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Cancer

Cover image for Cancer

15 February 2007

Volume 109, Issue 4

Pages 645–812

  1. Commentary

    1. Top of page
    2. Commentary
    3. Original Articles
    4. Correspondence
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      Results of the 2006 Innsbruck International Consensus Conference on intraperitoneal chemotherapy in patients with ovarian cancer (pages 645–649)

      Christian Marth, Joan L. Walker, Richard R. Barakat, Antonio Casado, Angiolo Gadducci, Brigitte Miller, Franco Odicino, Eric Pujade-Lauraine, Jalid Sehouli, Claes Tropé, Lari Wenzel and Alain G. Zeimet

      Article first published online: 19 JAN 2007 | DOI: 10.1002/cncr.22467

      In February 2006, the International Consensus Conference on Intraperitoneal Chemotherapy in Ovarian Cancer Patients in provided the first worldwide consensus after the National Cancer Institute issued an announcement encouraging the treatment of advanced ovarian cancer with anticancer drugs after surgery, including intraperitoneal (IP) therapy. At that conference, a consensus was obtained on important questions regarding the standard of care in IP therapy for patients with ovarian cancer.

  2. Original Articles

    1. Top of page
    2. Commentary
    3. Original Articles
    4. Correspondence
    1. Disease Site

      Breast Disease
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      Rates of myocardial infarction and coronary artery disease and risk factors in patients treated with radiation therapy for early-stage breast cancer (pages 650–657)

      Reshma Jagsi, Kent A. Griffith, Todd Koelling, Rachel Roberts and Lori J. Pierce

      Article first published online: 19 JAN 2007 | DOI: 10.1002/cncr.22452

      Early-stage breast cancer patients treated with breast-conserving surgery and radiation therapy at the University of Michigan from 1984–2000 were found to have a lower risk of myocardial infarction and coronary artery disease requiring intervention in follow-up than expected from analysis of an age-, sex-, and race-matched population. Although small in absolute magnitude, patients radiated to the left side in this series had a statistically significant increase in the risk of myocardial infarction compared with those radiated to the right side.

    2. Gastrointestinal Tract
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      Expression of epidermal growth factor receptor in esophageal and esophagogastric junction adenocarcinomas : Association with poor outcome (pages 658–667)

      Kim L. Wang, Tsung-Teh Wu, In Seon Choi, Huamin Wang, Erika Resetkova, Arlene M. Correa, Wayne L. Hofstetter, Stephen G. Swisher, Jaffer A. Ajani, Asif Rashid and Constance T. Albarracin

      Article first published online: 8 JAN 2007 | DOI: 10.1002/cncr.22445

      The results from this study indicated that epidermal growth factor receptor (EGFR) plays an important role in tumor growth, progression, and metastasis in esophageal and esophagogastric junction adenocarcinoma. These findings suggested that EGFR expression is correlated with poor prognostic factors and may be used to predict patient outcomes.

      Corrected by:

      Erratum: Erratum

      Vol. 115, Issue 9, 2024, Article first published online: 11 MAR 2009

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      Clinical and endoscopic factors predict higher pathologic grades of Barrett dysplasia (pages 668–674)

      Sharmila Anandasabapathy, Jagriti Jhamb, Marta Davila, Caimiao Wei, Jeffrey Morris and Robert Bresalier

      Article first published online: 8 JAN 2007 | DOI: 10.1002/cncr.22451

      Clinical, endoscopic, and histologic data were reviewed on 109 patients (26 women, 83 men) with a new Barrett diagnosis between 2002 and 2005. Patients were classified, by an expert gastrointestinal pathologist, as having intestinal metaplasia, indefinite-for-dysplasia, low-grade dysplasia, high-grade dysplasia, and esophageal adenocarcinoma. Gender, age, race, ethnicity, hiatal hernia presence and size, Barrett segment length, Helicobacter pylori status, alcohol, smoking, proton pump inhibitor (PPI) use and duration, and reflux symptom duration were evaluated for their association with dysplasia severity. On logistic regression analysis, duration of reflux symptoms for ≥20 years (odds ratio [OR]: 5.66, P = .012), longer Barrett segment length (OR for 3–6 cm vs <3 cm: 9.05, P < .0001; OR for ≥6 cm: 8.374, P < .0001), hernia size ≥4 cm (OR: 10.63, P = .014), and male gender (OR: 4.03, P = .0019) were associated with higher pathologic grade. Absence of H. pylori (OR: 2.731, P = .060) approached significance in predicting dysplasia severity.

