Disease Site Breast Disease You have free access to this content Mammography screening of women in their 40s : Impact of changes in screening guidelines (pages 473–480)
Lisa Calvocoressi, Albert Sun, Stanislav V. Kasl, Elizabeth B. Claus and Beth A. Jones
Version of Record online: 10 DEC 2007 | DOI: 10.1002/cncr.23210
In 1997, American Cancer Society mammography screening guidelines changed from 1 screening every 1 to 2 years to annual screening of women beginning at age 40 years. A prospective study conducted from 1996 to 2000 found a significant increase in the proportion of women in their 40s who endorsed annual screening after this change in guidelines.
You have free access to this content Elderly breast cancer patients treated by conservative surgery alone plus adjuvant tamoxifen : Fifteen-year results of a prospective study (pages 481–488)
Gabriele Martelli, Rosalba Miceli, Aurora Costa, Danila Coradini, Stefano Zurrida, Domenico Piromalli, Gaetano Vetrella and Marco Greco
Version of Record online: 20 DEC 2007 | DOI: 10.1002/cncr.23213
A cohort of elderly patients with breast cancer who were treated with combined conservative surgery and tamoxifen had low rates of breast recurrence and axillary disease after a median 15-year follow-up, and 83% of deaths were unrelated to breast cancer. The authors concluded that neither axillary treatment nor radiotherapy is necessary in elderly patients with early breast cancer.
You have free access to this content Understanding the impact of breast reconstruction on the surgical decision-making process for breast cancer (pages 489–494)
Amy K. Alderman, Sarah T. Hawley, Jennifer Waljee, Mahasin Mujahid, Monica Morrow and Steven J. Katz
Version of Record online: 21 DEC 2007 | DOI: 10.1002/cncr.23214
Most general surgeons do not discuss reconstruction with their breast cancer patients before surgical treatment. When it occurs, this discussion significantly impacts women's treatment choice, making many more likely to choose mastectomy.
Gastrointestinal Disease You have free access to this content Multimarker phenotype predicts adverse survival in patients with lymph node-negative colorectal cancer (pages 495–502)
Inti Zlobec, Parham Minoo, Daniel Baumhoer, Kristi Baker, Luigi Terracciano, Jeremy R. Jass and Alessandro Lugli
Version of Record online: 12 DEC 2007 | DOI: 10.1002/cncr.23208
The objective of this study was to define a multimarker prognostic model of 5-year survival in patients with lymph node-negative mismatch-repair (MMR)-proficient colorectal cancer (CRC). A combined analysis of the absence of CD8+ tumor infiltrating lymphocytes, loss of p27, and positive urokinase-type plasminogen activator expression was predictive of an adverse prognosis in patients with lymph node-negative, MMR-proficient CRC and suggested that a subgroup of patients with high-risk, lymph node-negative pathologic T3 tumors should be considered for adjuvant therapy.
You have free access to this content Value of endoscopic ultrasound staging in conjunction with the evaluation of lymphovascular invasion in identifying low-risk esophageal carcinoma (pages 503–510)
Putao Cen, Wayne L. Hofstetter, Jeffery H. Lee, William A. Ross, Tsung-Teh Wu, Stephen G. Swisher, Marta Davila, Asif Rashid, Arlene M. Correa and Jaffer A. Ajani
Version of Record online: 10 DEC 2007 | DOI: 10.1002/cncr.23217
With increasing emphasis on endoscopic therapy for patients with T1 esophageal carcinoma, the identification of low-risk patients is critical. It was hypothesized that endoscopic ultrasonography in concert with detailed histopathologic evaluation would identify patients with low-risk cancers for an appropriate but organ-preserving strategy.
Genitourinary Disease You have free access to this content Renal and cardiovascular morbidity after partial or radical nephrectomy (pages 511–520)
David C. Miller, Matthias Schonlau, Mark S. Litwin, Julie Lai and Christopher S. Saigal
Version of Record online: 10 DEC 2007 | DOI: 10.1002/cncr.23218
Among Medicare recipients who were diagnosed with kidney cancer between 2000 and 2002, partial nephrectomy was associated with a 26% lower risk of developing at least 1 adverse renal outcome. These data substantiated the clinical benefits of nephron-sparing surgery among patients with early-stage kidney cancer.
