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Cancer

Cover image for Cancer

15 July 2008

Volume 113, Issue 2

Pages 225–445

  1. Review Article

    1. Top of page
    2. Review Article
    3. Original Articles
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      Can a “prompt list” empower cancer patients to ask relevant questions? (pages 225–237)

      Aneta Dimoska, Martin H.N. Tattersall, Phyllis N. Butow, Heather Shepherd and Paul Kinnersley

      Version of Record online: 16 MAY 2008 | DOI: 10.1002/cncr.23543

  2. Original Articles

    1. Top of page
    2. Review Article
    3. Original Articles
    1. Disease Site

      Breast Disease
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      Taxanes as primary chemotherapy for early breast cancer : Meta-analysis of randomized trials (pages 238–246)

      Federica Cuppone, Emilio Bria, Paolo Carlini, Michele Milella, Alessandra Felici, Isabella Sperduti, Cecilia Nisticò, Edmondo Terzoli, Francesco Cognetti and Diana Giannarelli

      Version of Record online: 9 MAY 2008 | DOI: 10.1002/cncr.23544

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      To clarify the impact of adding taxanes to anthracyclines as primary chemotherapy for early breast cancer, a literature-based meta-analysis of randomized trials was performed. Such a combination improves the chance of achieving both higher breast-conserving surgery and pathologic complete response rate, which are currently considered primary endpoints for clinical trial design in this disease setting.

    2. Endocrine Disease
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      Hypermethylation of the DNA mismatch repair gene hMLH1 and Its association with lymph node metastasis and T1799A BRAF mutation in patients with papillary thyroid cancer (pages 247–255)

      Haixia Guan, Meiju Ji, Peng Hou, Zhi Liu, Cuifang Wang, Zhongyan Shan, Weiping Teng and Mingzhao Xing

      Version of Record online: 9 MAY 2008 | DOI: 10.1002/cncr.23548

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      In the current study, 23 DNA repair genes were examined for methylation in papillary thyroid cancer, and the mismatch repair gene hMLH1 was found to be hypermethylated particularly often in association with lymph node metastasis and BRAF mutation, suggesting a role for this epigenetic alteration in thyroid tumorigenesis.

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      Prognostic relevance of a novel TNM classification system for upper gastroenteropancreatic neuroendocrine tumors (pages 256–265)

      Ulrich-Frank Pape, Henning Jann, Jacqueline Müller-Nordhorn, Angelina Bockelbrink, Uta Berndt, Stefan N. Willich, Martin Koch, Christoph Röcken, Guido Rindi and Bertram Wiedenmann

      Version of Record online: 27 MAY 2008 | DOI: 10.1002/cncr.23549

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      The authors evaluated the prognostic significance of a recently proposed, novel TNM staging and grading system for neuroendocrine tumors (NETs) of the stomach, duodenum, and pancreas compared with previous classification systems, including the World Health Organization classification. The results demonstrated that the newly proposed classification system allows a significant, prognostically relevant stratification of patients with NET that is easily applicable in both clinical practice and research.

    4. Gastrointestinal Disease
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      Gene-expression profiling in Chinese patients with colon cancer by coupling experimental and bioinformatic genomewide gene-expression analyses : Identification and validation of IFITM3 as a biomarker of early colon carcinogenesis (pages 266–275)

      Junwei Fan, Zhihai Peng, Chongzhi Zhou, Guoqiang Qiu, Huamei Tang, Yuhao Sun, Xiaoliang Wang, Qiang Li, Xiangdong Le and Keping Xie

      Version of Record online: 9 MAY 2008 | DOI: 10.1002/cncr.23551

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      Expression microarrays are widely used for investigating the nature and extent of global gene-expression changes in human cancer. Accurate genomewide gene-expression profiles have not been conducted in colon tumor and normal colon tissue specimens obtained from Chinese patients.