    4. Genitourinary Disease
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      Prospective study of adiposity and weight change in relation to prostate cancer incidence and mortality (pages 675–684)

      Margaret E. Wright, Shih-Chen Chang, Arthur Schatzkin, Demetrius Albanes, Victor Kipnis, Traci Mouw, Paul Hurwitz, Albert Hollenbeck and Michael F. Leitzmann

      Article first published online: 8 JAN 2007 | DOI: 10.1002/cncr.22443

      In a prospective study of 287,760 men who participated in the National Institutes of Health-AARP Diet and Health Study, body mass index was inversely associated with incident prostate cancer. Conversely, body mass index and adult weight gain were associated both positively and significantly with prostate cancer mortality.

    5. Gynecologic Oncology
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      Secondary cytoreductive surgery for localized, recurrent epithelial ovarian cancer : Analysis of prognostic factors and survival outcome (pages 685–691)

      Ritu Salani, Antonio Santillan, Marianna L. Zahurak, Robert L. Giuntoli II, Ginger J. Gardner, Deborah K. Armstrong and Robert E. Bristow

      Article first published online: 11 JAN 2007 | DOI: 10.1002/cncr.22447

      A localized recurrence of ovarian cancer diagnosed if patients had 1 or 2 radiographic sites of recurrence. In this select population, a diagnosis-recurrence interval ≥18 months and complete secondary surgical cytoreduction were associated with a median postrecurrence survival of approximately 50 months.

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      Intraperitoneal chemotherapy in the first-line treatment of women with stage III epithelial ovarian cancer : A Systematic Review With Metaanalyses (pages 692–702)

      Laurie Elit, Thomas K. Oliver, Allan Covens, Janice Kwon, Michael Fung-Kee Fung, Holger W. Hirte and Amit M. Oza

      Article first published online: 19 JAN 2007 | DOI: 10.1002/cncr.22466

      Based on the significant improvements in overall survival that were observed in 3 randomized, controlled trials, in this review, the authors concluded that cisplatin-containing intraperitoneal chemotherapy should be offered to patients with advanced ovarian cancer. The appropriate clinical and institutional multidisciplinary facilities are needed for the safe delivery of this treatment in optimally debulked patients.

    7. Head and Neck Disease
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      Inactivation of human mutL homolog 1 and mutS homolog 2 genes in head and neck squamous cell carcinoma tumors and leukoplakia samples by promoter hypermethylation and its relation with microsatellite instability phenotype (pages 703–712)

      Shiladitya Sengupta, Susmita Chakrabarti, Anup Roy, Chinmay K. Panda and Susanta Roychoudhury

      Article first published online: 11 JAN 2007 | DOI: 10.1002/cncr.22430

      The results from this study implicated tobacco-dependent hypermethylation of the mismatch-repair genes human mutL homolog 1 (hMLH1) and human mutS homolog 2 (hMSH2) in samples of leukoplakia, in squamous cell carcinoma of the head and neck, and in adjacent normal tissues. The results suggested that tobacco-addicted individuals are more susceptible to promoter hypermethylation of hMLH1 and hMSH2 and that such events in the normal squamous epithelium of the head and neck region may lead to microsatellite instability pathway-dependent tumorigenesis.

    8. Hematologic Malignancies
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      Activity of decitabine, a hypomethylating agent, in chronic myelomonocytic leukemia (pages 713–717)

      Ahmed Aribi, Gautam Borthakur, Farhad Ravandi, Jianqin Shan, Jan Davisson, Jorge Cortes and Hagop Kantarjian

      Article first published online: 11 JAN 2007 | DOI: 10.1002/cncr.22457

      Decitabine, a hypomethylating agent, was given at 100 mg/m2 per course every 4 weeks to 19 patients with chronic myelomonocytic leukemia and resulted in 11 complete responses and 2 hematologic improvements, for an overall response rate of 69%.

    9. Hepatobiliary Tract
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      Survival after hepatic resection in metastatic colorectal cancer : A population-based study (pages 718–726)

      Linda C. Cummings, Jonathan D. Payes and Gregory S. Cooper

      Article first published online: 19 JAN 2007 | DOI: 10.1002/cncr.22448

      Hepatectomy for patients with colorectal cancer who have liver metastases was associated with improved survival in this population-based analysis. However, 5-year survival rates were lower than those reported in prior case series from tertiary referral centers.