You have free access to this content A phase 2 study of carboplatin plus docetaxel in men with metastatic hormone-refractory prostate cancer who are refractory to docetaxel (pages 521–526)
Robert W. Ross, Tomasz M. Beer, Susanna Jacobus, Glenn J. Bubley, Mary-Ellen Taplin, Christopher W. Ryan, Jiaoti Huang and William K. Oh
Version of Record online: 17 DEC 2007 | DOI: 10.1002/cncr.23195
In men with hormone-refractory prostate cancer (HRPC) who progress after docetaxel-based chemotherapy, docetaxel plus carboplatin led to prostate-specific antigen declines of ≥50% in 18% of patients, and the median response duration was 5.7 months. The current results indicated that platinum chemotherapy has activity in HRPC.
Head and Neck Disease You have free access to this content Tongue cancer patients have a high frequency of allelic loss at the von Hippel-Lindau gene and other loci on 3p (pages 527–534)
Takeshi Asakawa, Mariko Esumi, Sohei Endo, Akinori Kida and Minoru Ikeda
Version of Record online: 10 DEC 2007 | DOI: 10.1002/cncr.23200
Loss of heterozygosity (LOH) of the
von Hippel-Lindau ( VHL) gene was found at a high frequency (45.5%) in patients with tongue cancer. LOH of several microsatellites on 3p was also detected in a significant proportion of tongue cancer patients, and such deletions were often observed simultaneously across a large region of 3p within the same tumor sample. You have free access to this content Adjuvant radiotherapy improves overall survival for patients with lymph node-positive head and neck squamous cell carcinoma (pages 535–543)
Amir Lavaf, Eric M. Genden, Jamie A. Cesaretti, Stuart Packer and Johnny Kao
Version of Record online: 12 DEC 2007 | DOI: 10.1002/cncr.23206
In what to the authors' knowledge is the largest reported analysis of adjuvant radiotherapy (RT) in patients with locally advanced squamous cell carcinoma of the head and neck (HNSCC) published to date, RT was found to result in an approximately 10% absolute increase in 5-year cancer-specific survival and overall survival for patients with lymph node-positive HNSCC compared with surgery alone.
You have free access to this content Identification of serum biomarkers for nasopharyngeal carcinoma by proteomic analysis (pages 544–551)
Ye-Sheng Wei, Yan-Hua Zheng, Wei-Bo Liang, Jian-Zhong Zhang, Zhi-Hui Yang, Mei-Li Lv, Jing Jia and Lin Zhang
Version of Record online: 17 DEC 2007 | DOI: 10.1002/cncr.23204
Serum samples from patients with nasopharyngeal carcinoma and from a group of noncancer controls were analyzed by using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry. Four protein peaks at 4097 Da, 4180 Da, 5912 Da, and 8295 Da were chosen automatically as a biomarker pattern that discriminated cancer from noncancer.
Hematologic Malignancies You have free access to this content The helix-loop-helix protein Id2 is expressed differentially and induced by myc in T-cell lymphomas (pages 552–561)
Claudiu V. Cotta, Vasiliki Leventaki, Vassilis Atsaves, Athina Vidaki, Ellen Schlette, Dan Jones, L. Jeffrey Medeiros and George Z. Rassidakis
Version of Record online: 17 DEC 2007 | DOI: 10.1002/cncr.23196
The expression and potential pathogenetic role of inhibitor of DNA binding 2 (Id2) was assessed in T-cell lymphomas. Id2 was expressed commonly in highly proliferating tumors and appeared to depend on myc activation.
