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Cancer

Cover image for Cancer

15 November 2007

Volume 110, Issue 10

Pages 2119–2362

  1. Commentary

    1. Top of page
    2. Commentary
    3. Editorial
    4. Review Articles
    5. Original Articles
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      Annual report to the nation on the status of cancer, 1975–2004, featuring cancer in American Indians and Alaska Natives (pages 2119–2152)

      David K. Espey, Xiao-Cheng Wu, Judith Swan, Charles Wiggins, Melissa A. Jim, Elizabeth Ward, Phyllis A. Wingo, Holly L. Howe, Lynn A. G. Ries, Barry A. Miller, Ahmedin Jemal, Faruque Ahmed, Nathaniel Cobb, Judith S. Kaur and Brenda K. Edwards

      Article first published online: 15 OCT 2007 | DOI: 10.1002/cncr.23044

      The American Cancer Society, the Centers for Disease Control and Prevention, the National Cancer Institute, and the North American Association of Central Cancer Registries collaborate annually to provide updated information on cancer occurrence and trends in the U.S. The 2007 report features a comprehensive compilation of cancer information for American Indians and Alaska Natives.

  2. Editorial

    1. Top of page
    2. Commentary
    3. Editorial
    4. Review Articles
    5. Original Articles
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      Race, biochemical disease recurrence, and prostate–specific antigen doubling time in the SEARCH database (pages 2153–2154)

      Isaac Powell

      Article first published online: 12 SEP 2007 | DOI: 10.1002/cncr.23045

      In their study in the current issue of Cancer, Hamilton et al. attempt to resolve conflicting data regarding prostate cancer and racial outcomes. The most interesting findings include a significantly younger population of black men with higher prostate–specific antigen levels, similar tumor grade, and less extracapsular extension, yet with a higher rate of biochemical disease recurrence compared with white men. Recent genetic studies have reported that variants on chromosome 8q24 and CYP3A4 on chromosome 7 are associated with aggressive prostate cancer in young black men.

  3. Review Articles

    1. Top of page
    2. Commentary
    3. Editorial
    4. Review Articles
    5. Original Articles
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      Positron emission tomography imaging in nonsmall-cell lung cancer (pages 2155–2168)

      Jeremy J. Erasmus, Homer A. Macapinlac and Stephen G. Swisher

      Article first published online: 26 SEP 2007 | DOI: 10.1002/cncr.23051

      Positron emission tomography using 18F-2-deoxy-D-glucose, a D-glucose analog labeled with fluorine-18, complements conventional radiologic assessment in the evaluation of patients with nonsmall-cell lung cancer.

  4. Original Articles

    1. Top of page
    2. Commentary
    3. Editorial
    4. Review Articles
    5. Original Articles
    1. Disease Site

      Breast Disease
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      Disentangling the effects of race on breast cancer treatment (pages 2169–2177)

      Mousumi Banerjee, Julie George, Cecilia Yee, William Hryniuk and Kendra Schwartz

      Article first published online: 8 OCT 2007 | DOI: 10.1002/cncr.23026

      In this investigation of racial disparities in breast cancer treatment, the authors conducted a comprehensive review of medical records and used multivariable logistic regression analyses controlled for sociodemographic factors, tumor characteristics, comorbidities, and health insurance status to assess whether there were differences between white American women and African-American women in the receipt of breast-conserving surgery, radiation, tamoxifen, and chemotherapy. The results indicated that white American women were more likely to receive tamoxifen and/or chemotherapy for regional-stage disease than African-American women and that married women with regional disease were more likely to receive chemotherapy than nonmarried women.

