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Cancer

Cover image for Cancer

15 June 2007

Volume 109, Issue 12

Pages 2387–2625

  1. Commentary

    1. Top of page
    2. Commentary
    3. Review Articles
    4. Original Articles
    5. Correspondence
    6. Erratum
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      Moving forward with breast cancer prevention (pages 2387–2391)

      Wendy Y. Chen, Bernard Rosner and Graham A. Colditz

      Article first published online: 26 APR 2007 | DOI: 10.1002/cncr.22711

      Despite randomized controlled trial data supporting the use of selective estrogen receptor modulators (SERMs) to reduce the incidence of breast cancer, to the authors' knowledge uptake has been limited. Similar to cardiovascular risk models, the routine use of breast cancer risk prevention models in the clinical setting to identify those patients at highest risk of developing breast cancer can maximize the risk‒benefit ratio of SERMs and provide an impetus to move forward with implementing breast cancer prevention.

  2. Review Articles

    1. Top of page
    2. Commentary
    3. Review Articles
    4. Original Articles
    5. Correspondence
    6. Erratum
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      Manipulating the chemokine-chemokine receptor network to treat cancer (pages 2392–2404)

      Pier A. Ruffini, Paolo Morandi, Neslihan Cabioglu, Kadri Altundag and Massimo Cristofanilli

      Article first published online: 14 MAY 2007 | DOI: 10.1002/cncr.22706

      Human cancer cells are wired in a complex ‘chemokine-chemokine receptor’ network, which favors survival and metastatic spread and protects them from immune recognition. Therapeutic approaches interfering with this network have shown promise in preclinical models and clinical trials of these approaches have just begun.

  3. Original Articles

    1. Top of page
    2. Commentary
    3. Review Articles
    4. Original Articles
    5. Correspondence
    6. Erratum
    1. Disease Site

      Breast Disease
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      Reported drop in mammography : Is this cause for concern? (pages 2405–2409)

      Nancy Breen, Kathleen A. Cronin, Helen I. Meissner, Stephen H. Taplin, Florence K. Tangka, Jasmin A. Tiro and Timothy S. McNeel

      Article first published online: 14 MAY 2007 | DOI: 10.1002/cncr.22723

      After robust, rapid increases in reported use of mammography by women in the U.S. since 1987, estimates from the 2005 National Health Interview Survey showed a decline compared with 2000 (from 70% to 66%). Although it is small, this decline is cause for concern, because it signals a change in direction.

    2. Gastrointestinal Disease
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      The impact of chronic illnesses on the use and effectiveness of adjuvant chemotherapy for colon cancer (pages 2410–2419)

      Cary P. Gross, Gail J. McAvay, Zhenchao Guo and Mary E. Tinetti

      Article first published online: 17 MAY 2007 | DOI: 10.1002/cncr.22726

      Among older patients who underwent surgical resection for stage III colon cancer, the receipt of adjuvant therapy was related significantly to heart failure (36.2% vs 64.9% of patients with and without heart failure, respectively) and chronic obstructive pulmonary disease (COPD) (55.2% vs 61.5% of patients with and without COPD, respectively). The current results also indicated that these conditions adversely altered the risks and benefits of adjuvant therapy, suggesting that chronic conditions may affect patterns of cancer care in a manner that does not reflect their relation to clinical effectiveness.

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      Small bowel carcinoid (enterochromaffin cell) neoplasia exhibits transforming growth factor–β1-mediated regulatory abnormalities including up-regulation of C-Myc and MTA1 (pages 2420–2431)

      Mark Kidd, Irvin M. Modlin, Roswitha Pfragner, Geeta N. Eick, Manish C. Champaneria, Anthony K. Chan, Robert L. Camp and Shrikant M. Mane

      Article first published online: 27 APR 2007 | DOI: 10.1002/cncr.22725

      The neoplastic enterochromaffin cell is characterized by loss of transforming growth factor-β1 (TGFβ-1)-mediated growth inhibition and, similar to glioblastomas, utilizes the TGFβ system to induce gene responses associated with growth promotion (c-Myc and the ERK pathway), invasion (E-cadherin), and metastasis (MTA1).

