You have free access to this content


Cover image for Cancer

1 August 2009

Volume 115, Issue 15

Pages 3373–3590

  1. News

    1. Top of page
    2. News
    3. Editorial
    4. Review Article
    5. Original Articles
    1. You have free access to this content
      CancerScope (pages 3373–3375)

      Carrie Printz

      Article first published online: 20 JUL 2009 | DOI: 10.1002/cncr.24381

  2. Editorial

    1. Top of page
    2. News
    3. Editorial
    4. Review Article
    5. Original Articles
    1. You have free access to this content
      Twenty years of controversy surrounding combined androgen blockade for advanced prostate cancer (pages 3376–3378)

      Judd W. Moul

      Article first published online: 29 MAY 2009 | DOI: 10.1002/cncr.24393

      The current issue of Cancer includes a report on a concise, randomized controlled trial (RCT) with long-term follow-up that favors combined androgen blockade with bicalutamide versus lutenizing hormone-releasing hormone monotherapy in Japanese men with locally advanced and metastatic prostate cancer. It has been 20 years since the first RCT on CAB was published, and the debate continues.

  3. Review Article

    1. Top of page
    2. News
    3. Editorial
    4. Review Article
    5. Original Articles
    1. You have free access to this content
      Perineural invasion in cancer : A Review of the Literature (pages 3379–3391)

      Catherine Liebig, Gustavo Ayala, Jonathan A. Wilks, David H. Berger and Daniel Albo

      Article first published online: 29 MAY 2009 | DOI: 10.1002/cncr.24396

      Perineural invasion is emerging as an important prognostic feature in many malignancies, yet much remains to be understood about this pathologic process. For this review, the authors set forth a clear definition of perineural invasion and summarized the current literature regarding its clinical significance, molecular pathogenesis, and areas of targeted research.

  4. Original Articles

    1. Top of page
    2. News
    3. Editorial
    4. Review Article
    5. Original Articles
    1. Disease Site

      Endocrine Disease
      You have free access to this content
      Gemcitabine and oxaliplatin combination chemotherapy for metastatic well-differentiated neuroendocrine carcinomas : A single-center experience (pages 3392–3399)

      Philippe A. Cassier, Thomas Walter, Beatrice Eymard, Philippe Ardisson, Maurice Perol, Carole Paillet, Jean-Alain Chayvialle, Jean-Yves Scoazec, Valerie Hervieu and Catherine Lombard Bohas

      Article first published online: 26 MAY 2009 | DOI: 10.1002/cncr.24384

      In a retrospective study of 20 patients with metastatic neuroendocrine tumors, gemcitabine-oxaliplatin combination chemotherapy showed interesting activity, with a manageable toxicity profile, including in heavily pretreated patients.

    2. Gastrointestinal Disease
      You have free access to this content
      Macroscopic assessment of mesorectal excision in rectal cancer : A useful tool for improving quality control in a multidisciplinary team (pages 3400–3411)

      Eduardo García-Granero, Omar Faiz, Elena Muñoz, Blas Flor, Samuel Navarro, Carmen Faus, Stephannie Anne García-Botello, Salvador Lledó and Andrés Cervantes

      Article first published online: 28 MAY 2009 | DOI: 10.1002/cncr.24387

      Good surgical proficiency in the conduct of total mesorectal excision in patients with rectal cancer have been associated with lower rates of tumor recurrence after curative surgery. This paper sets out to audit the quality of mesorectal resection in these patients in a specialized university coloproctology unit.

    3. You have free access to this content
      The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history : A target for risk diagnosis and prevention of esophageal cancers (pages 3412–3426)

      Daiji Oka, Satoshi Yamashita, Tadashi Tomioka, Yukihiro Nakanishi, Hoichi Kato, Michio Kaminishi and Toshikazu Ushijima

      Article first published online: 26 MAY 2009 | DOI: 10.1002/cncr.24394

      Background mucosae of esophageal squamous cell carcinomas (ESCCs) accumulated aberrant DNA methylation, and methylation levels of 5 genes had significant correlation with smoking duration (P = .001 for the ubiquitin carboxyl-terminal esterase L1 gene UCHL1). The epigenetic field defect for ESCCs will provide novel target for risk diagnosis and cancer prevention.

    4. You have free access to this content
      Outcomes associated with cytoreductive surgery and intraperitoneal hyperthermic chemotherapy in colorectal cancer patients with peritoneal surface disease and hepatic metastases (pages 3427–3436)

      Oliver Varban, Edward A. Levine, John H. Stewart, Thomas P. McCoy and Perry Shen

      Article first published online: 4 JUN 2009 | DOI: 10.1002/cncr.24385

      Patients with peritoneal surface disease (PSD) + synchronous hepatic metastases (HM) who were treated with cytoreductive surgery + intraperitoneal hyperthermic chemotherapy for colorectal cancer were found to have no significant difference with regard to overall survival or morbidity compared with those with PSD alone. Most patients had a small hepatic tumor burden treated by wedge resection or ablative therapy.