You have free access to this content Significance of age in acute myeloid leukemia patients younger than 30 years : A common analysis of the pediatric trials AML-BFM 93/98 and the adult trials AMLCG 92/99 and AMLSG HD93/98A (pages 562–571)
Ursula Creutzig, Thomas Büchner, Maria C. Sauerland, Martin Zimmermann, Dirk Reinhardt, Hartmut Döhner and Richard F. Schlenk
Version of Record online: 12 DEC 2007 | DOI: 10.1002/cncr.23220
Biological data were comparable in the age groups children (2 to <13), adolescents (13 to <21), and young adults (21 to <30). In contrast to reports about acute lymphoblastic leukemia, differences in outcome were minimal between the AML-trial groups when comparing the same age groups; however, prognosis decreased after childhood independent of other risk factors.
You have free access to this content Prognostic value of immunophenotyping in elderly patients with acute myeloid leukemia : A single-institution experience (pages 572–580)
Claudiu Plesa, Youcef Chelghoum, Adriana Plesa, Mohamed Elhamri, Isabelle Tigaud, Mauricette Michallet, Charles Dumontet and Xavier Thomas
Version of Record online: 17 DEC 2007 | DOI: 10.1002/cncr.23219
In a cohort of 273 elderly patients with newly diagnosed acute myeloid leukemia, the expression of the membrane antigens CD13, CD15, CD33, and CD34 was investigated. When combining immunophenotypic and cytogenetic parameters, patients were classified into 4 groups to assess a prognostic system of immediate clinical utility for prognostic stratification and risk-adapted therapeutic choices.
Neuro-oncology You have free access to this content Intraarterial chemotherapy and osmotic blood-brain barrier disruption for patients with embryonal and germ cell tumors of the central nervous system (pages 581–588)
Kristoph Jahnke, Dale F. Kraemer, Kristin R. Knight, David Fortin, Susan Bell, Nancy D. Doolittle, Leslie L. Muldoon and Edward A. Neuwelt
Version of Record online: 10 DEC 2007 | DOI: 10.1002/cncr.23221
Response, survival, and toxicity data appear promising in this study of embryonal and germ cell central nervous system tumors treated with intraarterial chemotherapy and blood-brain barrier disruption, especially when considering that many patients carried adverse prognostic factors. A plateau in survival curves along with the long median follow-up in the study suggest a possible cure for some patients, even with subsequent focal or reduced dose radiotherapy only.
You have free access to this content Neurocognitive function in patients with small cell lung cancer : Effect of prophylactic cranial irradiation (pages 589–595)
David R. Grosshans, Christina A. Meyers, Pamela K. Allen, Samuel D. Davenport and Ritsuko Komaki
Version of Record online: 20 DEC 2007 | DOI: 10.1002/cncr.23222
Neurocognitive testing demonstrated that a substantial portion of patients with small cell lung cancer had impaired brain function at baseline. Persistent declines in cognitive function were not observed after prophylactic cranial irradiation.
You have free access to this content Combination of all- trans retinoic acid and paclitaxel-induced differentiation and apoptosis in human glioblastoma U87MG xenografts in nude mice (pages 596–607)
Surajit Karmakar, Naren L. Banik and Swapan K. Ray
Version of Record online: 20 DEC 2007 | DOI: 10.1002/cncr.23223
Glioblastoma is the most malignant brain tumor that still remains incurable. The investigation provides proof-of-principle of a combination therapy with all-
trans retinoic acid and paclitaxel for controlling the malignant growth of human glioblastoma U87MG xenografts in athymic nude mice. Sarcoma You have free access to this content Tumor mitotic rate, size, and location independently predict recurrence after resection of primary gastrointestinal stromal tumor (GIST) (pages 608–615)
Ronald P. DeMatteo, Jason S. Gold, Lisa Saran, Mithat Gönen, Kui Hin Liau, Robert G. Maki, Samuel Singer, Peter Besmer, Murray F. Brennan and Cristina R. Antonescu
Version of Record online: 12 DEC 2007 | DOI: 10.1002/cncr.23199
Recurrence after complete resection of localized, primary gastrointestinal stromal tumor in the absence of tyrosine kinase inhibition depends on mitotic rate, tumor size, and tumor site. In addition, specific mutations of the
KIT gene correlated with outcome. Discipline Cancer Disparities You have free access to this content Economic stress among low-income women with cancer : Effects on quality of life (pages 616–625)
Kathleen Ell, Bin Xie, Anjanette Wells, Frances Nedjat-Haiem, Pey-Jiuan Lee and Betsy Vourlekis
Version of Record online: 17 DEC 2007 | DOI: 10.1002/cncr.23203
Economic stress in this predominantly Latina population was negatively associated with quality of life (QOL), suggesting a need to address economic stress in minority low-income women with cancer.
