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Cancer

Cover image for Cancer

1 December 2008

Volume 113, Issue 11

Pages 3059–3274

  1. News

    1. Top of page
    2. News
    3. Editorials
    4. Review Articles
    5. Original Articles
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      CancerScope (pages 3059–3061)

      Carrie Printz

      Version of Record online: 23 NOV 2008 | DOI: 10.1002/cncr.23907

  2. Editorials

    1. Top of page
    2. News
    3. Editorials
    4. Review Articles
    5. Original Articles
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      Prostate cancer risk assessment : Choosing the sharpest tool in the shed (pages 3062–3066)

      Matthew R. Cooperberg

      Version of Record online: 14 OCT 2008 | DOI: 10.1002/cncr.23920

      Prostate cancer risk assessment has become increasingly complex, with a long and growing menu of risk assessment tools available. Instrument selection for clinical practice and research must balance accuracy, validation, and applicability.

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      Screening for prostate cancer with serum prostate-specific antigen : What should we recommend while waiting for randomized clinical trial results? (pages 3067–3068)

      John W. Davis

      Version of Record online: 17 OCT 2008 | DOI: 10.1002/cncr.23933

      Nguyen et al compared the cancer recurrence-free survival after radical prostatectomy among 2 groups of men diagnosed with prostate cancer due to an elevated serum prostate-specific antigen (PSA): 1) those whose initial screening PSA was abnormal and 2) those with a history of previous normal screening PSAs. The study found group 1 to have more adverse pathologic features and recurrence-free survival.

  3. Review Articles

    1. Top of page
    2. News
    3. Editorials
    4. Review Articles
    5. Original Articles
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      Use of platinum derivatives during pregnancy (pages 3069–3074)

      Olivier Mir, Paul Berveiller, Stanislas Ropert, François Goffinet and François Goldwasser

      Version of Record online: 4 NOV 2008 | DOI: 10.1002/cncr.23935

      The authors performed a comprehensive review of the English literature to collect updated information and evaluate the potential toxicity of platinum derivatives during pregnancy. The results suggest the feasibility of using cisplatin and carboplatin during the second and third trimesters of pregnancy; however, close neonatal surveillance is warranted. Platinum derivatives may cross the placenta during the last weeks of pregnancy, and the potential for short-term and long-term toxicity remains unknown.

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      An updated catalog of prostate cancer predictive tools (pages 3075–3099)

      Shahrokh F. Shariat, Pierre I. Karakiewicz, Claus G. Roehrborn and Michael W. Kattan

      Version of Record online: 29 SEP 2008 | DOI: 10.1002/cncr.23908

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      Accurate estimates of risk are essential for physicians if they are to recommend specific management to patients with prostate cancer. The authors of this review recommend wider adoption of risk-prediction models and believe that many more predictive tools, comparisons between them, and improvements to existing tools are needed.

  4. Original Articles

    1. Top of page
    2. News
    3. Editorials
    4. Review Articles
    5. Original Articles
    1. Disease Site

      Breast Disease
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      A prospective feasibility trial to determine the significance of the sentinel node gradient in breast cancer : A predictor of nodal metastasis location (pages 3100–3107)

      Richard J. Bleicher, Martin J. O'Sullivan, Vincenzo Ciocca, Robin M. Ciocca, L. Allen Perkins, Eric Ross, Tianyu Li, Arthur S. Patchefsky, Elin R. Sigurdson, Natalie E. Joseph, Linda Sesa and Monica Morrow

      Version of Record online: 30 OCT 2008 | DOI: 10.1002/cncr.23932

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      The dyes used in sentinel lymphadenectomy cause visible dye gradients in many sentinel lymph nodes (SNs), although this has not yet been characterized. This trial has demonstrated that the SN gradient is easily identifiable, nearly universal, and correlates with the site of SN metastasis, suggesting that its use in focused pathologic examination of SNs should be investigated.

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      Correlates and effect of suboptimal radiotherapy in women with ductal carcinoma in situ or early invasive breast cancer (pages 3108–3115)

      Heather Taffet Gold, Huong T. Do and Andrew W. Dick

      Version of Record online: 17 OCT 2008 | DOI: 10.1002/cncr.23923

      Women of nonwhite race were more likely to delay radiotherapy initiation after surgery for ductal carcinoma in situ (DCIS) or early invasive breast cancer. Radiotherapy delay and noncompletion were associated with poorer health outcomes in women with DCIS or stage I breast cancer compared with timely and complete radiotherapy.

