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Cancer

Cover image for Cancer

1 October 2007

Volume 110, Issue 7

Pages 1405–1640

  1. Review Articles

    1. Top of page
    2. Review Articles
    3. Original Articles
    4. Original Site
    5. Original Articles
    6. Original Site
    7. Original Articles
    8. Original Site
    9. Original Articles
    1. You have free access to this content
      Management of prostate cancer recurrences after radiation therapy-brachytherapy as a salvage option (pages 1405–1416)

      Gregory W. Allen, Andrew R. Howard, David F Jarrard and Mark A. Ritter

      Article first published online: 8 AUG 2007 | DOI: 10.1002/cncr.22940

      There is no consensus on optimal salvage therapy for men with prostate cancer who experience an organ-confined recurrence after definitive radiation therapy. This review summarizes the published reports of salvage prostatectomy, cryotherapy, and brachytherapy and reports our own institution's experience with salvage brachytherapy.

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      Patient selection, cancer control, and complications after salvage local therapy for postradiation prostate-specific antigen failure : A systematic review of the literature (pages 1417–1428)

      Paul L. Nguyen, Anthony V. D'Amico, Andrew K. Lee and W. Warren Suh

      Article first published online: 10 AUG 2007 | DOI: 10.1002/cncr.22941

      The results from this review indicated that, among men who experience prostate-specific antigen (PSA) failure after external beam radiation or brachytherapy, many will harbor occult micrometastases, but a significant minority will have a true local-only failure and, thus, potentially may benefit from a salvage local therapy. For this review, the authors addressed the factors associated with a greater likelihood of having local-only disease at the time of PSA failure and systematically evaluated the efficacy and toxicity of salvage prostatectomy, cryosurgery, and brachytherapy.

      See related original article on pages XXX–XXX, this issue.

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      Trends in head and neck cancer incidence in relation to smoking prevalence : An emerging epidemic of human papillomavirus-associated cancers? (pages 1429–1435)

      Erich M. Sturgis and Paul M. Cinciripini

      Article first published online: 27 AUG 2007 | DOI: 10.1002/cncr.22963

      In the U.S., the decreasing prevalence of cigarette smoking has resulted in a lower incidence of head and neck cancer. However, a stagnation of oropharyngeal cancer incidence likely reflects a rising attribution of this disease to oncogenic human papillomavirus. Planned vaccination of the adolescent and young adult female population should result in a lower viral prevalence and hopefully reduced oropharyngeal cancer incidence, but the vaccination of males should also be considered.

  2. Original Articles

    1. Top of page
    2. Review Articles
    3. Original Articles
    4. Original Site
    5. Original Articles
    6. Original Site
    7. Original Articles
    8. Original Site
    9. Original Articles
    1. Disease Site

      Breast Disease
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      Inflammatory breast cancer (IBC) and patterns of recurrence : Understanding the biology of a unique disease (pages 1436–1444)

      Massimo Cristofanilli, Vicente Valero, Aman U. Buzdar, Shu-Wan Kau, Kristine R. Broglio, Ana Maria Gonzalez-Angulo, Nour Sneige, Rabiul Islam, Naoto T. Ueno, Thomas A. Buchholz, Sonja E. Singletary and Gabriel N. Hortobagyi

      Article first published online: 10 AUG 2007 | DOI: 10.1002/cncr.22927

      Inflammatory breast cancer (IBC) has unique features represented by an aggressive clinical presentation and a peculiar pattern of early recurrence. New treatment and imaging modalities should address these issues to improve prognosis.

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      Multifocal breast cancer in women ≤35 years old (pages 1445–1450)

      Jennifer K. Litton, Yesim Eralp, Ana M. Gonzalez-Angulo, Kristine Broglio, Anne Uyei, Gabriel N. Hortobagyi and Banu Arun

      Article first published online: 3 AUG 2007 | DOI: 10.1002/cncr.22928

      The relation that multifocality at diagnosis had to survival in women < 35 years of age was evaluated.

    3. Endocrine Disease
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      Clinical management and outcome of papillary and follicular (differentiated) thyroid cancer presenting with distant metastasis at diagnosis (pages 1451–1456)

      Elliot Sampson, James D. Brierley, Lisa W. Le, Lorne Rotstein and Richard W. Tsang

      Article first published online: 17 AUG 2007 | DOI: 10.1002/cncr.22956

      Differentiated thyroid cancer presenting with distant metastatic disease should be managed aggressively with thyroidectomy and radioactive iodine. A 5-year survival of 50% is expected and young patients with papillary histology have an even better prognosis.

