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Cancer Cytopathology

Cover image for Cancer Cytopathology

25 December 2007

Volume 111, Issue 6

Pages 461–526

Currently known as: Cancer Cytopathology

  1. Editorials

    1. Top of page
    2. Editorials
    3. Commentary
    4. Original Articles
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  2. Commentary

    1. Top of page
    2. Editorials
    3. Commentary
    4. Original Articles
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      Reporting risk of malignancy/dysplasia in cytology : A potential way to improve communication, if not reputation (pages 465–466)

      Andrew A. Renshaw

      Article first published online: 9 OCT 2007 | DOI: 10.1002/cncr.23123

      Cytology can be used as a diagnostic or screening test. The inclusion of a quantitative assessment of risk in screening cytology may improve the ability of cytopathologists to communicate with clinicians.

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      The dysfunctional federally mandated proficiency test in cytopathology : A statistical analysis (pages 467–476)

      George K. Nagy and Sonya Naryshkin

      Article first published online: 29 OCT 2007 | DOI: 10.1002/cncr.23154

      Statistical considerations have demonstrated that the design of the federally mandated “short” proficiency test in cytopathology fundamentally is unsound because of the lack of sufficient validity and reliability. The authors believe that, to render it suitable for its intended purpose, complete redesign of the test, with the participation of experts in modern test theory, would be advisable.

  3. Original Articles

    1. Top of page
    2. Editorials
    3. Commentary
    4. Original Articles
    1. Gynecologic Cytopathology

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      Papanicolaou test interpretations of “atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion” : An investigation of requisite duration and number of colposcopic procedures to a definitive diagnosis of high-grade dysplasia in routine practice (pages 477–481)

      Amanda Bonvicino, Sonny Huitron and Oluwole Fadare

      Article first published online: 11 OCT 2007 | DOI: 10.1002/cncr.23121

      In this study, the authors investigated the number of colposcopic procedures and the time frame that is typically required for a histologic diagnosis of a CIN2+ lesion after a Pap test interpretation of ASC-H. The results indicated that a substantial subset of patients with biopsy-proven CIN2+ after ASC-H interpretations required more than 1 colposcopy for a definitive diagnosis of CIN2+.

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      Comparative sensitivities of ThinPrep and Papanicolaou smear for adenocarcinoma in situ (AIS) and combined AIS/high-grade squamous intraepithelial lesion (HSIL): Comparison with HSIL (pages 482–486)

      Jennifer M. Roberts and Julia K. Thurloe

      Article first published online: 29 OCT 2007 | DOI: 10.1002/cncr.23117

      Sensitivities were calculated for the Papanicolaou smear (PS) and ThinPrep (TP) based on 100 women with histologic adenocarcinoma in situ (AIS), 94 women with AIS plus high-grade squamous intraepithelial lesion (HSIL), and 558 women with HSIL. There was no significant difference in sensitivity for high-grade disease between PS and TP or between any of the histologic categories.

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      The significance of high-risk human papillomavirus detection in women aged ≥ 50 years with atypical squamous cells of undetermined significance cytologic preparations (pages 487–490)

      Domingo Rosario, Christopher M. Zahn, Anneke C. Bush and Brian S. Kendall

      Article first published online: 31 OCT 2007 | DOI: 10.1002/cncr.23118

      Reflex viral testing from liquid-based specimens that were classified as “atypical squamous cells of undetermined significance” in women aged ≥50 years indicated the presence of high-risk human papillomavirus (HRHPV) in 13.8%. Follow-up of women with HRHPV indicated a squamous abnormality in 49.2%, including 41.3% low-grade squamous intraepithelial lesions and 7.9% high-grade lesions.

    4. Fine-Needle Aspiration

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      Fine-needle aspiration biopsy of high-grade sarcoma : A report of 107 cases (pages 491–498)

      Ranleigh Fleshman, Joel Mayerson and Paul E. Wakely Jr

      Article first published online: 16 OCT 2007 | DOI: 10.1002/cncr.23122

      Few studies exist that demonstrate the reliability of fine-needle aspiration (FNA) biopsy for the detection of high-grade sarcoma (HGS). In the current study, the authors reviewed their cytopathology database and identified all FNA cases diagnosed as HGS. They also searched their tissue database for all HGS cases for which prior FNA biopsy findings were available. An FNA biopsy diagnosis of HGS is reliable in a high percentage of cases.

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      Cytomorphologic examination of anaplastic large cell lymphoma by fine-needle aspiration cytology (pages 499–507)

      Amy Rapkiewicz, Hannah Wen, Filiz Sen and Kasturi Das

      Article first published online: 16 OCT 2007 | DOI: 10.1002/cncr.23120

      The cytomorphology of anaplastic large cell lymphoma (ALCL) is distinctive yet variable. In the current study, which to the authors' knowledge is the largest case series presented to date, the authors retrospectively reviewed the cytomorpholgic findings noted in patients with ALCL, with specific attention paid to individuals with anaplastic lymphoma kinase-negative ALCL.

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      Long-term assessment of a multidisciplinary approach to thyroid nodule diagnostic evaluation (pages 508–516)

      Leila Yassa, Edmund S. Cibas, Carol B. Benson, Mary C. Frates, Peter M. Doubilet, Atul A. Gawande, Francis D. Moore Jr., Brian W. Kim, Vânia Nosé, Ellen Marqusee, P. Reed Larsen and Erik K. Alexander

      Article first published online: 12 NOV 2007 | DOI: 10.1002/cncr.23116

      A more detailed classification of inconclusive aspirates in conjunction with ultrasound-guided fine-needle aspiration resulted in improved preoperative detection of thyroid cancer, supporting adherence to recently published guidelines.

    7. Molecular Diagnosis

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      Combined morphologic and fluorescence in situ hybridization analysis of voided urine samples for the detection and follow-up of bladder cancer in patients with benign urine cytology (pages 517–524)

      Michal Daniely, Roni Rona, Tal Kaplan, Shirley Olsfanger, Lea Elboim, Avner Freiberger, Sylvia Lew and Ilan Leibovitch

      Article first published online: 26 OCT 2007 | DOI: 10.1002/cncr.23119

      The combination of morphologic evaluation followed by fluorescence in situ hybridization allows for the highly sensitive detection of cancerous cells in voided urine samples. The absolute negative predictive value of this test might influence the management of patients with negative combined analysis results.

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