    10. Lung Disease
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      Sequential chemotherapy in nonsmall-cell lung cancer : Cisplatin and gemcitabine followed by docetaxel (pages 727–731)

      Anna Ceribelli, Maria S. Pino, Alain J. Gelibter, Michele Milella, Fabiana L. Cecere, Mauro Caterino, Francesco Facciolo, Alessandra Mirri and Francesco Cognetti

      Article first published online: 19 JAN 2007 | DOI: 10.1002/cncr.22480

      Sequential treatment with cisplatin and gemcitabine followed by docetaxel is a feasible chemotherapeutic option in first-line therapy for nonsmall-cell lung cancer patients without incurring cumulative toxicity.

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      Randomized phase II trial of two different schedules of docetaxel plus cisplatin as first-line therapy in advanced nonsmall cell lung cancer (pages 732–740)

      Se Hoon Park, Soo Jin Choi, Sun Young Kyung, Chang Hyeok An, Sang Pyo Lee, Jeong Woong Park, Sung Hwan Jeong, Eun Kyung Cho, Dong Bok Shin and Jae Hoon Lee

      Article first published online: 8 JAN 2007 | DOI: 10.1002/cncr.22446

      There is increasing interest in the use of a weekly administration of docetaxel as a way of reducing its hematologic toxicity. The purpose of the current randomized study was to evaluate the toxicity and efficacy of docetaxel plus cisplatin combination on 2 schedules in patients with previously untreated, advanced nonsmall cell lung cancer (NSCLC).

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      Abnormalities of epidermal growth factor receptor in lung squamous-cell carcinomas, adenosquamous carcinomas, and large-cell carcinomas : Tyrosine kinase domain mutations are not rare in tumors with an adenocarcinoma component (pages 741–750)

      Kouki Ohtsuka, Hiroaki Ohnishi, Masachika Fujiwara, Tomonori Kishino, Satsuki Matsushima, Go Furuyashiki, Hidefumi Takei, Yoshihiko Koshiishi, Tomoyuki Goya and Takashi Watanabe

      Article first published online: 19 JAN 2007 | DOI: 10.1002/cncr.22476

      Epidermal growth factor receptor (EGFR) tyrosine kinase domain mutations are not rare in nonsmall-cell lung cancers with an adenocarcinoma component. EGFRvIII can be found in patients with large-cell carcinoma.

    13. Neuro-Oncology
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      Enhanced chemotherapy delivery by intraarterial infusion and blood-brain barrier disruption in the treatment of cerebral metastasis (pages 751–760)

      David Fortin, Cathy Gendron, Marie Boudrias and Marie-Pierre Garant

      Article first published online: 8 JAN 2007 | DOI: 10.1002/cncr.22450

      The use of increased chemotherapy delivery (intraarterial with or without blood-brain barrier disruption) is supported in the treatment of multiple brain metastasis of ovarian carcinoma, adenocarcinoma of the lung, small cell lung carcinoma, and systemic lymphoma.

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      Brain tumors in individuals with familial adenomatous polyposis : A cancer registry experience and pooled case report analysis (pages 761–766)

      Thomas M. Attard, Pierre Giglio, Sireesha Koppula, Carrie Snyder and Henry T. Lynch

      Article first published online: 19 JAN 2007 | DOI: 10.1002/cncr.22475

      Familial Adenomatous Polyposis (FAP) is associated with an increased risk of brain tumors (BT). Herein the authors describe a hereditary polyposis registry experience and pool their patient characteristics with prior reports. FAP-BTP2 is more common in females and more likely in individuals harboring APC mutation between codons 679–1224 (odds ratio 13). Targeted CNS surveillance may be warranted in this subpopulation at risk.

    15. Sarcoma
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      Clinical outcome of patients with Ewing sarcoma family of tumors of bone in Japan : The Japanese Musculoskeletal Oncology Group cooperative study (pages 767–775)

      Hideto Obata, Takafumi Ueda, Akira Kawai, Takeshi Ishii, Toshifumi Ozaki, Satoshi Abe, Kazuhiro Tanaka, Hiroyuki Tsuchiya, Akihiko Matsumine and Hiroo Yabe

      Article first published online: 19 JAN 2007 | DOI: 10.1002/cncr.22481

      The incidence of Ewing sarcoma family of tumors (ESFT) is extremely low in the Asian population. Results from the Japanese Musculoskeletal Oncology Group cooperative study demonstrated that the recent clinical outcome of patients with localized ESFT of bone in Japan improved remarkably with the application of current chemotherapy regimens that included ifosfamide and etoposide.