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      High circulating HER2 extracellular domain levels correlate with reduced efficacy of an aromatase inhibitor in hormone receptor-positive metastatic breast cancer: A confirmatory prospective study (pages 2178–2185)

      Ramon Colomer, Antonio Llombart-Cussac, Belen Lloveras, Manuel Ramos, Jose I. Mayordomo, Roberto Fernández, Ignasi Tusquets, Miguel Gil, Agustí Barnadas, Manuel Constenla, Montserrat Gilabert and Emilio Alba

      Article first published online: 9 OCT 2007 | DOI: 10.1002/cncr.23043

      The predictive value of circulating levels of the extracellular domain (ECD) of HER2 was investigated in patients with metastatic breast cancer who were treated with letrozole. Elevated HER2 ECD concentrations predicted poorer outcomes in postmenopausal women with metastatic, hormone receptor-positive breast cancer who received aromatase inhibitors letrozole.

    3. Gastrointestinal Disease
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      Effect of timing of metastasis/disease recurrence and histologic differentiation on survival of patients with advanced gastric cancer (pages 2186–2190)

      Pooja R. Patel, James C. Yao, Kenneth Hess, Isac Schnirer, Asif Rashid and Jaffer A. Ajani

      Article first published online: 26 SEP 2007 | DOI: 10.1002/cncr.23046

      Patients with advanced gastric cancer have a median survival (MS) of <9 months. It is unclear whether the MS of patients who have advanced cancer at the time of diagnosis (synchronous, Group A) is different from that of patients who develop advanced cancer after curative surgery (metachronous, Group B). It was hypothesized that survival would be similar.

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      Radiation therapy is associated with improved survival in patients with pancreatic adenocarcinoma: Results of a study from the surveillance, epidemiology, and end results (SEER) registry data (pages 2191–2201)

      Lisa Hazard, Jonathan D Tward, Aniko Szabo and Dennis C Shrieve

      Article first published online: 4 OCT 2007 | DOI: 10.1002/cncr.23047

      By using the Surveillance, Epidemiology, and End Results Registry database, the authors identified patients with adenocarcinoma of the pancreas who underwent surgical resection with or without radiation therapy. Radiation therapy was associated with improved survival.

    5. Genitourinary Disease
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      Race, biochemical disease recurrence, and prostate–specific antigen doubling time after radical prostatectomy : Results from the SEARCH database (pages 2202–2209)

      Robert J. Hamilton, William J. Aronson, Joseph C. Presti Jr, Martha K. Terris, Christopher J. Kane, Christopher L. Amling and Stephen J. Freedland

      Article first published online: 17 SEP 2007 | DOI: 10.1002/cncr.23012

      Despite presenting with an earlier clinical stage of disease and similar pathologic features at the time of radical prostatectomy, black men were found to be at a slightly increased risk for biochemical disease recurrence. However, these recurrences appear to be no more aggressive than those in white men, as depicted by similar prostate–specific antigen doubling time.

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      Decision analysis using individual patient preferences to determine optimal treatment for localized prostate cancer (pages 2210–2217)

      Benjamin D. Sommers, Clair J. Beard, Anthony V. D'Amico, Douglas Dahl, Irving Kaplan, Jerome P. Richie and Richard J. Zeckhauser

      Article first published online: 24 SEP 2007 | DOI: 10.1002/cncr.23028

      The optimal therapy for localized prostate cancer depends not only on clinical features, but also on patient preferences. Our decision model and patient survey show that variations in individual preferences are critically important in selecting treatment for older patients and for patients with low-risk tumors.

    7. Anatomic Site

      Genitourinary Disease
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      Nomogram use for the prediction of indolent prostate cancer : Impact on screen-detected populations (pages 2218–2221)

      Stijn Roemeling, Monique J. Roobol, Michael W. Kattan, Theo H. van der Kwast, Ewout W. Steyerberg and Fritz H. Schröder

      Article first published online: 24 SEP 2007 | DOI: 10.1002/cncr.23029

      Because not all prostate cancers deserve immediate treatment, it has become more important to risk-stratify cases. With the help of a nomogram for screen-detected cancers substantial groups of cancers can be identified that are likely indolent and can therefore be considered for active surveillance.