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      Influence of family history and preventive health behaviors on colorectal cancer screening in African Americans (pages 276–285)

      Kathleen A. Griffith, Deborah B. McGuire, Renee Royak-Schaler, Keith O. Plowden and Eileen K. Steinberger

      Version of Record online: 9 JUN 2008 | DOI: 10.1002/cncr.23550

      The results from this study indicated that recommendations for colorectal cancer (CRC) screening tests and preventive health behaviors were predictive of risk-appropriate screening regardless of whether there was a family history of CRC among African Americans. Individuals who had a family history of CRC were less likely to complete screening than their average-risk counterparts.

    6. Genitourinary Disease
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      Role of repeated biopsy of the prostate in predicting disease progression in patients with prostate cancer on active surveillance (pages 286–292)

      Mohammed Al Otaibi, Philip Ross, Nader Fahmy, Suganthiny Jeyaganth, Helen Trottier, Kanishka Sircar, Louis R. Bégin, Luis Souhami, Wassim Kassouf, Armen Aprikian and Simon Tanguay

      Version of Record online: 16 MAY 2008 | DOI: 10.1002/cncr.23575

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      The impact of repeated prostatic biopsy was evaluated in patients on active surveillance for localized prostate cancer. The presence of cancer on repeated biopsy after the diagnosis of prostate cancer is associated with an increased risk of disease progression. A prostate-specific antigen doubling time of <67 months was associated with an increased risk of pathologic disease progression.

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      High-dose interleukin-2 for the treatment of metastatic renal cell carcinoma : A retrospective analysis of response and survival in patients treated in the surgery branch at the National Cancer Institute between 1986 and 2006 (pages 293–301)

      Jacob A. Klapper, Stephanie G. Downey, Franz O. Smith, James C. Yang, Marybeth S. Hughes, Udai S. Kammula, Richard M. Sherry, Richard E. Royal, Seth M. Steinberg and Steven Rosenberg

      Version of Record online: 5 MAY 2008 | DOI: 10.1002/cncr.23552

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      High-dose interleukin-2 can be administered safely and can mediate complete tumor regression in patients with metastatic renal cell carcinoma. Although to the authors' knowledge there are few factors known to be predictive of response, patients who completely respond can expect long-term survival.

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      High mobility group AT-hook 1 (HMGA1) is an independent prognostic factor and novel therapeutic target in pancreatic adenocarcinoma (pages 302–314)

      Siong-Seng Liau, Flavio Rocha, Evan Matros, Mark Redston and Edward Whang

      Version of Record online: 12 MAY 2008 | DOI: 10.1002/cncr.23560

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      High mobility group AT-hook 1 (HMGA1) proteins are architectural transcriptional factors that are overexpressed in pancreatic adenocarcinomas. In this study, the authors demonstrated that HMGA1 is an independent predictor of poor postoperative survival in patients with pancreatic adenocarcinoma, and that HMGA1 promotes anchorage-independent cellular proliferation and in vivo tumorigenicity.

    9. Gynecologic Oncology
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      Cytoreductive surgery (peritonectomy procedures) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of diffuse peritoneal carcinomatosis from ovarian cancer (pages 315–325)

      Angelo Di Giorgio, Enzo Naticchioni, Daniele Biacchi, Simone Sibio, Fabio Accarpio, Monica Rocco, Sergio Tarquini, Marisa Di Seri, Antonio Ciardi, Daniele Montruccoli and Paolo Sammartino

      Version of Record online: 12 MAY 2008 | DOI: 10.1002/cncr.23553

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      Peritonectomy procedures plus HIPEC are suitable for the treatment of diffuse ovarian carcinomatosis. Morbidity and mortality rates are acceptable and the long-term results are promising for a significant improvement in survival for patients with primary or secondary diffuse ovarian carcinomatosis.