    16. Discipline

      Epidemiology
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      Testicular cancer mortality in the Americas, 1980–2003 (pages 776–779)

      Paola Bertuccio, Matteo Malvezzi, Liliane Chatenoud, Cristina Bosetti, Eva Negri, Fabio Levi and Carlo La Vecchia

      Article first published online: 19 JAN 2007 | DOI: 10.1002/cncr.22473

      The current study is an updated analysis of testicular cancer mortality trends across the Americas, which indicates that mortality from testicular cancer in (young) men remains exceedingly high in most Latin American countries as compared with North America. These excess mortality rates essentially reflect an inadequate adoption of modern platinum-based chemotherapy regimens.

    17. Sarcoma
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      Adjuvant and neoadjuvant chemotherapy for Ewing sarcoma family tumors in patients aged between 40 and 60 : Report of 35 cases and comparison of results with 586 younger patients treated with the same protocols in the same years (pages 780–786)

      Gaetano Bacci, Alba Balladelli, Cristiana Forni, Stefano Ferrari, Alessandra Longhi, Patrizia Bacchini, Marco Alberghini, Nicola Fabbri, MariaSerena Benassi, Antonio Briccoli and Piero Picci

      Article first published online: 11 JAN 2007 | DOI: 10.1002/cncr.22456

      Between 1972 and 2000 systemic chemotherapy and local surgery, radiotherapy, or both was used to treat 35 patients aged 40 to 60 with Ewing sarcoma family tumor; the results were compared with 586 younger patients treated in the same way at the authors' institute in the same years. The final outcome was essentially the same in the 2 groups, although toxicity related to chemotherapy was higher in the older group.

    18. Quality of Life
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      A pooled analysis of quality of life measures and adverse events data in north central cancer treatment group lung cancer clinical trials (pages 787–795)

      Mashele M. Huschka, Sumithra J. Mandrekar, Paul L. Schaefer, James R. Jett and Jeff A. Sloan

      Article first published online: 8 JAN 2007 | DOI: 10.1002/cncr.22444

      Information gleaned from the single-item Uniscale was comparable to information from multiple-item global measures. A 10-point decline in quality of life occurred earlier than Common Toxicity Criteria for Adverse Events reporting of a severe adverse event.

    19. Radiation Oncology
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      Use of adjuvant radiotherapy at hospitals with and without on-site radiation services (pages 796–801)

      Sandra L. Wong, Yongliang Wei and John D. Birkmeyer

      Article first published online: 8 JAN 2007 | DOI: 10.1002/cncr.22458

      In many areas of health care, whether patients receive specific medical interventions may be influenced by the local availability of resources for delivering those services. The availability of on-site radiation services appears to significantly increase the likelihood that patients with pancreatic cancer receive adjuvant radiotherapy.

    20. Symptom Control and Palliative Care
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      A pilot study of the vulnerable elders survey-13 compared with the comprehensive geriatric assessment for identifying disability in older patients with prostate cancer who receive androgen ablation (pages 802–810)

      Supriya G. Mohile, Kathryn Bylow, William Dale, James Dignam, Kandis Martin, Daniel P. Petrylak, Walter M. Stadler and Miriam Rodin

      Article first published online: 11 JAN 2007 | DOI: 10.1002/cncr.22495

      Functional and cognitive impairments are highly prevalent among older patients with prostate cancer who receive androgen ablation while attending an oncology clinic. A brief, functionally based screening tool, the Vulnerable Elders Survey-13, performed nearly as well as a conventional comprehensive geriatric assessment in detecting geriatric impairment in this population.

  3. Correspondence

    1. Top of page
    2. Commentary
    3. Original Articles
    4. Correspondence
    1. You have free access to this content
      Effect of obesity on survival in epithelial ovarian cancer (page 811)

      Karsten Münstedt, Richard von Georgi and Folker E. Franke

      Article first published online: 11 JAN 2007 | DOI: 10.1002/cncr.22392

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      Author reply (page 812)

      James C. Pavelka, Beth Y. Karlan and Andrew J. Li

      Article first published online: 11 JAN 2007 | DOI: 10.1002/cncr.22393

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