Outcomes You have free access to this content Cost analysis of the National Breast and Cervical Cancer Early Detection Program : Selected states, 2003 to 2004 (pages 626–635)
Donatus U. Ekwueme, James G. Gardner, Sujha Subramanian, Florence K. Tangka, Bela Bapat and Lisa C. Richardson
Version of Record online: 21 DEC 2007 | DOI: 10.1002/cncr.23207
The authors examined the economic cost of providing cancer screening and diagnostic services in the National Breast and Cervical Cancer Early Detection Program. With limited program resources, costs per woman served, woman screened, and cancers detected are needed for programs to accurately determine the resources required to reach and screen eligible women.
Pathology You have free access to this content Strong immunohistochemical expression of fibroblast growth factor receptor 3, superficial staining pattern of cytokeratin 20, and low proliferative activity define those papillary urothelial neoplasms of low malignant potential that do not recur (pages 636–644)
Francesca Barbisan, Alfredo Santinelli, Roberta Mazzucchelli, Antonio Lopez-Beltran, Liang Cheng, Marina Scarpelli, Theodorus van der Kwast and Rodolfo Montironi
Version of Record online: 10 DEC 2007 | DOI: 10.1002/cncr.23212
Papillary urothelial neoplasm of low malignant potential (PUNLMP) is a clinically significant lesion because recurrence occurs in approximately 35% of patients. To date, it is not possible to identify those cases that will recur based on conventional histopathologic assessment. Strong immunohistochemical expression of fibroblast growth factor receptor 3, a superficial staining pattern of cytokeratin 20, and a low proliferative activity appear to define those cases of PUMLMP that do not recur.
You have free access to this content A nonrandom association between gastrointestinal stromal tumors and myeloid leukemia (pages 645–649)
Markku Miettinen, Ewa Kraszewska, Leslie H. Sobin and Jerzy Lasota
Version of Record online: 26 NOV 2007 | DOI: 10.1002/cncr.23216
Gastrointestinal stromal tumors (GISTs) are KIT-positive mesenchymal tumors of the gastrointestinal tract. These tumors most commonly occur in the stomach and small intestine and encompass a clinical spectrum from benign to malignant. In the current study, the authors examined long-term follow-up data from 1892 GIST patients from the U.S., and found increased incidence of acute myeloid leukemia in these patients.
Radiation Oncology You have free access to this content A prospective pilot study of curative-intent stereotactic body radiation therapy in patients with 5 or fewer oligometastatic lesions (pages 650–658)
Michael T. Milano, Alan W. Katz, Ann G. Muhs, Abraham Philip, Daniel J. Buchholz, Michael C. Schell and Paul Okunieff
Version of Record online: 10 DEC 2007 | DOI: 10.1002/cncr.23209
The hypothesized state of oligometastatic disease is potentially curable with stereotactic body radiation therapy. Patients with less volume burden of metastatic disease fared better as did patients with primary breast cancer.
Translational Research You have free access to this content Sensitivity of tumor cells to proteasome inhibitors is associated with expression levels and composition of proteasome subunits (pages 659–670)
Antonia Busse, Marianne Kraus, Il-Kang Na, Anika Rietz, Carmen Scheibenbogen, Christoph Driessen, Igor Wolfgang Blau, Eckhard Thiel and Ulrich Keilholz
Version of Record online: 7 JAN 2008 | DOI: 10.1002/cncr.23224
The authors demonstrated that sensitivity to proteasome inhibition was correlated with expression levels of proteasome subunits. Interferon γ induced the expression of immunoproteasome subunits and, in some cases, this was associated with increased sensitivity to proteasome inhibition.