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Cancer

Cover image for Cancer

15 December 2008

Volume 113, Issue 12

Pages 3275–3478

  1. Editorials

    1. Top of page
    2. Editorials
    3. Review Article
    4. Original Articles
    5. Orginal Articles
    6. Original Articles
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      Androgen suppression therapy and prostate cancer : Balancing the harms and the benefits (pages 3275–3278)

      Michael G. Oefelein

      Version of Record online: 5 NOV 2008 | DOI: 10.1002/cncr.23971

      Men with localized, low-risk carcinoma of the prostate with multiple comorbidities may experience few benefits from androgen suppression therapy (AST), and probably would be better served by an active surveillance approach, with delayed AST if evidence of progression develops. A proactive position regarding the potential for AST to unmask existing or occult coronary artery disease or for AST to facilitate development of cardiovascular disease warrants consideration.

  2. Review Article

    1. Top of page
    2. Editorials
    3. Review Article
    4. Original Articles
    5. Orginal Articles
    6. Original Articles
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      Rates and predictors of chemotherapy use for stage III colon cancer : A systematic review (pages 3279–3289)

      David A. Etzioni, Anthony B. El-Khoueiry and Robert W. Beart Jr

      Version of Record online: 24 OCT 2008 | DOI: 10.1002/cncr.23958

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      The authors systematically reviewed reports of the rates of use of chemotherapy in patients with stage III colon cancer. Based on this analysis, they found significant underuse, and therefore propose a conceptual model with which to guide future efforts.

  3. Original Articles

    1. Top of page
    2. Editorials
    3. Review Article
    4. Original Articles
    5. Orginal Articles
    6. Original Articles
    1. Disease Site

      Genitourinary Disease
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      Causes of death in men undergoing androgen suppression therapy for newly diagnosed localized or recurrent prostate cancer (pages 3290–3297)

      Anthony V. D'Amico, Ming-Hui Chen, Andrew A. Renshaw, Marian Loffredo and Philip W. Kantoff

      Version of Record online: 3 NOV 2008 | DOI: 10.1002/cncr.23970

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      The ability to measure an increase in the risk of death in men with moderate to severe as compared with no or minimal comorbidity undergoing androgen suppression therapy (AST) decreases as the risk of prostate cancer-specific mortality increases. This observation may explain the discordance in the literature regarding the risk of cardiovascular death and AST use.

    2. Gynecologic Oncology
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      Improved survival for fallopian tube cancer : A comparison of clinical characteristics and outcome for primary fallopian tube and ovarian cancer (pages 3298–3306)

      Stephanie L. Wethington, Thomas J. Herzog, Venkatraman E. Seshan, Nisha Bansal, Peter B. Schiff, William M. Burke, Carmel J. Cohen and Jason D. Wright

      Version of Record online: 12 NOV 2008 | DOI: 10.1002/cncr.23957

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      Fallopian tube cancer is associated with a more favorable long-term outcome than ovarian cancer. Women with fallopian tube carcinomas are more likely to be diagnosed at an early stage, but the differential stage distribution between primary tumor sites does not account entirely for the survival difference. Fallopian tube carcinomas appear to follow a course that is distinct from ovarian cancers.

    3. Head and Neck Disease
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      p73 G4C14-to-A4T14 polymorphism and risk of human papillomavirus-associated squamous cell carcinoma of the oropharynx in never smokers and never drinkers (pages 3307–3314)

      Xingming Chen, Erich M. Sturgis, Carol J. Etzel, Qingyi Wei and Guojun Li

      Version of Record online: 5 NOV 2008 | DOI: 10.1002/cncr.23976

      The p73 G4C14-to-A4T14 polymorphism may modulate the risk of human papillomavirus type 16 (HPV-16)–associated squamous cell carcinoma of the oropharynx, and the p73 variant genotypes may be markers genetic susceptibility to HPV-16-associated squamous cell carcinoma of the oropharynx, particularly in never smokers and never drinkers.