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      The American Cancer Society guidelines for breast screening with magnetic resonance imaging : An argument for genetic testing (pages 3116–3120)

      Colleen D. Murphy, Janie M. Lee, Brian Drohan, David M. Euhus, Daniel B. Kopans, Michele A. Gadd, Elizabeth A. Rafferty, Michelle C. Specht, Barbara L. Smith and Kevin S. Hughes

      Version of Record online: 17 OCT 2008 | DOI: 10.1002/cncr.23913

      The American Cancer Society guidelines for breast magnetic resonance imaging (MRI) screening may exclude MRI screening systematically for many women who have a substantial risk of carrying a BRCA breast cancer gene mutation.

    4. Chest
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      Pathomorphologic evaluation of pulmonary radiofrequency ablation : Proof of cell death is characterized by DNA fragmentation and apoptotic bodies (pages 3121–3129)

      Stephan Clasen, Stefan-Martin Krober, Bora Kosan, Hermann Aebert, Falko Fend, Andrea Bomches, Claus D. Claussen and Philippe L. Pereira

      Version of Record online: 30 OCT 2008 | DOI: 10.1002/cncr.23882

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      Radiofrequency ablation of primary and secondary pulmonary malignancies is a locally effective treatment. The tissue seems to be thermally fixed still showing characteristics of vital tumor tissue in standard histological staining; however, it has proven to be in regression toward coagulative necrosis verified ultrastructurally and by TUNEL, indicating DNA fragmentation.

    5. Endocrine Disease
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      Adrenocortical carcinoma in the United States : Treatment utilization and prognostic factors (pages 3130–3136)

      Karl Y. Bilimoria, Wen T. Shen, Dina Elaraj, David J. Bentrem, David J. Winchester, Electron Kebebew and Cord Sturgeon

      Version of Record online: 30 OCT 2008 | DOI: 10.1002/cncr.23886

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      This article examines treatment utilization and factors associated with long-term survival after resection of adrenocortical carcinoma in a large, national patient population. Survival is not affected by tumor size but is diminished with increasing age, poorly differentiated tumors, involved margins, and the presence of regional and distant disease.

    6. Genitourinary Disease
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      Multicenter phase 2 study of neoadjuvant paclitaxel, estramustine phosphate, and carboplatin plus androgen deprivation before radiation therapy in patients with unfavorable-risk localized prostate cancer : Results of Cancer and Leukemia Group B 99811 (pages 3137–3145)

      William Kevin Kelly, Susan Halabi, Aymen Elfiky, San-San Ou, Jeff Bogart, Michael Zelefsky and Eric Small

      Version of Record online: 6 NOV 2008 | DOI: 10.1002/cncr.23910

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      The safety and feasibility of using paclitaxel, estramustine, and carboplatin neoadjuvant chemohormonal therapy with high-dose radiotherapy was demonstrated in a multi-institutional setting in patients with high-risk localized prostate cancer.

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      Biochemical recurrence after radical prostatectomy for prevalent versus incident cases of prostate cancer : Implications for management (pages 3146–3152)

      Paul L. Nguyen, Ming-Hui Chen, William J. Catalona, Brian M. Alexander, Kimberly A. Roehl, Stacy Loeb and Anthony V. D'Amico

      Version of Record online: 17 OCT 2008 | DOI: 10.1002/cncr.23926

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      The authors investigated whether the detection of prostate cancer at initial screening versus subsequent screenings is associated with the time to prostate-specific antigen (PSA) failure in patients with screen-detected, clinically localized prostate cancer after adjusting for PSA level, biopsy Gleason score, and clinical tumor classification. The results suggested that the detection of cancer at an initial screening resulted in a poorer outcome and may be an indicator that a patient harbors unmeasured poor prognostic features.

    8. Head and Neck Disease
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      Risk of radiation-related salivary gland carcinomas among survivors of Hodgkin lymphoma : A population-based analysis (pages 3153–3159)

      Houda Boukheris, Elaine Ron, Graça M. Dores, Marilyn Stovall, Susan A. Smith and Rochelle E. Curtis

      Version of Record online: 29 SEP 2008 | DOI: 10.1002/cncr.23918

      Radiotherapy for Hodgkin lymphoma increases the risk of salivary gland carcinomas. However, to the authors' knowledge, the magnitude of the risk has not been assessed.

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      Head and neck squamous cell carcinoma in patients aged ≥80 years : Patterns of care and survival (pages 3160–3168)

      Antoine Italiano, Cecile Ortholan, Olivier Dassonville, Gilles Poissonnet, Juliette Thariat, Karen Benezery, Jacques Vallicioni, Frédéric Peyrade, Pierre-Yves Marcy and René-Jean Bensadoun

      Version of Record online: 17 OCT 2008 | DOI: 10.1002/cncr.23931

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      In this retrospective study, the outcome of elderly patients with stage I/II head and neck squamous cell carcinoma was similar to that of younger patients, and the results indicated that age should not be used to deny them optimal treatment. Geriatric tools should be used to identify elderly patients who are eligible for optimal locoregional treatment.