    4. Gastrointestinal Disease
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      PKC 412 small-molecule tyrosine kinase inhibitor : Single-compound therapy for pancreatic cancer (pages 1457–1468)

      Jamael El Fitori, Yun Su, Peter Büchler, Roman Ludwig, Nathalia A. Giese, Markus W. Büchler, Hilmar Quentmeier, Oscar J. Hines, Ingrid Herr and Helmut Friess

      Article first published online: 3 AUG 2007 | DOI: 10.1002/cncr.22931

      PKC412 is a small molecule inhibitor that blocks Ser/Thr and Tyr protein kinases such as FLT3, VEGFR2, and PDGFR signaling. Single–compound-driven inhibition of these receptors in experimental pancreatic cancer inhibited pancreatic cancer growth in vitro and vivo.

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      Immunotherapy of murine colon cancer using receptor tyrosine kinase EphA2-derived peptide-pulsed dendritic cell vaccines (pages 1469–1477)

      Shinjiro Yamaguchi, Tomohide Tatsumi, Tetsuo Takehara, Ryotaro Sakamori, Akio Uemura, Tsunekazu Mizushima, Kazuyoshi Ohkawa, Walter J. Storkus and Norio Hayashi

      Article first published online: 8 AUG 2007 | DOI: 10.1002/cncr.22958

      Immunization with dendritic cells pulsed with EphA2-derived peptides (Eph-DCs) resulted not only in the inhibition of murine colorectal adenocarcinoma (MC38) mouse colon tumor growth but also in long-term protection against distal rechallenge with MC38 tumor cells. These results suggested the usefulness of Eph-DC vaccines in colon cancer.

    6. Genitourinary Disease
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      Inverse correlation between body mass index and clinical outcomes in men with advanced castration–recurrent prostate cancer (pages 1478–1484)

      Susan Halabi, San-San Ou, Nicholas J. Vogelzang and Eric J. Small

      Article first published online: 30 JUL 2007 | DOI: 10.1002/cncr.22932

      In the current study, the correlation between an elevated body mass index (BMI) and clinical outcomes in 1226 men with metastatic, castration–recurrent prostate cancer was evaluated. Obesity, as defined by an elevated BMI, appears to have a protective effect against overall mortality and prostate cancer–specific mortality. Further studies are needed to gain a more comprehensive understanding of the mechanisms behind these clinical observations.

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      Magnetic resonance image-guided salvage brachytherapy after radiation in select men who initially presented with favorable-risk prostate cancer : A prospective phase 2 study (pages 1485–1492)

      Paul L. Nguyen, Ming-Hui Chen, Anthony V. D'Amico, Clare M. Tempany, Graeme S. Steele, Michele Albert, Robert A. Cormack, David L. Carr-Locke, Ronald Bleday and W. Warren Suh

      Article first published online: 13 AUG 2007 | DOI: 10.1002/cncr.22934

      Magnetic resonance imaging-guided salvage brachytherapy in men who were selected based on presenting characteristics and postfailure prostate-specific antigen (PSA) kinetics produced high PSA control rates, although complications that required surgical intervention occurred in 10% to 15% of men. Prospective randomized studies will be needed to characterize the relative disease control and toxicity after all forms of salvage local therapy.

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      Androgen deprivation therapy increases cardiovascular morbidity in men with prostate cancer (pages 1493–1500)

      Christopher S. Saigal, John L. Gore, Tracey L. Krupski, Janet Hanley, Matthias Schonlau and Mark S. Litwin

      Article first published online: 26 JUL 2007 | DOI: 10.1002/cncr.22933

      Androgen deprivation therapy (ADT) is associated with increased cardiovascular morbidity in men with prostate cancer. These data have particular relevance to decisions regarding the use of ADT in men with prostate cancer in settings in which the benefit has not been clearly established.