    8. Disease Site

      Gynecologic Oncology
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      Quantitative assessment of the impact of chemotherapy on ovarian follicle reserve and stromal function (pages 2222–2229)

      Ozgur Oktem and Kutluk Oktay

      Article first published online: 11 OCT 2007 | DOI: 10.1002/cncr.23071

      The study provides the first quantitative evidence of the impact of chemotherapy on ovarian infrastructure and shows that, although alkylating agents can significantly reduce ovarian reserve, both alkylating and nonalkylating regimens may affect ovarian stromal function.

    9. Head and Neck
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      Fluorescence in situ hybridization for detecting genomic alterations of cyclin D1 and p16 in oral squamous cell carcinomas (pages 2230–2239)

      Narikazu Uzawa, Itaru Sonoda, Kunihiro Myo, Ken-Ichiro Takahashi, Ryozo Miyamoto and Teruo Amagasa

      Article first published online: 24 SEP 2007 | DOI: 10.1002/cncr.23030

      Although the cyclin D1 gene (CCND1) numerical aberration is a good predictor of aggressive tumors, recurrence, and poor prognosis in patients with oral squamous cell carcinomas, in the current study, the authors were able to identify subgroups of patients with early recurrences and poor prognosis more efficiently by assessment of p16 deletion in addition to CCND1 status using fluorescence in situ hybridization on fine-needle aspiration biopsy samples compared with the analysis of either alteration alone.

    10. Hematologic Malignancies
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      The role of rituximab in combination with pentostatin or cladribine for the treatment of recurrent/refractory hairy cell leukemia (pages 2240–2247)

      Monica Else, Nnenna Osuji, Francesco Forconi, Claire Dearden, Ilaria Del Giudice, Estella Matutes, Andrew Wotherspoon, Francesco Lauria and Daniel Catovsky

      Article first published online: 20 SEP 2007 | DOI: 10.1002/cncr.23032

      The current study provided evidence that the combination of a purine analog with rituximab is safe and effective for patients with recurrent and/or refractory hairy cell leukemia. Moreover, the results suggest an added benefit compared with standard treatment.

    11. Lung Disease
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      Accuracy of pleural biopsy using thoracoscopy for the diagnosis of histologic subtype in patients with malignant pleural mesothelioma (pages 2248–2252)

      Laurent Greillier, Arnaud Cavailles, Anne Fraticelli, Arnaud Scherpereel, Fabrice Barlesi, Gianfranco Tassi, Pascal Thomas and Philippe Astoul

      Article first published online: 20 SEP 2007 | DOI: 10.1002/cncr.23034

      Pleural biopsy performed using thoracoscopy is the cornerstone of the diagnosis and pleural staging of patients with malignant pleural mesothelioma. However, this procedure is less efficient in distinguishing the histologic subtype as either epithelial or biphasic.

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      Primary salivary gland-type lung cancer : Spectrum of clinical presentation, histopathologic and prognostic factors (pages 2253–2259)

      Julian R. Molina, Marie Christine Aubry, Jean E. Lewis, Jason A. Wampfler, Brent A. Williams, David E. Midthun, Ping Yang and Stephen D. Cassivi

      Article first published online: 4 OCT 2007 | DOI: 10.1002/cncr.23048

      Mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) are uncommon tumors of the chest that, if they are resected completely, carry a good prognosis. The survival rate of patients with MEC who achieved complete surgical resection was 94% at 3 years and 87% at 5 years and 10 years. For patients with ACC, the survival rate was 73% at 3 years, 57% at 5 years, and 45% at 10 years.

