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Cancer Cytopathology

Cover image for Cancer Cytopathology

25 August 2008

Volume 114, Issue 4

Pages 219–284

Currently known as: Cancer Cytopathology

  1. Editorial

    1. Top of page
    2. Editorial
    3. Commentary
    4. Original Articles
    5. Erratum
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      Screening for endometrial cancer? (pages 219–221)

      William J. Frable

      Version of Record online: 10 JUL 2008 | DOI: 10.1002/cncr.23705

      Even with direct endometrial sampling as an outpatient/office procedure, a screening program to detect endometrial cancer remains elusive. In this issue of Cancer Cytopathology, Kipp et al report on the feasibility of direct uterine sampling using the Tao brush sampler and a liquid–based cytology preparation for the detection of endometrial cancer.

  2. Commentary

    1. Top of page
    2. Editorial
    3. Commentary
    4. Original Articles
    5. Erratum
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      PEL and HHV8-unrelated effusion lymphomas : Classification and diagnosis (pages 225–227)

      Antonino Carbone and Annunziata Gloghini

      Version of Record online: 12 MAY 2008 | DOI: 10.1002/cncr.23597

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      Primary effusion lymphoma (PEL) cases are universally associated with Kaposi sarcoma herpesvirus/human herpesvirus 8 (KSHV/HHV8). PEL needs to be differentiated from those lymphomas occurring in patients in whom effusions complicate a tissue-based lymphoma, the so-called secondary lymphomatous effusion. A more subtle diagnosis consists of differentiating PEL from other types of lymphomas primarily involving the serous body cavities.

  3. Original Articles

    1. Top of page
    2. Editorial
    3. Commentary
    4. Original Articles
    5. Erratum
    1. Gynecologic Cytopathology

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      Direct uterine sampling with the Tao brush sampler using a liquid-based preparation method for the detection of endometrial cancer and atypical hyperplasia : A feasibility study (pages 228–235)

      Benjamin R. Kipp, Fabiola Medeiros, Michael B. Campion, Tammy J. Distad, Lisa M. Peterson, Gary L. Keeney, Kevin C. Halling and Amy C. Clayton

      Version of Record online: 11 JUN 2008 | DOI: 10.1002/cncr.23636

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      Endometrial cytology specimens collected with the Tao brush sampler (direct uterine sampling) and processed by using liquid-based cytology can detect endometrial cancer and atypical hyperplasia.

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      Assessment of reflex human papillomavirus DNA testing in patients with atypical endocervical cells on cervical cytology (pages 236–241)

      Longwen Chen and Bin Yang

      Version of Record online: 11 JUN 2008 | DOI: 10.1002/cncr.23639

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      Reflex high-risk human papillomavirus DNA testing has a high sensitivity and specificity in the detection of cervical adenocarcinoma in situ/adenocarcinoma and high-grade squamous dysplasia among patients with atypical endocervical cells on cervical cytology. It can be a useful ancillary tool in the selection of high-risk patients for colposcopy.

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      Adjunctive high-risk human papillomavirus DNA testing is a useful option for disease risk assessment in patients with negative Papanicolaou tests without an endocervical/transformation zone sample (pages 242–248)

      Chengquan Zhao and R. Marshall Austin

      Version of Record online: 16 MAY 2008 | DOI: 10.1002/cncr.23598

      High-risk (hr) human papillomavirus (HPV) DNA testing is highly effective in stratifying risk for the presence of squamous intraepithelial lesions in women with and without an endocervical/transformation zone sample (EC/TZS). hrHPV DNA results provide a useful new optional adjunctive tool for the objective stratification of disease risk in women with negative Papanicolaou smears with no EC/TZS.