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      Head and neck squamous cell carcinoma in 13 patients with Fanconi anemia after hematopoietic stem cell transplantation (pages 3315–3322)

      Caroline Masserot, Régis Peffault de Latour, Vanderson Rocha, Thierry Leblanc, Arnaud Rigolet, Francis Pascal, Anne Janin, Jean Soulier, Eliane Gluckman and Gérard Socié

      Version of Record online: 2 OCT 2008 | DOI: 10.1002/cncr.23954

      In the current study, the authors report 13 cases of head and neck squamous cell carcinoma after hematopoietic stem cell transplantation for Fanconi anemia. This tumor is particularly aggressive and is correlated with a very poor prognosis; systematic oral surveillance is essential to permit early surgery, which to the authors' knowledge is the only curative treatment.

    5. Hematologic Malignancies
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      Early versus late intensification for patients with high-risk Hodgkin lymphoma—3 Cycles of intensive chemotherapy plus low-dose lymph node radiation therapy versus 4 cycles of combined doxorubicin, bleomycin, vinblastine, and dacarbazine plus myeloablative chemotherapy with autologous stem cell transplantation : Five-year results of a randomized trial on behalf of the GOELAMS group (pages 3323–3330)

      Nina Arakelyan, Christian Berthou, Bernard Desablens, Sophie de Guibert, Vincent Delwail, Marie-Pierre Moles, Philippe Quittet, Jean-Philippe Jais, Pierre Colonna, Jean-Marie Andrieu and and the Groupe Ouest-Est d'Etude des Leucémies et Autres Maladies du Sang

      Version of Record online: 5 NOV 2008 | DOI: 10.1002/cncr.23979

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      A phase 2 randomized trial conducted in 158 patients with high-risk/advanced Hodgkin lymphoma demonstrated that 3 cycles of intensive chemotherapy plus low-dose lymph node radiation therapy produced 5-year freedom from treatment failure and overall survival rates that were similar to the rates produced by 4 cycles of combined doxorubicin, bleomycin, vinblastine, and dacarbazine plus myeloablative chemotherapy associated with autologous stem cell transplantation.

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      Cytogenetic abnormalities in a series of 1029 patients with primary myelodysplastic syndromes : A report from the US with a focus on some undefined single chromosomal abnormalities (pages 3331–3340)

      Olga Pozdnyakova, Patricia M. Miron, Guilin Tang, Otto Walter, Azra Raza, Bruce Woda and Sa A. Wang

      Version of Record online: 5 NOV 2008 | DOI: 10.1002/cncr.23977

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      Clinicopathologic data were retrieved on 1029 patients who had a diagnosis of primary myelodysplastic syndrome (MDS) and had cytogenetic data (karyotype) available to investigate the prognostic significance of cytogenetics in MDS. The results indicated that some specific cytogenetic abnormalities carry different risk than their International Prognostic Scoring System cytogenetic risk-group assignment, especially in the new treatment era.

    7. Melanoma
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      Changes in the presentation of nodular and superficial spreading melanomas over 35 years (pages 3341–3348)

      Melanie A. Warycha, Paul J. Christos, Madhu Mazumdar, Farbod Darvishian, Richard L. Shapiro, Russell S. Berman, Anna C. Pavlick, Alfred W. Kopf, David Polsky and Iman Osman

      Version of Record online: 5 NOV 2008 | DOI: 10.1002/cncr.23955

      In comparing the clinical and histopathologic features of 1372 nodular and superficial spreading melanomas diagnosed at their institution over the last 35 years, the authors detected a statistically significant migration to earlier stages of disease at diagnosis for superficial spreading melanomas but not for nodular melanomas, which continue to present with aggressive histological features and at regionally advanced stages of disease. These findings indicate that improvements in the early detection of melanoma have been limited to superficial spreading melanoma, and suggest that current public education and screening practices may be ineffective at recognizing nodular melanoma at early stages in its progression.

    8. Neuro-Oncology
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      Management of malignant gliomas during pregnancy : A case series (pages 3349–3354)

      Deborah T. Blumenthal, Mary Grace H. Parreño, Julia Batten and Marc C. Chamberlain

      Version of Record online: 5 NOV 2008 | DOI: 10.1002/cncr.23973

      Six patients with previously diagnosed malignant gliomas who, while undergoing postradiation chemotherapy, discovered they were pregnant. All patients elected to proceed with their pregnancies and had no adverse events. Women with malignant gliomas and unplanned pregnancies complicated by chemotherapy exposure can experience uncomplicated pregnancy and healthy live birth.

