Array comparative genomic hybridization identifies genetic regions associated with outcome in aggressive diffuse large B-cell lymphomas (pages 3728–3737)
Cristina Robledo, Juan L. García, Dolores Caballero, Eulogio Conde, Reyes Arranz, Teresa Flores, Carlos Grande, José Rodríguez, Eva García, Ana I. Sáez, Marcos González, Norma C. Gutiérrez, Miguel A. Piris and Jesús M. Hernández
Version of Record online: 10 JUN 2009 | DOI: 10.1002/cncr.24430
Array comparative genomic hybridization identified multiple regions with common copy number changes in 40 patients with high-risk diffuse large B-cell lymphoma who were treated homogeneously with a regimen of dose-escalated cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) and intensification before high-dose therapy/autologous stem cell transplantation (Mega-CHOP). The results indicated that genomic changes may be associated with outcomes and response to Mega-CHOP.