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      Cost-effectiveness analysis of prevention strategies for gynecologic cancers in Lynch syndrome (pages 326–335)

      Janice S. Kwon, Charlotte C. Sun, Susan K. Peterson, Kristin G. White, Molly S. Daniels, Stephanie G. Boyd-Rogers and Karen H. Lu

      Version of Record online: 27 MAY 2008 | DOI: 10.1002/cncr.23554

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      The results from this study indicated that annual screening followed by prophylactic hysterectomy and bilateral salpingo-oophorectomy was the most effective gynecologic cancer prevention strategy in Lynch syndrome. This strategy was associated with significant cost over prophylactic surgery alone, which underscores the need for improving the effectiveness and reducing the costs of screening in this population.

    11. Head and Neck Disease
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      Serum fucosylation changes in oral cancer and oral precancerous conditions : α-L-fucosidase as a marker (pages 336–346)

      Manisha Shah, Shaila Telang, Gira Raval, Pankaj Shah and Prabhudas S. Patel

      Version of Record online: 2 JUN 2008 | DOI: 10.1002/cncr.23556

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      The results from the current study indicated that altered levels of serum fucose, fucosylated glycoproteins (fucoproteins), fucosyltransferase, and α-L-fucosidase were associated strongly with oral cancer development and response to anticancer treatment in patients with oral cancer. α-L-fucosidase activity may serve as an easy and useful marker for early detection and monitoring treatment response of patients.

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      Retropharyngeal lymph node metastasis in nasopharyngeal carcinoma detected by magnetic resonance imaging : Prognostic value and staging categories (pages 347–354)

      Linglong Tang, Li Li, Yanping Mao, Lizhi Liu, Shaobo Liang, Yong Chen, Ying Sun, Xinbiao Liao, Li Tian, Aihua Lin, Mengzhong Liu and Jun Ma

      Version of Record online: 5 MAY 2008 | DOI: 10.1002/cncr.23555

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      The results of the current magnetic resonance imaging-based study indicate that retropharyngeal lymph node metastasis affects the distant metastasis-free survival rates of patients with nasopharyngeal carcinoma. The authors propose that retropharyngeal lymph node metastasis be classified as N1, regardless of its laterality.

    13. Discipline

      Hematologic Malignancies
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      Complete remission sustained 3 years from treatment initiation is a powerful surrogate for extended survival in multiple myeloma (pages 355–359)

      Bart Barlogie, Elias Anaissie, Jeffrey Haessler, Fritz van Rhee, Mauricio Pineda-Roman, Klaus Hollmig, Yazan Alsayed, Joshua Epstein, John D. Shaughnessy Jr and John Crowley

      Version of Record online: 9 MAY 2008 | DOI: 10.1002/cncr.23546

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      Sustaining complete remission for at least 3 years after onset of Total Therapy 2 defines myeloma patients with a subsequent 5-year survival estimate of 85% (8 years from treatment start) compared with less than 20% and 50%, respectively, for patients who attained and lost complete response status and those who never entered remission during that time frame.

    14. Disease Site

      Hematologic Malignancies
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      Phase 1 study of XL119, a rebeccamycin analog, in patients with refractory hematologic malignancies (pages 360–366)

      Gautam Borthakur, Yesid Alvarado, Farhad Ravandi-Kashani, Jorge Cortes, Zeev Estrov, Stefan Faderl, Percy Ivy, Carlos Bueso-Ramos, B. Nebiyou Bekele and Francis Giles

      Version of Record online: 12 MAY 2008 | DOI: 10.1002/cncr.23559

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      XL119 is a water-soluble derivative of rebeccamycin with dose-dependent myelosuppression as dose-limiting toxicity in phase 1 studies of solid tumors. A phase 1 study was conducted to determine the maximum tolerated dose and toxicities of XL119 in patients with advanced myelodysplastic syndrome and relapsed or refractory acute leukemias.

