Prospective assessment of radiotherapy-associated cardiac toxicity in breast cancer patients: Analysis of data 3 to 6 years after treatment (pages 1840–1850)
Robert G. Prosnitz, Jessica L. Hubbs, Elizabeth S. Evans, Su-Min Zhou, Xiaoli Yu, Michael A. Blazing, Donna R. Hollis, Andrea Tisch, Terence Z. Wong, Salvador Borges-Neto, Patricia H. Hardenbergh and Lawrence B. Marks
Article first published online: 30 AUG 2007 | DOI: 10.1002/cncr.22965
It is not known whether modern radiotherapy (RT) methods of irradiating the breast and chest wall are associated with an increased risk of cardiac toxicity. To study this question, the authors conducted a prospective trial in which patients underwent serial cardiac single-photon emission computed tomography scans before and after RT. Herein, they have reported on 44 patients with 3 to 6 year follow-up data. Perfusion defects were observed in 52% to 71% of patients. However, these defects were not associated with wall motion abnormalities or changes in ejection fraction. The findings indicated that RT-induced perfusion defects may persist or may appear initially from 3 to 6 years post-RT in a high percentage of patients and that further study of these women is warranted.