    5. Genitourinary Disease
      You have free access to this content
      Combined androgen blockade with bicalutamide for advanced prostate cancer : Long-Term Follow-Up of a Phase 3, Double-Blind, Randomized Study for Survival (pages 3437–3445)

      Hideyuki Akaza, Shiro Hinotsu, Michiyuki Usami, Yoichi Arai, Hiroshi Kanetake, Seiji Naito and Yoshihiko Hirao

      Article first published online: 17 JUN 2009 | DOI: 10.1002/cncr.24395

      The long-term follow-up of the first double-blind, randomized study to directly compare combined androgen blockade (CAB) with bicalutamide 80 mg versus lutenizing hormone-releasing hormone agonist (LHRH-A) monotherapy demonstrated a significant overall survival advantage in favor of CAB. More patients who received CAB achieved a prostate-specific antigen (PSA) nadir of ≤1 ng/mL than patients who received LHRH-A monotherapy, and the patients who attained a PSA nadir of ≤1 ng/mL survived significantly longer than patients with PSA levels that remained above 1 ng/mL.

    6. You have free access to this content
      Does hormone treatment added to radiotherapy improve outcome in locally advanced prostate cancer? : Meta-Analysis of Randomized Trials (pages 3446–3456)

      Emilio Bria, Federica Cuppone, Diana Giannarelli, Michele Milella, Enzo Maria Ruggeri, Isabella Sperduti, Paola Pinnarò, Edmondo Terzoli, Francesco Cognetti and Paolo Carlini

      Article first published online: 29 MAY 2009 | DOI: 10.1002/cncr.24392

      To quantify the magnitude of the benefit of adding hormone treatment to exclusive radiotherapy for locally advanced prostate cancer, a literature-based meta-analysis was conducted. The addition of hormone suppression can significantly decrease the recurrences and improve the survival of patients affected by localized prostate cancer over radiotherapy, without affecting toxicity.

    7. You have free access to this content
      Activated extracellular signal-regulated kinase is an independent prognostic factor in clinically confined renal cell carcinoma (pages 3457–3467)

      Lee Campbell, Rosa Nuttall, David Griffiths and Mark Gumbleton

      Article first published online: 12 JUN 2009 | DOI: 10.1002/cncr.24389

      Expression of phosphorylated extracellular signal-regulated kinase was found to be an independent prognostic factor in renal cell carcinoma that is associated with advanced and aggressive pathologic features of renal tumors and predicts the onset of metastasis in patients with localized disease.

    8. You have free access to this content
      Single infusion of zoledronic acid to prevent androgen deprivation therapy-induced bone loss in men with hormone-naive prostate carcinoma (pages 3468–3474)

      Takefumi Satoh, Masaki Kimura, Kazumasa Matsumoto, Ken-ichi Tabata, Hiroshi Okusa, Hideharu Bessho, Masatsugu Iwamura, Hiromichi Ishiyama, Kazushige Hayakawa and Shiro Baba

      Article first published online: 29 MAY 2009 | DOI: 10.1002/cncr.24404

      A single infusion of zoledronic acid increased bone mineral density and decreased urine N-telopeptide levels in hormone-naive patients with prostate carcinoma. These effects were durable within 12 months after the initiation of androgen-deprivation therapy.

    9. Hematologic Malignancies
      You have free access to this content
      Vincristine sulfate liposomes injection (Marqibo) in heavily pretreated patients with refractory aggressive non-Hodgkin lymphoma : Report of the Pivotal Phase 2 Study (pages 3475–3482)

      M. A. Rodriguez, Robert Pytlik, Tomas Kozak, Mukesh Chhanabhai, Randy Gascoyne, Biao Lu, Steven R. Deitcher and Jane N. Winter

      Article first published online: 17 JUN 2009 | DOI: 10.1002/cncr.24359

      Sphingosomal vincristine is a new formulation of vincristine that can be safely administered to patients previously treated with vincristine, as well as other potential and neurotoxic agents. As a single agent, it has efficacy in the treatment of relapsed/refractory aggressive lymphomas, within an observed response rate of 44% of patients with previous sensitive disease, versus 17% in refractory patients.