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      Tumor recurrence and malignant progression of gangliogliomas (pages 3355–3363)

      Michael Majores, Marec von Lehe, Jana Fassunke, Johannes Schramm, Albert J. Becker and Matthias Simon

      Version of Record online: 5 NOV 2008 | DOI: 10.1002/cncr.23965

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      Epidemiological, clinical, and neuropathologic parameters were analyzed in a series of atypical gangliogliomas or gangliogliomas that developed disease recurrence or malignant progression. The results supported a 3-tiered histopathologic grading system that included an intermediate diagnostic category.

    10. Sarcoma
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      Extraskeletal myxoid chondrosarcoma : A retrospective review from 2 referral centers emphasizing long-term outcomes with surgery and chemotherapy (pages 3364–3371)

      Alex D. Drilon, Sanjay Popat, Gauri Bhuchar, David R. D'Adamo, Mary Louise Keohan, Cyril Fisher, Cristina R. Antonescu, Samuel Singer, Murray F. Brennan, Ian Judson and Robert G. Maki

      Version of Record online: 24 OCT 2008 | DOI: 10.1002/cncr.23978

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      Extraskeletal myxoid chondrosarcoma is a rare form of sarcoma characterized by a specific chromosomal translocation and a high rate of both local recurrence and metastatic disease over many years. No significant responses were noted in 21 patients receiving 32 lines of systemic therapy, indicating the need for new agents for the treatment of systemic disease.

    11. Skin
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      Incidence of cutaneous sebaceous carcinoma and risk of associated neoplasms : Insight into Muir-Torre syndrome (pages 3372–3381)

      Graça M. Dores, Rochelle E. Curtis, Jorge R. Toro, Susan S. Devesa and Joseph F. Fraumeni Jr

      Version of Record online: 17 OCT 2008 | DOI: 10.1002/cncr.23963

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      This population-based study of cutaneous sebaceous carcinoma revealed an association with a spectrum of early-onset cancers consistent with Muir-Torre syndrome. Etiologic heterogeneity was suggested by differences between eyelid and noneyelid sebaceous carcinoma in incidence patterns and associated cancer risks.

    12. Discipline

      Clinical Trials
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      Improving understanding of adjuvant therapy options by using simpler risk graphics (pages 3382–3390)

      Brian J. Zikmund-Fisher, Angela Fagerlin and Peter A. Ubel

      Version of Record online: 14 NOV 2008 | DOI: 10.1002/cncr.23959

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      The commonly used Adjuvant! risk calculator displays tailored estimates of breast cancer patients' mortality and recurrence risks by using a suboptimal graphical format (a set of 4 horizontal stacked bars). Simplifying the design graphics could significantly improve patients' comprehension of the statistical information essential for informed medical decision making about adjuvant therapies.

  4. Orginal Articles

    1. Top of page
    2. Editorials
    3. Review Article
    4. Original Articles
    5. Orginal Articles
    6. Original Articles
    1. Discipline

      Disparities Research
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      National Cancer Institute Patient Navigation Research Program : Methods, protocol, and measures (pages 3391–3399)

      Karen M. Freund, Tracy A. Battaglia, Elizabeth Calhoun, Donald J. Dudley, Kevin Fiscella, Electra Paskett, Peter C. Raich, Richard G. Roetzheim and The Patient Navigation Research Program Group

      Version of Record online: 24 OCT 2008 | DOI: 10.1002/cncr.23960

      To the authors' knowledge, the National Cancer Institute (NCI) Patient Navigation Research Program is the first multisite study to assess the benefits of patient navigation to reduce cancer disparities. The definitions, measures, and outcomes defined by this program will benefit other research investigating patient navigation.

  5. Original Articles

    1. Top of page
    2. Editorials
    3. Review Article
    4. Original Articles
    5. Orginal Articles
    6. Original Articles
    1. Discipline

      Disparities Research
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      Racial disparities and treatment trends in a large cohort of elderly African Americans and Caucasians with colorectal cancer, 1991 to 2002 (pages 3400–3409)

      Arica White, Chih-Chin Liu, Rui Xia, Keith Burau, Janice Cormier, Wenyaw Chan and Xianglin L. Du

      Version of Record online: 17 OCT 2008 | DOI: 10.1002/cncr.23924

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      The percentage of patients who received standard therapy for colorectal cancer increased over time for both African Americans and Caucasians. However, the disparities between both groups remained and decreased in recent years.