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      Haptoglobin and posttranslational glycan-modified derivatives as serum biomarkers for the diagnosis of nonsmall cell lung cancer (pages 2260–2268)

      Luke F. M. Hoagland IV, Michael J. Campa, Elizabeth B. Gottlin, James E. Herndon II and Edward F. Patz Jr

      Article first published online: 4 OCT 2007 | DOI: 10.1002/cncr.23049

      Serum Hp and 2 of its glycoforms, SAHp and FHp, are potentially useful in the clinical diagnosis of nonsmall cell lung cancer. The markers increase with stage, suggesting they may also be useful in stratifying patients at presentation and in following patients after treatment.

    14. Melanoma
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      Evaluation of interferon alpha-2B and thalidomide in patients with disseminated malignant melanoma, phase 2, SWOG 0026 (pages 2269–2275)

      Laura F. Hutchins, James Moon, Joseph I. Clark, John A. Thompson, Marianne K. Lange, Lawrence E. Flaherty and Vernon K. Sondak

      Article first published online: 11 OCT 2007 | DOI: 10.1002/cncr.23035

      In a phase 2 study, investigators observed that a regimen of interferon alpha-2b combined with thalidomide demonstrated a lack of response and excess toxicity in poor-prognosis patients with disseminated malignant melanoma. On the basis of these findings, there is no indication for further study within this study's trial parameters.

    15. Neuro-Oncology
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      Gamma knife radiosurgery for central neurocytoma : Primary and secondary treatment (pages 2276–2284)

      Chae-Yong Kim, Sun Ha Paek, Sang Soon Jeong, Hyun-Tai Chung, Jung Ho Han, Chul-Kee Park, Hee-Won Jung and Dong Gyu Kim

      Article first published online: 9 OCT 2007 | DOI: 10.1002/cncr.23036

      Retrospective analysis of 13 patients with central neurocytoma revealed that gamma knife stereotactic radiosurgery could be recommended as a primary or an adjuvant therapy.

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      Whole-brain radiotherapy versus stereotactic radiosurgery for patients in recursive partitioning analysis classes 1 and 2 with 1 to 3 brain metastases (pages 2285–2292)

      Dirk Rades, Andre Pluemer, Theo Veninga, Patrick Hanssens, Juergen Dunst and Steven E. Schild

      Article first published online: 5 OCT 2007 | DOI: 10.1002/cncr.23037

      In a series of 186 patients in recursive partitioning analysis (RPA) Classes 1 and 2 who had between 1 and 3 brain metastases, 91 patients who received 30 to 40 grays (Gy) of whole-brain radiotherapy (WBRT) alone were compared with 95 patients who received 18 to 25 Gy of stereotactic radiosurgery (SRS) alone with regard to overall survival (OS), control within the entire brain (BC), local control of treated metastases (LC), and brain control distant from treated metastases (DC). SRS alone was associated with improved BC and LC, whereas OS and DC were not significantly different in either group. Similar results were observed in the subgroup analyses of patients in RPA Classes 1 and 2.

    17. Sarcoma
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      Expression of receptor tyrosine kinases and apoptotic molecules in rhabdomyosarcoma : Correlation with overall survival in 105 patients (pages 2293–2303)

      Paul M. Armistead, Jason Salganick, Jae S. Roh, Dejka M. Steinert, Shreyaskumar Patel, Mark Munsell, Adel K. El-Naggar, Robert S. Benjamin, Wei Zhang and Jonathan C. Trent

      Article first published online: 26 SEP 2007 | DOI: 10.1002/cncr.23038

      Rhabdomyosarcoma (RMS) is a rare mesenchymal tumor with few treatment options after the failure of first-line therapy. Understanding the expression of kinases and apoptotic molecules in RMS tumors may lead to elucidation of mechanisms of resistance to chemotherapy and development of new therapies.

