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Cancer Cytopathology

Cover image for Cancer Cytopathology

25 April 2007

Volume 111, Issue 2

Pages 67–136

Currently known as: Cancer Cytopathology

  1. Original Articles

    1. Top of page
    2. Original Articles
    3. Original Article
    4. Original Articles
    1. Gynecologic Cytopathology

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      Testing for HPV as an objective measure for quality assurance in gynecologic cytology : Positive rates in equivocal and abnormal specimens and comparison with the ASCUS to SIL ratio (pages 67–73)

      Vincent Ko, Shabin Nanji, Rosemary H. Tambouret and David C. Wilbur

      Version of Record online: 28 FEB 2007 | DOI: 10.1002/cncr.22488

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      The appropriate use of the ASCUS interpretation is important to cost effectiveness of cervical cancer screening guidelines. However, current quality assurance methods are imperfect. To determine whether HPV testing could be used as an objective measure of quality, 17 months of ASCUS cases with HPV tests were analyzed by patient age, over time, and by individual cytopathologist and then compared with the ASCUS:SIL method. A correlation between the 2 methods was found, indicating that HPV testing can be a useful supplement to existing quality assurance tools.

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      Immunohistochemical detection of p16INK4a in liquid-based cytology specimens on cell block sections (pages 74–82)

      Haiyan Liu, Jianhui Shi, Myra Wilkerson, Yajue Huang, Steven Meschter, William Dupree and Fan Lin

      Version of Record online: 28 FEB 2007 | DOI: 10.1002/cncr.22577

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      The authors performed immunohistochemical detection of p16 in 75 cases of liquid-based cytology specimens on cell block sections, including 44 cases of ASC-H confirmed by cervical biopsy or HPV testing. The preliminary data show that p16 is a sensitive marker to confirm the diagnosis of ASC-H on cervical cell blocks.

  2. Original Article

    1. Top of page
    2. Original Articles
    3. Original Article
    4. Original Articles
    1. Gynecologic Cytopathology

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      Evaluation of p16INK4a expression in ThinPrep cervical specimens with the CINtec p16INK4a assay : Correlation with biopsy follow-up results (pages 83–92)

      Jane L. Meyer, David W. Hanlon, Birthe T. Andersen, Ole F. Rasmussen and Kirsten Bisgaard

      Version of Record online: 2 MAR 2007 | DOI: 10.1002/cncr.22580

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      This study examined p16INK4a protein expression in ThinPrep cervical specimens and compared these results with both the presence of high-risk human papillomavirus and histological follow-up. Results highlighted applications where the CINtec p16INK4a Cytology Kit (Dako, Glostrup, Denmark) may provide clinical value.

  3. Original Articles

    1. Top of page
    2. Original Articles
    3. Original Article
    4. Original Articles
    1. Gynecologic Cytopathology

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      Reliability of sparing papanicolaou test conventional reading in cases reported as No Further Review at AutoPap-assisted cytological screening : Survey of 30,658 cases with follow-up cytological screening (pages 93–98)

      Grazia Maria Troni, Maria Paola Cariaggi, Paolo Bulgaresi, Nehmat Houssami and Stefano Ciatto

      Version of Record online: 28 FEB 2007 | DOI: 10.1002/cncr.22578

      AutoPap-assisted reading is comparable to conventional reading, associated by a comparable negative predictive value. Subjects with a No Further Review report at AutoPap may safely return to periodic screening, and rapid review or full manual reading of a random sample are probably not necessary.

    2. Non-Gynecologic Cytopathology

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      Cytopathological diagnosis in a cancer registry : A useful diagnostic tool? (pages 99–105)

      Adele Caldarella, Emanuele Crocetti, Gian Luigi Taddei and Eugenio Paci

      Version of Record online: 2 MAR 2007 | DOI: 10.1002/cncr.22579

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      Cytology has been reported to be a better diagnostic modality in some lung and pleural tumors. Moreover, cytology has often been reported to be used together with histology in cervical uterine and breast tumors. The usefulness of cytology increases with tumor stage, particularly in sites where biopsy is performed with difficulty.

    3. Fine-Needle Aspiration

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      Applications of molecular techniques to fine-needle aspiration biopsy (pages 106–122)

      Savitri Krishnamurthy

      Version of Record online: 6 MAR 2007 | DOI: 10.1002/cncr.22489

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      The reported literature indicates the unlimited potential of material procured from fine-needle aspiration biopsy for performing almost any type of molecular test. Whereas some of these tests are currently used for patient care, the majority are investigational.

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      Comparison of ThinPrep and conventional smears in salivary gland fine-needle aspiration biopsies (pages 123–129)

      Jeremy R. Parfitt, C. Meg McLachlin and Michele M. Weir

      Version of Record online: 28 FEB 2007 | DOI: 10.1002/cncr.22575

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      There are morphological differences between ThinPrep (TP) and conventional smears (CS) in salivary gland fine-needle aspiration biopsies (FNABs), especially with respect to stromal appearance. Although CS appears to be preferable to TP in the diagnosis of pleomorphic adenoma overall, complementary use of both TP and CS preparations to achieve optimal diagnostic yield is recommended, given the artifacts of some CS and the not infrequent unsatisfactory nature of 1 preparation alone.

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      Parathyroid proliferations : A source of diagnostic pitfalls in FNA of thyroid (pages 130–136)

      Sofia Tseleni-Balafouta, Hariklia Gakiopoulou, Nikolaos Kavantzas, George Agrogiannis, Nikolaos Givalos and Efstratios Patsouris

      Version of Record online: 2 MAR 2007 | DOI: 10.1002/cncr.22576

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      A safe and reliable differential diagnosis between thyroid and parathyroid neoplasms on morphologic ground alone is difficult in cytologic smears due to the absence of well established criteria, which, in turn, are in great part due to overlapping cytologic features of these lesions. To avoid inadequate surgical management, it is essential, in every highly cellular lesion seen in the context of a colloid-free background, to consider and report the possibility of a parathyroid lesion, thus enabling the clinician to proceed to a more detailed preoperative evaluation in this direction.

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