    9. Head and Neck
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      Analysis of risk factors for distant metastases in squamous cell carcinoma of the oral cavity (pages 1501–1508)

      Chun-Ta Liao, Hung-Ming Wang, Joseph Tung-Chieh Chang, Shu-Hang Ng, Chuen Hsueh, Li-Yu Lee, Chih-Hung Lin, I-How Chen, Shiang-Fu Huang and Tzu-Chen Yen

      Article first published online: 20 AUG 2007 | DOI: 10.1002/cncr.22959

      In a series of 889 patients with oral cavity squamous cell carcinoma, the 5-year distant metastases (DM) rate was 9.6%. Lymph node metastasis with extracapsular spread was the only independent predictor of the 5-year DM rate for patients with either locoregional control or locoregional recurrence.

    10. Hematologic Malignancies
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      The prognosis for patients with chronic myeloid leukemia who have clonal cytogenetic abnormalities in philadelphia chromosome-negative cells (pages 1509–1519)

      Michael W. N. Deininger, Jorge Cortes, Ron Paquette, Byung Park, Andreas Hochhaus, Michele Baccarani, Richard Stone, Thomas Fischer, Hagop Kantarjian, Dietger Niederwieser, Carlo Gambacorti-Passerini, Charlene So, Insa Gathmann, John M. Goldman, Douglas Smith, Brian J. Druker and François Guilhot

      Article first published online: 14 AUG 2007 | DOI: 10.1002/cncr.22936

      Clonal cytogenetic abnormalities were detectable in a small proportion of patients with chronic myeloid leukemia who attained a cytogenetic response to imatinib mesylate. Although these abnormalities were similar to those observed in patients with myelodysplastic syndromes (MDS), the incidence of MDS and acute leukemia was low, and outcomes were comparable to the outcomes achieved by patients without such abnormalities.

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      Therapy may unmask hypoplastic myelodysplastic syndrome that mimics aplastic anemia (pages 1520–1526)

      Sergej Konoplev, L. Jeffrey Medeiros, Patrick A. Lennon, Sapana Prajapati, Anuradha Kanungo and Pei Lin

      Article first published online: 13 AUG 2007 | DOI: 10.1002/cncr.22935

      The authors studied 12 patients who were diagnosed initially with aplastic anemia (AA) and subsequently developed a myelodysplastic syndrome (MDS). The detection of monosomy 7 in specimens that were considered AA and the short time to the diagnosis of subsequent MDS suggested that these patients had hypoplastic MDS from the onset of pancytopenia.

    12. Lung Disease
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      Expression of TGFβ type-II receptor in association with markers of proliferation and apoptosis in premalignant lung lesions (pages 1527–1531)

      Teresita Muñoz-Antonia, Carlos Muro-Cacho, Swati Sharma, Alan Cantor and Gerold Bepler

      Article first published online: 3 AUG 2007 | DOI: 10.1002/cncr.22937

      An immunohistochemical study was undertaken to examine the correlation between TβR-II expression and expression of proliferation markers in premalignant lung lesions as well as DNA fragmentation as an indicator of apoptosis. Results confirmed (the type of premalignant lesion correlated positively with Ki-67 and MCM2) and extended (the type of premalignant lesion correlated negatively with apoptosis and TβR-II) our previous observations (BMCCancer. 2001;1:6).

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      Prognostic factors for survival of stage I nonsmall cell lung cancer patients : A population-based analysis of 19,702 stage I patients in the California Cancer Registry from 1989 to 2003 (pages 1532–1541)

      S.-H. Ignatius Ou, Jason A. Zell, Argyrios Ziogas and Hoda Anton-Culver

      Article first published online: 14 AUG 2007 | DOI: 10.1002/cncr.22938

      The authors identified and analyzed 19,702 patients with stage I nonsmall lung cancer (NSCLC) in the California Cancer Registry and identified independent poor prognostic factors for survival. Poorly differentiated tumors in both stage IA and stage IB NSCLC, stage IB tumors located in nonupper lobe locations, and tumors that measured ≥4 cm all carried an increased risk of mortality. These findings may help guide clinical decision to offer patients adjuvant chemotherapy or help identify high-risk patients to enroll in current and future clinical trials in adjuvant chemotherapy.

    14. Neuro-Oncology
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      Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors : A report from the Children's Oncology Group (pages 1542–1550)

      H. Stacy Nicholson, Cynthia S. Kretschmar, Mark Krailo, Mark Bernstein, Richard Kadota, Daniel Fort, Henry Friedman, Michael B. Harris, Nicole Tedeschi-Blok, Claire Mazewski, Judith Sato and Gregory H. Reaman

      Article first published online: 17 AUG 2007 | DOI: 10.1002/cncr.22961

      Temozolomide elicited limited objective responses against childhood CNS tumors, with 4 of 6 occurring in medulloblastoma/PNET; prolonged stable disease, however, was observed in 41% of those with low-grade astrocytoma. Toxicities were tolerable, with no long-term effects.

