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Cancer

Cover image for Cancer

15 July 2009

Volume 115, Issue 14

Pages 3163–3372

  1. News

    1. Top of page
    2. News
    3. Review Article
    4. Original Articles
    5. Correspondence
    6. Erratum
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      CancerScope (pages 3163–3165)

      Carrie Printz

      Article first published online: 3 JUL 2009 | DOI: 10.1002/cncr.24358

  2. Review Article

    1. Top of page
    2. News
    3. Review Article
    4. Original Articles
    5. Correspondence
    6. Erratum
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      Novel chemotherapy approaches for cervical cancer (pages 3166–3180)

      Sujana Movva, Lorna Rodriguez, Hugo Arias-Pulido and Claire Verschraegen

      Article first published online: 18 MAY 2009 | DOI: 10.1002/cncr.24364

      Cervical cancer is the second most common malignancy in women worldwide. The medical management of cervical cancer has been evolving with novel therapeutic agents and neoadjuvant treatment approaches to care.

  3. Original Articles

    1. Top of page
    2. News
    3. Review Article
    4. Original Articles
    5. Correspondence
    6. Erratum
    1. Disease Site

      Breast Disease
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      Ductal carcinoma in situ in African American versus Caucasian American women : Analysis of clinicopathologic features and outcome (pages 3181–3188)

      Hind Nassar, Bashar Sharafaldeen, Kala Visvanathan and Daniel Visscher

      Article first published online: 18 MAY 2009 | DOI: 10.1002/cncr.24376

      The authors reviewed cases of ductal carcinoma in situ (DCIS) diagnosed in African American (AA) and Caucasian American patients, and found that pathological features, treatment, and recurrence rate were similar in both groups, as was death due to breast cancer. DCIS was diagnosed at a later age, however, in AA women and overall survival was worse in this population.

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      The association of nonalcoholic steatohepatitis and tamoxifen in patients with breast cancer (pages 3189–3195)

      Tom Saphner, Shirley Triest-Robertson, Hailun Li and Paul Holzman

      Article first published online: 29 MAY 2009 | DOI: 10.1002/cncr.24374

      Nonalcoholic steatohepatitis (NASH) was present in 24 of 1105 patients who had breast cancer (2.2%). NASH was associated with the use of tamoxifen and improved when tamoxifen was stopped.

    3. Gastrointestinal Disease
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      The clinical application of 18F-fluorodeoxyglucose positron emission tomography to predict survival in patients with operable esophageal cancer (pages 3196–3203)

      Hiroyuki Kato, Masanobu Nakajima, Makoto Sohda, Naritaka Tanaka, Takanori Inose, Tatsuya Miyazaki, Minoru Fukuchi, Noboru Oriuchi, Keigo Endo and Hiroyuki Kuwano

      Article first published online: 26 MAY 2009 | DOI: 10.1002/cncr.24399

      The clinical application of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), highest standardized uptake value in the primary or regional area (peak standardized uptake value), and number of PET-positive lymph nodes were found to be independent predictive factors of overall survival. The number of PET-positive lymph nodes was the single prognostic factor found to be predictive of both disease-free survival and overall survival. In brief, pretreatment PET was predictive of patient survival after surgical resection of esophageal cancer.

    4. Gynecologic Oncology
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      NV-128, a novel isoflavone derivative, induces caspase-independent cell death through the Akt/mammalian target of rapamycin pathway (pages 3204–3216)

      Ayesha B. Alvero, Michele K. Montagna, Rui Chen, Ki Hyung Kim, Kim Kyungjin, Irene Visintin, Han-Hsuan Fu, David Brown and Gil Mor

      Article first published online: 26 MAY 2009 | DOI: 10.1002/cncr.24397

      The authors characterized a novel isoflavone derivative, NV-128, as an inducer of cell death through a caspase-independent pathway. The results indicated that inhibition of the mammalian target of rapamycin may represent a relevant pathway for induction of cell death in cells that are resistant to classic, caspase-dependent apoptosis.