    2. Epidemiology
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      Risk of cholecystitis in patients with cancer : A population-based cohort study in Denmark (pages 3410–3419)

      Reimar W. Thomsen, Henrik F. Thomsen, Mette Nørgaard, Karynsa Cetin, Joseph K. McLaughlin, Robert E. Tarone, Jon P. Fryzek and Henrik T. Sørensen

      Version of Record online: 24 OCT 2008 | DOI: 10.1002/cncr.23961

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      This population-based cohort study found that cancer patients have an increased risk of cholecystitis compared with the general population, particularly during the first 6 months after diagnosis. Pancreatic, colorectal, and thyroid cancer appear to confer an especially high relative risk for subsequent cholecystitis.

    3. Medical Oncology
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      A phase 1 trial of 2 dose schedules of ABT-510, an antiangiogenic, thrombospondin-1-mimetic peptide, in patients with advanced cancer (pages 3420–3429)

      Michael S. Gordon, David Mendelson, Robert Carr, Raymond A. Knight, Rod A. Humerickhouse, Maria Iannone and Alison T. Stopeck

      Version of Record online: 17 OCT 2008 | DOI: 10.1002/cncr.23953

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      ABT-510 is a nonapeptide that mimics the antiangiogenic activity of the endogenous inhibitor thrombospondin-1. The current trial reports the safety, pharmacokinetics, and efficacy of this drug at several dose levels in patients with refractory solid tumors.

    4. Outcomes Research
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      Safety and feasibility of aerobic training on cardiopulmonary function and quality of life in postsurgical nonsmall cell lung cancer patients : A pilot study (pages 3430–3439)

      Lee W. Jones, Neil D. Eves, Bercedis L. Peterson, Jennifer Garst, Jeffrey Crawford, Miranda J. West, Stephanie Mabe, David Harpole, William E. Kraus and Pamela S. Douglas

      Version of Record online: 5 NOV 2008 | DOI: 10.1002/cncr.23967

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      This pilot study provided proof of principle that supervised aerobic training is safe and feasible for postsurgical nonsmall cell lung cancer patients. Aerobic exercise training was also associated with significant improvements in quality of life and select cardiopulmonary endpoints, particularly among patients not receiving systemic therapy.

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      Adopting helical CT screening for lung cancer : Potential health consequences during a 15-year period (pages 3440–3449)

      Pamela M. McMahon, Chung Yin Kong, Milton C. Weinstein, Angela C. Tramontano, Lauren E. Cipriano, Bruce E. Johnson, Jane C. Weeks and G. Scott Gazelle

      Version of Record online: 5 NOV 2008 | DOI: 10.1002/cncr.23962

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      Results from a comprehensive microsimulation model of lung cancer suggested that the introduction of helical CT screening in 1990 might have led to modest reductions in lung cancer mortality by 2005.

    6. Psychosocial Oncology
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      Psychologic intervention improves survival for breast cancer patients : A randomized clinical trial (pages 3450–3458)

      Barbara L. Andersen, Hae-Chung Yang, William B. Farrar, Deanna M. Golden-Kreutz, Charles F. Emery, Lisa M. Thornton, Donn C. Young and William E. Carson III

      Version of Record online: 17 NOV 2008 | DOI: 10.1002/cncr.23969

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      Psychologic and behavioral variables can have profound effects on health. In the current study, a randomized clinical trial of a psychologic intervention for breast cancer patients was found to lower risk of disease recurrence and death.

    7. Symptom Control and Palliative Care
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      Cancer patient preferences for quality and length of life (pages 3459–3466)

      Neal J. Meropol, Brian L. Egleston, Joanne S. Buzaglo, Al B. Benson III, Donald J. Cegala, Michael A. Diefenbach, Linda Fleisher, Suzanne M. Miller, Daniel P. Sulmasy OFM, Kevin P. Weinfurt and CONNECT Study Research Group

      Version of Record online: 5 NOV 2008 | DOI: 10.1002/cncr.23968

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      Among 459 patients with advanced cancer, a preference for quality of life (QOL) over length of life was associated with lower levels of cancer-related distress, older age, male sex, and higher education. Furthermore, patients who preferred QOL desired more supportive and less pessimistic communication from the oncologist. An awareness of these values during the clinical encounter could improve decision making by influencing the nature and content of the communication between oncologists and their patients.

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