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Cancer

Cover image for Cancer

15 May 2007

Volume 109, Issue 10

Pages 1929–2155

  1. Commentary

    1. Top of page
    2. Commentary
    3. Original Articles
    4. Erratum
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  2. Original Articles

    1. Top of page
    2. Commentary
    3. Original Articles
    4. Erratum
    1. Disease Site

      Breast Disease
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      Elevated plasma tissue inhibitor of metalloproteinase-1 level predicts decreased response and survival in metastatic breast cancer (pages 1933–1939)

      Allan Lipton, Suhail M. Ali, Kim Leitzel, Laurence Demers, Dean B. Evans, Peter Hamer, Sheryl Brown-Shimer, Karen Pierce and Walter Carney

      Article first published online: 3 APR 2007 | DOI: 10.1002/cncr.22637

      Pretreatment plasma tissue inhibitor of metalloproteinase-1 (TIMP-1) was assayed from 251 patients who were enrolled in a Phase III, second-line, hormone therapy trial and from a control group of 50postmenopausal women by using the TIMP-1 enzyme-linked immunosorbent assay. Elevated pretreatment plasma TIMP-1 levels predicted decreased response to second-line hormone therapy and reduced survival and remained an independent prognostic factor for reduced survival in multivariate analysis.

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      Age-specific association of steroid hormone pathway gene polymorphisms with breast cancer risk (pages 1940–1948)

      David A. Ralph, Lue Ping Zhao, Christopher E. Aston, Sharmila Manjeshwar, Thomas W. Pugh, Daniele C. DeFreese, Bobby A. Gramling, Craig D. Shimasaki and Eldon R. Jupe

      Article first published online: 13 APR 2007 | DOI: 10.1002/cncr.22634

      This investigation of steroid hormone pathway genes in a large case-control study resulted in the identification and confirmation of age-specific genetic associations with breast cancer risk for single nucleotide polymorphisms (SNPs) in 4 genes. Age-related associations with risk may have profound implications for the use of SNP genotyping to accurately predict breast cancer risk in women.

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      Randomized controlled trial comparing a low-fat diet with a weight-reduction diet in breast cancer-related lymphedema (pages 1949–1956)

      Clare Shaw, Peter Mortimer and Patricia A. Judd

      Article first published online: 28 MAR 2007 | DOI: 10.1002/cncr.22638

      An intervention study of weight reduction or a low-fat diet showed a significant correlation between weight loss and a reduction in excess arm volume. This suggests that weight reduction helps in the treatment of breast cancer-related lymphedema.

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      The safety of breast-conserving therapy in patients with breast cancer aged ≤40 years (pages 1957–1964)

      Marloes van der Leest, Lisette Evers, Maurice J. C. van der Sangen, Philip M. Poortmans, Lonneke V. van de Poll-Franse, Ans J. Vulto, Grard A. P. Nieuwenhuijzen, Stefan J. Brenninkmeijer, Geert-Jan Creemers and Adri C. Voogd

      Article first published online: 29 MAR 2007 | DOI: 10.1002/cncr.22639

      In a cohort of 758 patients with breast cancer aged ≤40 years who underwent breast-conserving therapy between 1988 and 2002, the 10-year actuarial risks of local recurrence and contralateral breast cancer were 17.9% and 9.6%, respectively. These risks were reduced by >50% in patients who received adjuvant systemic treatment.

    5. Endocrine Disease
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      Clinicopathologic features and BRAFV600E mutation analysis in cutaneous metastases from well-differentiated thyroid carcinomas (pages 1965–1971)

      Lori A. Erickson, Long Jin, Nobuki Nakamura, Alina G. Bridges, Svetomir N. Markovic and Ricardo V. Lloyd

      Article first published online: 26 MAR 2007 | DOI: 10.1002/cncr.22641

      Cutaneous metastases of well differentiated thyroid carcinomas are uncommon, but may show prominent clear cell change requiring differentiation from cutaneous clear cell tumors and from other metastases. These cutaneous metastases can show BRAFV600E mutation, occur at unusual sites, and are associated with very poor prognosis.