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      Claudin 1 overexpression increases invasion and is associated with aggressive histological features in oral squamous cell carcinoma (pages 3169–3180)

      Patricia Pintor dos Reis, Rikki R. Bharadwaj, Jerry Machado, Christina MacMillan, Melania Pintilie, Mahadeo A. Sukhai, Bayardo Perez-Ordonez, Patrick Gullane, Jonathan Irish and Suzanne Kamel-Reid

      Version of Record online: 7 NOV 2008 | DOI: 10.1002/cncr.23934

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      This study is the first to show an association of overexpression of claudin 1, which encodes a tight junction protein, with aggressive histological features in oral squamous cell carcinomas. The authors also demonstrate the involvement of this protein in the invasive potential of oral carcinoma cells.

    11. Hematologic Malignancies
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      Treatment of core-binding-factor in acute myelogenous leukemia with fludarabine, cytarabine, and granulocyte colony-stimulating factor results in improved event-free survival (pages 3181–3185)

      Gautam Borthakur, Hagop Kantarjian, Xuemei Wang, William K. Plunkett Jr, Varsha V. Gandhi, Stefan Faderl, Guillermo Garcia-Manero, Farhad Ravandi, Sherry Pierce and Elihu H. Estey

      Version of Record online: 17 OCT 2008 | DOI: 10.1002/cncr.23927

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      The authors demonstrate that in patients with newly diagnosed core-binding-factor acute myelogenous leukemia, after accounting for prognostic covariates other than treatment (including year in which treatment was administered); FA, and in particular FLAG, were associated with longer event-free survival than IA/IAG. Thus, our data lends clinical credence to the observed modulation of ara-C by fludarabine and GCSF.

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      Outcome of adults with acute lymphocytic leukemia after second salvage therapy (pages 3186–3191)

      Susan O'Brien, Deborah Thomas, Farhad Ravandi, Stefan Faderl, Jorge Cortes, Gautum Borthakur, Sherry Pierce, Guillermo Garcia-Manero and Hagop M. Kantarjian

      Version of Record online: 7 OCT 2008 | DOI: 10.1002/cncr.23919

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      In this study, 288 adults with acute lymphocytic leukemia who received second salvage therapy were analyzed. The complete response rate was 18%, the median remission duration was 7 months, and the median overall survival was 3 months. Prognostic factors for achieving complete remission and survival were developed to help in more precisely predicting the estimated outcome of patients with this condition.

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      A multicenter phase 2 study of risk-adjusted salvage chemotherapy incorporating vinorelbine and gemcitabine for relapsed and refractory lymphoma (pages 3192–3198)

      Sant-Rayn Pasricha, Andrew Grigg, John Catalano, Michael Leahy, Craig Underhill, Chris Arthur, James D'Rozario, Ray Lowenthal, Kate Reed and Andrew Spencer

      Version of Record online: 17 OCT 2008 | DOI: 10.1002/cncr.23915

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      Salvage chemotherapy for relapsed and refractory Hodgkin and non-Hodgkin lymphoma can be effectively and safely achieved using gemcitabine-based and vinorelbine-based outpatient administered chemotherapy regimens. Incorporating a standardized interim evaluation and treatment escalation may augment the response to these therapies.

    14. Lung Disease
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      Reversed mutation rates of KRAS and EGFR genes in adenocarcinoma of the lung in Taiwan and their implications (pages 3199–3208)

      Chun-Chieh Wu, Hui-Yu Hsu, Hui-Ping Liu, John Wen-Cheng Chang, Ya-Ting Chen, Wen-Yu Hsieh, Jia-Juan Hsieh, Meng-Shu Hsieh, Yi-Rong Chen and Shiu-Feng Huang

      Version of Record online: 17 OCT 2008 | DOI: 10.1002/cncr.23925

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      This study indicated that the Kirsten ras oncogene homolog gene KRAS mutation rate was too low (3.8%) to play a significant role in tyrosine kinase inhibitor resistance or tumorigenesis in Taiwanese patients with nonsmall cell lung cancer. This finding was the complete reverse of what has been reported in western countries.

    15. Discipline

      Clinical Trials
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      Reliability of staging, prognosis, and comorbidity data collection in the National Comprehensive Cancer Network (NCCN) non-Hodgkin lymphoma (NHL) multicenter outcomes database (pages 3209–3212)

      Michelle E. Kho, Eva M. Lepisto, Joyce C. Niland, Jonathan W. Friedberg, Ann S. LaCasce and Jane C. Weeks

      Version of Record online: 14 OCT 2008 | DOI: 10.1002/cncr.23911

      Clinical trials and outcomes studies often rely on nonphysicians to abstract complex data from medical records, but the reliability of these data are rarely assessed. In this study, trained CRAs abstracted key clinical variables with a very high degree of reliability, and performed at a level similar to study trainers and oncologists.