    4. Genitourinary Disease
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      Clinical predictors of gleason score upgrading : Implications for patients considering watchful waiting, active surveillance, or brachytherapy (pages 2432–2438)

      Girish S. Kulkarni, Gina Lockwood, Andrew Evans, Ants Toi, John Trachtenberg, Michael A. S. Jewett, Antonio Finelli and Neil E. Fleshner

      Article first published online: 11 MAY 2007 | DOI: 10.1002/cncr.22712

      Patients with low-risk prostate cancer who have elevated PSA levels or who have had their prostate biopsy interpreted by a nonspecialist pathologist are at significantly higher risk of harboring occult high-grade disease and, thereby, potentially being undertreated. The authors present a nomogram (C statistic 0.71) that can help physicians risk-stratify patients with low-risk prostate cancer and subsequently facilitate appropriate treatment recommendations.

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      Redefining pT3 renal cell carcinoma in the modern era : A proposal for a revision of the current TNM primary tumor classification system (pages 2439–2444)

      Vitaly Margulis, Pheroze Tamboli, Surena F. Matin, Matthew Meisner, David A. Swanson and Christopher G. Wood

      Article first published online: 8 MAY 2007 | DOI: 10.1002/cncr.22713

      Survival analyses of 419 patients treated with nephrectomy for pT3N0/NxM0 renal cell carcinoma (RCC) demonstrated that the current primary tumor classification does not correlate with disease-specific outcome. Based on their data, the authors propose a clinically simple reclassification within the pT3 RCC staging category, which demonstrates significantly improved prognostic accuracy and retains its independent predictive value among prognostic factors shown to impact disease-specific outcome in RCC patients.

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      The quality of surgical pathology care for men undergoing radical prostatectomy in the U.S. (pages 2445–2453)

      David C. Miller, Benjamin A. Spencer, Rajal B. Shah, Jamie Ritchey, Andrew K. Stewart, E. Greer Gay, Rodney L. Dunn, John T. Wei and Mark S. Litwin

      Article first published online: 9 MAY 2007 | DOI: 10.1002/cncr.22698

      This report provides national data describing the completeness of pathology reporting for men who underwent radical prostatectomy for early-stage prostate cancer. Although the surgical pathology reports contained most of the recommended data elements, the frequent absence of pathologic stage identified an opportunity for quality improvement.

    7. Gynecologic Oncology
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      Lymphadenectomy in endometrioid uterine cancer staging : How many lymph nodes are enough? A study of 11,443 patients (pages 2454–2460)

      John K. Chan, Renata Urban, Michael K. Cheung, Jacob Y. Shin, Amreen Husain, Nelson N. Teng, Jonathan S. Berek, Joan L. Walker, Daniel S. Kapp and Kathryn Osann

      Article first published online: 14 MAY 2007 | DOI: 10.1002/cncr.22727

      The data suggest that the removal of 21 to 25 lymph nodes significantly increases the probability of detecting at least 1 positive lymph node in endometrioid uterine cancer. The definition of an adequate lymphadenectomy deserves further investigation.

    8. Head and Neck
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      p53 codon 72 polymorphisms in human papillomavirus-negative and human papillomavirus-positive squamous cell carcinomas of the oropharynx (pages 2461–2465)

      Federica Perrone, Luigi Mariani, Elisa Pastore, Marta Orsenigo, Simona Suardi, Barbara Marcomini, Luca DaRiva, Lisa Licitra, Antonino Carbone, Marco A. Pierotti and Silvana Pilotti

      Article first published online: 9 MAY 2007 | DOI: 10.1002/cncr.22702

      Tobacco smoking, alcohol abuse, and high-risk human papillomavirus are risk factors in the etiology of oropharyngeal squamous cell carcinomas. The TP53 polymorphism, in which an arginine is changed to proline at codon 72, is functionally significant and could therefore be a predisposing genetic defect.

    9. Hematologic Malignancies
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      Characterization of Ph-negative abnormal clones emerging during imatinib therapy (pages 2466–2472)

      Elisabetta Abruzzese, Alessandro Gozzetti, Sara Galimberti, Malgorzata Monika Trawinska, Tommaso Caravita, Agostina Siniscalchi, Giulia Cervetti, Alessandro Mauriello, Angela Maria Coletta and Paolo De Fabritiis

      Article first published online: 14 MAY 2007 | DOI: 10.1002/cncr.22699

      Patients with Philadelphia chromosome clones emerging during imatinib therapy were studied and followed over time. None of the patients presented with clinical and laboratory signs of myelodysplastic syndrome after up to 49 months of follow-up.

