNA isolated from FNA biopsy of lymph nodes that was collected in Trizol was superior both quantitatively and qualitatively to that collected using an RNA stabilization reagent.

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      Grading follicular lymphomas in fine-needle aspiration biopsies : The role of ThinPrep slides and flow cytometry (pages 319–323)

      Guilherme D.A. Brandao, Ruth Rose, Susan Mckenzie, Peter Maslak and Oscar Lin

      Article first published online: 25 AUG 2006 | DOI: 10.1002/cncr.22173

      Follicular lymphomas are graded according to the number of centroblasts/high-power field. In the current study, the feasibility of grading follicular lymphomas (FLs) using ThinPrep (TP) slides and flow cytometry studies was evaluated. Counting centroblasts, either in 300 lymphoid cells or per 10 high-power microscopic fields (HPFs) in TP slides, represented a statistically significant method to separate different grades of FL in fine-needle aspiration (FNA) samples. Analysis of cell size by flow cytometry was not as reliable in distinguishing different grades of FL, especially Grade 2 from 3.

    9. Immunocytochemistry

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      Validation of a novel immunocytochemical assay for topoisomerase II-α and minichromosome maintenance protein 2 expression in cervical cytology (pages 324–330)

      Kenneth R. Shroyer, Petra Homer, David Heinz and Meenakshi Singh

      Article first published online: 25 AUG 2006 | DOI: 10.1002/cncr.22171

      Cervical cytopathology has limited specificity for the detection of underlying clinically significant lesions in cases with low-grade cytologic abnormalities. The current study evaluated the performance of a novel immunocytochemical test (ProEx C) for topoisomerase II alpha (TOP2A) and minichromosome maintenance protein 2 (MCM2) in normal versus high-grade squamous intraepithelial lesion (HSIL) and positive control (SiHa) pooled cytology preparations and in a pilot series of prospectively collected patient specimens.

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      The role of immunolocalization of CD57 and GLUT-1 in cell blocks in fine-needle aspiration diagnosis of papillary thyroid carcinoma (pages 331–336)

      Vishal S. Chandan, William C. Faquin, David C. Wilbur and Kamal K. Khurana

      Article first published online: 30 AUG 2006 | DOI: 10.1002/cncr.22172

      Cytologic diagnosis of papillary carcinoma of the thyroid can sometimes be diagnostically challenging. The results of the current study demonstrate that CD57 immunostaining is a useful adjunct in equivocal cases using cell block material.

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