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      A boost in addition to whole-brain radiotherapy improves patient outcome after resection of 1 or 2 brain metastases in recursive partitioning analysis class 1 and 2 patients (pages 1551–1559)

      Dirk Rades, Andre Pluemer, Theo Veninga, Juergen Dunst and Steven E. Schild

      Article first published online: 25 JUL 2007 | DOI: 10.1002/cncr.22960

      A total of 99 recursive partitioning analysis class 1 and 2 patients with 1 to 2 resectable brain metastases who were treated with surgical resection of the metastases plus 10 fractions of 3 grays (Gy) each or 20 fractions of 2 Gy each of whole-brain radiotherapy were compared with 102 patients who received the same treatment plus a boost of 5 fractions of 2 to 3 Gy each to the metastatic site. The patients who received the additional boost were found to have better overall survival and intracerebral control.

  3. Original Site

    1. Top of page
    2. Review Articles
    3. Original Articles
    4. Original Site
    5. Original Articles
    6. Original Site
    7. Original Articles
    8. Original Site
    9. Original Articles
    1. Discipline

      Psychosocial Oncology
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      Changes in cognitive functioning in the year after hematopoietic stem cell transplantation (pages 1560–1567)

      Sheri R. Jacobs, Brent J. Small, Margaret Booth-Jones, Paul B. Jacobsen and Karen K. Fields

      Article first published online: 8 AUG 2007 | DOI: 10.1002/cncr.22962

      The cognitive performance of patients undergoing hematopoietic stem cell transplantation (HSCT) was examined from pretransplantation to 12 months posttransplantation. The results indicate that cognitive performance was impaired initially but steadily improved throughout the year after HSCT to levels that were equal to or superior to population normative values.

  4. Original Articles

    1. Top of page
    2. Review Articles
    3. Original Articles
    4. Original Site
    5. Original Articles
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    7. Original Articles
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    9. Original Articles
    1. Disease Site

      Sarcoma
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      Expression of granulocyte-colony-stimulating factor and its receptor in human Ewing sarcoma cells and patient tumor specimens : Potential consequences of granulocyte-colony-stimulating factor administration (pages 1568–1577)

      Jaime Morales-Arias, Paul A. Meyers, Marcela F. Bolontrade, Nidra Rodriguez, Zhichao Zhou, Krishna Reddy, Alexander J. Chou, Nadezhda V. Koshkina and Eugenie S. Kleinerman

      Article first published online: 10 AUG 2007 | DOI: 10.1002/cncr.22964

      In the current study, the authors examined whether Ewing sarcoma cells and patient tumor samples express granulocyte-colony-stimulating factor and its receptor and whether treatment with this factor enhances tumor growth.

    2. Discipline

      Cancer Disparities
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      Differences in predictors of cervical and breast cancer screening by screening need in uninsured Latina women (pages 1578–1585)

      Lydia P. Buki, Jorja Jamison, Carolyn J. Anderson and Anai M. Cuadra

      Article first published online: 14 AUG 2007 | DOI: 10.1002/cncr.22929

      Predictors of cancer screening among 467 urban Latina women without health insurance differed by type of screening and by screening need. Women who reported exposure to cancer education were more likely to have ever had a mammogram and to be up-to-date with Pap smear screening than women without such exposure.

  5. Original Site

    1. Top of page
    2. Review Articles
    3. Original Articles
    4. Original Site
    5. Original Articles
    6. Original Site
    7. Original Articles
    8. Original Site
    9. Original Articles
    1. Discipline

      Cancer Disparities
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      Risk factors for early catheter-related infections in cancer patients (pages 1586–1592)

      Nicolas Penel, Jean-Charles Neu, Stéphanie Clisant, Helga Hoppe, Patrick Devos and Yazdan Yazdanpanah

      Article first published online: 8 AUG 2007 | DOI: 10.1002/cncr.22942

      In this prospective study, the authors identified age <10 years and difficulties during insertion as risk factors for early catheter-related infections that were assessable at insertion. These findings may be useful in the design of future randomized studies.