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      Increased cancer incidence after radioiodine treatment for hyperthyroidism (pages 1972–1979)

      Saara Metso, Anssi Auvinen, Heini Huhtala, Jorma Salmi, Heikki Oksala and Pia Jaatinen

      Article first published online: 28 MAR 2007 | DOI: 10.1002/cncr.22635

      Cancer incidence, especially cancer of the stomach, kidney, and breast, was increased in a Finnish cohort of 2793 hyperthyroid patients treated with radioactive iodine in 1965–2002.

    7. Gastrointestinal Disease
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      Efficient automated assessment of genetic abnormalities detected by fluorescence in situ hybridization on brush cytology in a Barrett esophagus surveillance population (pages 1980–1988)

      Agnieszka M. Rygiel, Jantine W. P. M. van Baal, Francesca Milano, Kenneth K. Wang, Febo J. ten Kate, Paul Fockens, Wilda D. Rosmolen, Jacques J. G. H. M. Bergman, Maikel P. Peppelenbosch and Kausilia K. Krishnadath

      Article first published online: 23 MAR 2007 | DOI: 10.1002/cncr.22643

      The feasibility of using automated DNA fluorescence in situ hybridization (FISH) analysis to evaluate genetic abnormalities in Barrett esophagus (BE) brush cytology samples was demonstrated. The automated FISH analysis demonstrated that loss of 17p13.1 loci, loss of chromosome Y, and polysomy of chromosomes 17 and 9 are promising markers that correlate with dysplasia grade in patients with BE.

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      The impact on survival of thromboembolic phenomena occurring before and during protocol chemotherapy in patients with advanced gastroesophageal adenocarcinoma (pages 1989–1995)

      Eric D. Tetzlaff, Arlene M. Correa, Jackie Baker, Joe Ensor and Jaffer A. Ajani

      Article first published online: 30 MAR 2007 | DOI: 10.1002/cncr.22626

      Thromboembolic events (TEEs) are considered common in patients with gastroesophageal carcinoma, but their frequency at baseline and during chemotherapy is not known. In this analysis of patients with advanced gastroesophageal carcinoma who were treated on 4 prospective chemotherapy trials, the results indicated that TEEs at baseline and/or during chemotherapy were frequent and resulted in poor overall survival for patients with advanced gastroesophageal carcinoma and that aggressive methods to treat or prevent TEEs are warranted.

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      XAF1 mediates apoptosis through an extracellular signal-regulated kinase pathway in colon cancer (pages 1996–2003)

      Li Fen Yu, Jide Wang, Bing Zou, Marie C. M. Lin, Yun Lin Wu, Harry H. X. Xia, Yun Wei Sun, Qing Gu, Hua He, S. K. Lam, Hsiang Fu Kung and Benjamin C. Y. Wong

      Article first published online: 23 MAR 2007 | DOI: 10.1002/cncr.22624

      XAF1 expression was up-regulated by inhibition of the ERK1/2 pathway through transcriptional regulation, which required de novo protein synthesis. The results suggest that XAF1 mediates apoptosis induced by the ERK1/2 pathway in colon cancer.

    10. Genitourinary Disease
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      Short- vs long-term androgen suppression plus external beam radiation therapy and survival in men of advanced age with node-negative high-risk adenocarcinoma of the prostate (pages 2004–2010)

      Anthony V. D'Amico, James W. Denham, Michel Bolla, Laurence Collette, David S. Lamb, Keen-Hun Tai, Allison Steigler and Ming-Hui Chen

      Article first published online: 30 MAR 2007 | DOI: 10.1002/cncr.22628

      After adjusting for known prognostic factors, the treatment of node-negative high-risk prostate cancer using 3 years as compared with 6 months of androgen suppression therapy with radiation therapy was not associated with prolonged survival in men of advanced age. The European Organization for Research and Treatment of Cancer randomized trial will help to answer whether unknown confounding factors have affected the results of the study.

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      Role of radiotherapy in ductal (endometrioid) carcinoma of the prostate (pages 2011–2015)

      Thomas N. Eade, Tahseen Al-Saleem, Eric M. Horwitz, Mark K. Buyyounouski, David Y.T. Chen and Alan Pollack

      Article first published online: 9 APR 2007 | DOI: 10.1002/cncr.22644

      Ductal carcinoma of the prostate may be treated effectively with external beam radiotherapy. Aggressive management is indicated, even with low-volume metastatic disease.