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      Leukemic involvement is a common feature in mantle cell lymphoma (pages 2473–2480)

      Ana Ferrer, Itziar Salaverria, Francesc Bosch, Neus Villamor, María Rozman, Silvia Beà, Eva Giné, Armando López-Guillermo, Elías Campo and Emili Montserrat

      Article first published online: 3 MAY 2007 | DOI: 10.1002/cncr.22715

      In a series of patients with mantle cell lymphoma, leukemic expression at diagnosis detected by flow cytometry was a highly common feature, even in patients with a normal lymphocyte count. Although morphologically apparent leukemic expression was not associated with specific chromosomal alterations detected by comparative genomic hybridization, a lymphocyte count ≥5 × 109/L was found to be correlated with particular genetic abnormalities and a poor outcome.

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      Pretransplant positive positron emission tomography/gallium scans predict poor outcome in patients with recurrent/refractory Hodgkin lymphoma (pages 2481–2489)

      Elias Jabbour, Chitra Hosing, Gregory Ayers, Rodolfo Nunez, Paolo Anderlini, Barbara Pro, Issa Khouri, Anas Younes, Fredrick Hagemeister, Larry Kwak and Luis Fayad

      Article first published online: 11 MAY 2007 | DOI: 10.1002/cncr.22714

      Pretransplant functional imaging results appear to be independent prognostic factors for outcome in patients with recurrent/refractory Hodgkin lymphoma. The objective of the current study was to determine the prognostic value of functional imaging in predicting the outcome of patients with recurrent/refractory Hodgkin lymphoma prior to high-dose chemotherapy with autologous stem cell transplantation.

    12. Hepatobiliary Disease
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      Hepatic steatosis is associated with increased frequency of hepatocellular carcinoma in patients with hepatitis C-related cirrhosis (pages 2490–2496)

      Joel R. Pekow, Atul K. Bhan, Hui Zheng and Raymond T. Chung

      Article first published online: 8 MAY 2007 | DOI: 10.1002/cncr.22701

      In patients with HCV-related cirrhosis, the presence of hepatic steatosis is independently associated with development of hepatocellular carcinoma. These findings suggest that steatosis poses an additional risk for HCC and that increased vigilance should be practiced in surveillance of persons with both HCV and steatosis.

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      Overexpression of vitamin D receptor indicates a good prognosis for cholangiocarcinoma : Implications for therapeutics (pages 2497–2505)

      Wunchana Seubwai, Chaisiri Wongkham, Anucha Puapairoj, Narong Khuntikeo and Sopit Wongkham

      Article first published online: 8 MAY 2007 | DOI: 10.1002/cncr.22716

      Overexpression of VDR is associated with tumor development and better survival of cholangiocarcinoma patients. The antiproliferative effects of 1,25(OH)2D3 in cholangiocarcinoma cell lines appear to be mediated by VDR, thus suggesting a use for vitamin D or its analogs in treatment of cholangiocarcinoma.

    14. Lung Disease
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      Prognostic implications of cell cycle-related proteins in primary resectable pathologic N2 nonsmall cell lung cancer (pages 2506–2514)

      Sherif Mohamed, Kazuhiro Yasufuku, Kenzo Hiroshima, Takahiro Nakajima, Shigetoshi Yoshida, Makoto Suzuki, Yasuo Sekine, Kiyoshi Shibuya, Toshihiko Iizasa, Atef Farouk and Takehiko Fujisawa

      Article first published online: 8 MAY 2007 | DOI: 10.1002/cncr.22651

      The current results indicated that preoperative patients with pathologic N2 nonsmall cell lung cancer—even those with clinical N2 status—who had positive protein expression of p21 and p16 in their primary tumors are expected to have a favorable postoperative prognosis and may be candidates for primary resection.

    15. Neuro-oncology
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      Stereotactic radiosurgery alone versus resection plus whole-brain radiotherapy for 1 or 2 brain metastases in recursive partitioning analysis class 1 and 2 patients (pages 2515–2521)

      Dirk Rades, Guenther Bohlen, Andre Pluemer, Theo Veninga, Patrick Hanssens, Juergen Dunst and Steven E. Schild

      Article first published online: 8 MAY 2007 | DOI: 10.1002/cncr.22729

      Stereotactic radiosurgery (SRS) alone produced an outcome similar to that produced by resection plus whole-brain radiotherapy (WBRT) for recursive partitioning analysis class 1 and 2 patients who had 1 or 2 brain metastases. SRS alone was a reasonable option that was less invasive, less time-consuming, and more cost-effective than resection plus WBRT for these patients.