    5. Hematologic Malignancies
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      Survival is poorer in patients with secondary core-binding factor acute myelogenous leukemia compared with de novo core-binding factor leukemia (pages 3217–3221)

      Gautam Borthakur, E Lin, Nitin Jain, Elihu E. Estey, Jorge E. Cortes, Susan O'Brien, Stefan Faderl, Farhad Ravandi, Sherry Pierce and Hagop Kantarjian

      Article first published online: 13 MAY 2009 | DOI: 10.1002/cncr.24367

      Clinical outcomes in patients with secondary core–binding factor (CBF) acute myelogenous leukemia (AML) were considered to be equivalent to those of patients with de novo CBF AML. Worse overall survival was documented in patients with secondary CBF AML compared with matched de novo counterparts.

    6. Lung Disease
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      Promoter methylation of glutathione S-transferase π1 and multidrug resistance gene 1 in bronchioloalveolar carcinoma and its correlation with DNA methyltransferase 1 expression (pages 3222–3232)

      Peng Gao, Xi Yang, Yu-Wen Xue, Xiao-Fang Zhang, Yan Wang, Wen-Jun Liu and Xiao-Juan Wu

      Article first published online: 29 MAY 2009 | DOI: 10.1002/cncr.24369

      Glutathione S-transferase π1 promoter methylation mediated by DNA methyltransferase 1 (DNMT1) was investigated to determine whether it promotes the progression of bronchioloalveolar carcinoma (BAC). The results indicated that DNMT1 protein expression may be considered a prognostic indicator, that methylation of the multidrug resistance gene 1 promoter may be mediated through pathways other than DNMT1 in BAC, and that it does not appear to be associated with disease progression or prognosis in patients with BAC.

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      Is sex associated with the outcome of patients treated with radiation for nonsmall cell lung cancer? (pages 3233–3242)

      Susan L. McGovern, Zhongxing Liao, M. Kara Bucci, Mary Frances McAleer, Melenda D. Jeter, Joe Y. Chang, Michael S. O'Reilly, James D. Cox, Pamela K. Allen and Ritsuko Komaki

      Article first published online: 26 MAY 2009 | DOI: 10.1002/cncr.24361

      A retrospective review of 831 nonsmall cell lung cancer (NSCLC) patients treated with radiation revealed that despite equivalent treatment, women with medically inoperable stage I disease have improved overall survival compared with men. Along with known prognostic factors for NSCLC, such as age, weight loss, and stage, sex remained significant on multivariate analysis of overall survival, supporting the hypothesis that sex is an important determinant of outcome in NSCLC patients receiving radiation.

    8. Neuro-Oncology
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      Carboplatin-based primary chemotherapy for infants and young children with CNS tumors (pages 3243–3253)

      Maryam Fouladi, Sri Gururangan, Albert Moghrabi, Peter Phillips, Lindsey Gronewold, Dana Wallace, Robert A. Sanford, Amar Gajjar, Larry E. Kun and Richard Heideman

      Article first published online: 29 MAY 2009 | DOI: 10.1002/cncr.24362

      In this report, the authors demonstrate that a moderately dose-intense carboplatin-based regimen is associated with response and outcome similar to that reported for cisplatin-containing regimens in young children with central nervous system malignancies. Of note is the marked activity of this regimen in patients with choroid plexus carcinomas and completely resected ependymomas.

    9. Sarcoma
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      Radiosensitivity translates into excellent local control in extremity myxoid liposarcoma : A comparison with other soft tissue sarcomas (pages 3254–3261)

      Peter W. M. Chung, Benjamin M. Deheshi, Peter C. Ferguson, Jay S. Wunder, Anthony M. Griffin, Charles N. Catton, Robert S. Bell, Lawrence M. White, Rita A. Kandel and Brian O'Sullivan

      Article first published online: 26 MAY 2009 | DOI: 10.1002/cncr.24375

      After combined limb conserving surgery and radiotherapy, the 5-year local recurrence free survival of 88 patients with extremity myxoid liposarcoma compared with a contemporary cohort of 603 patients with other extremity soft tissue sarcoma subtypes was 97.7% and 89.6%, respectively (P = .008). The overall local control rates were excellent, these results suggest the radiosensitivity of myxoid liposarcoma may allow further improvement in local control rates, in the appropriate setting.