    18. Discipline

      Outcomes
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      The medicare modernization act and reimbursement for outpatient chemotherapy : Do patients perceive changes in access to care? (pages 2304–2312)

      Joeëlle Y. Friedman, Lesley H. Curtis, Bradley G. Hammill, Jatinder K. Dhillon, Charles H. Weaver, Sugata Biswas, Amy P. Abernethy and Kevin A. Schulman

      Article first published online: 8 OCT 2007 | DOI: 10.1002/cncr.23042

      The findings do not support anecdotal reports that patients have been affected by changes in reimbursement to oncologists for chemotherapy as a result of the Medicare Modernization Act. Further research is needed to examine the effects of the legislation on vulnerable populations.

    19. Pediatric Oncology
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      Obesity and hypertension among children after treatment for acute lymphoblastic leukemia (pages 2313–2320)

      Eric J. Chow, Catherine Pihoker, Kathryn Hunt, Karen Wilkinson and Debra L. Friedman

      Article first published online: 26 SEP 2007 | DOI: 10.1002/cncr.23050

      In this longitudinal study, contemporary childhood survivors of acute lymphoblastic leukemia were found to remain at an increased risk of obesity and hypertension after therapy despite reductions in the usage of cranial radiotherapy. Higher exposure to corticosteroids was found to be a significant risk factor.

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      Dexamethasone alters sleep and fatigue in pediatric patients with acute lymphoblastic leukemia (pages 2321–2330)

      Pamela S. Hinds, Marilyn J. Hockenberry, Jami S. Gattuso, Deo Kumar Srivastava, Xin Tong, Heather Jones, Nancy West, Kathy S. McCarthy, Avi Sadeh, Monica Ash, Cheryl Fernandez and Ching-Hon Pui

      Article first published online: 9 OCT 2007 | DOI: 10.1002/cncr.23039

      Children and adolescents who received outpatient continuation therapy for acute lymphoblastic leukemia were found to have significantly disrupted sleep and increased fatigue secondary to dexamethasone. They were in bed longer but slept more poorly than other well, chronically ill, or hospitalized pediatric patients.

    21. Symptom Control and Palliative Care
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      Is radiologic placement of an arm port mandatory in oncology patients? : Analysis of a large bi-institutional experience (pages 2331–2338)

      Pierre-Yves Marcy, Nicolas Magné, Pierre Castadot, Antoine Italiano, Nicolas Amoretti, Cédric Bailet, Franck Bentolila and Jean-Claude Gallard

      Article first published online: 20 SEP 2007 | DOI: 10.1002/cncr.23040

      The objectives of the current study were to evaluate a percutaneous radiologic arm port device (PRAPD) in a large set of 1000 consecutive cancer patients undergoing chemotherapy in terms of safety, efficacy, complications, and quality of life and to propose future recommendations. The results indicated that PRAPD is a safe, effective, and well-tolerated technique in oncology patients. PRAPD could be recommended in selected patients rather than a surgical port device.

    22. Translational Research
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      Frequency, risk factors, and trends for venous thromboembolism among hospitalized cancer patients (pages 2339–2346)

      Alok A. Khorana, Charles W. Francis, Eva Culakova, Nicole M. Kuderer and Gary H. Lyman

      Article first published online: 4 OCT 2007 | DOI: 10.1002/cncr.23062

      Venous thromboembolism is increasingly frequent in hospitalized cancer patients. Risk factors for venous thromboembolism include older age, female sex, black ethnicity, chemotherapy, cancer type, and comorbidities.

    23. You have full text access to this OnlineOpen article
      Zone-specific remodeling of tumor blood vessels affects tumor growth (pages 2347–2362)

      Derya Tilki, Nerbil Kilic, Sema Sevinc, Friedrich Zywietz, Christian G. Stief and Suleyman Ergun

      Article first published online: 11 SEP 2007 | DOI: 10.1002/cncr.23024

      Vascular stabilization leads to a remodeling of tumor vasculature accompanied by a reduction of vascular density because of partial regression of blood vessels and an extensive necrosis of tumor tissue. Thus, a better understanding of tumor vascular remodeling might optimize the assessment of the efficiency of tumor therapeutics via imaging and open additional strategies in tumor therapy.

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