    4. Fine-Needle Aspiration

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      Large, clear cytoplasmic vacuolation : An under-recognized cytologic clue to distinguish solid pseudopapillary neoplasms of the pancreas from pancreatic endocrine neoplasms on fine-needle aspiration (pages 249–254)

      Nirag Jhala, Gene P. Siegal and Darshana Jhala

      Version of Record online: 16 MAY 2008 | DOI: 10.1002/cncr.23595

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      Solid pseudopapillary neoplasm (SPN) and pancreatic endocrine neoplasm (PEN) of the pancreas share many morphologic similarities on fine–needle aspiration. In this article, the authors demonstrate that large, clear cytoplasmic vacuoles noted on Diff-Quik stains should serve as a critical clue to distinguish SPN from PEN in challenging cases.

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      Endoscopic ultrasound-guided fine-needle aspiration cytology of pancreatic neuroendocrine tumors : A study of 48 cases (pages 255–262)

      Paschalis Chatzipantelis, Charitini Salla, Panagiotis Konstantinou, Ioannis Karoumpalis, Stratigoula Sakellariou and Irini Doumani

      Version of Record online: 10 JUL 2008 | DOI: 10.1002/cncr.23637

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      The authors present cytopathologic and immunocytochemical features of neuroendocrine tumors of the pancreas obtained by endoscopic ultrasound-guided fine-needle aspiration in the largest series (48 cases) in the literature. Special emphasis is given in the specific cytomorphologic findings and differential diagnostic dilemmas of these tumors.

    6. Analytical Cytopathology

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      Contribution of DNA ploidy image cytometry to the management of ASC cervical lesions (pages 263–269)

      Marianne Lorenzato, Stephanie Caudroy, Jean-Marie Nou, Veronique Dalstein, Karine Joseph, Salima Bellefqih, Anne Durlach, Corinne Thil, Francine Dez, Dominique Bouttens, Christine Clavel and Philippe Birembaut

      Version of Record online: 10 JUL 2008 | DOI: 10.1002/cncr.23638

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      The Bethesda system classifies smears that suggest an underlying cervical intraepithelial neoplasia (CIN) as ASC (atypical squamous cell) smears. ASC smears are subdivided into ASCUS (of undetermined significance) and ASCH (cannot exclude a high-grade lesion). Today the management of ASCUS is a triage with HR-HPV testing, and colposcopy is recommended for ASCH. The aim was to conduct a study on ASC smears to determine if DNA ploidy measurement could help for the detection of CIN2+.

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      Diagnostic significance of ‘atypia’ in instrumented versus voided urine specimens (pages 270–274)

      Umesh Kapur, Girish Venkataraman and Eva M. Wojcik

      Version of Record online: 11 JUN 2008 | DOI: 10.1002/cncr.23656

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      Urine cytology plays an important role in monitoring patients with a history of urothelial carcinoma. Because it is difficult to reliably discriminate artifacts induced by instrumentation, inflammation, or therapy from malignant cells, many of these specimens are categorized as atypical. The current study attempted to examine the prevalence and significance of atypical urine specimens. In the absence of benchmark for atypia rate, it is important to restrict the diagnosis of atypia to cases with cytological features worrisome for malignancy that require a careful follow-up, thus keeping the atypia rate low and more meaningful.

    8. Molecular Diagnostics

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      Magnetic enrichment of bronchial epithelial cells from sputum for lung cancer diagnosis (pages 275–283)

      Qi Qiu, Nevins W. Todd, Ruiyun Li, Hong Peng, Zhenqiu Liu, Harris G. Yfantis, Ruth L. Katz, Sanford A. Stass and Feng Jiang

      Version of Record online: 16 MAY 2008 | DOI: 10.1002/cncr.23596

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      The enrichment of bronchial epithelial cells by magnetic-assisted cell sorting could improve the diagnostic value of sputum and efficiency of genetic and cytologic analysis of lung cancer.

  4. Erratum

    1. Top of page
    2. Editorial
    3. Commentary
    4. Original Articles
    5. Erratum
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      Erratum (page 284)

      Version of Record online: 21 JUL 2008 | DOI: 10.1002/cncr.23634

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