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      Heparin-binding epidermal growth factor-like growth factor isoforms and epidermal growth factor receptor/ErbB1 expression in bladder cancer and their relation to clinical outcome (pages 2016–2024)

      Christopher Kramer, Kai Klasmeyer, Hans Bojar, Wolfgang A. Schulz, Rolf Ackermann and Marc-Oliver Grimm

      Article first published online: 29 MAR 2007 | DOI: 10.1002/cncr.22627

      Immunohistochemical analysis of heparin-binding epidermal growth factor-like growth factor (HB-EGF) isoforms and epidermal growth factor receptor (EGFR) expression in 121 bladder cancers from patients treated with cystectomy with curative intent revealed that the prognostic value of EGFR overexpression depends critically on whether the membranous or the nuclear isoform of HB-EGF is expressed.

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      Renal cell carcinoma clinically involving adjacent organs : Experience with aggressive surgical management (pages 2025–2030)

      Vitaly Margulis, Ricardo F. Sánchez-Ortiz, Pheroze Tamboli, Daniel D. Cohen, David A. Swanson and Christopher G. Wood

      Article first published online: 9 APR 2007 | DOI: 10.1002/cncr.22629

      Historically, patients with nonmetastatic renal cell carcinoma (RCC) involving adjacent organs have been considered inoperable and incurable. The oncologic efficacy of an aggressive surgical approach was evaluated in a selected subpopulation of RCC patients. Further, an attempt was made to define the clinical and pathologic characteristics predictive of surgical failure.

    14. Gynecologic Oncology
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      Predictors of comprehensive surgical treatment in patients with ovarian cancer (pages 2031–2042)

      Barbara A. Goff, Barbara J. Matthews, Eric H. Larson, C. Holly A. Andrilla, Michelle Wynn, Denise M. Lishner and Laura-Mae Baldwin

      Article first published online: 9 APR 2007 | DOI: 10.1002/cncr.22604

      Comprehensive surgical care for women with ovarian cancer is independently associated with multiple factors, including age, race, payer, cancer stage, surgeon volume, and surgeon specialty. The results from this study indicated that many women with ovarian cancer, especially those in poor, elderly, or minority groups, are not receiving recommended comprehensive surgery.

    15. Head and Neck Disease
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      Multivariate prediction of the probability of recurrence in patients with carcinoma of the parotid gland (pages 2043–2051)

      José F. Carrillo, Rafael Vázquez, Margarita C. Ramírez-Ortega, Ana Cano, Francisco J. Ochoa-Carrillo and Luis F. Oñate-Ocaña

      Article first published online: 4 APR 2007 | DOI: 10.1002/cncr.22647

      In this report, the authors propose a definition of the probability of recurrence after treatment of parotid gland carcinoma. Three risk groups were defined based on clinical prognostic factors. This method may help in the design of the best treatment strategy for each patient.

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      The role of interstitial brachytherapy with salvage surgery for the management of recurrent head and neck cancers (pages 2052–2057)

      Michael E. Kupferman, William H. Morrison, Alfredo A. Santillan, Dianna Roberts, Eduardo M. Diaz Jr., Adam S. Garden and Randal Weber

      Article first published online: 3 APR 2007 | DOI: 10.1002/cncr.22648

      Regional lymph node recurrences of head and neck cancer after external beam radiation therapy are therapeutic dilemmas. Data from the current study suggest that salvage neck dissection with interstitial brachytherapy may provide durable regional control for recurrent carcinomas.

    17. Hematologic Malignancies
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      Proportion of long-term event-free survivors and lifetime of adult patients not cured after a standard acute lymphoblastic leukemia therapeutic program : Adult acute lymphoblastic leukemia-94 trial (pages 2058–2067)

      Quoc-Hung Le, Xavier Thomas, Reneé Ecochard, Jean Iwaz, Veéronique Lheéritier, Mauricette Michallet and Denis Fiere

      Article first published online: 3 APR 2007 | DOI: 10.1002/cncr.22632

      In the current study, the authors investigated the influence of different covariates on patient outcomes in the Adult Acute Lymphoblastic Leukemia-94 multicenter trial, which involved 922 adults with newly diagnosed acute lymphoblastic leukemia. Results were expressed in terms of the proportion of long-term disease-free survivors and in terms of the lifetime in patients who developed recurrent disease or died. These data highlight and specify the importance of some classic prognostic factors in acute lymphoblastic leukemia.