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      Randomized comparison of cladribine alone or in combination with cyclophosphamide, and cyclophosphamide, vincristine and prednisone in previously untreated low-grade B-cell non-Hodgkin lymphoma patients : Final report of the Polish Lymphoma Research Group (pages 367–375)

      Ewa Kalinka-Warzocha, Jaroslaw Wajs, Ewa Lech-Maranda, Bernadetta Ceglarek, Jerzy Holowiecki, Irena Federowicz, Jan Walewski, Jaroslaw Czyz, Tadeusz Robak, Krzysztof Warzocha and the Polish Lymphoma Research Group

      Version of Record online: 9 MAY 2008 | DOI: 10.1002/cncr.23558

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    16. Discipline

      Hematologic Malignancies
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      Prophylactic antibiotics reduce morbidity due to septicemia during intensive treatment for pediatric acute myeloid leukemia (pages 376–382)

      Beth Kurt, Patricia Flynn, Jerry L. Shenep, Stanley Pounds, Shelly Lensing, Raul C. Ribeiro, Ching-Hon Pui, Bassem I. Razzouk and Jeffrey E. Rubnitz

      Version of Record online: 5 MAY 2008 | DOI: 10.1002/cncr.23563

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      Children with AML given prophylactic intravenous cefepime or a vancomycin regimen experienced reduced rates of Streptococcus viridans sepsis and overall bacterial sepsis. Prophylactic antibiotic administration was associated with reduced days of hospitalization and healthcare charges.

    17. Disease Site

      Hematologic Malignancies
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      Multiple-dose granulocyte-macrophage–colony-stimulating factor plus 23-valent polysaccharide pneumococcal vaccine in patients with chronic lymphocytic leukemia : A prospective, randomized trial of safety and immunogenicity (pages 383–387)

      Amar Safdar, Gilhen H. Rodriguez, Adriana M. Rueda, William G. Wierda, Alessandra Ferrajoli, Daniel M. Musher, Susan O'Brien, Charles A. Koller, Gerald P. Bodey and Michael J. Keating

      Version of Record online: 9 MAY 2008 | DOI: 10.1002/cncr.23561

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      The objective of this study was to determine whether the administration of multiple-dose granulocyte-macrophage–colony-stimulating factor (GM-CSF) could improve response to standard 23-valent polysaccharide pneumococcal vaccine (PPV) in patients with chronic lymphocytic leukemia. The response to PPV was low despite immune enhancement with multiple doses of GM-CSF.

    18. Lung Disease
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      Randomized phase 2 study of irinotecan plus cisplatin versus gemcitabine plus vinorelbine as first-line chemotherapy with second-line crossover in patients with advanced nonsmall cell lung cancer (pages 388–395)

      Ji-Youn Han, Dae Ho Lee, Jung Eun Song, Sung Young Lee, Hyae Young Kim, Heung Tae Kim and Jin Soo Lee

      Version of Record online: 16 MAY 2008 | DOI: 10.1002/cncr.23582

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      Based on the favorable activity and tolerability of the combination of gemcitabine and vinorelbine reported in patients with nonsmall cell lung cancer (NSCLC), the authors conducted a phase 2 randomized trial to compare the nonplatinum-based regimen of gemcitabine plus vinorelbine with that of the combination of irinotecan plus cisplatin as first-line chemotherapy in patients with NSCLC to investigate the efficacy, toxicity, and survival of these alternating sequential treatment schedules. At the time of disease progression, crossover would occur.

    19. Discipline

      Lung Disease
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      Impact of computed tomography screening for lung cancer on participants in a randomized controlled trial (NELSON trial) (pages 396–404)

      Karien A. M. van den Bergh, Marie-Louise Essink-Bot, Eveline M. Bunge, Ernst Th. Scholten, Mathias Prokop, Carola A. van Iersel, Rob J. van Klaveren and Harry J. de Koning

      Version of Record online: 16 MAY 2008 | DOI: 10.1002/cncr.23590

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      To the authors' knowledge, the current study is the first empiric report to demonstrate that computed tomography (CT) screening for lung cancer has limited adverse effects on health-related quality of life. Waiting for the CT scan results was found to be discomforting to approximately half of the respondents.