    16. Sarcoma
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      Myxoid/round cell and pleomorphic liposarcomas : Prognostic factors and survival in a series of patients treated at a single institution (pages 2522–2531)

      Marco Fiore, Federica Grosso, Salvatore Lo Vullo, Elisabetta Pennacchioli, Silvia Stacchiotti, Andrea Ferrari, Paola Collini, Laura Lozza, Luigi Mariani, Paolo G. Casali and Alessandro Gronchi

      Article first published online: 17 MAY 2007 | DOI: 10.1002/cncr.22720

      Myxoid/round cell liposarcomas share prognostic factors similar to those for other soft tissue sarcomas, and they display an indolent clinical outcome. In this study, a cut-off level at 5% in the round cell component singled out a group of diseases that had a broad spectrum of aggressiveness. Further studies are needed to determine whether more precise tools may be obtained by stratifying the round cell cut-off level further or by looking at the different molecular subtypes.

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      Endogenous secretory receptor for advanced glycation endproducts as a novel prognostic marker in chondrosarcoma (pages 2532–2540)

      Akihiko Takeuchi, Yasuhiko Yamamoto, Koichi Tsuneyama, Chunmei Cheng, Hideto Yonekura, Takuo Watanabe, Katsuji Shimizu, Katsuro Tomita, Hiroshi Yamamoto and Hiroyuki Tsuchiya

      Article first published online: 11 MAY 2007 | DOI: 10.1002/cncr.22731

      The receptor for advanced glycation endproducts (RAGE) is a multiligand receptor that has been implicated in diabetic vascular complications, neurodegenerative disorders, proinflammatory reactions, and cancer. The study revealed that the expression of endogenous secretory RAGE (esRAGE, a splice variant form of RAGE) was associated with histologic tumor grade and clinical behavior in chondrosarcoma, the second most frequent primary malignant bone tumor. Assessment of esRAGE expression is useful in diagnostic and prognostic determinations in chondrosarcoma.

    18. Discipline

      Clinical Trials
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      Age disparity between a cancer population and participants in clinical trials submitted as a new drug application of anticancer drugs in Japan (pages 2541–2546)

      Akiko Hori, Taro Shibata, Masahiro Kami, Eiji Kusumi, Hiroto Narimatsu, Yukiko Kishi, Naoko Murashige and Kazuhiko Mori

      Article first published online: 3 MAY 2007 | DOI: 10.1002/cncr.22721

      To evaluate disparities in age between actual cancer patients and those enrolled in clinical trials, the authors examined all the review reports of the Pharmaceuticals and Medical Devices Agency in Tokyo, Japan, and summaries of data submitted by applicants for the approval of new cancer drugs and that for a partial change in approved cancer drugs. The results of the current study demonstrated that participants of cancer clinical trials are younger than the actual cancer patient population in Japan.

    19. Epidemiology
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      Passive smoking and the use of noncigarette tobacco products in association with risk for pancreatic cancer: A case-control study (pages 2547–2556)

      Manal M. Hassan, James L. Abbruzzese, Melissa L. Bondy, Robert A. Wolff, Jean-Nicolas Vauthey, Peter W. Pisters, Douglas B. Evans, Rabia Khan, Renato Lenzi, Li Jiao and Donghui Li

      Article first published online: 9 MAY 2007 | DOI: 10.1002/cncr.22724

      The results of this study confirmed the previously reported association between active smoking and increased risk for pancreatic cancer but did not support a role of passive smoking or the use of noncigarette tobacco products in the etiology of pancreatic cancer. The association between cigar use and the risk of pancreatic cancer needs to be confirmed in other study populations.

    20. Pathology
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      Histopathologic grading of adult medulloblastomas (pages 2557–2565)

      Fausto J. Rodriguez, Charles Eberhart, Brian Patrick O'Neill, Jeff Slezak, Peter C. Burger, Patricia Goldthwaite, Wenting Wu and Caterina Giannini

      Article first published online: 8 MAY 2007 | DOI: 10.1002/cncr.22717

      The degree and extent of anaplasia were assessed in a retrospective series of 74 adult patients with histologically confirmed medulloblastomas. Severe anaplasia was found in 5% of cases and was associated with a worse prognosis.

    21. Pediatric Oncology
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      Germline mutations of the perforin gene are a frequent occurrence in childhood anaplastic large cell lymphoma (pages 2566–2571)

      Sonia Cannella, Alessandra Santoro, Giuseppa Bruno, Marta Pillon, Lara Mussolin, Giovanna Mangili, Angelo Rosolen and Maurizio Aricò

      Article first published online: 3 MAY 2007 | DOI: 10.1002/cncr.22718

      In the current study, the incidence of PRF1 mutations was found to be significantly higher in patients with anaplastic large cell lymphoma (27.3%) than in 400 control subjects (10.2%).