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      Imatinib compared with chemotherapy as front-line treatment of elderly patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) (pages 2068–2076)

      Oliver G. Ottmann, Barbara Wassmann, Heike Pfeifer, Aristoteles Giagounidis, Matthias Stelljes, Ulrich Dührsen, Marc Schmalzing, Lydia Wunderle, Anja Binckebanck and Dieter Hoelzer

      Article first published online: 11 APR 2007 | DOI: 10.1002/cncr.22631

      To assess the value of front-line imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia, 55 elderly patients (median age, 68 years) were randomly assigned to induction therapy with either imatinib (IndIM) or multiagent, age-adapted chemotherapy (Indchemo), followed by coadministration of imatinib and consolidation chemotherapy for all patients. Results of induction were significantly superior in patients randomly assigned to IndIM with a complete remission rate of 96% vs 50% (P = .0001) and a lower incidence of severe adverse events compared with Indchemo (39% vs 90%; P = .005), although this initial benefit did not translate into improved survival with subsequent combined imatinib and chemotherapy consolidation.

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      Introduction of rituximab in front-line and salvage therapies has improved outcome of advanced-stage follicular lymphoma patients (pages 2077–2082)

      Stefano Sacchi, Samantha Pozzi, Luigi Marcheselli, Alessia Bari, Stefano Luminari, Francesco Angrilli, Francesco Merli, Daniele Vallisa, Luca Baldini and Maura Brugiatelli

      Article first published online: 29 MAR 2007 | DOI: 10.1002/cncr.22649

      Failure-free survival and overall survival have significantly improved in advanced-stage follicular lymphoma patients treated on Gruppo Italiano Studio Linfomi (GISL) protocols during the last 18 years. These improvements are related to evolving therapies, particularly the introduction of rituximab in combination with chemotherapy.

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      Validation and comparison of contemporary prognostic models in primary myelofibrosis : Analysis based on 334 patients from a single institution (pages 2083–2088)

      Ayalew Tefferi, Jocelin Huang, Susan Schwager, Chin-Yang Li, Wenting Wu, Animesh Pardanani and Ruben A. Mesa

      Article first published online: 3 APR 2007 | DOI: 10.1002/cncr.22630

      The Mayo prognostic scoring system (PSS) for survival in primary myelofibrosis is an objective complete blood count-derived prognostic model that might be superior in its performance over that of both the Dupriez and Cervantes PSSs.

    21. Hepatobiliary Disease
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      Hepatic metastasectomy in children (pages 2089–2092)

      Wendy T. Su, Daniel N. Rutigliano, Maryam Gholizadeh, William R. Jarnagin, Leslie H. Blumgart and Michael P. La Quaglia

      Article first published online: 4 APR 2007 | DOI: 10.1002/cncr.22650

      Liver metastases are frequent in pediatric solid tumors. Hepatic metastasectomy in children is feasible, has low operative mortality and morbidity, and is associated with good local control.

    22. Discipline

      Cancer Disparities
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      Does having insurance affect differences in clinical presentation between Hispanic and non-Hispanic white women with breast cancer? (pages 2093–2099)

      A. Tyler Watlington, Tim Byers, Judy Mouchawar, Angela Sauaia and Jenn Ellis

      Article first published online: 9 APR 2007 | DOI: 10.1002/cncr.22640

      Differences in clinical presentation with breast cancer for Hispanic women compared with non-Hispanic white women persist despite membership in a comprehensive, equal-access health care system.

    23. Epidemiology
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      The burden of liver cancer in Asians and Pacific Islanders in the Greater San Francisco Bay Area, 1990 through 2004 (pages 2100–2108)

      Ellen T. Chang, Theresa H. M. Keegan, Scarlett L. Gomez, Gem M. Le, Christina A. Clarke, Samuel K. S. So and Sally L. Glaser

      Article first published online: 23 MAR 2007 | DOI: 10.1002/cncr.22642

      Between 1990 and 2004, the incidence rate of liver cancer in the Greater San Francisco Bay Area decreased in Chinese men, Japanese men, and Japanese women but remained high for Vietnamese, Korean, and Filipino men and women. Liver cancer continues to affect Asian/Pacific Islander Americans disproportionately, and consistently elevated incidence rates were observed in most subgroups.

