Use of hyperspectral imaging to distinguish normal, precancerous, and cancerous cells (pages 13–21)
Anwer M. Siddiqi, Hui Li, Fazlay Faruque, Worth Williams, Kent Lai, Michael Hughson, Steven Bigler, James Beach and William Johnson
Version of Record online: 22 JAN 2008 | DOI: 10.1002/cncr.23286
The Papanicolaou test has resulted in a significant decline in the mortality rate of cervical cancer despite of its high rate of false‒negative findings in patients with invasive cancer. In the current study, the authors report a new methodology with which to examine cervical cells using hyperspectral imaging that demonstrates an overall specificity of 95.8%, and a sensitivity for low‒grade, high‒grade, and squamous cell carcinoma of 66.7%, 93.5%, and 98.6%, respectively.