  6. Original Articles

    1. Top of page
    2. Review Articles
    3. Original Articles
    4. Original Site
    5. Original Articles
    6. Original Site
    7. Original Articles
    8. Original Site
    9. Original Articles
    1. Discipline

      Epidemiology
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      Prospective investigation of the cigarette smoking–head and neck cancer association by sex (pages 1593–1601)

      Neal D. Freedman, Christian C. Abnet, Michael F. Leitzmann, Albert R. Hollenbeck and Arthur Schatzkin

      Article first published online: 27 AUG 2007 | DOI: 10.1002/cncr.22957

      Cigarette smoking is a strong risk factor for head and neck cancer, although very few prospective studies have investigated this association in women. The incidence rates of head and neck cancer were higher in male smokers than female smokers, but smoking explains a higher proportion of head and neck cancer in women than in men.

  7. Original Site

    1. Top of page
    2. Review Articles
    3. Original Articles
    4. Original Site
    5. Original Articles
    6. Original Site
    7. Original Articles
    8. Original Site
    9. Original Articles
    1. Discipline

      Epidemiology
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      Improving colorectal cancer screening by using community volunteers : Results of the Carolinas cancer education and screening (CARES) project (pages 1602–1610)

      Mira L. Katz, Cathy Tatum, Stephanie L. Dickinson, David M. Murray, Kristie Long-Foley, M. Robert Cooper, Morgan Daven and Electra D. Paskett

      Article first published online: 30 JUL 2007 | DOI: 10.1002/cncr.22930

      Within a low-income population of medically underserved women a community-based intervention did not significantly increase colorectal cancer screening rates. There was a positive change in beliefs about screening and intention to be screened in the future, suggesting that the dissemination of an evidence-based behavioral intervention may require a longer duration to engage hard-to-reach populations and change behaviors.

  8. Original Articles

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    2. Review Articles
    3. Original Articles
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    5. Original Articles
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    9. Original Articles
    1. Discipline

      Medical Oncology
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      Dose intensity and hematologic toxicity in older cancer patients receiving systemic chemotherapy (pages 1611–1620)

      Michelle Shayne, Eva Culakova, Marek S. Poniewierski, Debra Wolff, David C. Dale, Jeffrey Crawford and Gary H. Lyman

      Article first published online: 17 AUG 2007 | DOI: 10.1002/cncr.22939

      The results from this prospective study of 976 patients age ≥70 years who received chemotherapy revealed that nearly 50% received substantial reductions in delivered chemotherapy dose intensity. Among patients who received the full dose intensity, there was no significant difference in neutropenic complications by age. Risk factors for neutropenic events included type of cancer, regimen, planned dose intensity, previous chemotherapy, and abnormal chemistries and decreased with prophylactic colony-stimulating factor. Increasing age alone did not appear to increase the risk of hematologic toxicity.

    2. Symptom Control and Palliative Care
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      Challenges and recommendations for advancing the state-of-the-science of quality of life assessment in symptom management trials (pages 1621–1628)

      David R. Buchanan, Ann M. O'Mara, Joseph W. Kelaghan, Maria Sgambati, Worta McCaskill-Stevens and Lori Minasian

      Article first published online: 20 AUG 2007 | DOI: 10.1002/cncr.22893

      This article presents major findings from a workshop on Quality of Life Assessment in Cancer Symptom Management Trials, sponsored by the National Cancer Institute. To advance the state-of-the-science, recommendations are presented on the rationale and utility of health-related quality of life assessment, conceptual models, and measurement and design issues in phase 3 cancer symptom management trials

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      Assessing symptom burden using the M. D. Anderson symptom inventory in patients with chemotherapy-induced anemia : Results of a multicenter, open-label study (SURPASS) of patients treated with darbepoetin-α at a dose of 200 μg every 2 weeks (pages 1629–1640)

      Janice L. Gabrilove, Edith A. Perez, Dianne K. Tomita, Greg Rossi and Charles S. Cleeland

      Article first published online: 10 AUG 2007 | DOI: 10.1002/cncr.22943

      Darbepoetin-α administered at a dose of 200 μg every 2 weeks to patients with chemotherapy-induced anemia (CIA) is associated with improved symptom burden as measured using the M. D. Anderson Symptom Inventory (MDASI). The MDASI is a simple and effective tool that may improve the management of symptoms for patients with CIA.

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