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      Risk factors for malignancy in Japanese renal transplant recipients (pages 2109–2115)

      Tetsuya Imao, Naotsugu Ichimaru, Shiro Takahara, Yukito Kokado, Masayoshi Okumi, Ryoichi Imamura, Yukiomi Namba, Yoshitaka Isaka, Norio Nonomura and Akihiko Okuyama

      Article first published online: 3 APR 2007 | DOI: 10.1002/cncr.22636

      The results of multivariate analysis suggested that age at transplantation and the use of tacrolimus were independent risk factors for the development of malignancy in recipients of renal transplants.

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      Effect of familial history and smoking on common cancer risks in Japan (pages 2116–2123)

      Takeshi Suzuki, Keitaro Matsuo, Kenji Wakai, Akio Hiraki, Kaoru Hirose, Shigeki Sato, Ryuzo Ueda and Kazuo Tajima

      Article first published online: 4 APR 2007 | DOI: 10.1002/cncr.22685

      To determine genetic susceptibility for 14 common cancers, with a further emphasis on interactions with smoking, a large–scale case–control study of the impact of a family history of cancer in first-degree relatives was conducted. Excess risks with a family history for several cancers were shown.

    26. Pediatric Oncology
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      Intracystic bleomycin therapy for craniopharyngioma in children : The Canadian experience (pages 2124–2131)

      Juliette Hukin, Paul Steinbok, Lucie Lafay-Cousin, Glenda Hendson, Douglas Strother, Claude Mercier, Yvan Samson, William Howes and Eric Bouffet

      Article first published online: 3 APR 2007 | DOI: 10.1002/cncr.22633

      The standard therapy for childhood craniopharyngioma is associated with significant morbidity. The Canadian experience is reported using intracystic bleomycin therapy as a feasible and potentially effective therapy for at least delaying radiotherapy or aggressive surgery, particularly in the young child with large, mainly cystic, lesions.

    27. Translational Research
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      Epigenetic combination therapy as a tumor-selective treatment approach for hepatocellular carcinoma (pages 2132–2141)

      Sascha Venturelli, Sorin Armeanu, Anita Pathil, Chih-Jen Hsieh, Thomas S. Weiss, Reinhard Vonthein, Manfred Wehrmann, Michael Gregor, Ulrich M. Lauer and Michael Bitzer

      Article first published online: 3 APR 2007 | DOI: 10.1002/cncr.22652

      The combined treatment with 2 innovative epigenetic therapeutics, a histone deacetylase inhibitor and a DNA demethylating agent, was found to produce significant antitumor effects in human-derived hepatocellular carcinoma cell lines and in a xenograft hepatoma model. In contrast, this dual epigenetic approach showed no relevant cellular damage on primary human hepatocytes, even when applying high doses; therefore, it is now considered for further investigation in clinical trials.

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      Mechanisms of synthetic serine protease inhibitor (FUT-175)-mediated cell death (pages 2142–2153)

      Tadashi Uwagawa, Zhongkui Li, Zhe Chang, Qianghua Xia, Bailu Peng, Guido M. Sclabas, Satoshi Ishiyama, Mien-Chie Hung, Douglas B. Evans, James L. Abbruzzese and Paul J. Chiao

      Article first published online: 4 APR 2007 | DOI: 10.1002/cncr.22658

      FUT-175, a synthetic serine protease inhibitor, blocks IκBα phosphorylation and nuclear factor-κB (NF-κB) activation, thereby suppressing the antiapoptotic activity of NF-κB. Concurrently, FUT-175 up-regulates expression of PEA3, which in turn induces the expression of tumor necrosis factor receptor-1 (TNFR1) to provoke apoptosis. Taken together, these results suggest a possible mechanism by which FUT-175 may disrupt interconnected signaling pathways by both suppressing the NF-κB antiapoptotic activity and inducing TNFR-mediated apoptosis.

  3. Erratum

    1. Top of page
    2. Commentary
    3. Original Articles
    4. Erratum
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    2. You have free access to this content
      Erratum (page 2155)

      Article first published online: 26 MAR 2007 | DOI: 10.1002/cncr.22695

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