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Cancer Cytopathology

Cover image for Cancer Cytopathology

25 February 2008

Volume 114, Issue 1

Pages 1–64

Currently known as: Cancer Cytopathology

  1. Original Articles

    1. Top of page
    2. Original Articles
    1. Gynecologic Cytopathology

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      Cytologic findings after fertility-sparing radical trachelectomy (pages 1–6)

      Rusmir Feratovic, Sharyn N. Lewin, Yukio Sonoda, Kay J. Park, Nadeem R. Abu-Rustum, Andre L. Moreira and Oscar Lin

      Version of Record online: 17 DEC 2007 | DOI: 10.1002/cncr.23256

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      Radical trachelectomy is a surgical procedure that is intended to preserve fertility in patients with early-stage cervical carcinoma. In this procedure, the cervix is amputated in continuity with the parametrium and upper vagina, sparing the uterus and adnexa. Follow-up is performed with periodic cytology specimens. The objective of the current study was to analyze the cytologic findings after this novel procedure.

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      Effectiveness of the Thin Prep® Imaging System in the detection of adenocarcinoma of the gynecologic system (pages 7–12)

      Maria A. Friedlander, Dorota Rudomina and Oscar Lin

      Version of Record online: 17 DEC 2007 | DOI: 10.1002/cncr.23257

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      The ThinPrep Imaging System (TIS) has been approved for use by the U.S. Food and Drug Administration to decrease the number of false-negative results in ThinPrep gynecologic specimens and increase cytotechnology productivity. The goal of the current study was to evaluate the effectiveness of the TIS in detecting glandular abnormalities in cervicovaginal specimens.

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      Use of hyperspectral imaging to distinguish normal, precancerous, and cancerous cells (pages 13–21)

      Anwer M. Siddiqi, Hui Li, Fazlay Faruque, Worth Williams, Kent Lai, Michael Hughson, Steven Bigler, James Beach and William Johnson

      Version of Record online: 22 JAN 2008 | DOI: 10.1002/cncr.23286

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      The Papanicolaou test has resulted in a significant decline in the mortality rate of cervical cancer despite of its high rate of false‒negative findings in patients with invasive cancer. In the current study, the authors report a new methodology with which to examine cervical cells using hyperspectral imaging that demonstrates an overall specificity of 95.8%, and a sensitivity for low‒grade, high‒grade, and squamous cell carcinoma of 66.7%, 93.5%, and 98.6%, respectively.

    4. Fine-Needle Aspiration

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      Fine-needle aspiration of follicular adenoma versus parathyroid adenoma : The utility of multispectral imaging in differentiating lesions with subtle cytomorphologic differences (pages 22–26)

      Ibrahim Mansoor, Carola Zalles, Farhan Zahid, Kirk Gossage, Richard M. Levenson and David L. Rimm

      Version of Record online: 17 DEC 2007 | DOI: 10.1002/cncr.23252

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      The current study illustrates the use of multispectral imaging in distinguishing morphologically similar entities. The distinction between follicular adenoma of the thyroid and parathyroid adenoma is made with a high sensitivity and specificity.

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      Nodule heterogeneity as shown by size differences between the targeted nodule and the tumor in thyroidectomy specimen : A cause for a false-negative diagnosis of papillary thyroid carcinoma on fine-needle aspiration (pages 27–33)

      Masood A. Siddiqui, Kent A. Griffith, Claire W. Michael and Robert T. Pu

      Version of Record online: 17 DEC 2007 | DOI: 10.1002/cncr.23253

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      Whether the detection of papillary thyroid carcinoma is correlated with nodule heterogeneity has not been studied to date. The findings of the current study indicate that the heterogeneity of the targeted nodule is a significant factor for sampling error as highlighted by the size difference noted between the targeted nodule and the tumor in the thyroidectomy specimen.

    6. Immunocytochemistry

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      Evaluation of p16INK4a as a diagnostic tool in the triage of Pap smears demonstrating atypical squamous cells of undetermined significance (pages 34–48)

      Lisa Duncan, Sanjivini Jacob and Elizabeth Hubbard

      Version of Record online: 10 JAN 2008 | DOI: 10.1002/cncr.23255

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      p16 immunohistochemistry was performed on 178 ThinPrep Pap smears to determine if this marker can be used as a diagnostic tool in atypical squamous cells of undetermined significance (ASCUS) Pap smear triage that would allow recategorization of the smear to negative for intraepithelial lesion or malignancy (NILM) in cases having a p16 staining score of 0. p16 stains were scored and comparison was made with results of Hybrid Capture 2 and follow-up. The sensitivity and specificity of the p16 scoring system was found to be inadequate to justify its application as a tool in recategorizing ASCUS Pap smears to NILM before final case disposition as a means to prevent unnecessary and expensive follow-up.

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      Utility of anti-L523S antibody in the diagnosis of benign and malignant serous effusions (pages 49–56)

      Krisztina Z. Hanley, Michael S. Facik, Patricia A. Bourne, Qi Yang, Betsy O. Spaulding, Thomas A. Bonfiglio and Haodong Xu

      Version of Record online: 20 DEC 2007 | DOI: 10.1002/cncr.23254

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      Anti-L523S/KOC antibody is a useful marker for detection of malignant cells in serous effusions, and it has significant utility in differentiating reactive mesothelial cells from malignant mesothelioma and metastatic carcinoma in combination with calretinin and CK5/6 staining.

    8. Molecular Diagnostics

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      Quantitative methylation-specific PCR for the detection of aberrant DNA methylation in liquid-based Pap tests (pages 57–64)

      Steven L. Kahn, Brigitte M. Ronnett, Patti E. Gravitt and Karen S. Gustafson

      Version of Record online: 7 JAN 2008 | DOI: 10.1002/cncr.23258

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      Aberrant DNA methylation of 4 genes (DAPK1, IGSF4, SPARC, and TFPI2) detected by quantitative methylation-specific polymerase chain reaction (PCR) in cervical cytology samples can distinguish high-grade squamous intraepithelial lesions (HSIL) from combined negative for intraepithelial lesion or malignancy (NILM)/low-grade SIL (LSIL) Pap test samples. However, the identification of additional genes that are selectively methylated in HSIL is required to improve clinical performance.

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