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      A prospective, multicentric scoring system to predict mortality in febrile neutropenic children with cancer (pages 2572–2579)

      Hugo R. Paganini, Clarisa Aguirre, Gabriela Puppa, Cecilia Garbini, Ruiz Guiñazuú Javier, Gabriela Ensinck, Claudia Vrátnica, Luis Flynn, Marisa Iacono, Pedro Zubizarreta and for the Febrile Neutropenia Study Group

      Article first published online: 9 MAY 2007 | DOI: 10.1002/cncr.22704

      The use of a mortality score for high-risk patients was validated statistically in a multicentric study of children with fever and neutropenia. A better initial predictive approach may allow better therapeutic decisions for these children, with an eventual impact on reducing mortality.

    23. Psychosocial Oncology
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      Use of health-related and cancer-specific support groups among adult cancer survivors (pages 2580–2589)

      Jason E. Owen, Michael S. Goldstein, Jennifer H. Lee, Nancy Breen and Julia H. Rowland

      Article first published online: 14 MAY 2007 | DOI: 10.1002/cncr.22719

      Factors associated with health-related support group use are largely similar in cancer survivors and those with other chronic conditions. The use of cancer-specific support groups varies considerably by cancer type, and few survivors receive referrals to such programs from their physicians.

    24. Quality of Life
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      New measure of health-related quality of life for patients with oropharyngeal mucositis : Development and preliminary psychometric evaluation (pages 2590–2599)

      Karis K. F. Cheng, S. F. Leung, David R. Thompson, Josepha W. M. Tai, Raymond H. S. Liang, Alta S. T. Kan, Fion W. O. Ying and Rebecca M. W. Yeung

      Article first published online: 9 MAY 2007 | DOI: 10.1002/cncr.22730

      Oropharyngeal mucositis (OM) causes profound impairment of patients' health-related quality of life (HQoL). An HQoL instrument specific to OM (OMQoL) was developed and tested by qualitative and quantitative methodology for patients with different types of cancer therapies. An initial psychometric analysis of the OMQoL is very encouraging.

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      Medically related legal needs and quality of life in cancer care : A structural analysis (pages 2600–2606)

      Michael A. Zevon, Stephen Schwabish, James P. Donnelly and Kerry J. Rodabaugh

      Article first published online: 8 MAY 2007 | DOI: 10.1002/cncr.22682

      This study identified legal needs of cancer patients and documented the substantial relation of medically related legal needs to patient quality of life. The failure of standard medical and supportive care to address these needs is also clearly documented and, based on study findings, integrating support for medically related legal needs would appear to represent a significant opportunity to improve patient quality of life.

    26. Supportive Care
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      Lymphedema after gynecological cancer treatment : Prevalence, correlates, and supportive care needs (pages 2607–2614)

      Vanessa Beesley, Monika Janda, Elizabeth Eakin, Andreas Obermair and Diana Battistutta

      Article first published online: 1 MAY 2007 | DOI: 10.1002/cncr.22684

      Lymphedema and undiagnosed lower limb swelling are experienced by 10% and 15% of gynecological cancer survivors, respectively, and are associated with considerable levels of unmet support needs. Women at risk of developing this condition would benefit from instruction about early signs and symptoms and should be given referral information.

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      Risk factors for infections with multidrug-resistant Stenotrophomonas maltophilia in patients with cancer (pages 2615–2622)

      Shoaib R. Ansari, Hend Hanna, Ray Hachem, Ying Jiang, Kenneth Rolston and Issam Raad

      Article first published online: 8 MAY 2007 | DOI: 10.1002/cncr.22705

      The use of carbapenems, quinolones, trimethoprim/sulfamethoxazole (TMP/SMZ), prior intensive care unit stay, and a history of prior infection with Stenotrophomonas maltophilia were identified as risk factors for infection with multidrug-resistant Stenotrophomonas maltophilia. Judicious prophylactic and empiric use of quinolones, TMP/SMX, and carbapenems is necessary, especially in this high-risk cancer patient population.

  4. Correspondence

    1. Top of page
    2. Commentary
    3. Review Articles
    4. Original Articles
    5. Correspondence
    6. Erratum
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    2. You have free access to this content
      Author reply (page 2624)

      Pascal Seve, John Hanson and John R. Mackey

      Article first published online: 8 MAY 2007 | DOI: 10.1002/cncr.22710

  5. Erratum

    1. Top of page
    2. Commentary
    3. Review Articles
    4. Original Articles
    5. Correspondence
    6. Erratum
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