    20. Disease Site

      Neuro-Oncology
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      Incidence of early pseudo-progression in a cohort of malignant glioma patients treated with chemoirradiation with temozolomide (pages 405–410)

      Walter Taal, Dieta Brandsma, Hein G. de Bruin, Jacoline E. Bromberg, Annemarie T. Swaak-Kragten, Peter A. E. Sillevis Smitt, Corine A. van Es and Martin J. van den Bent

      Version of Record online: 16 MAY 2008 | DOI: 10.1002/cncr.23562

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      The objective of the retrospective analysis was to evaluate the occurrence of early nontumoral progression in a cohort of malignant glioma patients treated with chemoirradiation with temozolomide. The results indicate that up to 50% of the patients with progression immediately after radiotherapy and concomitant temozolomide suffer from pseudo-progression.

    21. Sarcoma
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      Mortality after cure of soft-tissue sarcoma treated with conservation surgery and radiotherapy (pages 411–418)

      B. Ashleigh Guadagnolo, Gunar K. Zagars, Matthew T. Ballo, Sara S. Strom, Raphael E. Pollock and Robert S. Benjamin

      Version of Record online: 27 MAY 2008 | DOI: 10.1002/cncr.23593

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      Soft-tissue sarcoma (STS) comprises a group of potentially lethal diseases with significant risk for local recurrence and metastases. Primary treatment often requires multimodality therapy in an attempt to eradicate the disease. Although surgery remains the mainstay of local treatment, other studies have confirmed the benefit of adding radiotherapy (RT) to the treatment of nonmetastatic STS. The objective of the current study was to analyze the potential treatment-related mortality in long-term survivors of STS treated with RT and conservation surgery.

    22. Discipline

      Sarcoma
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      Combination of gemcitabine and docetaxel in the treatment of children and young adults with refractory bone sarcoma (pages 419–425)

      Fariba Navid, Jennifer Reikes Willert, M. Beth McCarville, Wayne Furman, Amy Watkins, William Roberts and Najat C. Daw

      Version of Record online: 16 MAY 2008 | DOI: 10.1002/cncr.23586

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      Gemcitabine in combination with docetaxel is well tolerated and demonstrates antitumor activity in children and adolescents with recurrent or refractory osteosarcoma and malignant fibrous histiocytoma. Further evaluation of this drug combination is warranted in these patients.

    23. Disparities Research
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      Characteristics of the original patient navigation programs to reduce disparities in the diagnosis and treatment of breast cancer (pages 426–433)

      Roberto B. Vargas, Gery W. Ryan, Catherine A. Jackson, Rian Rodriguez and Harold P. Freeman

      Version of Record online: 9 MAY 2008 | DOI: 10.1002/cncr.23547

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      The first patient navigation programs combined community and culturally sensitive care-coordination with aspects of disease management programs to reduce racial, ethnic, and poverty-driven disparities in care. Future efforts to replicate and evaluate patient navigation should take into account these unique aspects of the original patient navigation programs.

    24. Pediatric Oncology
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      Cancer screening practices of adult survivors of retinoblastoma at risk of second cancers (pages 434–441)

      Victoria Sheen, Margaret A. Tucker, David H. Abramson, Johanna M. Seddon and Ruth A. Kleinerman

      Version of Record online: 12 MAY 2008 | DOI: 10.1002/cncr.23564

      Self-reported cancer screening practices of adult retinoblastoma survivors are similar to other childhood cancer survivors and national screening patterns. Survivors should be encouraged to maintain current screening practices to ensure the early detection of second cancers in this high-risk population.

    25. Psychosocial Oncology
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      Beyond breaking bad news : The roles of hope and hopefulness (pages 442–445)

      Simon N. Whitney, Laurence B. McCullough, Ernest Frugé, Amy L. McGuire and Robert J. Volk

      Version of Record online: 16 MAY 2008 | DOI: 10.1002/cncr.23588

      The clinician who makes a diagnosis of cancer, or of a cancer becoming incurable, faces the challenge of informing the patient honestly of the situation without eliminating all hope. This challenge may be met by distinguishing between hope for specific outcomes, such as cure, and a more general hopefulness that can be maintained even in situations in which the prognosis is poor.

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