    16. Diagnostic Imaging
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      Noninvasive diagnosis of solitary pulmonary lesions in cancer patients based on 2-fluoro-2-deoxy-D-glucose avidity on positron emission tomography/computed tomography (pages 3213–3221)

      Rachel Bar-Shalom, Olga Kagna, Ora Israel and Ludmila Guralnik

      Version of Record online: 15 OCT 2008 | DOI: 10.1002/cncr.23928

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      In this study, 2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography/computed tomography was highly accurate for the characterization of solitary pulmonary nodules (SPN) in patients with cancer, similar to its performance in patients with no known malignancy. FDG avidity was a significantly more sensitive criterion than semiquantitative review of FDG uptake. The results indicated that lower than mediastinal FDG uptake should be explored cautiously, particularly for second primary tumors, which were identified in 40% of patients; whereas no FDG avidity was a better predictor of a benign SPN.

    17. Disparities Research
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      Breast cancer survivors' health-related quality of life : Racial differences and comparisons with noncancer controls (pages 3222–3230)

      Electra D. Paskett, Catherine M. Alfano, Mario A. Davidson, Barbara L. Andersen, Michelle J. Naughton, Aurora Sherman, Paige Green McDonald and Jennifer Hays

      Version of Record online: 30 OCT 2008 | DOI: 10.1002/cncr.23891

      In the Women's Health Initiative-Observational Study, African American breast cancer survivors reported small but clinically meaningful decrements in physical health-related quality of life compared with white survivors and with African American women without cancer.

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      Ethnic variations in diagnosis, treatment, socioeconomic status, and survival in a large population-based cohort of elderly patients with non-Hodgkin lymphoma (pages 3231–3241)

      Michael Wang, Keith D. Burau, Shenying Fang, Harry Wang and Xianglin L. Du

      Version of Record online: 20 OCT 2008 | DOI: 10.1002/cncr.23914

      The risk of mortality in patients with non-Hodgkin lymphoma was associated with socioeconomic status and was reduced in patients receiving chemotherapy. No significant differences in the risk of mortality were observed between African American and Caucasian patients after controlling for factors such as treatment and socioeconomic status.

    19. Pediatric Oncology
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      Prevalence and clinical impact of anaplasia in childhood rhabdomyosarcoma : A report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group (pages 3242–3247)

      Stephen Qualman, James Lynch, Julia Bridge, David Parham, Lisa Teot, William Meyer and Alberto Pappo

      Version of Record online: 4 NOV 2008 | DOI: 10.1002/cncr.23929

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      Anaplasia was observed in 13% of samples of rhabdomyosarcoma and its presence was found to have a survival impact on univariate analysis in patients with embryonal rhabdomyosarcoma.

      Corrected by:

      Erratum: Erratum

      Vol. 115, Issue 12, 2806, Version of Record online: 7 MAY 2009

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      Bone mineral density in young adult survivors of acute lymphoblastic leukemia (pages 3248–3256)

      Inas H. Thomas, Janet E. Donohue, Kirsten K. Ness, Donald R. Dengel, K. Scott Baker and James G. Gurney

      Version of Record online: 17 OCT 2008 | DOI: 10.1002/cncr.23912

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      In a clinical follow-up study of 74 young adult survivors of childhood acute lymphoblastic leukemia (mean age, 30 years), bone mineral density (BMD) of ≥1 standard deviation below the mean was substantially more prevalent in men than in women and was strongly associated with short height. Growth hormone insufficiency, low insulin-like growth factor I, and current smoking were also found to be suggestive risk factors for low BMD.

    21. Psychosocial Oncology
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      A randomized controlled trial of an appearance-focused intervention to prevent skin cancer (pages 3257–3266)

      Joel Hillhouse, Rob Turrisi, Jerod Stapleton and June Robinson

      Version of Record online: 20 OCT 2008 | DOI: 10.1002/cncr.23922

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      An appearance-focused booklet intervention led to significant reductions in normative springtime increases in indoor tanning behavior and intentions in young female indoor tanners. Mediational analyses revealed cognitive and perceptual variables that could explain these effects.

    22. Symptom Control and Palliative Care
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      Impact of opening an acute palliative care unit on administrative outcomes for a general oncology ward (pages 3267–3274)

      Andrew Rigby, Monika Krzyzanowska, Lisa W. Le, Nadia Swami, Gary Coe, Gary Rodin, Malcolm Moore and Camilla Zimmermann

      Version of Record online: 17 OCT 2008 | DOI: 10.1002/cncr.23909

      The opening of an acute palliative care unit may result in specialization of admissions at a general oncology ward at the same center, including fewer admissions for palliative care and more admissions for cancer-directed treatments and interventions. Prospective studies with clinical endpoints are needed to determine whether such specialization improves the quality of care for patients and their families.

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