    10. Hepatobiliary Disease
      You have free access to this content
      A uniform residual tumor (R) classification : Integration of the R classification and the circumferential margin status (pages 3483–3488)

      Christian Wittekind, Carolyn Compton, Phil Quirke, Iris Nagtegaal, Susanne Merkel, Paul Hermanek and Leslie H. Sobin

      Article first published online: 17 JUN 2009 | DOI: 10.1002/cncr.24320

      Recognition of the importance of the circumferential resection margin in patients with rectal cancer raised the need for an alternative definition of resection margin involvement. To avoid confusion by different definitions, the authors proposed including the minimal distance between tumor and resection margin into the current residual tumor classification. By using the proposed expanded classification, comparisons of new data with previous publications will be possible.

    11. Lung Disease
      You have free access to this content
      Discrimination of multiple primary lung cancers from intrapulmonary metastasis based on the expression of four cancer-related proteins (pages 3489–3500)

      Kenji Ono, Kenji Sugio, Hidetaka Uramoto, Tetsuro Baba, Yoshinobu Ichiki, Mitsuhiro Takenoyama, Takeshi Hanagiri, Tsunehiro Oyama and Kosei Yasumoto

      Article first published online: 18 MAY 2009 | DOI: 10.1002/cncr.24382

      The results of this study suggest that immunohistochemical analyses of the differential protein expression profiles of multiple genes can be used to distinguish multiple primary lung cancers from intrapulmonary metastasis, which, in turn, can be used for selection of patients at high risk for a poor prognosis.

    12. Neuro-Oncology
      You have free access to this content
      Overall survival of newly diagnosed glioblastoma patients receiving carmustine wafers followed by radiation and concurrent temozolomide plus rotational multiagent chemotherapy (pages 3501–3511)

      Mary Lou Affronti, Christopher R. Heery, James E. Herndon II, Jeremy N. Rich, David A. Reardon, Annick Desjardins, James J. Vredenburgh, Allan H. Friedman, Darell D. Bigner and Henry S. Friedman

      Article first published online: 9 JUN 2009 | DOI: 10.1002/cncr.24398

      Carmustine wafer with concurrent temozolomide and radiation followed by rotational chemotherapy is a well tolerated and effective therapy, and resulted in a statistically significant survival benefit compared with radiation alone. Although comparable to the Stupp regimen, limitations in retrospective analysis require future prospective randomized trials to compare postradiation multimodality regimens.

    13. You have free access to this content
      Temozolomide concomitant and adjuvant to radiotherapy in elderly patients with glioblastoma : Correlation with MGMT promoter methylation status (pages 3512–3518)

      Alba A. Brandes, Enrico Franceschi, Alicia Tosoni, Francesca Benevento, Luciano Scopece, Valeria Mazzocchi, Antonella Bacci, Raffaele Agati, Fabio Calbucci and Mario Ermani

      Article first published online: 9 JUN 2009 | DOI: 10.1002/cncr.24406

      In this study, the authors evaluated activity and toxicity of temozolomide concurrent with and adjuvant to radiotherapy for elderly glioblastoma patients, exploring correlations between clinical outcome and O6 methylguanine-DNA methyltransferase promoter methylation status. The overall and progression-free survival of patients are greater than historical data with radiotherapy alone; however, this regimen incurs a significant deterioration in mental status.

    14. Sarcoma
      You have free access to this content
      [F-18]-fluorodeoxy-D-glucose–positron emission tomography response is associated with outcome for extremity osteosarcoma in children and young adults (pages 3519–3525)

      Douglas S. Hawkins, Ernest U. Conrad III, James E. Butrynski, Scott M. Schuetze and Janet F. Eary

      Article first published online: 10 JUN 2009 | DOI: 10.1002/cncr.24421

      Forty patients with extremity osteosarcoma underwent [F-18]-fluorodeoxy-D-glucose–positron emission tomography (FDG-PET) imaging before and after neoadjuvant chemotherapy. The FDG-PET standard uptake value after chemotherapy was associated with progression-free survival.

    15. You have free access to this content
      Ewing sarcoma demonstrates racial disparities in incidence-related and sex-related differences in outcome : An analysis of 1631 cases from the SEER database, 1973-2005 (pages 3526–3536)

      Muhammad U. Jawad, Michael C. Cheung, Elijah S. Min, Michaela M. Schneiderbauer, Leonidas G. Koniaris and Sean P. Scully

      Article first published online: 22 JUN 2009 | DOI: 10.1002/cncr.24388

      Patients who were diagnosed with Ewing sarcoma between 1973 and 2005 were identified from the Surveillance, Epidemiology, and End Results database. Caucasians were affected more frequently, and a survival benefit was observed for women only among Caucasian patients, although outcomes were similar between races.