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      Osteosarcoma of the jaw/craniofacial region : Outcomes after multimodality treatment (pages 3262–3270)

      B. Ashleigh Guadagnolo, Gunar K. Zagars, A. Kevin Raymond, Robert S. Benjamin and Erich M. Sturgis

      Article first published online: 20 APR 2009 | DOI: 10.1002/cncr.24297

      Osteosarcoma of the head and neck (OHN) is a rare presentation of osteosarcoma, and exhibits a clinical behavior and natural history that are distinct from those of osteosarcoma occurring in the trunk and extremity. Radical surgery is the mainstay of treatment in any attempt at curative management, although to the authors' knowledge, the role of radiotherapy (RT) has not been clearly defined to date. The current study was performed to evaluate outcomes in patients with OHN who were treated with surgery with or without RT.

    11. Discipline

      Complementary Medicine
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      Prevalence and predictors of antioxidant supplement use during breast cancer treatment : The Long Island Breast Cancer Study Project (pages 3271–3282)

      Heather Greenlee, Marilie D. Gammon, Page E. Abrahamson, Mia M. Gaudet, Mary Beth Terry, Dawn L. Hershman, Manisha Desai, Susan L. Teitelbaum, Alfred I. Neugut and Judith S. Jacobson

      Article first published online: 8 JUN 2009 | DOI: 10.1002/cncr.24378

      The authors examined the prevalence and predictors of antioxidant supplement use in the form of multivitamins and single vitamin supplements during breast cancer treatment among women with breast cancer who participated in a population-based case-control study. The results indicated that many study participants used antioxidant supplements during breast cancer treatment, often at high doses and in conjunction with other complementary therapies.

    12. Disparities Research
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      Medical interpreter knowledge of cancer and cancer clinical trials (pages 3283–3292)

      Karen Donelan, Karin Hobrecker, Lidia Schapira, Johanna R. Mailhot, Bernardo H. Goulart and Bruce A. Chabner

      Article first published online: 29 MAY 2009 | DOI: 10.1002/cncr.24377

      A majority of participants in a medical interpreter training program reported basic knowledge gaps about key clinical concepts in cancer and concern about patient-physician communication. A content-specific training program improved participant knowledge and resulted in substantial interpreter satisfaction.

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      Under-representation of women in high-impact published clinical cancer research (pages 3293–3301)

      Reshma Jagsi, Amy R. Motomura, Sudha Amarnath, Aleksandra Jankovic, Nathan Sheets and Peter A. Ubel

      Article first published online: 8 JUN 2009 | DOI: 10.1002/cncr.24366

      This study reviewed cancer research published in 8 high-impact journals in 2006 and found that women continued to be under-represented as participants in recently published studies of non-sex–specific cancers. Studies that received government funding included a higher proportion of female subjects.

    14. Outcomes Research
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      Measuring therapeutic alliance between oncologists and patients with advanced cancer : The Human Connection Scale (pages 3302–3311)

      Jennifer W. Mack, Susan D. Block, Matthew Nilsson, Alexi Wright, Elizabeth Trice, Robert Friedlander, Elizabeth Paulk and Holly G. Prigerson

      Article first published online: 29 MAY 2009 | DOI: 10.1002/cncr.24360

      The authors developed and validated a measure of therapeutic alliance between patients with advanced cancer and their physicians (The Human Connection scale) and evaluated the effects of therapeutic alliance on end-of-life experiences and care. The results indicated that the scale is a valid and reliable measure of therapeutic alliance between patients with advanced cancer and their physicians, and a strong therapeutic alliance was associated with emotional acceptance of a terminal illness and with decreased intensive care unit care at the end of life among patients with advanced cancer.

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      Health status and quality of life among non-Hodgkin lymphoma survivors (pages 3312–3323)

      Sophia K. Smith, Sheryl Zimmerman, Christianna S. Williams and Bradley J. Zebrack

      Article first published online: 18 MAY 2009 | DOI: 10.1002/cncr.24391

      Although patients with lymphoma who had active disease reported more negative outcomes compared with off-treatment survivors, the length of time after diagnosis did not appear to matter with regard to outcomes for those who were in remission or who achieved a cure. In addition, mixed results from comparisons with general population norms suggested the need for supportive care for this diverse survivorship group.