    16. You have free access to this content
      Comparing children and adults with synovial sarcoma in the Surveillance, Epidemiology, and End Results program, 1983 to 2005 : An analysis of 1268 patients (pages 3537–3547)

      Iyad Sultan, Carlos Rodriguez-Galindo, Raya Saab, Sameer Yasir, Michela Casanova and Andrea Ferrari

      Article first published online: 9 JUN 2009 | DOI: 10.1002/cncr.24424

      This study compares clinical features and outcomes of SS across the different age groups, by analyzing 1268 cases. Our results show that children and adults with SS have a similar clinical presentation but a dissimilar outcome. Whether this is due to different biology or therapeutic approaches is unresolved.

    17. Discipline

      Diagnostic Imaging
      You have free access to this content
      Cervical cancer histology and tumor differentiation affect 18F-fluorodeoxyglucose uptake (pages 3548–3554)

      Elizabeth A. Kidd, Christopher R. Spencer, Phyllis C. Huettner, Barry A. Siegel, Farrokh Dehdashti, Janet S. Rader and Perry W. Grigsby

      Article first published online: 26 MAY 2009 | DOI: 10.1002/cncr.24400

      In the current study, 18F-fluorodeoxyglucose uptake in cervical cancer varied by histology and differentiation. Squamous cell tumors showed a significantly higher maximal standardized uptake value (SUVmax) compared with nonsquamous cell tumors, and poorly differentiated tumors also had a higher SUVmax.

    18. Epidemiology
      You have free access to this content
      Cancer mortality in patients with schizophrenia : An 11-year prospective cohort study (pages 3555–3562)

      Eric Tran, Frédéric Rouillon, Jean-Yves Loze, Françoise Casadebaig, Alain Philippe, Fabien Vitry and Frédéric Limosin

      Article first published online: 22 JUN 2009 | DOI: 10.1002/cncr.24383

      In a cohort of 3470 patients with schizophrenia, during the 11 years of follow-up, the mortality rate was nearly 4-times higher than in the general population, with cancer being the second most frequent cause of death. In particular, an increased risk of mortality was found in women from breast cancer and in men from lung cancer.

    19. Outcomes Research
      You have free access to this content
      Associations of physician supplies with breast cancer stage at diagnosis and survival in Ontario, 1988 to 2006 (pages 3563–3570)

      Kevin M. Gorey, Isaac N. Luginaah, Eric J. Holowaty, Karen Y. Fung and Caroline Hamm

      Article first published online: 29 MAY 2009 | DOI: 10.1002/cncr.24401

      The authors investigated whether the supply of primary care physicians had protective effects on breast cancer stage and survival in Ontario and whether supply losses during the 1990s were associated with diminished protection. The results indicated that community healthcare service endowments that include adequate physician supplies may be particularly critical to the performance healthcare systems that provide universal accessibility to medically necessary care.

    20. Radiation Oncology
      You have free access to this content
      Phase 1 study of concurrent sunitinib and image-guided radiotherapy followed by maintenance sunitinib for patients with oligometastases : Acute toxicity and preliminary response (pages 3571–3580)

      Johnny Kao, Stuart Packer, Ha Linh Vu, Myron E. Schwartz, Max W. Sung, Richard G. Stock, Yeh-Chi Lo, Delphine Huang, Shu-Hsia Chen and Jamie A. Cesaretti

      Article first published online: 17 JUN 2009 | DOI: 10.1002/cncr.24412

      Twenty-one patients with metastatic lesions were treated with concurrent sunitinib (Day 1 through Day 28) and IGRT (40-50 Gy in 10 fractions starting on Day 8) followed by maintenance sunitinib (50 mg daily, 4 weeks on/2 weeks off, starting on Day 43). The addition of sunitinib (25 to 37.5 mg) to IGRT is tolerable in patients with oligometastases, without potentiation of RT toxicity.

    21. Translational Research
      You have free access to this content
      Mucinous gastric carcinomas : Clinicopathologic and molecular analyses (pages 3581–3590)

      Jong Sun Choi, Min A Kim, Hee Eun Lee, Hye Seung Lee and Woo Ho Kim

      Article first published online: 28 MAY 2009 | DOI: 10.1002/cncr.24422

      The authors analyzed clinicopathologic characteristics, mucin gene expression profiles, microsatellite instability, and status of the human epidermal growth factor receptor 2 and epidermal growth factor receptor (EGFR) in 133 mucinous gastric carcinomas (MGCs) and compared them with the same variables in nonmucinous gastric carcinomas (NMGCs). The results indicated that clinicopathologic and molecular characteristics of MGCs differ from those of NMGCs and that EGFR overexpression and histologic subtyping by predominant tumor cell type in mucin pools may be helpful for predicting clinical outcome in patients with MGC.