    16. Pathology
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      Tumor budding in tumor invasive front predicts prognosis and survival of patients with esophageal squamous cell carcinomas receiving neoadjuvant chemotherapy (pages 3324–3334)

      Hiroshi Miyata, Akiko Yoshioka, Makoto Yamasaki, Yoichiro Nushijima, Shuji Takiguchi, Yoshiyuki Fujiwara, Toshiro Nishida, Masayuki Mano, Masaki Mori and Yuichiro Doki

      Article first published online: 18 MAY 2009 | DOI: 10.1002/cncr.24390

      To the authors' knowledge, the best method for evaluating the response to chemotherapy for esophageal cancers based on histopathologic examination has not been established to date. This study showed that tumor budding in the invasive front of tumors correlated significantly with clinical response and prognosis of patients with esophageal squamous cell carcinomas who received neoadjuvant chemotherapy.

    17. Pediatric Oncology
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      Emesis predicts bacteremia in immunocompromised children with central venous catheters and fever (pages 3335–3340)

      Matthew W. Richardson, Satkiran S. Grewal and Paul F. Visintainer

      Article first published online: 15 MAY 2009 | DOI: 10.1002/cncr.24380

      Immunocompromised children who had a central venous catheter and fever and who presented with vomiting were more likely to have bacteremia, particularly with Gram-negative organisms, than similar children who presented without vomiting. This finding may be useful in identifying children who are at high risk for bacteremia and in determining initial, empiric therapy.

    18. Psychosocial Oncology
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      Making a link between childhood physical abuse and cancer : Results from a regional representative survey (pages 3341–3350)

      Esme Fuller-Thomson and Sarah Brennenstuhl

      Article first published online: 26 MAY 2009 | DOI: 10.1002/cncr.24372

      A significant and highly stable association between childhood physical abuse and cancer was found. The association exists even when adjusting for 3 clusters of risk factors relating to cancer and childhood physical abuse.

    19. Symptom Control and Palliative Care
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      The cancer Support Person's Unmet Needs Survey : Psychometric properties (pages 3351–3359)

      H. Sharon Campbell, Rob Sanson-Fisher, Jill Taylor-Brown, Lynda Hayward, X. Sunny Wang and Donna Turner

      Article first published online: 26 MAY 2009 | DOI: 10.1002/cncr.24386

      Little is known about those who support cancer survivors after their active treatment is complete, yet they may play an important role in survivors' long-term adjustment and quality of life. The Support Person Unmet Needs Survey is a psychometrically robust instrument that can provide the cancer control community with valuable data for planning survivorship services with support persons in mind as well as cancer survivors.

    20. Translational Research
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      Targeting the urokinase plasminogen activator receptor with a monoclonal antibody impairs the growth of human colorectal cancer in the liver (pages 3360–3368)

      George Van Buren II, Michael J. Gray, Nikolaos A. Dallas, Ling Xia, Sherry J. Lim, Fan Fan, Andrew P. Mazar and Lee M. Ellis

      Article first published online: 29 MAY 2009 | DOI: 10.1002/cncr.24371

      Despite improvements with current first-line therapy for metastatic colorectal cancer (mCRC), the median overall survival for patients with mCRC is approximately 20 months. Therefore, new targeted therapeutics are necessary to further improve treatment options in the field. The results of the current study demonstrate the importance of urokinase plasminogen activator receptor (uPAR) in CRC tumor growth and supports the further study of uPAR as a therapeutic target for the treatment of CRC. uPAR monoclonal antibody therapy was found to impair colorectal carcinoma tumor growth in the liver in both small-volume and large-volume disease models.

  4. Correspondence

    1. Top of page
    2. News
    3. Review Article
    4. Original Articles
    5. Correspondence
    6. Erratum
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      Agent Orange exposure, Vietnam War veterans, and the risk of prostate cancer (pages 3369–3371)

      Arnold Schecter, Larry Needham, Marian Pavuk, Joel Michalek, Justin Colacino, Jake Ryan, Olaf Päpke and Linda Birnbaum

      Article first published online: 4 MAY 2009 | DOI: 10.1002/cncr.24365

  5. Erratum

    1. Top of page
    2. News
    3. Review Article
    4. Original Articles
    5. Correspondence
    6. Erratum
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      Erratum (page 3372)

      Article first published online: 26 MAY 2009 | DOI: 10.1002/cncr.24470

      This article corrects:

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